Rp Tehnica Farmaceutica

8/13/2019 Rp Tehnica Farmaceutica

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SOLUTII MAGISTRALE CU EXTRACTE USCATE

Rp1 Extractii Belladonnae 1 g

Procaini h drochloridi !"# g Sir$pi citri 1! g

A%$ae &enthae %'('ad 1!! g

M')'(ol'

*'S'int'+ ling$ri pe ,i

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie de $, intern' Substantele active ($nt repre,entate de extract$l de

-eladona (i clorhidrat$l de procaina" (irop$l de la&aie e(te excipient " )iind)olo(it ca aro&ati,ant iar apa de &enta repre,inta .ehicol$l' Pe langa rol$lde .ehicol" apa de &enta pre,inta (i acti$ne terape$tica proprie'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e e)ect$ea,a la &o0ar c$ a0$tor$l pi(til$l$iprin trit$rare' Operatiile de a&e(tecare (i o&ogeni,are (e )ac in &o0ar c$a0$tor$l pi(til$l$i di,ol.area extract$l$i de -eladona2 (i in )lacon$l deexpeditie o&ogeni,area t$t$ror co&ponentelor (ol$tiei2' Conditionarea (e)ace intr3$n recipient de (ticla de capacitate core(p$n,atoare" -ine inchi("&entionand$3(e pe eticheta 4A (e agita inainte de intre-$intare5'

Preparare: In (ticla de expeditie (e cantare(te (irop$l de la&aie'Extract$l de -eladona (e p$l.eri,ea,a la &o0ar" apoi (e di,ol.a in 6!37!picat$ri alcool dil$at in acela(i &o0ar" iar (ol$tia concentrata o-tin$ta (ead$ce cantitati. in )lacon pe(te (irop c$ &ici porti$ni de apa de &enta'

Clorhidrat$l de procaina (e di,ol.a intr3$n )lacon in cati.a &l de apa de&enta (i (ol$tia o-tin$ta (e co&pletea,a la &a(a cer$ta c$ apa de &enta'

Preparat$l )inal n$ (e &ai )iltrea,a chiar daca e(te (la- opale(cent"pentr$ a n$ indeparta prin a-(or-tie pe hartia de )iltr$ co&ponenteledi(per(ate coloidal'

Evaluare farmacotehnica: Con)or& 8R X control$l calitatii (ol$tiilorcon(ta in/

Descriere: preparat$l o-tin$t (e pre,inta ($- )or&a de (ol$tie gal-$ie"(la- opale(centa" c$ &iro( aro&at (i g$(t a&ar$i3acri(or'

pH: (e deter&ina potentio&etric' Preparat$l are reactie $(or acida'

1


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Masa totala pe recipient: (e deter&ina prin cantarirea indi.id$ala acontin$t$l$i din ,ece recipiente'

Dozare: (e e)ect$ea,a con)or& pre.ederilor &onogra)iilor de ($-(tanteacti.e'

Conservare: Se prepara la ne.oie' Alterarea e(te )a.ori,ata de (irop$lde la&aie care )er&entea,a $(or'

II' Pro)il )ar&acocinetic" )ar&acodina&ic (i )ar&acotoxicologic

Fcin:

Principiile acti.e din extract$l de -eladona ($nt repre,entate in principalde alcaloi,i tropanici hio(cia&ina" (copola&ina" atropina2'

Ace(te ($-(tante a$ (tr$ct$ra de a&ina tertiara" a.and o -$naa-(or-tie per o( (i di)$,i$ne in te($t$ri (i in S9C corelata c$ grad$l delipo)ilie al &olec$lei'

Procaina e(te $n ane(te,ic local' E(te hidroli,ata rapid in (ange la acid$lp3a&ino-en,oic (i dietila&inoetanol" catali,ata de procaine(tera,a(inteti,ata in )icat' Are d$rata (c$rta de acti$ne' Pentr$ acti$ne generala n$are e)icacitate ad&ini(trata per o( datorita $n$i )oarte &are e)ect al pri&$l$ipa(a0 hepatic'

Fdin:

Extract$l de -eladona/ Acti$nea de,.oltata e(te de tip para(i&patolitic"prin -locarea receptorilor &$(carinici din (inap(ele ne$roe)ectoarepara(i&patice'

E)ectele anti&$(carinice ale e(terilor tropanol$l$i atropina"(copola&ina2 (e &ani)e(ta prin/relaxarea &$(chilor nete,i .i(cerali de lani.el$l t$-$l$i dige(ti. inhi-a ton$($l" a&plit$dinea (i )rec.enta &i(carilorperi(taltice ga(trice (i inte(tinale" e)ect anti(pa(tic &oderat a($pra .e,ic$lei(i cailor -iliare2" -ronhiilor relaxea,a &$(c$lat$ra -ronhiilor2 (i .e,icii$rinare relaxea,a &$(c$lat$ra -a,inet$l$i" a $reterelor (i a .e,icii $rinare2'

Scopola&ina (e $tili,ea,a in preane(te,ie a(ociata c$ $n&or)ino&i&etic2" in &aladia Par:in(on" in ra$ de &i(care'

Procaina e(te $n ane(te,ic local' Ac;i$ne ane(te,ic< local< de-$t lent"d$rat< (c$rt


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Ac;i$ne ane(te,ic< local< de ($pra)a;


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SOLUTII APOASE CU SUBSTA9TE GREU SOLUBILE

Rp + Pheno-ar-itali !"+ g

Sir$pi (i&plici( 1!"! g

A%$ae %'('ad' +!"! g


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M')'(ol'

*'S'intern + ling$rite pe ,i

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie de $, intern' Substanta activa e(te repre,entata de )eno-ar-ital"(irop$l (i&pl$ e(te edulcorant, corector de g$(t iar vehicolul e(te apa'

Fenobarbitalul (e pre,inta ($- )or&a de cri(tale incolore (a$ p$l-erecri(talina al-a" )ara &iro(" c$ g$(t a&ar' E(te $(or (ol$-il in alcool" p$tin(ol$-il in cloro)or&" )oarte gre$ (ol$-il in apa' Se di,ol.a in (ol$tii dehidroxi,i (i car-onati alcalini' E(te o ($-(tanta p$ternic acti.a" (e pa(trea,ala Separanda" are do,e &axi&e pentr$ o data !"6 g2 (i pentr$ + ore !"7 g2'

Se o-(er.a ca in toata (ol$tia e(te pre(cri(a o cantitate de )eno-ar-ital&ai &ica decat do,a &axi&a pentr$ o data" deci n$ (e &ai i&p$ne.eri)icarea do,elor'

8eno-ar-ital$l acid e(te )oarte gre$ (ol$-il in apa 1/11!!2 iarcantitatea pre(cri(a depa(e(te &$lt coe)icient$l de (ol$-ilitate'

1g )eno-ar-ital acid'''''''''''''''''''''''11!! g apa

!"+ g''''''''''''''''''''''''''''''''''''''''''''' 'x x ++! g apa

Se .a inloc$i )eno-ar-ital$l acid c$ )eno-ar-ital (odic (ol$-il in apa1/1"?2 l$at in cantitate (toechio&etrica' Inloc$irea c$ )eno-ar-ital (odic incantitate (toechio&etrica e(te cea &ai indicata &etoda de preparare a(ol$tiilor c$ )eno-ar-ital at$nci cand ace(ta depa(e(te coe)icient$l de(ol$-ilitate c$ conditia ca p 3$l alcalin creat de )eno-ar-ital (odic (a n$in)l$ente,e n)a.ora-il (ta-ilitatea altor co&ponente din (ol$tie'

+6+"+ ) )eno-ar-ital acid''''''''''''''''''''+? "+6 )eno-ar-ital (odic!"+ g''''''''''''''''''''''''''''''''''''''''''''' ''''''''x x !"++ g

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" )iltrare" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$

?


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a0$tor$l pi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in)lacon$l de expeditie pentr$ o&ogeni,area t$t$ror co&ponentelor (ol$tiei'8iltrarea (e )ace prin inter&edi$l hartiei de )iltr$' Conditionarea (e )ace inrecipiente de (ticla de capacitate core(p$n,atoare" -ine inchi(e'

Preparare / 8eno-ar-ital$l (odic l$at in cantitate de !"++ g (e di,ol.a in1! &l apa" (ol$tia (e ad$ce pe(te (irop$l (i&pl$ cantarit in )lacon$l deexpeditie (i (e co&pletea,a la &a(a c$ apa'

Sol$tia (e )iltrea,a la ne.oie (i (e eli-erea,a in )lacon de capacitatecore(p$n,atoare" c$ eticheta de $, intern pe care (e (peci)ica &od$l dead&ini(trare'


Descriere: (ol$tie li&pede" c$ g$(t a&ar$i'

pH: (e deter&ina potentio&etric' Pre,inta p alcalin'



Conservare: (ol$tia c$ )eno-ar-ital (odic (e prepara la cerere (i (epa(trea,a in recipiente -ine inchi(e" la loc racoro('

II' Pro)il )ar&acocinetic" )ar&acodina&ic (i )ar&acitoxicologic

Fcin: 8eno-ar-ital$l/ a-(or-tie -$na pe toate caile' A-(or-tie prin&$coa(a ga(trica pentr$ acid$l nedi(ociat'

Tran(port in (ange in )or&a legata de al-$&inele pla(&atice" prinlegat$ri ionice'

*i)$,i$ne -$na in te($t$ri" prin -ariera he&atoence)alica (i placenta'

Meta-oli,area (e )ace prin hi(roxilare ali)atica (a$ aro&atica la radicaliide la C? SOM dependente de cit P ?!2" gl$c$ronocon0$garea &eta-olitilorhidroxilati en,i&ele &icro,o&ale hepatice2" hidroli,a inel$l$i -ar-it$ric'8eno-ar-ital$l n$ e(te -iotran()or&at in procent &are'

Eli&inare renala ca &eta-oliti (i ($- )or&a netran()or&ata' Eli&inareaco&pleta d$rea,a cate.a ,ile' In intoxicatii c$ )eno-ar-ital (e gra-e(teeli&inarea renala di&in$and rea-(or-tia t$-$lara prin alcalini,area $rinii'

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Fdin: 8eno-ar-ital$l e(te $n -ar-it$ric hipnocoerciti. c$ latenta (id$rata l$nga cca ? &in$te (i re(pecti. #31+ ore2' E(te indicat rar cahipnotic deoarece prod$ce (o&nolenta d$pa tre,ire (i (edare re,id$ala&arcata' E(te $tili,at ca (edati. la do,e &ici ($-hipnotice2 (i antiepileptic'

Ca (edati. (e indica in hiperexcita-ilitate" ne.ro,e" (indro&p(iho.egetati.'

Ca anticon.$l(i.ant (e indica in &arele ra$ epileptic" de electie la copii&ici (i in (tarea de ra$ epileptic'

Ftox: E(te p$ternic ind$ctor en,i&atic (i poate genera interacti$ni laa(ociere c$ n$&eroa(e &edica&ente/ anticoag$lante orale c$&arinice"anticonceptionale orale" digoxina" )enitoina etc'

RA/ la ni.el S9C/ excitare paradoxala la .ar(tnici" letargie" ce)alee"hal$cinatii" co&a' La do,e &ari antiepileptice/ (edare" ataxie" ane&ie

&egalo-la(tica" o(teo&alacie'SOLUTII APOASE CU SUBSTA9TE GREU SOLUBILE

Rp 6 Acidi acet l(alic lici 1 g

Sir$pi (i&plici( 1! g

A%$ae %'('ad' 7! g

M')'(ol'

*'S' intern 6 ling$rite pe ,i

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie de $, intern' Substanta activa e(te repre,entata de acid$lacetil(alicilic" (irop$l (i&pl$ e(te edulcorant, corector de g$(t iar aparepre,inta vehicolul (ol$tiei'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" )iltrare" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$a0$tor$l pi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in)lacon$l de expeditie pentr$ o&ogeni,area t$t$ror co&ponentelor (ol$tiei'8iltrarea (e )ace prin inter&edi$l hartiei de )iltr$' Conditionarea (e )ace inrecipiente de (ticla de capacitate core(p$n,atoare" -ine inchi(e'

D


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Preparare: In circa 1! &l apa (e di,ol.a prin agitare !"? g 9a CO 6' in(ol$tia o-tin$ta (e ada$ga a(pirina in preala-il p$l.eri,ata (i (e agita 1!31?&in$te' *$pa di,ol.are co&pleta (ol$tia (e ad$ce cantitati. pe(te (irop in)lacon$l tarat (i (e co&pletea,a la &a(a'

Sol$tia (e )iltrea,a la ne.oie (i (e eli-erea,a in )lacoane de capacitatecore(p$n,atoare" -ine inchi(e c$ eticheta de $, intern pe care (e indica&od$l de ad&ini(trare'

Evaluare farmacotehnica / Con)or& 8R X control$l calitatii (ol$tiilorcon(ta in/

Descriere: (ol$tie li&pede" c$ g$(t (la- (arat (i d$lceag'

pH: (e deter&ina potentio&etric' Pre,inta p ne$tr$'



Conservare: (ol$tia de prepara la ne.oie' Con(er.area e(te li&itata lacate.a ,ile' Se pa(trea,a la loc racoro(" in )lacoane -ine inchi(e'


A(pirina e(te acid$l +3acetoxi-en,oic >

Fcin : Absorbie p.o. relati. -$n


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n ti&p$l pri&$l$i pa(a0 inte(tinal =i hepatic" acid$l acetil(alicilic e(te p$;inhidroli,at' n (Fnge e(te repede hidroli,at'

Timpul de njumtaire al acid$l$i acetil(alicilic e(te )oarte (c$rt T Hcca 1? &in$te2'

9i.el$rile pla(&atice de (alicilat ($nt -ine corelate c$ e)ectele)ar&acodina&ice =i e)ectele ad.er(e de ($prado,are'

orelaia concentraiilor plasmatice de salicilat cu tipul de efectefarmacodinamice !i farmacoto"icolo#ice ale AA$ %dup $troescu &' ())*+

Salicilat$l e(te @n contin$are -iotran()or&at @n )icat pe trei c


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ter&ina;iilor ner.oa(e a)erente la ac;i$nea algogen< a hi(ta&inei =i-radi:ininei>

antipiretic &oderat &ecani(& hipotala&ic2> antiin)la&ator" antire$&atic p$ternic &ecani(& de inhi-are a

-io(inte,ei de PG in)la&atoare" prin acetilarea ire.er(i-il< aciclooxigena,ei ind$cti-ile tip COX3+2>

antiagregant plachetar" la do,e &ici ($-analge,ice &ecani(&de inhi-are a -io(inte,ei de TXA + proagregant" prin acetilareaire.er(i-il< a ciclooxigena,ei con(tit$ti.e tip COX312>

$rico,$ric" prin inhi-area rea-(or-;iei t$-$lare acti.e a acid$l$i$ric la do,e de cca + g ,i2>

hipocole(terole&iant> hipoglice&iant'Ftox:

a2 E)ecte (ec$ndare/

Aparat dige(ti./ e)ect $lcerigen" prin hiper(ecre;ie ga(tric< acid< =i (c

Aparat renal/

red$cerea )iltr

1!


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-2 Reac;ii alergice &ai )rec.ente pe teren alergic/

er$p;ii c$tanate erite& poli&or)" erite& nodo(" erite&pig&entat )ix2" p$rp$r


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SOLUTII ALCOOLICE

Rp Acidi -en,oici

Acidi (alic lici

Iodi aa 1"? g

9atrii -en,oati( 6"! g

Alcoholi D! ! 1!!"! g

M')'(ol'

*'S'extern

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie de $, extern' Substantele active ($nt repre,entate de acid$l-en,oic" acid$l (alicilic" iod (i -en,oat de (odi$ iar alcool$l dil$at e(tevehicolul.

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la -alantaelectronica' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in)lacoanele in care (e )ace di,ol.area ($-(tantelor acti.e prec$& (i in )lacon$lde expeditie" $nde (e o&ogeni,ea,a toate co&ponentele preparat$l$i'Conditionarea (e )ace in recipiente de (ticla de capacitate core(p$n,atoare"-ine inchi(e'

Preparare: Acid$l -en,oic" acid$l (alicilic (i iod$l (e di,ol.a in 7D"? galcool concentrat J? ! 2" iar -en,oat$l de (odi$ in 6+"? g apa' Sol$tia apoa(a(e ad$ce treptat pe(te (ol$tia alcoolic" ($- agitare contin$a'

Evaluare farmacotehnica: Con)or& 8R X control$l calitatii (ol$tiilor

con(ta in/Descriere: preparat$l (e pre,inta ($- )or&a de (ol$tie li&pede" de

c$loare -r$na" c$ &iro( de iod (i alcool'

pH: (e deter&ina potentio&etric'


1+


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Conservare: Se prepara la cerere (i (e conditionea,a in )lacoane de(ticla colorata" -ine inchi(e'

II'Pro)il )ar&acocinetic" )ar&acodina&ic (i )ar&acitoxicologic

Fcin : ($-(tantele acti.e n$ (e a-(ord'

Fdin:

Acid$l -en,oic" acid$l (alicilic (i iod$l ($nt anti(eptice (i de,in)ectante'

Acid$l -en,oic (i acid$l (alicilic actionea,a la ni.el$l &e&-ranei cel$lareprin &odi)icarea -r$tala a p 3$l$i'

Acid$l -en,oic e(te -acterio(tatic (i poate )i -actericid d$pa $n contactprel$ngit de cate.a ,ile' Are (i (la-a acti$ne anti)$ngica (i antipr$riginoa(a'

Acid$l (alicilic acid !3hidroxi-en,oic2 are acti$ne anti(eptica"anti)$ngica" cheratopla(tica (i cheratolitica in )$nctie de concentratie2'

Se $tili,ea,a in (pecial ($- )or&a de preparate &agi(trale/- anti)$ngic 136 in a(ociatie c$ alte anti)$ngice2

- cheratopla(tic !"?31 in $lcere c$tanate- cheratolitic 1!36! in hipercherato,a" p(oria,i(" -atat$ri'

Iod$l

n utilizare e"terna' are acti$ne anti(eptica inten(a indice )enolic 1?!36!!2" rapida'

Mecanism de actiune: iod$rarea gr$parilor K9 + proteice (i prin oxidareagr$parilor KS en,i&atice (i proteice -acteriene' Actionea,a -actericid"(poricid" )$ngicid (i &ai p$tin .ir$cid'

Ftox:

iod$l /iritant pentr$ &$coa(e" .aporii irita caile re(piratorii" ri(c de(en(i-ili,are alergica" la cei (en(i-ili,ati ind$ce )eno&en de iodi(&" er$ptiic$tanate" acnee" ad&ini(trat pe &$coa(e (i rani intin(e ca e)ect toxic

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(i(te&ic" poate a)ecta rinichii' La copii &ici (i &ai ale( la no$3na(c$ti poatedeter&ina t$l-$rari tiroidiene epider& &ai per&ea-il2'

Preparat$l (e $tili,ea,a extern" in der&ato,e'

1


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SOLUTII I9 SOL E9TI A9 I*RI

Rp ? Glicerina -oraxata +!

9atrii tetra-ora( +! g

Gl cerol$& #! g

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie glicerinata de $, extern' Substanta activa e(te repre,entata de-orax iar glicerina e(te vehicolul (ol$tiei'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$ a0$tor$lpi(til$l$i" prin inter&edi$ .olatil alcool2' Operatiile de a&e(tecare (io&ogeni,are (e e)ect$ea,a in )lacon$l de expeditie" la cald pe -aia de apa'Conditionarea (e )ace in recipiente de (ticla de capacitate core(p$n,atoare"-ine inchi(e'

Preparare: Se incal,e(te glicerina intr3o cap($la de portelan" (e ad$ga-orax$l p$l.eri,at in preala-il c$ alcool (i (e incal,e(te $(or pe -aie de apa"agitand$3(e pana la o-tinerea (ol$tiei'


Descriere: preparat$l (e pre,inta ($- )or&a de lichid li&pede" incolor(a$ gal-$i" de con(i(tenta (iropoa(a" higro(copic" )ara &iro(" c$ g$(td$lceag'

pH: (e deter&ina potentio&etric' Preparat$l are reactie acida p "?3?"!2



Conservare: In .a(e -ine inchi(e" )erit de $&e,eala'

1?


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Fcin:

Fdin:Tetraboratul de sodiu (borax are acti$ne anti(eptica (la-a" (e$tili,ea,a ($- )or&a de (ol$tie apoa(a 6 " (ol$tii glicerinate +3 pentr$&$coa(e2 (i (ap$n$ri'

Se intre-$intea,a pentr$ -adi0onare in trata&ent$l a)telor" &ico,e" etc'

Ftox: preparat$l e(te -ine tolerat la aplicare locala'

SOLUTII I9 SOL E9TI A9 I*RI

Rp 7 Aet li( p3a&ino-en,oati( 1"! g

9atrii tetra-orati( "! g

Gl ceroli %'('ad +!"! g

M')'(ol

*'S'extern

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie glicerinata de $, extern' Substantele active ($nt repre,entate de-en,ocaina (i -orax iar glicerina e(te vehicolul solutiei '

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$ a0$tor$lpi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in )lacon$lde expeditie la cald pe -aia de apa in ca,$l -orax$l$i2" intr3$n )lacon (eparatin ca,$l di,ol.arii ane(te,inei (i in )inal in )lacon$l de expeditie cand (e

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o&ogeni,ea,a toate co&ponentele (ol$tiei' Conditionarea (e )ace inrecipiente de capacitate core(p$n,atoare" -ine inchi(e'

Preparare: Se cantare(te intr3o cap($la de portelan 11 g glicerina" (eada$ga -orax$l in preala-il p$l.eri,at (i (e incal,e(te $(or pe -aia de apa"agitand pana la o-tinerea (ol$tiei' *$pa racire (e ada$ga ane(te,inadi,ol.ata in 7 g alcool'


Descriere: preparat$l (e pre,inta ($- )or&a de lichid li&pede" c$ g$(td$lceag" pH: (e deter&ina potentio&etric' E(te $(or acid'



Conservare: In recipiente -ine inchi(e'


Fcin: ane(te,ina n$ (e a-(oar-e'

Borax$l n$ (e a-(oar-e'

Fdin /Ane(te,ina e(te $n ane(te,ic local de (inte,a din gr$pa e(teriloralchilici' Tetra-orat$l de (odi$ -orax2 are acti$ne anti(eptica (la-a" (e$tili,ea,a ($- )or&a de (ol$tie apoa(a 6 " (ol$tii glicerinate +3 pentr$&$coa(e2 (i (ap$n$ri'

Ftox: Reactii ad.er(e (peci)ice gr$pei e(terilor/ reactii alergice c$er$ptii c$tanate'

SOLUTII CU APLICARE SPECIALA

Rp D Acidi (alicilici +"! g

Alcoholi dil$ti

A%$ae aa ?! g

Menthae Aetherolei !"!? g1D


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M')'(ol'

*'S'ext' 1 ling$ra la $n pahar de apa pentr$ clatirea g$rii

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie de $, extern" pentr$ clatirea g$rii' Substanta activa e(terepre,entata de acid$l (alicilic" $lei$l .olatil de &enta e(te excipient )iind)olo(it ca aro&ati,ant" corector de g$(t (i &iro( dar pre,inta (i acti$neterape$tica proprie iar .ehicol$l e(te con(tit$it din alcool dil$at (i apa'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$ a0$tor$lpi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in )lacon$lde expeditie $nde are loc o&ogeni,area t$t$ror co&ponentelor (ol$tiei'Conditionarea (e )ace in recipiente de (ticla de capacitate core(p$n,atoare"-ine inchi(e'

Preparare: Acid$l (alicilic (e di,ol.a in alcool dil$at" (e ada$ga $lei$lde &enta' Pe(te (ol$tia alcoolica (e ada$ga treptat (i ($- agitare apa' Seco&pletea,a la &a(a pre.a,$ta'

Evaluare farmacotehnica: Con)or& 8R X control$l calitatiii (ol$tiilorcon(ta in/

Descriere: preparat$l (e pre,inta ($- )or&a de (ol$tie li&pede" incolora"c$ &iro( caracteri(tic'

pH: (e deter&ina potentio&etric' E(te $(or acid'



Conservare: In )lacoane de (ticla -r$na" la loc racoro('


Fcin: acid$l (alicilic n$ (e a-(oar-e'

Acid$l (alicilic e(te anti(eptic (i de,in)ectant'

1#


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Fdin: Actionea,a la ni.el$l &e&-ranei cel$lare prin &odi)icarea -r$talaa p 3$l$i' Are acti$ne anti(eptica" anti)$ngica" cheratopla(tica (i cheratolitica

in )$nctie de concentratie2'

Se $tili,ea,a in (pecial ($- )or&a de preparate &agi(trale/

- anti)$ngic 136 in a(ociatie c$ alte anti)$ngice2- cheratopla(tic !"?31 in $lcere c$tanate- cheratolitic 1!36! in hipercherato,a" p(oria,i(" -atat$ri'

Ftox: acid$l (alicilic e(te -ine tolerat'

1J


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MO*I8ICARI 8I ICE SI C IMICE I9 SOLUTIE

Rp # Re(orcinoli

drochinoni

Acidi (alic lici aa !"? g+!


21/118

Acidi pho(phorici !" g

Spirti ca&phorati ? g

Gl ceroli 1! g

A%$ae ?! g

M')'(ol'

*'S' extern

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie in a&e(tec de (ol.enti" de $, extern' Substantele active ($nt

repre,entate de re,orcina" hidrochinona" acid (alicilic" acid )o()oric iarvehicolul e(te $n a&e(tec de (ol.enti/ (pirt ca&)orat" glicerina (i apa'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$ a0$tor$lpi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in )lacon$lde di,ol.are a ($-(tantelor acti.e prec$& (i in )lacon$l de expeditie $ndeare loc o&ogeni,area t$t$ror co&ponentelor' Conditionarea (e )ace inrecipiente de (ticla de capacitate core(p$n,atoare" -ine inchi(e'

Preparare:

u alcool diluat #ata preparat: Se di,ol.a in alcool$l dil$at re,orcina"hidrochinona" acid$l (alicilic' Pe(te glicerina cantarita in )lacon$l de expeditie(e ada$ga (ol$tia alcoolica co&p$(a" (ol$tia de (pirt ca&)orat (i in )inalacid$l )o()oric 1g +! pic2'

u alcool diluat e" tempore

1!! g alcool dil$at''''''''''''7D"? g alcool'''''''''''6+"? g apa

?! g alcool dil$at''''''''''''''x''''''''''''''''''''''''''''''

In cantitatea de alcool concentrat 66"D? g (e di,ol.a hidrochinona (iacid$l (alicilic" iar in cantitatea de apa 17"+? g nece(ara prepararii alcool$l$idil$at (e di,ol.a re,orcina' Pe(te glicerina cantarita in )lacon$l de expeditie(e ad$ce (ol$tia alcoolica co&p$(a preparata anterior" (pirt$l ca&)orat"(ol$tia apoa(a de re,orcina (i acid$l )o()oric in picat$ri'

Evaluare farmacotehnica: con)or& 8R X control$l calitatii (ol$tiilorcon(ta in/

+1


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Descriere: preparat$l (e pre,inta ($- )or&a de (ol$tie li&pede" incolora"c$ &iro( predo&inant de ca&)or

pH: (e deter&ina potentio&etric' E(te $(or acid'



Conservare: (e prepara la cerere' Se con(er.a in )lacoane -r$ne" la locracoro('

II' Pro)il )ar&acocinetic" )ar&acodina&ic (i )ar&acitoxicologic Fcin: acid$l (alicilic n$ (e a-(oar-e'

re,orcina n$ (e a-(oar-e

hidrochinona n$ (e a-(oar-e

Fdin:

Re,orcina are acti$ne a(tringenta" anti(eptica" de,in)ectanta":eratolitica'

idrochinona are acti$ne depig&entanta" (e poate )olo(i in co&-inatiec$ agenti :eratolitici" in hiperpig&entare' Utili,area ace(teia tre-$ie )ac$tac$ pr$denta" deoarece poate prod$ce iritatie (i hiperpig&entarepo(tin)la&atorie tip ocrono,a exogena2'

Acid$l (alicilic e(te anti(eptic (i de,in)ectant'

8din/ Actionea,a la ni.el$l &e&-ranei cel$lare prin &odi)icarea -r$talaa p 3$l$i' Are acti$ne anti(eptica" anti)$ngica" cheratopla(tica (i cheratolitica

in )$nctie de concentratie2'

8ter (i )gra)/ Se $tili,ea,a in (pecial ($- )or&a de preparate &agi(trale/- anti)$ngic 136 in a(ociatie c$ alte anti)$ngice2- cheratopla(tic !"?31 in $lcere c$tanate- cheratolitic 1!36! in hipercherato,a" p(oria,i(" -atat$ri'

++


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*atorita acti$nii a(tringente" de,in)ectante" cheratolitice preparat$l (e)olo(e(te in acnee'

Ftox: acid$l (alicilic e(te -ine tolerat'

re,orcina e(te -ine tolerata'

hidrochinona e(te -ine tolerata'

MO*I8ICARI 8I ICE SI C IMICE I9 SOLUTIE

Rp J Papa.erini h drochloridi

Codeini pho(phati aa !"+ g

Co))eini !"? g

9atrii -en,oati( 6 g

Sir$pi :alii g$a0acol($l)onati( 1! g

A%$ae %'('ad 1!! g

+6


24/118

M')'(ol

*'S'int' 6 ling$rite pe ,i

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de(ol$tie apoa(a de $, intern . Substantele active ($nt repre,entate declorhidrat$l de papa.erina" )o()at$l de codeina" co)eina (i -en,oat$l de(odi$" (irop$l de tiocol are rol de aro&ati,ant" corector de g$(t (i &iro( darpre,inta (i acti$ne terape$tica proprie iar vehicolul e(te repre,entat de apa'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$ a0$tor$lpi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in)lacoanele in care are loc di,ol.area ($-(tantelor acti.e prec$& (i in )lacon$l

de exepditie $nde are loc o&ogeni,area t$t$ror co&ponentelor (ol$tiei'Conditionarea (e )ace in recipiente de (ticla" de capacitate core(p$n,atoare"-ine inchi(e'

Preparare: Intr3o porti$ne de apa (e di,ol.a -en,oat$l de (odi$' In altaporti$ne (e di,ol.a clorhidrat$l de papa.erina" )o()at$l de codeina (i co)einacitrica' In )lacon$l de expeditie anterior tarat (e cantare(te (irop$l de tiocol"(e ada$ga (ol$tia de -en,oat de (odi$ (i (e ne$trali,ea,a alcalinitatea c$ o(ol$tie de acid citric 1! in pre,enta hartiei indicator' Se ada$ga (ol$tia declorhidrat de papa.erina" )o()at$l de codeina (i co)eina citrica (i (eco&pletea,a la &a(a c$ apa'


Descriere: preparat$l (e pre,inta ($- )or&a de (ol$tie li&pede" incolora"c$ g$(t caracteri(tic'

pH: (e deter&ina potentio&etric' E(te acid'



Conservare: 8lacoane colorate" la loc racoro('

+


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Fcin:Papa.erina clorhidrat e(te $n alcaloid din opi$ c$ (tr$ct$ra

i,ochinolinica'Are a-(or-tie p'o'-$na" e(te -iotran()or&ata hepatic inprocent ridicat" eli&inare $rinara ca &eta-oliti" T1 + (c$rt 13+h2" di)$,ea,ain laptele &atern'

Codeina a-(or-;ie p'o' -$n datorit lipo)iliei cre(c$te" )a; de&or)in 2' Biotran()or&are la ni.el &icro,o&al hepatic" @n do$ etape/

de&etilarea gr$p rii &etoxil din po,i;ia 6" la &or)in " &eta-olit$lacti. al codeinei>

gl$c$ronocon0$garea radical$l$i hidroxil din po,i;ia 6" eli-erat @npri&a etap >

Ti&p de @n0$& t ;ire (c$rt +3 ore2'Co)eina e(te $n alcaloid p$rinic din -oa-ele de ca)ea (i )r$n,ele de ceai"

a-(or-tie p'o'-$na" di)$,i$ne (i di(tri-$tie prin -ariera he&ato3ence)alica increier" prin -ariera placentara la )at (i prin -ariera (ange3lapte" in laptele&atern'

Fdin:

Papa.erina are acti$ne anti(pa(tica &$(c$lotropa prin inhi-area

)o()odie(tera,ei en,i&a ce catali,ea,a degradarea AMPc2 a(t)el cre(teconcentratia de AMPc care declan(ea,a &ecani(&ele de relaxare &$(c$lara'Are acti$ne anti(pa(tica" relaxanta" la ni.el$l &$(chilor nete,i ca.itari/.e,ica -iliara" cai $rinare" t$- dige(ti." acti$ne -ronhodilatatoare"antia(t&atica" .a(odilatatoare &oderata" depri&a cond$cerea atrio3.entric$lara" prel$nge(te perioada re)ractara'

Codeina e (te agoni(t total al receptorilor N (i :" c$ e)icacotate($-&axi&ala' E(te analge,ic opioid (la- p'o'" de circa 1+ ori &ai p$;inpotent )a; de &or)in 2> antit$(i. &oderat de circa 6 ori &ai p$;in potent"co&parati. c$ &or)ina2'

Co)eina e(te $n antagoni(t al adeno,inei ne$ro&ediator p$rinergic2prin -locarea receptorilor p$rinergici P1' *e a(e&enea inhi-a)o()odie(tera,a" cre(cand concentratia de AMPc' Are e)ect p(iho(ti&$lant&oderat la ni.el S9C" (ti&$lea,a toate )$nctiile cardiace la do,e terape$tice"cre(te de-it$l cardiac" cre(te TA" cre(te re,i(tenta .a(c$lara cere-rala"cre(te a&plit$dinea (i )rec.enta &i(carilor re(piratorii" prod$ce

+?


26/118

-ronhodilatatie" (ti&$lea,a (ecretia ga(trica c$ acti$ne $lcerigena la do,e&ari" are acti$ne di$retica'

Ftox:

Papa.erina/ (o&nolenta" con(tipatie" ce)alee" inro(irea )etei" tran(piratii"hTA" arit&ii" -loc atrio3.entric$lar" oprirea re(piratiei i. rapid2'

Codeina : n$ intr @n categoria analge,icelor opioide (t$pe)iante"deoarece poten;ial$l toxico&anogen e(te (la- =i ri(c$l de a-$, negli0a-il

poate de,.olta )ar&acodependen; d$p ad&ini(trare prel$ngit de do,e&ari2> depri&are re(piratorie red$( " la do,e &ari e(te inhi-itor al centr$l$ire(pirator -$l-ar" de circa 6 ori &ai (la- ca &or)ina2> e)ect con(tipant" n$&aila do,e &ari'

Atenie/ Poate ind$ce con.$l(ii la copil'

Co)eina/anxietate" agitatie" tahicardie" extra(i(tole" d$reri anginoa(e"hiperaciditate ga(trica" di$re,a cre(c$ta'

+7


27/118


28/118

Re(orcinol$& 1"! g

Acid$& -oric$& 1"6 g

Sol$tio phen lh drarg ri -orati( !"+ !"? g

A%$a de(tillata %'('ad' 1!!"! g

Formulare: Preparat$l e(te o)icinal in 8R X" (teril (i e(te )or&$lat ($-)or&a de picat$ri pentr$ ochi' Substanta activa e(te repre,entata dere,orcinol" acid$l -oric are rol de (ta-ili,ant (i ($-(tanta ta&pon" (ol$tia de-orat de )enil&erc$r are rol de con(er.ant iar vehicolul (ol$tiei e(te apadi(tilata'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" )iltrare" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$a0$tor$l pi(tl$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in)lacon$l de expeditie pentr$ o&ogeni,area t$t$ror co&ponentelor (ol$tiei'8iltrarea (e )ace prin hartie de )iltr$ (terila' Conditionare (e )ace in recipiente(terile de capacitate de cel &$lt 1! &l" inchi(e etan(" pre.a,$te c$ (i(te& depic$rare'

Preparare: (e prepara prin &etode care (a a(ig$re (terilitatea (i careper&it e.itarea $nei conta&inari $lterioare c$ &icroorgani(&e'

In #! gra&e apa di(tilata (e di,ol.a prin incal,ire la )ier-ere acid$l -oric'

*$pa racirea (ol$tiei (e .a di,ol.a re,orcinol$l (i (e .a ada$ga (ol$tia de-orat de )enil&erc$r !"+ ' Sol$tia o-tin$ta (e .a co&pleta c$ apa di(tilata la1!! g (i (e )iltrea,a'

8iltrarea e(te nece(ara deoarece colirele tre-$ie (a )ie li&pe,i" lip(ite departic$le (olide in ($(pen(ie care irita ochi$l (i )a.ori,ea,a o lacri&area-$ndenta" deter&inand eli&inarea colir$l$i2' Inainte de a )olo(i hartia de)iltr$ (e (pala de &ai &$lte ori c$ apa di(tilata pentr$ indepartareai&p$ritatilor care pot )i cedate de acea(ta" (e (terili,ea,a la et$.a (i (epa(trea,a in )lacoane (terile -ine inchi(e" n$ (e $&ectea,a inainte de)iltrarea (ol$tiei pentr$ a n$ dil$a (ol$tia o)tal&ica' Se )olo(e(c )iltre dedi&en(i$ni &ici pentr$ a n$ retine prin ad(or-tie o cantitate prea &are din(ol$tia o)tal&ica d$pa )iltrare n$ (e &ai co&pletea,a la &a(a2'

Evaluare farmacotehnica: Con)or& 8R X control$l calitatii picat$rilorpentr$ ochi con(ta in/

Descriere: Se o-tine o (ol$tie li&pede incolora' O e.ent$ala coloratie n$tre-$ie (a )ie &ai inten(a decat a $n$i etalon de c$loare pre.a,$t de 8R X'

+#


29/118

pH: (e deter&ina potentio&etric' p 3$l (ol$tiei e(te de ?37'

Marimea particulelor: (e deter&ina prin exa&inarea la &icro(cop a $nei&a(e de preparat care contine aproxi&ati. 1! &g ($-(tanta acti.a($(pendata" intin(a in (trat ($-tire pe o la&a' J! din partic$lele exa&inatetre-$ie (a pre,inte $n dia&etr$ de cel &$lt +? N&> pentr$ 1! dinpartic$lele exa&inate (e ad&ite $n dia&etr$ de cel &$lt ?! N&'

Masa totala pe recipient: (e (ta-ile(te prin cantarirea indi.id$ala acontin$t$l$i din ,ece recipiente'


$terilitate: (e procedea,a con)or& pre.ederilor de la 4Control$l(terilitatii5'

Conservare: Se con(er.a in )lacoane colorate" la Separanda'


Fcin: re,orcina n$ (e a-(oar-e'

Fdin: Re,orcina are acti$ne anti-acteriana" anti(eptica" :eratolitica'

Ftox: re,orcina e(te -ine tolerata'

+J


30/118

PICATURI PE9TRU OC I

11 Oc$log$ttae Atropini ($l)ati( 1 8R X2

Atropini ($l)a( 1"!! g

Acid$& -oric$& 1"?! g

9atrii tetra-orati( !"1? g

Sol$tio phen lh drarg ri -orati( !"+ 1"!! g6!


31/118

A%$a de(tillata %'('ad' 1!!"!! g

Formulare: Preparat$l e(te o)icinal in 8R X" (teril (i e(te )or&$lat ($-)or&a de picat$ri pentr$ ochi' Substanta activa e(te repre,entata de($l)at$l de atropina" (i(te&$l acid -oric -orax are rol de i,otoni,ant (i (i(te&ta&pon" (ol$tia de -orat )enil&erc$ric are rol de con(er.ant anti&icro-ianiar vehicolul e(te repre,entat de apa di(tilata'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" )iltrare" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$a0$tor$l pi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in)lacon$l de expeditie pentr$ o&ogeni,area t$t$ror co&ponentelor (ol$tiei'8iltrarea (e reali,ea,a prin hartie de )iltr$ (terili,ata' Conditionarea (e )ace inrecipiente (terile" de capacitate de cel &$lt 1! &l" inchi(e etan(" pre.a,$tec$ (i(te& de pic$rare'

Preparare: In J! g apa di(tilata (e di,ol.a prin incal,ire la )ier-ereacid$l -oric (i -orax$l' Sol$tia o-tin$ta (e race(te (i in acea(ta (ol$tie (edi,ol.a ($l)at$l de atropina' Se ada$ga apoi (ol$tia de -orat )enil&erc$ric'Se co&pletea,a la apa la 1!! g (i (e )iltrea,a'



Descriere: Se o-tine o (ol$tie li&pede incolora'

pH: (e deter&ina potentio&etric' p 3$l (ol$tiei e(te de 7"?3D"?'



61


32/118



Conservare: In )lacoane pre.a,$te c$ dop picator" pe eticheta (e&entionea,a 4Atentie otra.a 5 (a$ (e p$ne eticheta 4cap de &ort5' Secon(er.a la enena'


!tropina e(te $n alcaloid din )r$n,ele (i radacina de Atropa -elladona")or&a race&ica' E(te $n e(ter al tropinei )or&a ci(2' Se pre,inta ($- )or&ade ($l)at de atropina'

Fcin: a-(or-tie p'o' (i di)$,i$ne -$na" incl$(i. in S9C" di)$,ea,a prinplacenta in (angele )etal" prec$& (i in laptele &atern" e(te &eta-oli,ata prinhidroli,a en,i&atica la e(ter" pre,inta eli&inare $rinara (i prin &$coa(aga(trica 1 6 ne&eta-oli,ata2" are T1 + de 1+36# ore datorita circ$it$l$ienteroga(tric2'

Fdin: e(te $n para(i&patolitic" a.and acti$ne anti&$(carinicane(electi.a -loca0 M1" M+" M62' Acti$ni/ hipo(ecretie (ali.ara" hipo(ecretie-ron(ica (i ($dorala" hipo(ecretie ga(trica (la-a" di&in$a ton$($l (iperi(talti(&$l nor&al al t$-$l$i dige(ti." acti$ne anti(pa(tica la ni.el$lt$-$l$i dige(ti. (i aparat$l$i -iliar" hipo(ecretia glandelor cailor re(piratorii"

-ronhodilatatie" (ti&$lea,a re(piratia" &idria,a pa(i.a relaxarea &$(chi$l$icirc$lar al iri($l$i2" cre(terea pre(i$nii intraoc$lare" cicloplegie relaxarea&$(chi$l$i ciliar2" acti$ne (ti&$latoare S9C'

Ftox: $(caci$nea g$rii" t$l-$rari de degl$titie" con(tipatie" retentie$rinara" t$l-$rarea .ederii pentr$ aproape (i )oto)o-ie'

6+


33/118

PICATURI PE9TRU OC I

1+ Oc$log$ttae Pilocarpini nitrati( + 8R X2

Pilocarpini nitrati( +"!! g

Acid$& -oric$& 1"?! g

9atrii tetra-orati( !"1? g

Sol$tio phen lh drarg ri -orati( !"+ 1"!! g

A%$a de(tillata %'('ad' 1!!"!! g

Formulare: Preparat$l e(te o)icinal in 8R X" (teril (i e(te )or&$lat ($-)or&a de picat$ri pentr$ ochi' Substanta activa e(te repre,entata denitrat$l de pilocarpina" (i(te&$l acid -oric -orax are rol de i,otoni,ant (i(i(te& ta&pon" (ol$tia de -orat )enil&erc$ric are rol de con(er.antanti&icro-ian iar vehicolul e(te repre,entat de apa di(tilata'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" )iltrare" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace la &o0ar prin trit$rare c$

a0$tor$l pi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in)lacon$l de expeditie pentr$ o&ogeni,area t$t$ror co&ponentelor (ol$tiei'8iltrarea (e reali,ea,a prin hartie de )iltr$ (terili,ata' Conditionarea (e )ace inrecipiente (terile" de capacitate de cel &$lt 1! &l" inchi(e etan(" pre.a,$tec$ (i(te& de pic$rare'

Preparare: (e prepara pe cale a(eptica pentr$ a a(ig$ra (terilitatea (i ae.ita conta&inarea $lterioara c$ &icroorgani(&e'

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In J! g apa di(tilata (e di,ol.a prin incal,ire la )ier-ere acid$l -oric (i-orax$l' Sol$tia o-tin$ta (e race(te (i in acea(ta (e di,ol.a nitrat$l depilocarpina' Se ada$ga (ol$tia de -orat )enil&erc$ric' Se co&pletea,a c$ apala 1!! g (i (e )iltrea,a'



Descriere: Se o-tine o (ol$tie li&pede incolora'

pH: (e deter&ina potentio&etric' p 3$l (ol$tiei e(te de ?"?37"?'





Conservare: In )lacoane pre.a,$te c$ dop picator" pe eticheta (e&entionea,a 4Atentie otra.a 5 (a$ (e p$ne eticheta 4cap de &ort5' Secon(er.a la enena'


Pilocarpina e(te $n alcaloid din )r$n,ele (peciilor de Pilocarp$('

Fdin : e(te $n para(i&pato&i&etic c$ acti$ne directa a($prareceptorilor colinergici' Pre,inta e)ecte &$(carinice" c$ predo&inanta de

6


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acti$ne la ni.el$l ochi$l$i/ &io,a acti.a prin contractia &$(chi$l$i circ$lar aliri($l$i2 c$ (caderea pre(i$nii intraoc$lare" contractia &$(chi$l$i ciliar c$)ocali,area .ederii pentr$ aproape (i (caderea ac$itatii .ederii la di(tanta" lani.el$l t$t$ror glandelor exocrine (ti&$lare c$ hiper(ecretie" e)ect p$ternica($pra glandelor (ali.are c$ hiper(ialie (i ($dorale'

Ftox: indice terape$tic &ic' Uili,area (i(te&ica excl$(i. in (cop antidot'E)ecte (ec$ndare dige(ti.e ar($ri epiga(trice" colici" diaree2 pot (a apara (id$pa ad&ini(trarea locala in (ac$l con0$ncti.al'

EMULSII

6?


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Rp 16 Olei Ricini 6! g

Aetherolei Menthae III g$ttae

Sir$pi (i&plici( 1! g A%$ae %'('ad' 1!! g

M')'e&$l(io

*'S'intern d$pa a.i,

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a dee&$l(ie U A de $, intern' Substanta activa e(te repre,entata de $lei$l dericin" $lei$l .olatil de &enta are rol de aro&ati,ant" corector de g$(t (i &iro("(irop$l (i&pl$ e(te ed$lcorant iar apa e(te vehicolul " )a,a externa ae&$l(iei'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la -alantaelectronica' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a initial in&o0ar" cand (e o-tine (i (e dil$ea,a e&$l(ia pri&ara (i apoi in )lacon$l deexepeditie pentr$ o&ogeni,area t$t$ror co&ponentelor e&$l(iei'Conditionarea (e )ace in recipiente -ine inchi(e" la #31? ! C'

Preparare: (e trit$rea,a g$&a ara-ica la &o0ar c$ o &ica porti$ne deapa di(tilata pana la o-tinerea $nei di(per(ii o&ogene" apoi (e ada$ga re(t$lde apa nece(ar o-tinerii e&$l(iei pri&are in total 1# g2 (i (e trit$rea,a panala o-tinerea $n$i &$cilag c$ a(pect o&ogen'

Ulei$l de ricin in preala-il a&e(tecat c$ $lei$l .olatil de &enta (eada$ga treptat in &ici porti$ni (i (e trit$rea,a pana la o-tinerea e&$l(ieipri&are care (e .a dil$a c$ re(t$l de apa treptat' In )lacon$l de expeditie (ecantare(te (irop$l (i&pl$ (i pe(te ace(ta (e ad$ce cantitati. e&$l(iapreparata la &o0ar' Se co&pletea,a c$ apa la &a(a pre.a,$ta'

Evaluare farmacotehnica: Con)or& 8R X" control$l calitatii e&$l(iilorcon(ta in/

Descriere: lichid lapto(" c$ a(pect o&ogen" .a(co(" c$ g$(t d$lceag'*il$ata c$ )a,a externa apa2 in proportie de 1/1! tre-$ie (a ra&anao&ogena exa&inare c$ l$pa "?X2

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Conservare: (e prepara la cerere' Se pa(trea,a in )lacoane -ine inchi(ela loc racoro(' Se eli-erea,a in )lacoane de capacitate &ai &are pe etichetacarora (e &entionea,a 4A (e agita inainte de ad&ini(trare 5


"leiul de ricin e(te )olo(it in trata&ent$l con(tipatiei'

Fcin : e(te &eta-oli,at ($- acti$nea lipa,ei pancreatice la acid ricinoleic"care e(te &eta-olit$l acti." ce (ti&$lea,a che&oreceptorii'

Fdin: E(te $n p$rgati. iritant" de contact" (ti&$lator al peri(talti(&$l$iinte(tinal' Actionea,a la ni.el$l inte(tin$l$i ($-tire $nde irita &$coa(ainte(tinala" declan(and re)lexe .egetati.e" c$ $r&atoarele con(ecinte/

- cre(te peri(talti(&$l inte(tinal- cre(te per&ea-ilitatea &$coa(ei (i (ecretia acti.a a electrolitilor (i

apei (pre l$&en$l inte(tinal" )l$idi)icand contin$t$l (i )a.ori,andeli&inarea'

Ftox : la ad&ini(trare prel$ngita prod$ce iritatia &$coa(elor" c$ diaree(i colici a-do&inale" hipo:alie&ie" c$ a(tenie" 4-oalalaxati.elor5 de(hidratare c$ (cadere ponderala" a(tenie datoritahipo:alie&iei2'

6D


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EMULSII

Rp 1 Ephedrini h drochloride !"1! g

Aetherolei E$calipti !"1? g

Mentholi !"!? g6#


39/118

Olei elianthi %'('ad' +!"!! g

M')'e&$l(io

*'S'extern pentr$ na(

Formulare: Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a dee&$l(ie A U de(tinata ad&ini(trarii externe" pe &$coa(a na,ala' Substantaactiva e(te repre,entata de clorhidrat$l de e)edrina" $lei$l .olatil de e$calipt(i &entol$l ($nt )olo(ite c$ rol de aro&ati,ant iar $lei$l de )loarea (oarel$ie(te vehicol, )a,a externa' Mentol$l (i $lei$l .olatil de e$calipt pre,inta (iacti$ne terape$tica proprie'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace in &o0ar" prin trit$rare c$ a0$tor$lpi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in cap($la

de portelan $nde (e pregate(te )a,a externa" in &o0ar $nde (e o-tine (i (edil$ea,a e&$l(ia pri&ara (i in )lacon$l de expeditie pentr$ o&ogeni,areat$t$ror co&ponentelor e&$l(iei' Conditionarea (e )ace in recipiente -ineinchi(e pre.a,$te c$ (i(te& de pic$rare'

Preparare: (e p$l.eri,ea,a la &o0ar e)edrina clorhidrica (i (e di,ol.a in1! picat$ri de apa' Pe(te (ol$tia o-tin$ta (e ada$ga 1 g lanolina (i (etrit$rea,a energic pana la incorporarea (ol$tiei apoa(e ca )a,a interna'Separat intr3o cap($la de portelan (e cantare(te $lei$l de )loarea3(oarel$i" (edi,ol.a &entol$l la te&perat$ra ca&erei (i (e ada$ga $lei$l .olatil dee$calipt in picat$ri" a&e(tecand$3(e pentr$ o&ogeni,are' Sol$tia $leioa(a (ead$ce treptat pe(te e&$l(ia din &o0ar ($- trit$rare contin$a' Prod$($lo-tin$t (e trece cantitati. in )lacon$l de expeditie (i (e co&pletea, c$ $lei la&a(a pre.a,$ta'

Evaluare farmacotehnica: Con)or& 8R X" control$l calitatii e&$l(iilorcon(ta in/

Descriere: lichid .a(co(" o&ogen" de c$loare al-3gal-$ie" c$ &iro( de&entol (i e$caliptol' *il$ata c$ )a,a externa apa2 in proportie de 1/1!tre-$ie (a ra&ana o&ogena exa&inare c$ l$pa "?X2

Masa totala pe recipient: (e (ta-ile(te prin cantarirea indi.id$ala a

contin$t$l$i din ,ece recipiente'Dozare: (e e)ect$ea,a con)or& pre.ederilor &onogra)iilor de ($-(tante

acti.e'

Conservare: Recipiente -ine inchi(e" loc racoro(" )erit de l$&ina'Reipient$l tre-$ie (a )ie pre.a,$t c$ (i(te& de pic$rare' Pe eticheta (e&entionea,a 4A (e agita inainte de ad&ini(trare5

6J


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Efedrina e(te $n alcaloid din (pecii de E)edra" deri.at de -eta3)eniletila&ina (tr$ct$ra de adrenalina" )ara hidroxilii )enolici (i c$ radical&etil in po,itia al)a2'

Fcin: e)edrina n$ (e a-(oar-e'

Fdin:

Acti$ni/ .a(ocon(trictoare locala"

Ftox: e)edrina a(te -ine tolerata'

Fepid: contraindicat in TA" atero(clero,a" cardiopatie i(che&ica"arit&ii" in($)icienta circ$latorie cere-rala' Preca$tii la hipertiroidieni" -oala

Par:in(on potentea,a tre&or$l2" dia-etici (i a(ociere ci antidia-etice'

!


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EMULSII

Rp 1? Para))in$& li%$id$& +!"!! g

Cera 1"!! g

Adep( lanae anh dric$( 6"!! g 9atri$& tetra-oric$& !"17 g

A%$ae +!"!! g

M')'e&$l(io1


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*'S'extern

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a dee&$l(ie tip A U de(tinata ad&ini(trarii externe' E(te $n preparat co(&etic"($-(tantele pe care le contine a.and rol de c$ratare (i e&oliere a pielii'Para)ina lichida (i apa )or&ea,a .ehicol$l e&$l(iei" para)ina lichida )or&and)a,a externa iar apa )a,a interna' Para)ina lichida are (i rol de c$ratare apielii' Ceara are rol de e&$lgator A U" con)era con(i(tenta preparat$l$i darare (i rol de hidratare a pielii' Lanolina (e )olo(e(te c$ rol de e&$lgator A Udar are (i acti$ne hidratatnta' Borax$l are rol in )or&area $n$i e&$lgator detip U A (ap$n$l de (odi$2 dar are (i acti$ne anti(eptica (la-a'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$ a0$tor$lpi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in cap($lape -aia de apa pentr$ o&ogeni,area co&ponentelor lipo)ile" in )lacon$l incare (e di,ol.a -orax$l la cald (i in )inal in &o0ar$l in care (e a&e(teca toateco&ponentele o&ogeni,area contin$and pana la racirea e&$l(iei'Conditionarea (e )ace in recipiente -ine inchi(e" la loc racoro('

Preparare: (e incal,e(c para)ina lichida" ceara" lanolina anhidra intr3ocap($la (a$ patent$la pe -aia de apa' Separat (e di,ol.a -orax$l in apa lacald' A&e(tec$l de ($-(tante gra(e topite (e ad$ce la &o0ar (i pe(te ace(ta(e ada$ga (ol$tia apoa(a de -orax incal,ita la aceea(i te&perat$ra treptat (i($- agitare contin$a' Trit$rarea contin$a pana la racirea e&$l(iei'

Evaluare farmacotehnica: Con)or& 8R X control$l calitatii e&$l(iilorcon(ta in/

Descriere: lichid al-" lapto(" c$ a(pect o&ogen' *il$ata c$ )a,a externa$leioa(a2 in proportie de 1/1! tre-$ie (a ra&ana o&ogena exa&inare c$

l$pa "?X2


Dozare: (e e)ect$ea,a con)or& pre.ederilor &onogra)iilor de ($-(tante

acti.e'Conservare: recipiente -ine inchi(e" loc racoro(' Pe eticheta (e

&entionea,a 4A (e agita inainte de ad&ini(trare5

II'Pro)il )ar&acocinetic" )ar&acodina&ic" )ar&acotoxicologic

+


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Spre deo(e-ire de preparatele der&atologice" preparatele co(&etice n$po(eda acti$ne (i(te&ica ci ($nt $tili,ate pentr$ pre.enirea" &ic(orarea (a$a&eliorarea $nor (tari de)ecte2 ($per)iciale nedorite" de)ecte ale pielii"par$l$i" $nghiilor'

Preparat$l are acti$ne la ($pra)ata pielii" a.and ,ona terape$tica cea&ai acce(i-ila' Acti$nea preparat$l$i e(te de c$ratire datorita $lei$l$i depara)ina ce di,ol.a i&p$ritatile gra(e de pe piele" hidratanta datorita cerii (ilanolinei ce )or&ea,a $n )il& ocl$,i. care i&piedica e.aporarea apei'Sap$n$l de (odi$ )or&at in ti&p$l prepararii e&$l(iei actionea,a a(e&anator(palarii c$ apa (i (ap$n' Se )olo(e(te ca e&$l(ie de&achianta pentr$ ten$(cat'

6


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SUSPE9SII

Rp 17 Ben,ocaini !" g

Procaini h drochloridi !"? g

Sir$pi (i&plici( 6! g

A%$ae &enthae #! g

M')'($(pen(io

*'S'intern 6 ling$ri pe ,i

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, intern' Substantele active ($nt repre,entate de-en,ocaina (i clorhidrat de procaina" (irop$l (i&pl$ e(te ed$lcorant (i agentde cre(tere a .a(co,itatii iar apa de &enta e(te vehicolul ($(pen(iei' Apade &enta pre,inta (i acti$ne terape$tica proprie'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e )ace la-alanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$ a0$tor$lpi(til$l$i' Operatiile de a&e(tecare (i o&ogeni,are (e e)ect$ea,a in )lacon$lde expeditie pentr$ o&ogeni,area t$t$ror co&ponentelor ($(pen(iei'Conditionarea (e )ace in recipiente -ine inchi(e'


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Preparare: (e p$l.eri,ea,a -en,ocaina la &o0ar" (e ada$ga &$cilag$lde &etilcel$lo,a in &ici porti$ni (i ($- trit$rare' *i(per(ia o-tin$ta (e ad$cecantitati. c$ a0$tor$l apei aro&atice pe(te (irop$l (i&pl$ cantarit in )lacon$lde expeditie' Procaina clorhidrica (e di,ol.a intr3o porti$ne de apa aro&atica(i (e ad$ce pe(te ($(pen(ia din )lacon' Se co&pletea,a c$ re(t$l de apa de

&enta la &a(a pre.a,$ta'Evaluare farmacotehnica: con)or& 8R X control$l calitatii ($(pen(iilor

con(ta in/

Descriere: ($(pen(ie lichida c$ a(pect opac" c$ g$(t d$lce (i &iro(aro&at'

Marimea particulelor: (e deter&ina prin exa&inarea la &icro(cop a $nei&a(e de preparat care contine aproxi&ati. 1! &g ($-(tanta acti.a($(pendata" intin(a in (trat ($-tire pe la&a de &icro(cop' J! dinpartic$lele exa&inate tre-$ie (a pre,inte $n dia&etr$ de cel &$lt ?! N&>pentr$ 1! din partic$lele exa&inate (e ad&ite $n dia&etr$ de cel &$lt 1#!N&'

$tabilitate: ($(pen(iile pot (edi&enta in ti&p> d$pa o agitare ti&p de 13+ &in$te tre-$ie (a (e di(per(e,e (i (a3(i &entina o&ogenitatea pe d$rataad&ini(trarii'

Masa totala pe recipient / (e (ta-ile(te prin cantarirea indi.id$ala acontin$t$l$i din ,ece recipiente'


Conservare / recipiente -ine inchi(e" de capacitate &ai &are decat.ol$&$l ($(pen(iei' Pe eticheta (e &entionea,a 4 A (e agita inainte dead&ini(trare 5'

II'Pro)il )ar&acocinetic" )ar&acodina&ic (i )ar&acotoxicologic

Fcin:

Procaina e(te $n ane(te,ic local" n$ (e a-(oar-e'

Ane(te,ina n$ (e a-(oar-e'

Fdin: procaina/ Ac;i$ne ane(te,ic< local< de-$t lent" d$rat< (c$rt


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Ane(te,ina/ Mecani(&$l de acti$ne ane(te,ic local e(te di&in$areaper&ea-ilitatii &e&-ranei )i-rei ner.oa(e" la ionii 9a" prin -locarea canalelorde 9a dependente de .olta0'

Ane(te,ina pre,inta e)ect l$ng'

Ftox: Procaina de;ine $n poten;ial alergi,ant )oarte &are la aplicarelocala pe teg$&ente =i &$coa(e (e .a e.ita ad&ini(trarea pe ace(te c


47/118

SUSPE9SII

Rp 1D Bi(&$thi ($-nitra( 1!"!! g Calcii car-onati( 1?"!! g

Extracti Belladonnae (icc' !"1! g

A%$ae &enthae %'('ad' 1!!"!! g

M')'($(pen(io

*'S'intern 63 ling$ri pe ,i

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, intern' Substantele active ($nt repre,entate de nitrat$l-a,ic de -i(&$t" car-onat$l de calci$ (i extract$l de -eladona iar vehicolule(te apa de &enta' Apa de &enta are (i acti$ne terape$tica proprie'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" cernere" o&ogeni,are" a&e(tecare" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace in &o0ar" prin trit$rare c$a0$tor$l pi(til$l$i' Cernerea (e )ace pin (ita nr III" prin cernere reali,and$3(e(i o&ogeni,area p$l-erilor' Operatiile de a&e(tecare (i o&ogeni,are (ee)ect$ea,a in &o0ar (i in )lacon$l de expeditie pentr$ o&ogeni,area t$t$rorco&ponentelor ($(pen(iei' Conditionarea (e )ace in recipiente -ine inchi(e'

Preparare: Pe(te nitrat$l -a,ic de -i(&$t care (e p$l.eri,ea,a la &o0ar(e ada$ga car-onat$l de calci$ trit$rand pentr$ o&ogeni,are (i p$l-ereaa(t)el o-tin$ta (e trece prin (ita III' Se ada$ga la &o0ar $nde (e trit$rea,ac$ 1!31? &l apa de &enta' S$(pen(ia o-tin$ta (e trece cantitati. in )lacon$lde expeditie' Separat (e di,ol.a extract$l de -eladona intr3o porti$ne de apaaro&atica la &o0ar (i (ol$tia o-tin$ta (e ad$ce cantitati. pe(te ($(pen(ia din)lacon' Se co&pletea,a c$ apa de &enta la &a(a pre.a,$ta'

Evaluare farmacotehnica / con)or& 8R X control$l calitatii ($(pen(iilorcon(ta in/

Descriere: ($(pen(ie lichida" c$ (edi&ent .ol$&ino( (i &iro(caracteri(tic de &enta'

D


48/118

Marimea particulelor: (e deter&ina prin exa&inarea la &icro(cop a $nei&a(e de preparat care contine aproxi&ati. 1! &g ($-(tanta acti.a($(pendata" intin(a in (trat ($-tire pe la&a de &icro(cop' J! dinpartic$lele exa&inate tre-$ie (a pre,inte $n dia&etr$ de cel &$lt ?! N&>pentr$ 1! (in partic$lele exa&inate (e ad&ite $n dia&etr$ de cel &$lt 1#!

N&'$tabilitate: ($(pen(iile pot (edi&enta in ti&p> d$pa o agitare ti&p de 13

+ &in$te tre-$ie (a (e di(per(e,e (i (a3(i &entina o&ogenitatea pe d$rataad&ini(trarii'



Conservare: recipiente -ine inchi(e de capacitate &ai &are decat.ol$&$l ($(pen(iei' Pe eticheta (e &entionea,a 4A (e agita inainte dead&ini(trare5'


Fcin:

9itrat$l -a,ic de -i(&$t )ace parte din cla(a antiacide ad(or-ante" (ar$ride -i(&$t' Reactionea,a c$ hidrogen$l ($l)$rat din inte(tin" )or&and ($l)$ra

de -i(&$t ce i&pri&a )ecalelor c$loarea neagra'Bi(&$t$l are a-(or-tie dige(ti.a red$(a> nitrat$l red$( la nitrit (e

a-(oar-e'

Car-onat$l de calci$

3 per o(" c$ acid$l clorhidric din ($c$l ga(tric" reactie de ne$trali,areprin d$-l$ (chi&-/ CaCO 6 + Cl CaCl + +CO6 CaCl + +O CO+>

3 din CaCl+ (ol$-ila" Ca + (e a-(oar-e &ax' +! > re(t$l )or&ea,a (ar$riin(ol$-ile car-onati" )o()ati2" ce (e eli&ina prin (ca$n>

3 in exce(" car-onat$l de calci$ &ai poate reactiona (i c$ aci,ii dincolon$l a(cendent" ne$trali,and$3i> (ar$rile )or&ate (e eli&ina prin (ca$n'

Principiile acti.e din extract$l de -eladona ($nt repre,entate in principalde alcaloi,i tropanici hio(cia&ina" (copola&ina" atropina2'Ace(te ($-(tantea$ (tr$ct$ra de a&ina tertiara" a.and o -$na a-(or-tie per o( (i di)$,i$ne inte($t$ri (i in S9C corelata c$ grad$l de lipo)ilie al &olec$lei'

#


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?!


51/118

SUSPE9SII

Rp 1# inci ox di +6"! g

Talci +?"! g

Gl ceroli 1+"? g

A%$ae 6D"? g

M')'($(pen(io

*'S'extern

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, extern' Substantele active ($nt repre,entate de oxid$l de,inc (i talc" glicerina are rol de umectant (i de agent de cre(tere a.a(co,itatii" dar pre,inta (i acti$ne -$na anti(eptica" iar vehicolul e(terepre,entat de apa'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" cernere" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace in &o0ar" prin trit$rare c$

a0$tor$l pi(til$l$i' Cernerea (e )ace c$ a0$tor$l (itei II" cand are loc (io&ogeni,area p$l-erilor' Operatiile de a&e(tecare (i o&ogeni,are (ee)ect$ea,a in &o0ar initial pentr$ o&ogeni,area p$l-erilor" apoi pentr$o&ogeni,area t$t$ror co&ponentelor ($(pen(iei' Conditionarea (e )ace inrecipiente de (ticla" -ine inchi(e'

Preparare: oxid$l de ,inc (i talc$l (e trit$rea,a la &o0ar (i (e trec prin(ita II pentr$ o&ogeni,area a&e(tec$l$i' Se trit$rea,a la &o0ar c$ glicerina

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apoi (e ada$ga in porti$ni apa di(tilata din )or&$la" trit$rand d$pa )iecareada$gare' Se ad$ce a&e(tec$l cantitati. in (ticla de expeditie'

Evaluare farmacotehnica / Con)or& 8R X control$l calitatii ($(pen(iilorcon(ta in/

Descriere: S$(pen(ie al-a" con(i(tenta care (edi&entea,a $(or dar laagitare (e reo&ogeni,ea,a'

Marimea particulelor: (e deter&ina prin exa&inarea la &icro(cop a $nei&a(e de preparat care contine aproxi&ati. 1! &g ($-(tanta acti.a($(pendata" intin(a in (trat ($-tire pe la&a de &icro(cop' J! dinpartic$lele exa&inate tre-$ie (a pre,inte $n dia&etr$ de cel &$lt ?! N&>pentr$ 1! (in partic$lele exa&inate (e ad&ite $n dia&etr$ de cel &$lt 1#!N&'

$tabilitate: ($(pen(iile pot (edi&enta in ti&p> d$pa o agitare ti&p de 13

+ &in$te tre-$ie (a (e di(per(e,e (i (a3(i &entina o&ogenitatea pe d$rataad&ini(trarii'



Conservare: (e prepara la ne.oie


Fcin: talc$l (i oxid$l de ,inc n$ (e a-(or-'

Fdin: Preparat$l (e )olo(e(te ($- )or&a de pen($latii' Are acti$neracoritoare" (icati.a (i $(or a(tringenta'

E)ect$l a(tringent e(te e)ect de contractare a te($t$rilor" de (cadere a(ecretiilor glandelor (i &$coa(elor" de oprire a he&oragiilor capilare (i adiareei' In ace(t preparat e)ect$l a(tringent (e &ani)e(ta prin (caderea(ecretiilor glandelor (e-acee' E(te a(ig$rat de catre oxid$l de ,inc" ace(ta

a.and rol a-(or-ant a-(oar-e (ecretiile in exce(2 (i a(tringent'E)ect$l (icati. e(te e)ect de $(care" in ace(t preparat de $(care a pielii'

Talc$l are rol a-(or-ant (i (icati.'

Preparat$l are e)ect la ($pra)ata pielii $nde )or&ea,a d$pa e.aporarea.ehicol$l$i" o pelic$la contin$a protectoare (i la ni.el$l glandelor (e-acee$nde are rol de (cadere a (cretiilor a(tringent2'

?+


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Ftox: talc$l (i oxid$l de ,inc ($nt -ine tolerate'

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SUSPE9SII

Rp 1J Mentholi !"? g

Talci

inci ox di

Caolini

Alcoholi

Gl ceroli aa 1!"! g

A%$ae 6!"! g

M')'($(pen(io

*'S'extern

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, extern . Substantele active ($nt repre,entate de &entol"talc" oxid de ,inc (i caolin" iar vehicolul e(te $n a&e(tec de (ol.enti/ alcool"glicerina (i apa' Mentol$l are rol (i de aro&ati,ant'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" cernere" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e)ace la -alanta electronica' P$l.eri,area (e )ace in &o0ar" prin trit$rare c$a0$tor$l pi(til$l$i' Cernerea (e )ace c$ a0$tor$l (itei II" cand (e reali,ea,a (io&ogeni,area p$l-erilor' Operatiile (e a&e(tecare (i o&ogeni,are (ereali,ea,a in &o0ar initial pentr$ o&ogeni,area p$l-erilor" apoi pentr$o&ogeni,area t$t$ror co&ponentelor ($(pen(iei" prec$& (i in )lacon$l deexpeditie' Con(er.area (e )ace in recipiente de (ticla" de capacitatecore(p$n,atoare" -ine inchi(e" pe eticheta (e &entionea,a 4A (e agitainainte de intre-$intare 5'

Preparare: (e prepara o p$l-ere co&p$(a o&ogena din talc" oxid de,inc (i caolin' P$l-erea o-tin$ta (e trece prin (ita n$&ar$l II' Pe(te p$l-ere(e ada$ga (ol$tia alcoolica de &entol trit$rand -ine a&e(tec$l' Se ada$ga

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glicerina (i apoi apa" treptat trit$rand pentr$ o&ogeni,are' Se ad$ce in)lacon$l de expeditie (i pe eticheta (e .a (crie 4A (e agita inainte deintre-$intare 5'

Evaluare farmacotehnica: Con)or& 8R X control$l calitatii ($(pen(iilorcon(ta in/

Descriere: ($(pen(ie al-a" c$ &iro( de &entol' Sedi&entea,a $(or darla agitare (e reo&ogeni,ea,a'

Marimea particulelor: (e deter&ina prin exa&inarea la &icro(cop a $nei&a(e de preparat care contine aproxi&ati. 1! &g ($-(tanta acti.a($(pendata" intin(a in (trat ($-tire pe la&a de &icro(cop' J! dinpartic$lele exa&inate tre-$ie (a pre,inte $n dia&etr$ de cel &$lt ?! N&>pentr$ 1! din partic$lele exa&inate (e ad&ite $n dia&etr$ de cel &$lt 1#!N&'




Conservare: (e prepara la ne.oie'

II'Pro)il )ar&acocinetic" )ar&acodina&ic (i )ar&acotoxicologic'

Fcin: talc$l" &entol$l" caolin$l (i oxid$l de ,inc n$ (e a-(or-'

Fdin:

Preparat$l de )olo(e(te ($- )or&a de pen($latii externe c$ e)ectcal&ant" a(tringent" antipr$rigino(" antialergic'

E)ect$l a(tringent e(te e)ect de contractare a te($t$rilor" de (cadere a(ecretiilor glandelor (i &$coa(elor" de oprire a he&oragiilor capilare (i adiareei' In ace(t preparat e)ect$l a(tringent (e &ani)e(ta prin (caderea(ecretiilor glandelor (e-acee'

E)ect$l antipr$rigino( e(te e)ect de ($pri&are a pr$rit$l$i &ancari&ii2'

Mentol$l are acti$ne racoritoare" antipr$riginoa(a" antialergica'

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Oxid$l de ,inc e(te a-(or-ant a-(oar-e (ecretiile in exce(2 (ia(tringent'

Talc$l are acti$ne (icati.a'

Caolin$l e(te a-(or-ant'

Preparat$l are e)ect la ($pra)ata pielii $nde )or&ea,a d$pa e.aporarea.ehicol$l$i" o pelic$la contin$a protectoare (i la ni.el$l glandelor (e-acee$nde are rol de (cadere a (cretiilor a(tringent2'

Ftox: talc$l" &entol$l" caolin$l (i oxid$l de ,inc ($nt -ine tolerate'

SUSPE9SII

?7


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Rp +! Aeth li p3a&ino-en,oati( +"! g

Mentholi !"? g

Talci inci ox di

Gl ceroli aa 1!"! g

A%$ae 6!"! g

M')'($(pen(io

*'S'extern

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, extern' Substantele active ($nt repre,entate deane(te,ina" &entol" talc (i oxid de ,inc" iar vehicolul e(te co&p$( dinglicerina (i apa' Mentol$l are rol (i de aro&ati,ant' Glicerina e(te (i$&ectant" agent de cre(tere a .a(co,itatii (i pre,inta (i -$na acti$neanti(eptica'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" cernere" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e)ace la -aalanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$a0$tor$l pi(til$l$i' Cernerea (e )ace c$ a0$tor$l (itei nr II cand (e reali,ea,a(i o&ogeni,area p$l-erilor' Operatiile (e a&e(tecare (i o&ogeni,are (ereali,ea,a in &o0ar initial pentr$ o&ogeni,area p$l-erilor" apoi pentr$o&ogeni,area t$t$ror co&ponentelor ($(pen(iei" prec$& (i in )lacon$l deexpeditie' Con(er.area (e )ace in recipiente de (ticla" de capacitatecore(p$n,atoare" -ine inchi(e" pe eticheta (e &entionea,a 4A (e agitainainte de intre-$intare 5'

Preparare: (e trit$rea,a &entol$l (i ane(te,ina la &o0ar" (e ada$gaalcool$l in care (3a$ ada$gat cele !"? g tQeen #!' Se ada$ga p$l-erile detalc (i oxid de ,inc trec$te in preala-il prin (ita II" (e o&ogeni,ea,a (i (etrit$rea,a apoi c$ glicerina (i c$ apa' Se ad$ce in (ticla de expeditie (i peeticheta (e .a (crie 4A (e agita inainte de intre-$intare5'


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Descriere: ($(pen(ie al-a" con(i(tenta" c$ &iro( de &entol'Sedi&entea,a $(or dar la agitare (e reo&ogeni,ea,a'





Conservare: (e prepara la ne.oie'


Fcin: talc$l" &entol$l" ane(te,ina (i oxid$l de ,inc n$ (e a-(or-'

Fdin:

Preparat$l (e )olo(e(te ($- )or&a de pen($latii c$ e)ect cal&ant"a(tringent" antipr$rigino(" ane(te,ic in trata&ent$l di.er(elor a)ecti$nider&atologice'



Preparat$l are e)ect la ($pra)ata pielii $nde )or&ea,a d$pa e.aporarea.ehicol$l$i" o pelic$la contin$a protectoare (i a-(or-anta" la ni.el$l glandelor(e-acee $nde are rol de (cadere a (cretiilor a(tringent2 (i la ni.el$l&e&-ranei )i-relor ner.oa(e hipoder&2 $nde are acti$ne ane(te,ica'

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Ane(te,ina e(te $n ane(te,ic local de (inte,a din gr$pa e(teriloralchilici'

Oxid$l de ,inc e(te a-(or-ant" a(tringent (la-'


Mentol$l are acti$ne racoritoare" antipr$riginoa(a'

Ftox: Reactii ad.er(e (peci)ice gr$pei e(terilor/ reactii alergice c$er$ptii c$tanate'

SUSPE9SII

Rp +1 Ichta&&oli +"! g

Talci

inci ox di aa ?"! g

Gl ceroli?J


60/118

A%$ae aa 1!"! g

M')'($(pen(io

*'S'extern

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, extern' Substantele active ($nt repre,entate de ihtiol" talc(i oxid de ,inc iar vehicolul e(te co&p$( din glicerina (i apa' Glicerina are (irol de $&ectant (i agent de cre(tere a .a(co,itatii prec$& (i acti$ne -$naanti(eptica'

Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" cernere" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e)ace la -aalanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$a0$tor$l pi(til$l$i' Cernerea (e )ace c$ a0$tor$l (itei nr II cand (e reali,ea,a(i o&ogeni,area p$l-erilor' Operatiile (e a&e(tecare (i o&ogeni,are (ereali,ea,a in &o0ar initial pentr$ o&ogeni,area p$l-erilor" apoi pentr$o&ogeni,area t$t$ror co&ponentelor ($(pen(iei" prec$& (i in )lacon$l deexpeditie' Con(er.area (e )ace in recipiente de (ticla" de capacitatecore(p$n,atoare" -ine inchi(e" pe eticheta (e &entionea,a 4A (e agitainainte de intre-$intare 5'

Preparare: Oxid$l de ,inc (i talc$l" trec$te prin (ita II" (e trit$rea,a la&o0ar pana la o-tinerea $nei p$l-eri o&ogene' Ihtiol$l (e di(per(ea,a in

glicerina intr3o cap($la de portelan (i (e ad$ce pe(te p$l-erile din &o0ar' Apa(e ad$ce in porti$ni (i a&e(tec$l (e trece cantitati. in )lacon$l de expeditie"pe eticheta car$ia (e .a (crie 4A (e agita inainte de intre-$intare 5'


Descriere: ($(pen(ie de c$loare gal-en3-r$n" con(i(tenta" c$ &iro($lcaracteri(tic co&ponentelor'



7!


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Conservare : (e prepara la ne.oie'


Fcin: talc$l" ihtiol (i oxid$l de ,inc n$ (e a-(or-'

Fdin: Preparat$l de )olo(e(te ($- )or&a de pen($latii' Se ad&ini(trea,aextern pe piele in trata&ent$l di.er(elor a)ecti$ni der&atologice" datoritaacti$nii a(tringente" a-(or-ante" anti(e-oreice" :eratopla(tice'


E)ect$l :eratopla(tic (e &ani)e(ta la ni.el$l (trat$l$i corno( prinpro&o.area cheratini,arii (i ingro(arii (trat$rilor de cheratina'

Preparat$l are e)ect la ($pra)ata pielii $nde )or&ea,a d$pa e.aporarea.ehicol$l$i" o pelic$la contin$a protectoare (i a-(or-anta" la ni.el$l glandelor(e-acee $nde are rol de (cadere a (cretiilor a(tringent" anti(e-oreic2 (i lani.el$l (trat$l$i corno( $nde are acti$ne :eratopla(tica'

Ihtiol$l are acti$ne anti(e-oreica" antiin)la&atoare" :eratopla(tica'

Oxid$l de ,inc e(te a-(or-ant" a(tringent (la-'


8tox/ talc$l" ihtiol (i oxid$l de ,inc ($nt -ine tolarate la aplicare locala'

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SUSPE9SII

Rp ++ S$l)$ri( praecipitati 1! g

Sol'ca&phorae (pirit$o(a +! g

Acidi lactici + g

Gl ceroli ? g

A%$ae %'('ad' 1!! g

M')'($(pen(io

*'S'extern

7+


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8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, extern' Substantele active ($nt repre,entate de ($l) (iacid lactic iar vehicolul e(te co&p$( din (ol$tia alcoolica de ca&)or"glicerina (i apa' Sol$tia alcoolica de ca&)or are (i acti$ne terape$ticaproprie' Glicerina e(te (i $&ectant" agent de cre(tere a .a(co,itatii (i

pre,inta (i -$na acti$ne anti(eptica'Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"

p$l.eri,are" cernere" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e)ace la -aalanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$a0$tor$l pi(til$l$i' Cernerea (e )ace c$ a0$tor$l (itei nr II' Operatiile (ea&e(tecare (i o&ogeni,are (e reali,ea,a initial in &o0ar pentr$o&ogeni,area t$t$ror co&ponentelor ($(pen(iei apoi in )lacon$l deexpeditie' Con(er.area (e )ace in recipiente de (ticla" de capacitatecore(p$n,atoare" -ine inchi(e" pe eticheta (e &entionea,a 4A (e agitainainte de intre-$intare 5'

Preparare: Se p$l.eri,ea,a ($l)$l la &o0ar (i (e trece prin (ita II' Setrit$rea,a c$ glicerina (i c$ cele !"? g tQeen #!' Se ada$ga in porti$ni &ici(ol$tia alcoolica de ca&)or' Se ad$ce tot$l in (ticla de expeditie (i (edil$ea,a treptat (i ($- agitare c$ apa' La ()ar(it de ada$ga acid$l lactic' Peeticheta (e .a (crie 4A (e agita inainte de intre-$intare 5'


Descriere: di(per(ie al-3gal-$ie c$ tendinta la (edi&entare de(t$l derapida" c$ &iro( de ca&)or'





Conservare: (e prepara la ne.oie' Se pa(trea,a in (ticle -ine inchi(e'76


64/118


Fcin: ($l)$l (i acid$l lactic n$ (e a-(or-'

Fdin:Preparat$l (e )olo(e(te in trata&ent$l alopeciei (e-oreice" datorita

acti$nii :eratolitice" anti(eptice" antipr$rigino(e'

E)ect$l :eratolitic (e &ani)e(ta la ni.el$l (trat$l$i corno( prinindepartarea te($t$l$i ingro(at (i a $nor (c$a&e groa(e care ($nt re,$ltat$l$nor a)ecti$ni la ace(t ni.el" c$& ar )i p(oria,i($l'


Preparat$l are e)ect la ni.el$l pielii cap$l$i $nde are rol de (cadere a

(cretiilor anti(e-oreic2" rol :eratolitic (i antipr$rigino('S$l)$l ad&ini(trat extern are acti$ne :eratolitica" antipara,itara'

Acid$l lactic e(te acidi)iant" :eratolitic" anti(eptic'

Ftox: ($l)$l (i acid$l lactic ($nt -ine tolerate'

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SUSPE9SII

Rp +6 S$l)$ri( praecipitati

inci ox di aa 1! g

Ca&phorae

Re(orcinoli aa 1 g

Alcoholi Gl ceroli aa 1! g

A%$ae calci( %'('ad' 1!! g

M')'($(pen(io

*'S'extern

8or&$lare/ Preparat$l e(te &agi(tral (i e(te )or&$lat ($- )or&a de($(pen(ie de $, extern' Substantele active ($nt repre,entate de ($l)" oxidde ,inc" ca&)or (i re,orcinol" vehicolul e(te co&p$( din/ alcool" glicerol (iapa' Glicerina are (i rol de $&ectant" agent de cre(tere a .a(co,itatii (iacti$ne -$na anti(eptica'

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Operatiile farmaceutice care (e ($cced la preparare ($nt/ cantarire"p$l.eri,are" cernere" a&e(tecare" o&ogeni,are" conditionare' Cantarirea (e)ace la -aalanta electronica' P$l.eri,area (e )ace in &o0ar prin trit$rare c$a0$tor$l pi(til$l$i' Cernerea (e )ace c$ a0$tor$l (itei nr II cand (e reali,ea,a(i o&ogeni,area p$l-erilor' Operatiile (e a&e(tecare (i o&ogeni,are (e

reali,ea,a initial in &o0ar pentr$ o&ogeni,area t$t$ror co&ponentelor($(pen(iei apoi in )lacon$l de expeditie' Con(er.area (e )ace in recipiente de(ticla" de capacitate core(p$n,atoare" -ine inchi(e" pe eticheta (e&entionea,a 4A (e agita inainte de intre-$intare 5'

Preparare: Oxid$l de ,inc (i ($l)$l (e p$l.eri,ea,a )in" (e trec prin (itaII" apoi (e di(per(ea,a c$ glicerina (i c$ cele !"? g tQeen #!' Ca&)or$l (e

di,ol.a in alcool (i (ol$tia (e ad$ce treptat (i ($- trit$rare pe(te di(per(ia de&ai ($(' Se trece tot$l cantitati. in )lacon$l de expeditie' Se di,ol.are,orcina in apa (i (ol$tia o-tin$ta (e ada$ga treptat in (ticla de expeditieagitand d$pa )iecare ada$gare' Se co&pletea,a c$ apa la &a(a pre.a,$ta'Pe eticheta (e .a (crie 4A (e agita inainte de intre-$intare 5'


Descriere: ($(pen(ie al-3gal-$ie" o&ogena la agitare" care (epara inti&p" dar (e reo&ogeni,ea,a $(or" are &iro( de ca&)or'





Rp Tehnica Farmaceutica

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