acad.ro · Web viewWord Bioetics Day, Grigore T. Popa University of Medicine and Pharmacy Iasi,...

CENTRUL DE CERCETĂRI BIOMEDICALE IAȘI

Email: [email protected]

RAPORT DE CERCETARE 2017

Lucrări ISI in extenso: 24

Lucrări ISI în rezumat: 28

Lucrări BDI in extenso: 12

Lucrări (orale și postere) la Congrese/Conferințe Internaționale: 17

Lucrări (orale și postere) la Congrese/Conferințe Naționale: 12

Membru în comitete de organizare, comitete științifice, manifestări științifice: 9

Cărți:4

Editorial Board: 3

Reviewer: 17 reviste

Structura Institutului

Centrul de Cercetări Biomedicale funcționează cu următoarea structură de personal,

enumerată în tabelul alăturat: 1 coordonator onorific centru, 3 cercetători științifici cu

jumătate de normă, 1 certător științific normă întreagă și 1 referent cu normă întreagă.

Nr. ctr

Numele și prenumele Funcția Normă

1. Carol Stanciu Coordonator Centru

2. Walther Bild C.S II ½ normă

3. Veronica Bild C.S. III ½ normă

4. Alin Ciobica C.S. III ½ normă

5. Radu Lefter C.S. Întreagă

6. Gabriela Dănilă Referent III Întreagă

Obiectivele generale:

Dezvoltarea cercetărilor fundamentale în științele exacte, în științele vieții și în cele ale Terrei, pentru generarea bazei cercetărilor aplicate.

Program de cercetare:

Relevanța modificărilor patofiziologice în unele boli neuropsihiatrice și gastrointestinale

Teme de cercetare din plan

Tema 1 – Manifestări gastrointestinale în patologia autistică.

Tema 2 – Dezvoltarea unor modele animale cu relevanță pentru metabolismul stresului nervos și digestiv.

Lucrări ISI in extenso:

1. Trifan, A. and C. Stanciu (2017). "Beta-Blockers in Decompensated Cirrhosis: More

Questions Than Answers." Clinical Gastroenterology and Hepatology 15(1): 149-149. I F

7,398

2. Gheorghe, L., I. Sporea, S. Iacob, R. Sirli, A. Trifan, D. Dobru, M. I. Diculescu, C.

Stanciu, O. Pascu, M. Acalovschi, C. Brisc, C. Cijevschi, C. Gheorghe, Z. Sparchez, I.

Rogoveanu and D. Dumitrascu (2017). "Position Paper on Treatment of Hepatitis C in

Romania, 2017. Part One." Journal of Gastrointestinal and Liver Diseases 26(2): 171-181.

IF 1,837

3. Gheorghe, L., L. Sporea, S. Iacob, R. Sirli, A. Trifan, M. Diculescu, C. Stanciu, O. Pascu,

M. Acalovschi, C. Brisc, C. Cijevschi, C. Gheorghe, Z. Sparchez, I. Rogoveanu, D. Dobru

and D. L. Dumitrascu (2017). "Position Paper on Treatment of Hepatitis C in Romania

2017. Part Two." Journal of Gastrointestinal and Liver Diseases 26(3): 309-317. IF 1,837

4. Gheorghe, L., S. Iacob, M. Curescu, C. Brisc, C. Cijevschi, F. Caruntu, C. Stanciu, I.

Simionov, L. Sporea, C. Gheorghe, R. Iacob, V. Arama, R. Sirli and A. Trifan (2017). "Real-

Life Use of 3 Direct-Acting Antiviral Regimen in a Large Cohort of Patients with

Genotype-lb HCV Compensated Cirrhosis." Journal of Gastrointestinal and Liver Diseases

26(3): 275-281. IF 1,837

5. Trifan, A., C. Stanciu, I. Girleanu, O. C. Stoica, A. M. Singeap, R. Maxim, S. A. Chiriac,

A. Ciobica and L. Boiculese (2017). "Proton pump inhibitors therapy and risk of

Clostridium difficile infection: Systematic review and meta-analysis." World Journal of

Gastroenterology 23(35): 6500-6515. I F 3,365

6. Mihai, C., Mihai, B., Trifan, A., Stanciu, C., Gheorghe, L., Diculescu, M., Curescu, M.,

Brisc, C., Goldis, A., Bataga, S., Sandulescu, L., Rogoveanu, I., Seicean, A., Cijevschi

Prelipcean, C., Metabolic syndrome and genotype 1 virus C compensated liver cirrhosis

in the era of directly acting antiviral therapy, (2017) Hepatitis Monthly, 17 (7), art. no.

e58022, .DOI: 10.5812/hepatmon.58022, Factor de impact 1.677

7. C. Stanciu, A. Trifan, Gheorghe L., Iacob S., Curescu M., Cijevschi Prelipcean C.;

Efficacy and safety of paritaprevir/ritonavir, ombitasvir and dasabuvir with ribavirin

for the treatment of HCV genotype 1b compensated cirrhosis in patients aged 70 year or

older, Medicine – in press

8. A. Trifan, C.Stanciu, S. Chiriac, C. Sfarti, I. Girleanu; Clostridium difficile infections in

octogenarians hospitalized patients, Geriartics et Gerantology International – in press

9. Andrei Ciobica, Manuela Padurariu, Alin Ciobica, Daniel Timofte, Cristinel Stefanescu,

Ziad Nasreddine, General issues encountered while diagnosing mild cognitive

impairment in Romanian patients, International Journal of Geriatric Psychiatry, Volume

32, Issue 1, January 2017, Pages 116–117, doi 10.1002/gps.4531 IF 3.086.

10. Anisia Iuliana Alexa, Alina Cantemir, Alin Ciobica, Ioannis Gardikiotis, Iulia Antioch,

Cezar Honceriu, Carmen Lacramioara Zamfir, Vladimir Poroch, Preliminary Data

Regarding Decreased Catalase Specific Activity In The Tears As A Result Of

Environmental Stress, Rev.Chim.(Bucharest), REV.CHIM.(Bucharest), 68, 1, 2017, 90-93.

IF 2014 0.95.

11. Manuela Padurariu, Alin Ciobica, Understanding the Importance of Oxytocin in

Depression, Nobel Medicus, 2017. IF 0.05.

12. Florin Trofin, Alin Ciobica, Cezar Honceriu, Sabina Cojocaru, Bogdan Stoica, Dumitru

Cojocaru, Elena Ciornea, Daniel Timofte, Modulatory effects of vitamin C and smoking

status in the relation between physical exercising and oxidative stress , Romanian

Biotechnological Letters, 2017, Vol. 22 no. 2, 12439- 12447. IF 2013 0.404.

13. Foyet SH, Balmus IM, Hervé Hervé NA, Emmanuel AA, Guenne S, Kiendrebéogo M,

Ciobica A. Etnopharmacological Approaches in Mood and Anxiety Disorders. The

Relevance of the Oxidative Stress Status. Journal of Complementary and Integrative

Medicine, 2017 Mar 9. doi:10.1515/jcim-2016-0059.2017. IF 0.4.

14. Iulia Antioch, Alin Ciobica, Moussa Compaore, Adama Hilou, Martin Kiendrebeogo,

Harquin Foyet, Samson Guenné, Phytotherapeutical implications in pain perception -

focusing on schizophrenia, International Journal of Phytomedicine, 9 (2017) 167-180. DOI:

http://dx.doi.org/10.5138/09750185.1891. IF 1, 06.

15. Ioana Miruna Balmus, Alin Ciobica, Main Plant Extracts Active Properties Effective

On Scopolamine-Induced Memory Loss, American Journal of Alzheimer's Disease and

Other Dementias, 2017. IF 1.86.

16. Vargáné Kis Anna, Ciobica A, J Topal, The effect of oxytocin on human-directed

social behaviour in dogs (Canis familiaris), Hormones and Behavior, 2017 Jun 28;94:40-

52. doi: 10.1016/j.yhbeh.2017.06.001. IF 3.34.

17. Daniela Carmen Ababei, Radu Lefter, Alin Ciobica, Iulia Antioh, Roxana Mihaela

Barbu, Oana Dana Arcan, Sorin Beșchea Chiriac, Cristina Zbârcea, Walther Bild, Veronica

Bild, Effects Of Renin-Angiotensin System Blockade On Anxiety And Memory In Mice,

Farmacia, 2017, Vol. 65, 3, 381-389. IF 1,348.

18. Ioana-Miruna Balmuș, Stefan-Adrian Strungaru, Alin Ciobica, Mircea-Nicusor Nicoara,

Romeo Dobrin, Gabriel Plavan, Cristinel Ștefănescu, Preliminary data on the interaction

between some biometals and oxidative stress status in mild cognitive impairment and

Alzheimer’s disease patients, Oxidative Medicine and Cellular Longevity, 2017, Article ID

7156928, pages 1-7, https://doi.org/10.1155/2017/7156928. IF 4.59.

19. M Padurariu, I. Antioch, A Ciobica, R Lefter, L Simion, Intranasal Oxytocin in

Autism: Models, Pain and Oxidative Stress, REV.CHIM.(Bucharest), 68, No. 8 , 2017,

1879-1883. IF 1.3

20. Iulia Antioch, Dana Ababei, Radu Lefter, Alin Ciobica, Cezar Honceriu, Veronica

Bild, The Effect Of Exercising On Oxidative Stress Status And Pain In A Valproic-Acid

Induced Model Of Autism Possible Relevance Of Oxytocin, Rev.Chim.(Bucharest), 2017,

68, No. 9, 2028- 2033. IF 1.3

21. 1. Ababei D.C, Beschea Chiriac S, Bild W, Solcan C, Luca A, Rusu R.N, Bulea D, Bild

V. Synergistic effects ot the doxepin-candesartan combination on the thermoalgesic

sensibility in mice, Farmacia, 2017, 65(5): 726-730. IF = 1,348

22. Bild Veronica, Ababei Daniela Carmen, Neamțu Monica, Vasincu Alexandru, Bild

Walther, Stanciu Gabriela Dumitrița, Tamba Bogdan Ionel, Beșchea Chiriac Sorin, Isobolar

analysis of the binary fixed-ratio combination of acetylsalicilic acid-acetaminophen,

FARMACIA, Volume 65, Issue 4, Pages 563-566, 2017 IF = 1,348

23. Voicu Mirela, Cristescu Carmen, Zbârcea Cristina Elena, Voicu Adrian, Buda Valentina,

Suciu Liana, Proks Maria, Bild Veronica, Comparative study of antimicrobials use and

the antibiotic resistance of gram negative strains, Farmacia, Volume: 65, Issue: 2, Pages:

225-229, 2017, IF = 1,348

24. Vasincu, D., C. Andriescu, E. G. Vasincu, J. F. Kolb, W. Bild and C. Miron (2017).

"Method for Study Myocardial Tissue in Vitro: Application of Nanosecond Pulsed

Electric Fields (nsPEFs)." Romanian Journal of Oral Rehabilitation 9(2): 81-88.

Lucrări ISI în rezumat

1. Gheorghe, L., S. Iacob, C. C. Prelipcean, A. Trifan, C. Stanciu, I. Sporea, R. Sirli, M.

Curescu, C. Brisc, C. Mihai, L. Alexandrescu, L. D. Sandulescu, A. Goldis, V. Arama, F.

Caruntu, L. Hara, I. Rogoveanu, M. Diculescu, C. Gheorghe, A. Seicean, R. Iacob, I. I.

Simionov, R. Vadan, I. Pirvulescu and C. Pietrareanu (2017). "Prospective Analysis of

Discordant Results between Fibromax (R) and Fibroscan (R) in Patients with HCV

Compensated Liver Cirrhosis before 3d Antiviral Therapy Initiation." Gastroenterology

152(5): S1102-S1102. IF 18,392

2. Girleanu, I., A. Trifan, A. M. Singeap, C. Sfarti, C. Stanciu and C. Cojocariu (2017).

"Outcomes of Patients with Alcoholic Related Acute-on-Chronic Liver Failure (Aclf) by

a New Classification According to the Severity of Underlying Liver Disease."

Gastroenterology 152(5): S909-S909. IF 18,392

3. Chiriac, S. A., A. Trifan, C. Stanciu, C. C. Prelipcean, G. Stefanescu, C. Mihai, C. Sfarti,

C. Cojocariu, T. Cuciureanu, F. Mihai and A. M. Singeap (2017). "A Low Incidence of

Hepatocellular Carcinoma in Patients with Genotype 1b Compensated Cirrhosis

Treated with Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir a +/- Ribavirin in a

Tertiary Center: A Matter of Better Selection?" Gastroenterology 152(5): S903-S903. IF

18,392

4. Trifan, A., C. C. Prelipcean, L. Gheorghe, M. Curescu, C. Brisc, S. Bataga, E. Miftode, V.

Arama, I. Rogoveanu, A. I. Suceveanu, A. M. Singeap, S. A. Chiriac, T. Cuciureanu, I.

Sporea, A. Goldis, A. Popescu, S. Iacob, C. Sfarti, C. Cojocariu, G. Stefanescu, I. Girleanu,

O. Stoica, C. Mihai, I. Ciortescu and C. Stanciu (2017). "Efficacy and Safety of

Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir Plus/ Minus Ribavirin for

Treatment of Hcv Genotype 1b Compensated Cirrhosis in Patients Aged 70 Years or

Older." Gastroenterology 152(5): S904-S904. IF 18,392

5. Iacob, S., L. Gheorghe, C. C. Prelipcean, A. Trifan, C. Stanciu, I. Sporea, R. Sirli, M.

Curescu, C. Brisc, C. Mihai, L. Alexandrescu, L. D. Sandulescu, A. Goldis, V. Arama, F.

Caruntu, L. Hara, I. Rogoveanu, M. Diculescu, R. Iacob, C. Gheorghe, A. Seicean, I. I.

Simionov, R. Vadan, I. Pirvulescu and C. Pietrareanu (2017). "Predictors of Liver Stiffness

Regression after Svr in Cirrhotic Patients Treated with 3d Regimen." Gastroenterology

152(5): S904-S905. IF 18,392

6. Popa, R. C., C. Mihai, A. Trifan, C. Stanciu, L. Gheorghe, S. Iacob, V. Arama, I.

Rogoveanu, M. Diculescu, A. Goldis, S. Bataga, A. Seicean, L. Sandulescu, R. Nastase, V.

Molagic, C. Brisc, M. Curescu and C. C. Prelipcean (2017). "Efficacy and safety of

ombitasvir/paritaprevir/ritonavir and dasabuvir with or without ribavirin (RBV) in

hepatitis C virus genotype 1-infected patients with compensated cirrhosis and multiple

comorbidities." Journal of Hepatology 66(1): S732-S732. IF 12,486

7. Iacob, M. C. S., L. Gheorghe, C. Cijevschi, A. Trifan, C. Stanciu, C. Mihai, I. Sporea, R.

Sirli, M. Curescu, M. Diculescu, L. Alexandrescu, L. Sandulescu, A. Goldis, C. Brisc, I.

Simionov, R. Vadan, I. Pirvulescu, I. Rogoveanu, C. Pietrareanu, A. Seicean, R. Iacob and C.

Gheorghe (2017). "Predictors of persistence of clinical significant portal hypertension in

patients with HCV liver cirrhosis following 3D therapy and SVR." Journal of Hepatology

66(1): S666-S666. IF 12,486

8. Chiriac, S., A. Trifan, C. Stanciu, C. C. Prelipcean, G. Stefanescu, C. Mihai, C. Sfarti, C.

Cojocariu, T. Cuciureanu, F. Mihai and A. M. Singeap (2017). "A low incidence of

hepatocellular carcinoma in patients with genotype 1b compensated cirrhosis treated

with paritaprevir/ritonavir, ombitasvir and dasabuvir +/- ribavirin in a tertiary center:

a matter of better selection?" Journal of Hepatology 66(1): S630-S630. IF 12,486

9. Chiriac, S., A. Trifan, C. Stanciu, C. C. Prelipcean, G. Stefanescu, C. Mihai, C. Sfarti, C.

Cojocariu, T. Cuciureanu, F. Mihai and A. M. Singeap (2017). "A low incidence of

hepatocellular carcinoma in patients with genotype 1b compensated cirrhosis treated

with paritaprevir/ritonavir, ombitasvir and dasabuvir +/- ribavirin in a tertiary center:

a matter of better selection?" Journal of Hepatology 66(1): S630-S630. IF 12,486

10. Trifan, A., C. C. Prelipcean, L. Gheorghe, M. G. Curescu, C. Brisc, S. Bataga, E.

Miftode, V. Arama, S. A. Chiriac, T. Cuciureanu, I. Sporea, A. Goldis, A. Popescu, S. Iacob,

C. Cojocariu, G. Stefanescu, I. Girleanu, C. Mihai, I. Ciortescu and C. Stanciu (2017).

"Efficacy and safety of paritaprevir/ritonavir, ombitasvir and dasabuvir plus/minus

ribavirin for treatment of hepatitis C virus genotype 1b compensated cirrhosis in

patients aged 70 years or older." Journal of Hepatology 66(1): S284-S285. IF 12,486

11. Trifan, A., C. C. Prelipcean, L. Gheorghe, E. Miftode, S. A. Chiriac, T. Cuciureanu, I.

Sporea, A. Goldis, S. Iacob, C. Cojocariu, G. Stefanescu, I. Girleanu, C. Mihai, I. Ciortescu

and C. Stanciu (2017). "Early regression of liver fibrosis evaluated by non-invasive

methods after successful antiviral therapy in patients with HCV genotype 1b

compensated cirrhosis." Journal of Hepatology 66(1): S285-S285. IF 12,486

12. Trifan, A., A. M. Singeap, S. Chiriac, T. Cuciureanu, C. C. Prelipcean, I. Ciortescu, C.

Cojocariu, C. Sfarti, C. Mihai, G. Stefanescu, L. Gheorghe, S. Iacob and C. Stanciu (2017).

"Hepatic and non-hepatic events after obtaining a SVR in patients with genotype 1b

liver cirrhosis-short time follow-up-single center experience." Journal of Hepatology

66(1): S127-S127. IF 12,486

13. Chiriac S., Trifan A., Cojocariu C., Sfarti C., Girleanu I., C. Stanciu ; The prognostic

role of acute-on-chronic liver failure in patients with decompensated cirrhosis; Journal

of Gastrointestinal and Liver Diseases, vol.26, supplement 2017, Postere cu distinctie 2017

14. Cuciureanu T., A. M. Sangeap, Chiriac S. Garleanu I., Trifan A., C. Stanciu ; Chronic

hepatitis C a major health – related quality of life burden in compensated cirrhotic

patient;, Journal of Gastrointestinal and Liver Diseases, vol.26, supplement 2017, pp29

15. Stoica O.C., A. Trifan, Garleanu I., Chiriac S., Maxim R., Cojocariu C., C. Stanciu ,

Clostridium difficile infection in a gastroenterology department; Journal of

Gastrointestinal and Liver Diseases, vol.26, supplement 2017, pp 29

16. Stoica O.C., Trifan A., Garleanu I., A. M. Sangeap, Chiriac S., Cojocariu C., C. Stanciu ,

Taking a Chance: endpoints in anti-tnf therapy for inflammatory bowel disease

patients; Journal of Gastrointestinal and Liver Diseases, vol.26, supplement 2017, pp 30

17. Maxim R., Trifan A., Plesa A., Ciortescu I., Stoica O.C., Garleanu I., C. Stanciu ;

Severity of duodenal histology and tissue transglutaminase antibody levels correlate

well in adult celiac irrespective of clinical features; Journal of Gastrointestinal and

Liver Diseases, vol.26, supplement 2017, pp 58

18. Sangeap A., Trifan A., Chiriac S., Garleanu I., Cuciureanu T., C. Stanciu ; Gastric

empying in Crohn s disease – evaluation by small bowel capsule endoscopy; , Journal of

Gastrointestinal and Liver Diseases, vol.26, supplement 2017, pp 74

19. Sangeap A., Trifan A., Chiriac S., Garleanu I., Cuciureanu T., C. Stanciu ; C-reactive

protein in cirrhotic patient with acute-an-chronic liver failure: it is a good predictor for

mortality? Journal of Gastrointestinal and Liver Diseases, vol.26, supplement 2017, pp 75

20. Garleanu I., A. Trifan, Nechifor C., Huiban L., Stoica O., Cojocariu C., Sangeap A.

Chiriac S., Cuciureanu T., Dimache M., C. Stanciu ; Factor influencing infectious

complications in acute on chronic liver failure; Journal of Gastrointestinal and Liver

Diseases, vol.26, supplement 2017, pp 104

21. Maxim R., Trifan A., Plesa A., Ciortescu I., Cianga P., C. Stanciu ; Clinical implication

of molecular HLA typing among suspected adult celiac diseases patients: case report;

Journal of Gastrointestinal and Liver Diseases, vol.26, supplement 2017, pp121

22. Garleanu I., Trifan A., Nechifor C., Huiban L., Stoica O., Cojocariu C., Singeap A.,

Chiriac S., Cuciureanu T., Sfarti C., C. Stanciu ; Infectious complications in hospitalized

cirrhotic patients; Journal of Gastrointestinal and Liver Diseases, vol.26, supplement

2017, pp129

23. Girleanu I., Trifan A., Stoica O.C., Cojocariu C., Singeap A., Chiriac S., Cuciureanu T.,

Sfarti C., C. Stanciu ; Natural course of portal vein thrombosis in liver cirrhosis;


24. Chiriac S., Trifan A., C. Stanciu , Lungu C., Cojocariu C.; Results of a survey

completed by practicians concerning the real-life perception of ACLF in Romania;


25. Chiriac S., Trifan A., Singeap A., Huiban L., Muzica C., Bucataru S. P., Cuciureanu T.,

Malinoiu O., Jurcanu M., Arsine D., Leustean A., Anton C., C. Stanciu ; Proton pump

inhibitors – risk factor foe Clostridium difficile infections; Journal of Gastrointestinal and

Liver Diseases, vol.26, supplement 2017, pp165

26. Singeap A., Trifan A., Huiban L., Muzica C., Bucataru S. P., Chiriac S., Cuciureanu T.,

Malinoiu O., Jurcanu M., Arsine D., Leustean A., Anton C., C. Stanciu ; Proton pomp

inhibitors – a story of success, but a problem of excess; Journal of Gastrointestinal and

Liver Diseases, vol.26, supplement 2017, pp 181

27. Muzica C., Trifan A., Singeap A., Huiban L., C. Stanciu ; The nutritional status of

patients with chronic pancreatitis; Journal of Gastrointestinal and Liver Diseases, vol.26,

supplement 2017, pp 191

28. Cuciureanu T., Singeap A-M., Gîrleanu I., Trifan A., Chiriac S., C. Stanciu ; Chronic

hepatitis C a major health – related quality of life burden in compensated cirrhotic

patients; Journal of Gastrointestinal and Liver Diseases, vol.26, supplement 2017, pp11

Lucrări BDI in extenso:

1. Cuciureanu, T., A. M. Singeap, S. Chiriac, I. Girleanu, A. Trifan and C. Stanciu (2017).

"An Unusual Case of Cholecystoduodenal Fistula in a Nonagenarian Patient." Medical-

Surgical Journal-Revista Medico-Chirurgicala 121(2): 360-365.

2. Maxim, R., A. Trifan, A. Plesa, I. Ciortescu and C. Stanciu (2017). "Severity of

Duodenal Histology and Tissue Transglutaminase Antibody Levels Correlate Well in

Adult Celiac Disease Irrespective of Clinical Features." Medical-Surgical Journal -

Revista Medico-Chirurgicala 121(2): 237-244.

3. C. Stanciu, A. Trifan (2017).``Keeping an open mind on long-term use of protonpump

inhibitors``. Medical-Surgical Journal - Revista Medico-Chirurgicala 121(3):459-463.

4. Daniel Timofte, Andrei Ciobica, Cezar Honceriu, Florin Trofin, Alin Ciobica, Dumitru

Cojocaru, A Mini-Review on the Effects of Exercising and obsesity in Parkinson's

Disease, Academy of Romanian Scientists Annals Series on Biological Sciences, Volume 6,

No. 1, 2017, pp. 100 – 113, ISSN 2285 – 4169.

5. Andrei Ciobica, Cezar Honceriu, Alin Ciobica, Romeo Dobrin, Florin Trofin, Iulia

Antioch, Daniel Timofte, Is exercising beneficial in relation with substance abuse

disorder, quality of sleep, self-esteem and chronic pain? Bulletin of Integrative Psychiatry,

2017, 72 (1), 45-54.

6. Manuela Padurariu, Alin Ciobica, Irina Dobrin, Roxana Chirita, Cristinel Stefanescu,

Social and ethical implications of oxytocin intranasal administration in couple therapy.

Is this the next Cupid’s bow?, Bulletin of Integrative Psychiatry, 2017, 73 (2), 69-75.

7. Ioana Miruna Balmuș, Alin Ciobîcă , Pavlina Alexiou, Ioannis Mavroudis, Future

Perspectives On Alzheimer’s Disease Computational Modeling – A Review, Academy of

Romanian Scientists Annals Series on Biological Sciences, Volume 6, No. 1, 2017, pp. 40 –

55, ISSN 2285 – 4169.

8. Kinda PT, Zerbo P, Guenne S, Compaoré M, Ciobica A, Kiendrebeogo M. Medicinal

Plants Used for Neuropsychiatric Disorders Treatment in the Hauts Bassins Region of

Burkina Faso. Medicines. 2017; 4(2):32.

9. Padurariu Manuela, Antioch I., Balmus I., Ciobica A, Heba s el-Lethey, Mervet M. Kamel,

Behavioral animal models of anxiety in relation to oxidative stress and oxytocin

behavioral relevance, International Journal of Veterinary Science and Medicine, 2017.

10. Magdalena BÎRSAN, Carmen-Valerica RIPA, Ana-Caterina CRISTOFOR, Veronica

BILD, Change in sleep quality while using a β-blocker with α adrenolytic action and

organic nitrate analysis of a treatment regimen, Bulletin of integrative Psychiatry, New

Series, September 2017, year XXIII, no 3(17). Page 99-108 ISSN: 1453-7257

11. Iulia Antioch, A. Ciobica, Daniela Carmen Ababei, Radu Lefter, Oana Dana Arcan,

Veronica Bild, Sorin Beschea Chiriac, Pain in a Parkinson`s disease rodent animal model

induced with 6- hydroxydopamine, Veterinary Drug, Vol. 11(1) May- June, 2017, pp 40-46

12. Daniela Carmen Ababei , Raluca Stefanescu, Veronica Bild, Delia Bulea, Monica

Neamtu, Oana Dana Arcan, Alexandru Vasincu, Gabriela Dumitrita Stanciu, IR Popescu, S.

Beschea Chiriac, Demonstration of antinociceptive action of some antidepressants using

models of acute nociception in mice, Veterinary Drug, Vol. 11(1) May- June, 2017, pp 48-

52

Lucrări (orale și postere) la congrese naționale/conferințe naționale

1. Singeap., Trifan A., Huiban A., Muzica C., Bucataru S. P., Girlenu I., Chiriac S.,

Cuciureanu T., Malinoiu O., Jurcau M., Arsine D., Leustean A., Anton C., Ciorcila C., C.

Stanciu ; Autoimmune liver diseases – spectrum of clinical presentations; The XXXVII

National Congress of Gastroenterology Hepatology and digestive Endoscopy, Bucharest,

June 20-24, 2017, Journal of Gastrointestinal and Liver Diseases, vol.26, supplement 2017,

OP 9

2. Chiriac C., Trifan A., Singeap A., Cuciureanu T. Stoica O., C. Stanciu ; Comparison

between Child- Pugh, meld and the clif consortium acute-on- chronic liver failure scores

in predicting mortality in cirrhotic patients with-on-chronic liver failure; The XXXVII

National Congress of Gastroenterology Hepatology and digestive Endoscopy, Bucharest,

June 20-24, 2017, Journal of Gastrointestinal and Liver Diseases, vol.26, supplement 2017, O

P 20

3. Ciobica Alin, “Is oxytocin intranasal administration relevant in neuropsychiatric

behaviour models on rats and clinical trials?”, Bridging Eastern and Western

Psychiatry Romania, International Conference of Cognitive Behaviour Therapy, Iasi, 11-12

Martie 2017.

4. Ioana Miruna Balmuș, Alin Ciobica, Future Perspectives on Alzheimer's Disease

Computational Modeling, Sesiunea Științifică de Primăvară, Academia Oamenilor de

Știință din România, București, Vineri, 24 martie 2017, Sediul Academiei Oamenilor de

Știință din România, Sala de Conferințe, Moderatori: Natalia Roşoiu, Adrian Bavaru, Ion

Dediu, ora 11.50.

5. Daniel Timofte, Andrei Ciobica, Cezar Honceriu, Florin Trofin, Alin Ciobica, Dumitru

Cojocaru, The Effects of Exercising on Parkinson's Disease Pathophysiology, Sesiunea

Științifică de Primăvară Academia Oamenilor de Știință din România, București, Vineri, 24

martie 2017, Sediul Academiei Oamenilor de Știință din România, Sala de Conferințe,

Moderatori: Natalia Roşoiu, Adrian Bavaru, Ion Dediu, ora 12.

6. Manuela Padurariu, Alin Ciobica, Depressive-like Manifestations in Most of the

Neuropsychiatric Disorders Animal Models. Is Oxytocin Administration Relevant ?,

Sesiunea Științifică de Primăvară, Academia Oamenilor de Știință din România, Bucuresti,

Vineri, 24 martie 2017, Sediul Academiei Oamenilor de Știință din România, Sala de

Conferințe, Moderatori: Natalia Roşoiu, Adrian Bavaru, Ion Dediu, ora 12.10.

7. Daniel Timofte, Andrei, Ciobica, Cezar Honceriu, Florin Trofin, Alin, Ciobica, Dumitru,

Cojocaru, How Important Are The Animal Models Studies in Understanding Obesity,

the Relevance of the Pshysical Exercises or Exercise-Induced Muscle Enlargement ?,

Sesiunea Științifică de Primăvară Academia Oamenilor de Știință din România, Bucuresti,

Vineri, 24 martie 2017, Sediul Academiei Oamenilor de Știință din România, Sala de

Conferințe, Moderatori: Natalia Roşoiu, Adrian Bavaru, Ion Dediu, ora 12.20.

8. Antioch Iulia, Ciobica Alin, Is Oxytocin Involved In Schizophrenia-Pain Interactions?,

Conferința Științifică a Doctoranzilor „Tendințe contemporane ale dezvoltării științei: viziuni

ale tinerilor cercetători”, Sesiunea de Biologie, Ediția a VI-a, Chișinău, Joi, 15 iunie 2017,

pag 145.

9. Alin Ciobica, Iulia Antioch, Miruna Balmuș, Radu Lefter, Tratamentul cu ocitocină în

boli neuropsihiatrice/ Treatment with oxytocin in neuropsychiatric diseases, Day 2 –

Thursday, October 05, 2017, Al XXI–lea Simpozion Național de Psihoneuroendocrinologie,

4 - 6 Octombrie 2017, Iași, Între ghiduri și terapie personalizată în patologia

PsihoNeuroEndocrină.

10. Alin Ciobică, Elemente moderne de cercetare privind ocitocina și manifestările

neuropsihiatrice, Aspecte moderne în cercetarea neuropsihiatrica actuala, “Zilele Academice

Ieșene” ediția XXX-a, 12 Octombrie 2017.

11. Alin Ciobica, Anna Kis, Understanding the Importance of Oxytocin in Human-

Directed Social Behaviour of Dogs. How Relevant is This for Some Neuropsychiatric

Disorders Patho-Physiology?, Sesiunea Ştiinţifică de Toamnă 2017 a Academiei Oamenilor

de Ştiinţă din România, Biblioteca Universității Politehnica Timișoara, 12 – 14 octombrie

2017, pagina 14, 54.

12. Ioana Miruna Balmuș, Bogdan Stoica, Alin Ciobîcă, Irina Dobrin, Cristinel Ștefănescu,

Oxytocin levels variations in the blood of mild cognitive impairment and Alzheimer’s

disease patients. Further relevance for possible oxytocin treatment in dementia?, Zilele

Medicamentului - Medicamentul de la idee la Clinică, Ediția A XXV-a Iași, 12-14 Octombrie

2017, Pagina 7.

Lucrări (orale și postere) la congrese internaționale/conferințe internaționale

1. R. Maxim, Anca-Victorita Trifan, A. Plesa,C., S.C. Oana Cristina, I. Ciortescu, I.

Girleanu; Severity of mucosal damage and tissue transglutaminase antibodylevels correlate

well in adult celiac disease irrespective of clinical features P 1926, United European

Gastroenterology (UEG) Week Barcelona, 28 October – 1 November 2017 Barcelona, Spain

2. Simona Alina Popescu, R. Lupusoru, R. Sirli, M. Danila, L. Gheorghe, A. Seicean, A.-V.

Trifan, M. Curescu, A. Goldis, L. S. Sandulescu, C. Cijevschi Prelipcean, C. Stanciu, C.

Brisc, S. Iacob, I. Sporea; In how many patient we will misdiagnose esofageal varices by

using baveno VI criteria? P 1335, United European Gastroenterology (UEG) Week

Barcelona, 28 October – 1 November 2017 Barcelona, Spain

3. I. Girleanu, A.- V. Trifan, C. Cojocaru, A. M. Singeap, C. Sfarti, O. Stoica, S. Chiriac, T.

Cuciureanu, S., C. Stanciu; Carvedilol versus propranolol effect in the primary

prophilaxis variceal bleeding in cirrhotic patient with portal vein thrombosis, P 0639,

United European Gastroenterology (UEG) Week Barcelona, 28 October – 1 November 2017

Barcelona, Spain

4. A. M. Singeap, A.V. Trifan, S. Chiriac, I. Girlenu, T. Cuciureanu, C. Stanciu;

Cyanoacrylate injection therapy of small bowel varices by double-balloon enteroscopy

(DBE): a tretiary centre experience, United European Gastroenterology (UEG) Week

Barcelona, 28 October – 1 November 2017 Barcelona, Spain

5. Carmen Cristina Ester, l. Gheorghe, S. Iacob, C. Cijevschi, A.-V. Trifan, C. Stanciu, I.

Sporea, R. Sirli, M. Curescu, C. Brisc, A. Goldis, V. Arama, F. A. Caruntu, I. Rogoveanu, A.

Seicean, I. Simionov, R. Vadan, I. Pirvulescu, C. Pietrareanu, R. A. Iacob, C. Gheorghe, M.

Diculescu; Saftty efficacy and risk of complications for cirrhotic HCV patients with

trombocytopenia and hypoalbuminemia treated with Ombitas-

Vir/Paritaprevir/R+Dasabuvir+Ribavirin – A real life cohort, United European

Gastroenterology (UEG) Week Barcelona, 28 October – 1 November 2017, Barcelona, Spain

6. Ciobica Alin, The relevance of the oxidative stress status modifications in the possible

therapeutical effects of oxytocin for most of the neuropsychiatric disorders, 2nd

International Conference on Biochemistry September 28-29, 2017 UAE AND PUBLISHED

IN Biochem Anal Biochem, 2017, volume 6, issue 3, page 52, DOI 10.4172/2161-1009-C1-

015, ISSN 2161-4009.

7. Lefter R., Ciobica A., Padurariu M., Antioch I., Balmus I., R. Dobrin, Intranasal

oxytocin administration reduces memory, anxiety and depression-related deficits in a

valproic acid-induced perinatal model of autism, 3rd Congress of the European Academy

of Neurology (EAN) taking place in Amsterdam from June 24 to 27, 2017, poster number

#2689, Topic: Child neurology/developmental neurology.

8. Ioana-Miruna Balmus, S.A. Strungaru, G. Plavan, M. Nicoara, A. Ciobica, Direct

exposure to oxytocin results in increased social behavior and mobility performances in a

zebrafish animal model, 13th World Congress of Biological Psychiatry; the World

Federation of Societies of Biological Psychiatry (WFSBP) Copenhagen, 18 - 22 June 2017,

poster number 024, page 58, Session Anxiety, OCD & PTSD, Chair: Ulrike Schmidt,

Germany.

9. Radu Lefter, Alin Ciobica, Manuel Paulet, Iulia Antioch, Modified method for the

administration of intranasal drugs in rats, 5th International Congress on Neurobiology,

Psychopharmacology and Treatment Guidance which will take place in Chalikidiki, Greece,

on May 25-28, 2017, poster number P 05, page 84.

10. Radu Lefter, Alin Ciobica, Iulia Antioch, Ioana Miruna Balmus, Manuela Padurariu,

Romeo Dobrin, Intranasal oxytocin administration reduces memory, anxiety and

depression-related deficits in a valproic acid-induced rat model of autism, 5th

International Congress on Neurobiology, Psychopharmacology and Treatment Guidance

which will take place in Chalikidiki, Greece, on May 25-28, 2017, poster number P 27, page

108.

11. Radu Lefter, Alin Ciobica, Correlations between gastro-intestinal symptoms and

Autistic Manifestations – a Review, 5th International Congress on Neurobiology,



12. Manuela Padurariu, Alin Ciobica, Cristinel Stefanescu, Curent aspects in

understanding the relevance of intransal oxytocin in the management of depression, 5th

International Congress on Neurobiology, Psychopharmacology and Treatment Guidance

which will take place in Chalikidiki, Greece, on May 25-28, 2017, poster number P 54, page

137.

13. Radu Lefter, Alin Ciobica, Iulia Antioch, A comparison between the intranasal and

intraperitoneal effects of oxytocin administration in a valproic-acid induced rat model

of autism, 5th International Congress on Neurobiology, Psychopharmacology and Treatment

Guidance which will take place in Chalikidiki, Greece, on May 25-28, 2017, poster number P

79, page 166.

14. Stefan Strungaru, Miruna Balmus, Gabriel Plavan, Alin Ciobica, Mircea Nicoara,

Oxytocin water exposure significantly increases social behavior and locomotor activity

in a zebrafish animal model, 5th International Congress on Neurobiology,



15. Manuela Padurariu, Radu Lefter, Alin Ciobica, Heba El-lethey, Mervat Kamel,

Describing some behavioural animal models of anxiety and their mecanistics. Oxytocin

relevance?, 6th International Conference (The 14th Scientific Conference) of Veterinary

Medicine. Organized by the Faculty of Veterinary Medicine, Cairo University, Egypt,

January 28 – 31, 2017 at Sharm El Sheikh.

16. Schmidt, N., A. Kollewe, C. Constantin, S. Henrich, W. Bild, A. Saalbach, U. Schulte

and B. Fakler (2017). "Functional proteomics of plasma membrane Ca2+-ATPases

(PMCAs) in the brain." Abstracts of the 96th Annual Meeting of the German Physiological

Society, 16-18 March 2017, Greifswald, Germany, Acta Physiologica 219: 92-92.

17. V. Bild, D.C. Ababei, W. Bild, Synergism between doxepine and candesartan on hot

plate in mice. EFIC Congres, September 6-9, 2017, Copenhaga, Denmark

Editorial Board

3 reviste cotate ISI – prof. C. Stanciu

1. Journal of Gastrointestinal and Liver Diseases

2.Lancet Oncology

3. Rev. Med. Chir.

Reviewer

6 reviste cotate ISI – Prof. C. Stanciu

1. Journal of Gastrointestinal and Liver Diseases

2.Annals of Hepatology – prof. C. Stanciu

3.Clinical Gastroenterology and Hepatology

4.World Journal of Gastroenterology

5.Journal of Crohn' s Colitis

6. World Journal of Hepatology

11 reviste – C S III A. Ciobica

7. 1 Jan 2017 - The Open Neurology Journal- Pubmed indexed- Edited by Bentham - A.

Ciobica

8. 8 Jan 2017 - British Journal of Medicine and Medical Research – A. Ciobica

9. 27 February 2017 - Current Medical Imaging Reviews- IF 2015 – 0.6 – A. Ciobica

10. 7 Martie 2017 - British Journal of Pharmaceutical Research - Ciobica

11. 05 May 2017 - Frontiers in Psychology | Comparative Psychology- IF 2.4 – A. Ciobică

12. 16 June 2017- Phytomedicine- IF 3.5 – A. Ciobica

13. sept 2017 - Antioxidants (ISSN 2076-3921)- indexata Scopus si Pubmed - A. Ciobica

14. 04 October 2017 – Hippocampus – IF 3.945 - A. Ciobică

15. 02 October 2017 - Journal of Advances in Biology & Biotechnology – A. Ciobica

16. Noiembrie 2017 - Molecular Psychiatry – Nature – IF 14 - Ciobica

17. Noiembrie 2017- Oncotarget IF 5.1 – A. Ciobica

Prof. C. Stanciu - Membru în comitete științifice și moderator la manifestări științifice

naționale/ internaționale

1. Conferința Națională de Chirurgie, Iași 4-7 Octombrie, 2017, comitetul științific,

moderator;

2. Societatea Romana de Gastroenterologie și Hepatologie, Școala Națională de Vară, Ediția

a XIII-a, Păltiniș, 6-8 iulie 2017, moderator;

3. Al XXXVII-lea Congres Național de Gastroenterologie, Hepatologie și Endoscopie

Digestivă, 22-24 Iunie 2017, București, moderator;

4. RRCCC – Romanian Crohn s and Colites Diseses – 9 th National Symposium on

Inflamatory Bowel Diseses, Bucharest, 28 – 30th of Septembre 2017 – comitet științific ;

5. Hepatology 2017 – A panoramic view - 4 UpDATEON Hepatology, Course Bucharest

2017, Romania, 6-7 aprilie 2017, Bucharest - comitet stiințific;

6. JFHOD – Journees Francophones d' Hepato-gastroenterologie et d' Oncologie Digestive,

23-26 Mars, Paris 2017, membru

7. Digestive Endoscopy, Cluj, 24- 26 september 2017 – comitet științific

8. Zilele Academice Ieșene, Ediția a XXXIIa, 9 octombrie 2017 – Masa Rotundă – Aspecte

moderne în cercetarea neuropsihiatrică actuală – Descoperirea inhibitorilor pompei de protoni

– model de cercetare științifică, moderator

9. Word Bioetics Day, Grigore T. Popa University of Medicine and Pharmacy Iasi,

presentations – Exclusions of the patient with HCV and mild/moderate fibrosis

Cărți

În România

1. editor – Carol Stanciu – Noi concepte în gastroenterologie și hepatologie, 2017, Editura

Gr. T. Popa

2. autor – Carol Stanciu, Anca Trifan – Note de curs gastroenterologie, 2017, Editura Gr. T.

Popa

3. autor - Carol Stanciu – „ Ce se întâmplă după vindecarea virusologică în hepatita cronică

virală C?” În : Actualități în medicina internă, sub redacția C. Gherasim, Al. Oproiu, Editura

Medicală, București, 2017, pg. 337-386

În străinătate

1. Carol Stanciu – „Portal Vein Thrombosis in Patients with liver cirrhosis” În : Liver

Cirrhosis – Update and Current Chalenges, Editura INTECH, 2017

Cele mai importante lucrări pentru anul 2017

1. Trifan, A. and C. Stanciu (2017). "Beta-Blockers in Decompensated Cirrhosis: More

Questions Than Answers." Clinical Gastroenterology and Hepatology 15(1): 149-149. I F

7,398

2. Trifan, A., C. Stanciu, I. Girleanu, O. C. Stoica, A. M. Singeap, R. Maxim, S. A. Chiriac,

A. Ciobica and L. Boiculese (2017). "Proton pump inhibitors therapy and risk of

Clostridium difficile infection: Systematic review and meta-analysis." World Journal of

Gastroenterology 23(35): 6500-6515. I F 3,365

Rezumat Centrul de Cercetări Biomedicale

Vezi tabelul anexat

Nr. CCB …......./………………..

CENTRUL DE CERCETĂRI BIOMEDICALE

REZUMAT

2017

Nume și prenume ISI in extenso/nr.

ISI in rezumat/nr.

BDI in extenso/

nr.

Lucrări (orale și postere) la

congrese/conferințe

internaționale

Lucrări (orale și postere) la

congrese/conferințe

naționale

Membru in comitete de organizare,

comitete Științifice, manifestări

științifice

Cărți Editorial board/nr

.

Reviewer

Prof. Carol Stanciu 8 28 3 5 2 9 4 3 6

CS II Walther Bild 4 - - 2 - - - - -

C S III Veronica Bild 6 - 3 1 - - - -

C S III Alin Ciobica 13 - 6 10 10 11

C S Radu Lefter 5 5 2

Total Centru 24* 28 12 17* 12* 9 4 3 17

* Lucrările sunt în colaborare între membrii centrului, deci numărul de participări individuale este mai mare decât numărul total de lucrări.

Coordonator Centru,

Prof. Carol Stanciu

acad.ro · Web viewWord Bioetics Day, Grigore T. Popa University of Medicine and Pharmacy Iasi,...

Documents

Transcript of acad.ro · Web viewWord Bioetics Day, Grigore T. Popa University of Medicine and Pharmacy Iasi,...