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SCRAPIA

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Boala pruriginoasaBoala tremuratoare

- depresie- incoordonare in mers

- prurit intens

Cauza ANTC

I descriere – sec XVIII

Cuille si Chelle 1936 – 1940: inoculabilitate si

transmisibilitate la oaie si capra

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Epidemiologie:- raspandire geografica universala

Receptivitate: ovine si caprine 3-4 ani (chiar 12 luni) +

rase (Suffolk, Cheviot) + sensibilitate familiala

-determinism genetic alelele Sip sA si pA

-enzootica in efective: 2-5‰ (?)

Surse: majoritatea tesuturilor, excreta, pasuni, ape,

placenta, splina, lnn, amigdale, colon, SNC

Transmitere : verticala si orizontala

Transplacentar 

0,5% - 1%→ 10%

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CLINIC

Lent, tipic, atipic- incubatie 1-6 ani, mortala….. ?

- tulburari de comportament

- tremuraturi (la «tremblante» fr)- prurit («scrapie» en)

- tulburari locomotorii

- slabire – cahexie

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F. debut – insidios, tulb comportament, agitatie,

ortopnee, apatie, agresiv, rar depresie

F. pruriginoasa: prurit dorso-lombar 

Reflex pruriginos: coada, bucce m.post

Hiperestezie cu tremuraturi intermitente

F. cerebeloasa: tremuraturi muschi cap

“leganat”, .....

Ataxie, alearga trap/galop ebrios

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DIAGNOSTIC:

- histopatologic

- Western – Blot (ELISA)

- Electroforeza capilara- Imunohistochimic

Anatomopatologic

Exclusiv microscopic:

- glioza astrocitara

- rarefiere neuronala- spongioza prin vacuolizarea neuronilor 

- absenta infiltratiei mononucleare

- rareori depozite amiloide in boala naturala

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COMBATERE SI PROFILAXIE

Profilaxie

Sacrificarea efectivelor suspecte

Prohibarea importurilor Excluderea proteinei animale din alimentatie

Vid sanitar la pasuni

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ENCEFALOPATIA TRANSMISIBILA A NURCILOR

1965 in USASursa incriminata: carne si organe de la oi infectate

Epidemiologie

Transmisibila prin muscatura si zgarietura, consum decadavre

Clinic: incubatie 1-2 ani, tulburari de comportament, anorexie,

slabire, incoordonare motorie, moarte in 1-6 saptamaniProfilaxie:- sacrificarea efectivelor suspecte

- igiena alimentatiei

BOALA CAHECTIZANTA A CERVIDEELOR1980 – la turma de cerbi captivi in Colorado si la elani

ENCEFALOPATIA SPONGIFORMA A PISICILOR

1990 – Bristol primul caz