Sistemul Complement
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Transcript of Sistemul Complement
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Sistemul complement
Sistem multienzimatic format din peste 30 de componente, liber circulante in plasma (10% din totalul proteinelor plasmatice) – proenzime care se activeaza pe mai multe cai.
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C1
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Calea clasica
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Caracteristici comune celor doua cai de activare a complementului
Declansarea este conditionata de depunerea pe membrane tinta (non-self) a C4b in calea clasica si a C3b in calea alternanta;Cele doua convertaze C3 si C5 desi deosebite structural actioneaza identic si pe acelasi substrat;Indiferent de calea de activare in final se ajunge la MAC
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Functii
• Definitiveaza actiunea Ac asupra Ag• Realizeaza o recunoastere imunologica
nespecifica a structurilor non-self
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04/19/23 04:29 AM 6
Liza celulara prin interventia CMA - Faza-1
• IgG or IgM reactioneaza cu epitopi de pe membrana celulei gazda si activeaza calea clasica a cascadei complementului cu aparitia in final a CMA ce produce liza celulei.
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04/19/23 04:29 AM 7
Faza-2:
• Complexul membranar de atac ce induce liza celulara.
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04/19/23 04:29 AM 8
Liza celulara prin interventia celulelor NK - Faza-1
• Ac reactioneaza cu epitopi de pe membrana celulei gazda si limfocitele NK se leaga de fragmentul Fc al Ac;
• Celulele NK induc formarea de pori in celula gazda si-si varsa continutul granulelor citotoxice in interior.
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04/19/23 04:29 AM 9
Faza - 2:
• Liza celulara prin formarea de pori si revarsarea continutului garanulelor lizozomale.
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Liza celulara prin interventia fagocitelor Faza -1
• Fragmentul Fab al IgG leaga epitopi de pe membrana celulei gazda. Fagocitele se leaga de fragmentul Fc.
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04/19/23 04:29 AM 11
Faza-2
• Fagocitele se leaga de fragmentul Fc al IgG si descarca intregul continut lizozomal determinand liza celulara.
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Tip de intrebareFactorul B:a.Este activat de properdinab.Este activat de factorul Dc.Este activat de C1qd.Intra in constitutia C3-convertazeie.Intra in constitutia C5-convertazei