Hematopoieza
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Transcript of Hematopoieza
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Hemopoieza
Embrionară
-sacul vitelin-ficat-timus-măduva osoasă-splina-ganglionii limfatici
Postembrionară
-măduva osoasă
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I
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III
IV
V
VI
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V
Celula stem hemopoietică(totipotentă)
Celula semistem progenitoare a mielopoezei
(pluripotentă)
Celula semistem progenitoare a limfopoiezei
(pluripotentă)
I
II
III
IV
VI
Mitoză
sau
Celule precursoare unipotente(celule formatoare de colonii-CFC)
Blaste
Tinere(în maturatie)
Mature
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V
Celula stem hemopoietică(totipotentă)
Celula semistem precursoare a mielopoezei
(pluripotentă)
Celula semistem precursoare a limfopoiezei
(pluripotentă)
I
II
III
IV
VI
Mitoză
sau
CFC-E
eritroblastPronormocit
Eritrocit
Normocit bazofil
Normocit policromatofil
Normocit oxifil
Reticulocit
CFC-M
monoblast
Promonocit
Monocit
CFC-T
megacarioblast
Megacariocit
Trombocit
CFC-GE sau B sau N
mieloblast
Granulocit
PromielocitMielocitMetamielocitGranulocit nesegmentat
E sau B sau N
E sau B sau N
!
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V
Celula stem hemopoietică(totipotentă)
Celula semistem precursoare a mielopoezei
(pluripotentă)
Celula semistem precursoare a limfopoiezei
(pluripotentă)
I
II
III
IV
VI
Mitoză
sau
CFC-T CFC-B
T-limfoblast B-limfoblast
Prolimfocit-T Prolimfocit-B
Limfocit-T Limfocit-B
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I
II
III
IV V
VI
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V
Celula stem hemopoietică(totipotentă)
Celula semistem precursoare a mielopoezei
(pluripotentă)
Celula semistem precursoare a limfopoiezei
(pluripotentă)
I
II
III
IV
VI
CFC-T CFC-B
T-limfoblast B-limfoblast
Prolimfocit-T Prolimfocit-B
Limfocit-T Limfocit-Bantigenic nestimulatTimus
ThTs/k
antigenic nestimulaţi
Organele hem. şi prot.imună periferice
Ag
Blast BlastThTs/k
antigenic stimulaţi plasmocit
(pre-T)