Ceai Verde (Camellia Sinensis)

1 Ceai verde cu protectie anticarie, prin continutul de Flor de 0.01 % (cca.1 mg), are efect anticancer la 5-6 cesti de Ceai Verde infuzie

2 Ceai Verde cu continutul de catehine stimuleaza termogeneza in obezitate prin inhibarea enzimei catecol-o-metiltransferaza (COMT).

3 Ceai Verde stimuleaza termogeneza in obezitate si Spirulina moduleaza apetitul prin administrarea cu 30 min. inainte de masa

Ceai Verde (Camellia Sinensis) - foto

Ceai Verde (Camellia Sinensis)Regnul: Plantae - PlantaIncrengatura: Traheofitelor - Planta vascularaSubincrengatura: Spermatofita - Planta cu samintaClasa: Angiosperme - Dicotiledonate - EmbrionSubclasa: DillenidaeOrdinea: ThealesFamilia: TheaceaeGenul: Camellia L.Specia: Camellia Sinensis L. - Ceai Verde

Certified Organic Ceai Verde: Special Gunpowder

 

 

Ceai Verde infuzie 2-3 minute, cu apa fierbinte de 60-80 °C

Pentru a-si pastra aroma si gustul original

Ceai Verde cu aroma

Spirulina - Biscuiti

se recomanda cu:  

- Ceai verde contine: Flavonoizi, Polifenoli-cu monomeri sai catehine, cei mai importanti sint (-)-epigalocatehingalat (EGCG), (-)-epicatehingalat (ECG), (-)-epigalocatehin (EGC), (-)-epicatehin (EC), Cofeina (Teina), Metilxantine, Adenin, Guanin, Xantin und Hipoxantin, Flavonol si Flavone, Acizi fenolici, Depside, Saponine, Ulei eteric, Fluor, Potasium, Calciu, Zinc, Iod, Mangan, Teofilina (1,3-Dimetilxanthin, ca. 0,07-0,013%), Teobromina (3,7-Dimetilxanthin, ca. 0,002-0,013 %), Glutation, Carotina, Vitamin A, Vitamin B, Vitamin B2, Vitamin B12, Vitamin C.Fluorid si Bioflavonoide

- Polifenoli sint antioxidanti puternici (de 40 de ori mai tare ca Vitamina C si de 20 de ori mai mult ca: Vitamina E sau ca Glutationul redus (GSH), deasemenea au actiune radioprotectiva, antimutagene, antitumorale, antihipercolesterolemic, anti ulcer, reduce glicemia, antihipertensiv, antibacterial, antiviral, antitrombotic, previne si inhiba cancerul, anti-inflammator, termogenic si activitate, anticarie, actiune deodoranta.

Epigalocatehingalat (EGCG): Structura chimica

Epigalocatehingalat (EGCG): Formula moleculara: C22H18O11 Acetil L-Carnitina-HCl: Greutatea moleculara: 458.4

Epigalocatehingalat (EGCG ), Formula chimica: Epigalocatehin-3-galat(-)-epigalocatehingallat (EGCG)

4 Ceai verde compozitie

Teobromina

- Theobromin este un metabolit al cofeinei

- Ceaiul verde contine Teobromina = cca. 0,002-0,013%)

- Ceaiul verde contine cafeina si teobromina, substante stimulatoare ale sistemului nervos si muscular.Ideala pentru adolescentii care se pregatesc sau sustin examene. 

Teobromina: Structura chimica Teofilina: Structura chimica

Formula chimica este: 3,7-Dimethylxanthin,

Formula chimica este: 1,3-Dimethylxanthin,

Formula moleculara este: C7H8N4O2

Formula moleculara este: C7H8N4O2

- Ceaiul Verde contine Teofilina = cca. 0,07-0,013%)

- Teofilina indicat in tratamentul inotrop pozitiv al insuficientei cardiace, are efect vasodilatator coronarian, cu efect cronotrop negativ si actiune antiaritmica

5 Teofilina indicat in tratamentul de astm bronsic, destinde muschii si bronhiile pulmonare,

6 Teofilina indicat sindromul obstructiv pulmonar, un trial clinic randomizat

7 Alimente pentru promovarea sanatatii (Health Food): Fito-farmaceutice, alimente functionale (Functional foods) si terapii pentru combatera obezitatii

8 Ceaiul Verde cu continutul de lignan secoisolariciresinol si matairesinol polifenoli are efect cardioprotector in bolile cardiovasculare si bolile de ficat

9 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are activitate antioxidanta de neutralizare a radicalilor liberi: radicalul superoxid(O2

-), radicalul peroxil(RO2

-), radicalul peroxinitrit(OONO -), peroxid de hidrogen(H2O2) previne oxidarea LDL - biologia si medicina radicalilor liberi

Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina

Formarea de 8-hidroxi-2’-deoxiguanozina (8-OHdG) prin stress oxidativ

10 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are activitate antioxidanta de neutralizare a radicalilor liberi, inhiba peroxidarea lipidelor, degradarea ADN-ului, in 8-hidroxi-2’-deoxiguanozina (8-OHdG), este un biomarker a stresului oxidativ, acumulata in ADN cauzeaza disfunctia mitocondriala si criza energetica

11 In procesul de imbatrinire duplicarea ADN-ului nu se copiaza toata secventa, ci se pierde o bucatica din capatul cromozomului (Telomere), Ceaiul Verde antioxidant puternic intirzie procesul de imbatrinire (Anti Aging)

Cromozom cu secvente de telomere

Celula umana: Structura

12 Teoria radicalilor liberi in procesul de imbatrinire

Densitatea de neutralizare a radicalilor liberi

Celula este distrusa prin radicalii liberi:

Capacitate scazuta de neutralizare a radicalilor liberi

Suficienti antioxidanti de recomandat: Acid alfa lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari

Capacitate suficienta de neutralizare a radicalilor liberi

Antioxidantii neutralizeaza radicali liberi

Formarea de radicali liberi

Aparat de masurat capacitatea de neutralizare a radicalilor liberi - Potential redox ORP

13 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) antioxidant puternic un inhibitor enzimei de telomeraza

Studiu mecanizmului molecular in reglarea activitatii de telomeraza

14 Studiu mecanizmului molecular in reglarea activitatii de telomeraza enzima responsabila pentru multiplicarea celulei oncogene

15 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) previne cancerul, inhiba angiogeneza

16 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) inhiba cresterea tumorala

17 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are capacitatea de inhibare de enzima metaloproteinaza matricial -9(MMP-9) (cunoscut ca Gelatinaza B) si (Gelatinaza A) aceasta enzima detine un rol important pentru invazia tumorala si metastazarea cancerului

18 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) inhiba si actioneaza regresia la celulele de cancer de prostata (PC-3) si cancerul mamar

19 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) inhiba celulele oncogene

20 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) inhiba proteolitic enzima urokinaza si ornitin decarboxilaza, urokinaza este o enzima de care se foloseste celula de cancer pentru a intra in tesutul sanatos si a forma metastaze.

21 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) reduce enzima 5-alfa reductaza este un agent citostatic natural, inhiba proliferarea celulelor canceroase de prostata

Proliferarea celulelor canceroase

22 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) inhiba glioblastoma

23 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) previne riscul de melanom malign (cancer de piele) reduce inflamatia razelor UVB

24 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) este indicat in artrita, are actiune sinergica cu sulindac si tamoxifen

25 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) in efectul de productie de citokine proinflamatorii si anti-inflamator

26 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) indicat in tromboza venoasa

Tromboza venoasa

27 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are actiune antioxidanta reduce placa aterosclerotica, meta analiza

28 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) indicat la incidenta de infarct miocardic si bolile cardiovasculare, studiu Rotterdam

29 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) indicat la gastrita sau ulcer gastric

30 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) previne infectia cu Helicobacter pilori

31 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) indicat in infectiile intestinale cu Escherichia coli

32 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are efect terapeutic la infectia cu Legionella (Legionella pneumophila)

33 Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) cu actiune anti - HIV

34 L-Teanina din ceaiul verde cu gustul, aroma si efectul calmant, relaxant

Actiunea ceaiului verde fata de cafea

 

Ceai Verde infuzie 2-3 minute, cu apa fierbinte de 60-80 °C, pentru a-si pastra aroma si gustul original

L-Teanina:

Formula moleculara este C7H14O3 N,Greutatea moleculara este 160.19,Denumirea chimica este L-N-etilglutamina (L-N-ethylglutamine),L-Teanina din ceaiul verde este un derivat al aminoacidului L-Glutamic

L-Teanina: Structura chimica

L-Teanina din ceaiul verde (Camelia Sinensis) este predominant aminoacid din planta, in forma uscata cu un continut de 1% - 2%

35 L-Teanina in combinatie cu Adriamycin (Doxorubicin) este indicat in terapia cancerului mamar

36 L-Teanina coboara tensiunea arteriala, are efect de calmare reduce starile depresive si anxietate

37 L-Teanina ca stimulent cerebral cu eliberare de dopamina indicat in terapia Parkinson

Set: Cura de Slabire

 

Bibliografie-Referinte:

1. Otake S, Makimura M, Kuroki T, et al. Anticaries effects of polyphenolic compounds from Japanese green tea. Caries Res 1991; 25: 438-443.2. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity.Int J Obes Relat Metab Disord.2000 Feb;24(2):252-8. .- Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999; 70:1040-1045.3. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity.Int J Obes Relat Metab Disord.2000 Feb;24(2):252-8.4. Graham HN. Green tea composition, consumption, and polyphenol chemistry. Preventive Medicine 1992; 21: 334-350.5.Weinberger MM. Methylxanthines. In: Weiss EB, Stein M, editors. Bronchial asthma mechanisms and therapeutics. Boston: Little, Brown and Co, 1993: 746-83.- Fanta CH, Rossing TH, McFadden ER. Treatment of acute asthma is combination therapy with

sympathomimetics and methylxanthines indicated? Am J Med 1986; 80: 5-10.- Mahler DA, Matthay RA, Snyder PE, et al. Sustained release theophylline reduces dyspnea in nonreversible obstructive airway disease. Am Rev Respir Dis 1985; 131: 22-5.- Crescioli S, Spinazzi A, Plebani M, et al. Theophylline inhibits early and late asthmatic reactions induced by allergens in asthmatic subjects. Ann Allergy 1991; 66: 245-51.- Ward AJM, McKenniff M, Evans JM, et al. Theophylline an immunomodulatory role in asthma? Am Rev Respir Dis 1993; 147: 518-23.- Smolensky MH, D'Alonzo GE. Biologic rhythms and medicine. Am J Med 1988; 85 Suppl 1B: 34-46.6. Murciano D, Auclair MH, Pariente R, et al. A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary disease. N Engl J Med 1989; 320; 1521-5.- Vaz Fragoso CA, Miller MA. Review of the clinical efficacy of theophylline in the treatment of chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 147(2 Suppl): 40S-47S.7. Bloch AS. Nutrition for health promotion: phytochemicals, functional foods, and alternative approaches to combat obesity. Dent Clin North Am. 2003 Apr;47(2):411-23, viii-ix- Waltham, M.S. 1998. Roadmaps to Market: Commercializing Functional Foods and Nutraceuticals, Decision Resources, Inc., p. 5.- De Roos NM, Katan MB. Nutrition and health-sense and nonsense regarding food supplements and functional foods. Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijnsgeneeskunde, Postbus 85.500, 3508 GA Utrecht. Ned Tijdschr Geneeskd. 2003 Jan 11;147(2):56-60-5.- Clydesdale, F.M. 1997. A proposal for the establishment of scientific criteria for health claims for functional foods. Nutr. Rev. 55 (12): 413-422.8. Mazur WM, Wahala K, Rasku S, Salakka A, Hase T, Adlercreutz H. Lignan and isoflavonoid concentrations in tea. Department of Clinical Chemistry, University of Helsinki, Finland. Br J Nutr. 1998 Jan;79(1):37-45.- Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. British Medical Journal, 1995; 310: 693-696.9. Luo M, Kannar K, Wahlqvist ML, O'Brien RC. Inhibition of LDL oxidation by green tea extract. Lancet. 1997 Feb 1;349(9048):360-361.- Miura Y, Chiba T, Miura S, et al. Green tea polyphenols (flavan 3-ols) prevent oxidative modification of low density lipoproteins: an ex vivo study in humans. J Nutr Biochem. 2000; 11:216-222.- Yang TTC, Koo MWL. Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation. Atherosclerosis. 2000; 148:67-73.- Shi X, Ye J, Leonard SS, et al. Antioxidant properties of epicatechin gallate (ECG) and its inhibition of Cr (VI)-induced DNA damage and Cr (IV)- or TPA-stimulated NF-Kappa B activation. Mol Cell Biochem. 2000; 206:125-132.- Valcic S, Muders A, Jacobsen NE, Liebler DC, Timmermann BN. Antioxidant chemistry of green tea catechins. Identification of products of the reaction of (-)-epigallocatechin gallate with peroxyl radicals. Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, USA. Chem Res Toxicol. 1999 Apr;12(4):382-6.- Ketsawatsakul U., Whiteman M., Halliwell B. A reevaluation of the peroxynitrite scavenging activity of some dietary phenolics. Biochem. Biophys. Res. Commun., 279: 692-699, 2000.- Nakagawa K, Ninomiya M, Okubo T, Aoi N, Juneja LR, Kim M, Yamanaka K, Miyazawa T. Tea catechin supplementation increases antioxidant capacity and prevents phospholipid

hydroperoxidation in plasma of humans. Laboratory of Biodynamic Chemistry, Tohoku University Graduate School of Life Science and Agriculture, Sendai 981-8555, Japan. J Agric Food Chem. 1999 Oct;47(10):3967-73.- Wei H, Zhang X, Zhao JF, Wang ZY, Bickers D, Lebwohl M. Scavenging of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative DNA damage by aqueous extracts from green tea. Free Radic Biol Med. 1999;26(11-12):1427-1435.- Miyazawa T.Absorption, metabolism and antioxidative effects of tea catechin in humans. Biodynamics Chemistry, Lab., Tohoku University Graduate School of Life Science & Agriculture, Sendai, Japan. Biofactors. 2000;13(1-4):55-9.- Yang TTC, Koo MWI. Chinese green tea lowers cholesterol level through an increase in fecal lipid excreiton. Life Sciences. 1999:66:5:411-423.- M.K. Shigenaga and B.N. Ames. Free Radical Biology and Medicine 10:211-6,1991.10. Shigenaga MK, Ames BN. Assays for 8-hydroxy-2'-deoxyguanosine, a biomarker of in vivo oxidative DNA damage. Free Radic. Biol. Med., 1991; 10: 211-6.- H. Kasai, P.F. Crain, Y. Kuchino, S. Nishimura, A.Ootsuyama and H. Tanooka. Carcinogenesis 7:1849-51, 1986. 11. Boukamp P. Ageing mechansisms: the role of telomere loss. Clin Exp Dermatol, 2001; 26: 562-5.- Lorenz M, Saretzki, Sitte N, Metzkow S, Von Zglinicki T. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Rad Biol Med, 2001; 31: 824-31.- H. Ochi. Rouka seigyo syokuhin no kaihatsu (Development of foods for control of aging) Korin Press, p. 294, 1995.12. Beckman, K. & Ames, B. (1998) "The free radical theory of aging matures" Physiol Rev 78: 548-81.13. Naasani,I., Seimiya,H. and Tsuruo,T. (1998) Telomerase inhibition, telomere shortening and senescence of cancer cells by tea catechins. Biochem. Biophys. Res. Commun., 249, 391 –396.- Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Naasani I, Oh-Hashi F, Oh-Hara T, Feng WY, Johnston J, Chan K, Tsuruo T. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan. inaasani@biocrystal.com Cancer Res. 2003 Feb 15;63(4):824-30.14. Liu JP. Studies of the molecular mechanisms in the regulation of telomerase activity , FASEB J. 1999; 13: 2091-104.- Blackburn EH. Telomerase RNA structure and function. In "RNA Structure and Function"Ed. RW Simons and M Grunberg-Manago. Cold spring Harbor Laboratory Press, 1998; 669-693.- Kurfürst R, Joly R, Notarnicola C, Crabbé I, André P, Bonté F, Perrier P, Epidermal prevention of premature cellular senescence by telomerase and DNA protection, 2000; J Invest Dermatol, 115 (3): 54615. Imai K, Suga K, Nagachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med. 1997;26(6):769-775.- Mukhtar H., Ahmad N. Tea polyphenols: prevention of cancer and optimizing health. Am. J. Clin. Nutr., 71: 1698S-702S, 2000.- Cao Y., Cao R. Angiogenesis inhibited by drinking tea. Nature (Lond.), 398: 381 1999.- Brown MD. Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer. Alt Med Rev. 1999;4(5):360-370.

- Sazuka M, et al. Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells. Cancer Lett 1995;98:27-31.16. Sugiyama T, Sadzuka Y. Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma. Cancer letters 1998;133:19-26- Fujiki H, Suganuma M, Okabe S, et al. Cancer inhibition by green tea. Mutation Research. 1998;307-310.- Gao Yt, McLaughlin JK, Blot WJ Reduced risk of esophageal cancer associated with green tea consumption. J Natl Cancer Inst. 1994 Jun 1;86(11):855-8.- Hirose M. Inhibition of mammary gland carcinogenesis by green tea catechins. Cancer Lett 1994;83:149-156.- Inoue M, Tajima K, Mizutani M, et al. Regular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. Cancer Lett. 2001;167(2):175-182.- Kaegi E. Unconventional therapies for cancer: 2. Green tea. [Review]. The Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative. CMAJ. 1998;158(8):1033-1035.- Nakachi K, Suemasu K, Suga K, Takeo T, Imai K, Higashi Y. Influence of drinking green tea on breast cancer malignancy among Japanese patients. Jpn J Cancer Res. 1998;89(3):254-261.- Pianetti S, Guo S, Kavanagh KT, Sonenshein GE. Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells. Cancer Res. 2002;62(3):652-655.- Setiawan VW, Zhang ZF, Yu GP, et al. Protective effect of green tea on the risks of chronic gastritis and stomach cancer. Int J Cancer. 2001;92(4):600-604.- Sano T, Sasako M. Green tea and gastric cancer. N Engl J Med. 2001;344(9):675-676.- Tsubono Y, Nishino Y, Komatsu S, et al. Green tea and the risk of gastric cancer in Japan. N Engl J Med. 2001;344(9):632-636.- Yu GP, Hsieh CC, Wang LY, Yu SZ, Li XL, Jin TH. Green-tea consumption and risk of stomach cancer: a population-based case-control study in Shanghai, China. Cancer Causes Control. 1995;6(6):532-538.- Sugiyama T, Sadzuka Y. Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma. Cancer Lett. 1998;133(1):19–26.- Ji B-T, Chow W-H, Hsing AW, et al. Green tea consumption and the risk of pancreatic and colorectal cancers. Int J Cancer. 1997;70:255-258.- Fujiki H, Suganuma M, Okabe S, et al. Mechanistic findings of green tea as cancer preventive for humans. Proc Soc Exp Biol Med. 1999;220(4):225–228.- Ahmad N, Mukhtar H. Green tea polyphenols and cancer: biologic mechanisms and practical implications. Nutr Rev. 1999; 57:78-83.- Ahmad N, et al. Green tea constituent epigallocathechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. H Natl Cancer Inst 1997;89:1881-86.- Wang Z, et al. Antimutagenic activity of green tea polyphenols. Mutation Research. 1989;223:273-285.- Jankun J, et al. Why drinking green tea could prevent cancer. Nature 1997;387:561- Taniguchi S, et al. Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cells lines. Cancer Lett 1992;65:51-4.-Kaegi E, on behalf of the Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative. Unconventional therapies for cancer: 2. Green tea. Canadian Medical

Association 1998;158:1033-1035.17. Demeule M, Brossard M, Pagé, M, et al. Matrix metalloproteinase inhibition by green tea catechins. Biochim Biophys Acta. 2000; 1478:51-60.18. Liao S, Umekita Y, Guo J, Kokontis JM, Hiipakka RA. Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate. Cancer Lett. 1995;96:239-243.19. Hu G, Han C, Chen J.Inhibition of oncogene expression by green tea and (-)-epigallocatechin gallate in mice. Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China. Nutr Cancer. 1995;24(2):203-9.20. Carlin BI, Pretlow TG, Pretlow TP, et al. Green tea polyphenols inhibit growth of PC xenograft cwr-22 and decrease ornithine decarboxylase activity: implications for PC chemoprevention. J Urol 155: 510A, 1996.21. Liao S, Hipakka, RA. Selective inhibition of steroid 5-alfa-reductase [5AR] by tea epicatechin-3-gallate and epigallocatechin-3-gallate. Biochemical and Biophysical Research Communications; 214(3), 833-838,1995).- Gupta S, Ahmad N, Mukhtar H. Prostate cancer chemoprevention by green tea. Semin Urol Oncol. 1999; 17:70-76.- Suganuma M, Okabe S, Sueoka N, et al. Green tea and cancer chemoprevention. Mutation Res. 1999; 428:339-344.- Suganuma M, Okabe S, Kai Y, et al. Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Research 1999; 59: 44-47.22. Sachinidis A, Seul C, Seewald S, et al. Green tea compounds inhibit tyrosine phosphorylation of PDGF beta-receptor and transformation of A172 human glioblastoma. FEBS Lett. 2000; 471:51-55.23. Katiyar SK, Matsui MS, Elmets CA, Mukhtar H. Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem Photobiol 1999;69:148-153.- Mukhtar H., Katiyar S. K. et al. Green tea and skin: anticarcinogenic effects. J. Investig. Dermatol. 102: 3-7,24. Haqqi TM, Anthony DD, Gupta S, et al. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA. 1999; 96:4524-4529.- Suganuma M, Okabe S, Kai Y, et al. Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Research 1999; 59: 44-47.25. Crouvezier, S., Powell, B., Keir, D., and Yaqoob, P. (2001) The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro. Cytokine 13, 280-286.26. Kang WS, Lim IH, Yuk DY, et al. Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate. Throm Res. 1999; 96:229-237.27. Chyu KY, Babbidge SM, Zhao X, Dandillaya R, Rietveld AG, Yano J, Dimayuga P, Cercek B, Shah PK. Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice. Atherosclerosis Research Center, Division of Cardiology, and Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine at the University of California, Los Angeles, CA 90048, USA.Circulation. 2004 May 25;109(20):2448-53. Epub 2004 May 10

- Peters U, Poole C, Arab L. Does tea affect cardiovascular disease? A meta-analysis. Am J Epidemiol. 2001;154(6):495-503.28. Geleijnse JM, Launer LJ, Van der Kuip DA, Hofman A, Witteman JC. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr. 2002;75(5):880-886.- Sesso HD, Paffenbarger RS, Jr., Oguma Y, Lee IM. Lack of association between tea and cardiovascular disease in college alumni. Int J Epidemiol. 2003;32(4):527-53329. Mabe, K., Yamada, M., Oguni, I., and Takahashi, T. (1999) In vitro and in vivo activities of tea catechins against Helicobacter pylori. Antimicrob.Agents Chemother. 43, 1788-1791. (animals)- Lee,K.M.; Yeo,M.; Choue,J.S.; Jin,J.H.; Park,S.J.; Cheong,J.Y.; Lee,K.J.; Kim,J.H.; Hahm,K.B. (2004) Protective Mechanism of Epigallocatechin-3-Gallate against Helicobacter pylori-Induced Gastric Epithelial Cytotoxicity via the Blockage of TLR-4 Signaling. Helicobacter. 9, 632-42.30. Yee,Y.K.; Koo,M.W.; Szeto,M.L. (2002) Chinese tea consumption and lower risk of Helicobacter infection. J Gastroenterol.Hepatol. 17, 552-5.31. Sugita-Konishi Y, Hara-Kudo Y, Amano F, et al. Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli. O157:H7. Biochem Biophys Acta. 1999; 1472:42-50.32. Matsunaga, K., Klein, T. W., Friedman, H., and Yamamoto, Y. (2002) In vitro therapeutic effect of epigallocatechin gallate on nicotine-induced impairment of resistance to Legionella pneumophila infection of established MH-S alveolar macrophages. Journal of Infectious Diseases 185, 229-236.33. Fassina G, Buffa A, Benelli R, Varnier OE, Noonan DM, Albini A. Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent. Instituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. AIDS. 2002 Apr 12;16(6):939-41.34. Juneja LR, Chu D-C, Okubo T, et al. L-Theanine a unique amino acid of green tea and its relaxation effect in humans. Trends Food Sci Tech. 1999; 10:199-204.35. Sadzuka Y, Sugiyama T, Miyagishima A, et al. The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin. Cancer Lett. 1996; 105; 203-209.- Sugiyama T, Sadzuka Y. Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian carcinoma. Cancer Lett. 1998; 133:19-26.- Sugiyama T, Sadzuka Y. Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma. Clin Cancer Res. 1999; 5:413-416.- Sugiyama T, Sadzuka Y, Sonobe T. Theanine, a major amino acid in green tea, inhibits leukopenia and enhances antitumor activity induce by idarubicin. Proc Am Assoc Cancer Res. 1999; 40:10.36. Yokogoshi H, Kato Y, Sagesaka YM, et al. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneous hypertensive rats. Biosci Biotechnol Biochem. 1995; 59:615-618.- Yokogoshi H, Mochizuki M, Saitoh K. Theanine-induced reduction of brain serotonin concentration in rats. Biosci Biotechnol Biochem 1998;62:816- Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylmethylamide in spontaneously hypertensive rats. Life Sci. 1998; 62:1065-1068.37. Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T.Effect of theanine, r-

glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. School of Food and Nutritional Sciences, The University of Shizuoka, Yada, Shizuoka, Japan. yokogosi@fns1.u-shizuoka-ken.ac.jp Neurochem Res. 1998 May;23(5):667-73.

Literatura

- Chemistry and Applications of Green Tea by Takehiko Yamamoto, Lekh Raj Juneja, Djoing-Chi Chu, Mujo Kim, L.R. Juneja, D.C. Chu, M. Kim