Coordonator: Universitatea de Medicina si Farmacie “Iuliu Hatieganu” Cluj NapocaFarmacie Iuliu Hatieganu Cluj-Napoca

Director proiect: Conf. Dr. Iancu Cornel pCatedra Chirurgie 3 Cluj-Napoca

Parteneri în consorţiu: Parteneri în consorţiu: P1. Spitalul Clinic de Urgenta Prof. Dr. “Octavian Fodor”

Cluj-NapocaP2 Instit t l Naţional de Cercetare De oltare pentr P2. Institutul Naţional de Cercetare-Dezvoltare pentru Tehnologii Izotopice şi Moleculare Cluj-Napoca

P3. Institutul Naţional de Cercetare-Dezvoltare pentru Fizica M t i l l B tiMaterialelor-Bucuresti

Buget: 2.000.000 RONg Adresa web:http://clinicachirurgie3.ro/nanopan/

Obiectivele specifice caractere de originalitate:Cercetarea urmareste in premiera internationala urmatoarelep

obiective specifice: Identificarea target-urilor membranare specifice in scopul dirijarii

selective a nanotubulilor de carbon la nivelulcelulelor neoplazice Functionalizarea nanotuburilor de carbon cu elemente Functionalizarea nanotuburilor de carbon cu elemente

complementare target-urilor neoplazice pancreatice specifice identificate.

Cercetarea potentialului tumoricid al iradiere LASER in vitro asupra celulelor pancreatice tumorale continand SWCNT internalizatecelulelor pancreatice tumorale continand SWCNT internalizate

Identificarea modalitatilor practice de administrare a SWCNT functionalizate si marcate specific in organismul gazda

Obtinerea unei metode noi de tratament a neoplasmului pancreaticB fi i ii lt t lBeneficiarii rezultatelor:

pacientii cu cancer pancreatic personalul medical cercetatori ingineri cercetatori, ingineri, studenti agenti economici

Buget de stat: 240000 RON Investitii in echipamente CD:97500 RON Precursori/rezultate intermediare Precursori/rezultate intermediare

Infiintarea si dotarea Centrului de Cercetari in Nanomedicina al UMF Cluj-Napoca si SpitaluluiClinic O. Fodor (5 incaperi insumand 110 m2)Initierea formalitatilor de infiintare a SocietatiiRomane de Nanomedicina

model teoretic de sinteza si caracterizare a nanotuburilor de carbon cu un singur perete tip single walledperete tip single walled

model teoretic de intretinere si cultivare a celulelor neoplazice pancreatice PANC 1 model teoretic de functionalizare al nanotuburilor de carbon cu anticorpi specifici

celuleor tumorale pancreatice model teoretic de tratament in vitro al culturilor celulare neoplazice pancreatice cu

b f l fnanotuburi functionalizate cu anticorpi specifici model teoretic de iradiere LASER al culturilor celulare PANC-1 tratate cu nanotuburi

de carbon functionalizate cu anticorpi specifici model teoretic de cancer pancreatic uman reprodus la soarecii tip CD 1 model teoretic de tratament in vivo al culturilor celulare neoplazice pancreatice cumodel teoretic de tratament in vivo al culturilor celulare neoplazice pancreatice cu

nanotuburi functionalizate cu anticorpi specifici model teoretic de tratament in vivo al animalelor cu adenocarcinom pancreatic uman

cu nanotuburi functionalizate cu anticorpi specifici stabilirea unei colaborari cu Departamentul de Nanotehnologii al Universitatii Litle

Rock din Arkansas Statele UniteRock din Arkansas Statele Unite Infiintarea Societatii Romane de Nanomedicina

Materiale 1 Videoproiector Fact201822/

Echipamente de cercetare-Dotarea Centrului de Nanomedicina COORDONATOR-UMF CLUJ-NAPOCA p /

12.12.2007 2 Monitor LCD Fact201824/

12.12.2007 4 PDA agenda

electronica Fact482/

06.12.207

1 Platforma de Electrochirurgie pentru prelevarea tesuturilor

FactPHX071.0718/10.12.2007

57400

P I Spitalul Clinic de Urgenta Prof. Dr. “Octavian Fodor” Cluj-Napoca

5 Aparat de laminat Fact487/ 10.12.207

6 Laptop Fact 107707/ 12.12.2007

7 Laptop Fact 107708/ 12 12 2007

Napoca 2 Incubator CO2 Fact 5198/

29.11.2007 22100

3 Hota chimica Fact 5198/ 29.11.2007

12545.73

4 A i t dii d F t 0006114/ 6777 05 12.12.2007 8 Imprimanta Fact 107709/

12.12.2007 9 Aparat foto Fact3035314/30.11

.200

4 Aspirator medii de cultura

Fact 0006114/ 3.12.2007

6777.05

◦ Buget de stat: 767410 RON (din 859000 RON)Buget de stat: 767410 RON (din 859000 RON)◦ Rezultate intermediare in etapa II: Cereri de brevete depuse in etapa II:

Attorney Docket No. 999084BTITLE OF INVENTION: “Metallic nanoparticles coated with graphitic shells as localized radio frequency absorbers for cancer therapy” INVENTOR NAMES: Alexandru S. Biris, Yang Xu, Zhongrui Li, Meena Mahmood, and Alexandru R. Biris

Cererea de brevet cu titlul: “Procedeu de determinare a sulfamidelor din muşchi de pasăre prin extracţie dispersivă în fază solidă folosind nanotuburi de carbon de tip MWCNT”.Autori :Bele Constantin, Matea Cristian Tudor, Dan Lupu, Alexandru Biriş, Iancu Cornel, Mocan Lucian.

Dotarea si punerea in functiune a Centrului de Cercetari in Nanomedicina Investitii in echipamente de cercetare: 267635.78RON

model experimental de sinteza si caracterizare a nanotuburilor de carbon cu un singur perete tip single walledcarbon cu un singur perete tip single walled

model de laborator privind intretinerea si cultivarea celulelor neoplazice pancreatice PANC 1

model de laborator privind functionalizarea nanotuburilor de carbon pcu anticorpi specifici celuleor tumorale pancreatice (EGF)

model de laborator privind tratamentul in vitro al culturilor celulare neoplazice pancreatice cu nanotuburi functionalizate cu anticorpi

ifi ispecifici model de laborator privind iradierea LASER a culturilor celulare

PANC-1 tratate cu nanotuburi de carbon functionalizate cu anticorpi specificispecifici

Echipamente Cercetare-UMF Cluj

1 Vortex –agitator magnetic Fact 9202103/ 03.10.2008 1799.07

2 Lampa laser Fact 58/ 14.04.2008 21003.50

3 Di til t Fact 9203323/ 1799 98 3 Distilator Fact 9203323/ 19.11.2008 1799.98

4 Aparat sectionare tesuturi cu ultrasunete

Fact 0012733/ 30.10.2008 31951.5

5 Ph-metru de laboator Fact 9202723/ 30.10.2008 1798.79 30 0 008

5 Baie de apa termostatata cu accesorii Fact 9203334/ 20.11.2008 14778.24

6 Balanta Kern Fact 9202722/ 30.10.2008 1799.04

Echipamente Cercetare-P1 SCUCN Clujp j

7 Centrifuga de racire HETTICH Fact 9202091/ 03.10.2008 15.551,91

8 Masina pt. spalat sticlarie MIELE Fact 1359/ 13.10.2008 15.562,88

9 Microscop model AE-31 Fact 9202709/ 11 715 679 Microscop model AE 31 30.10.2008 11.715,67

Echipamente Cercetare-INCDTIM Cluj

10 Aparat pentru analiza termica

diferentiala ATD, simultan DCS si TGA-analizor termogravimetric

Fact 763/ 17.06.2008 71861.54

Buget de stat: 170237 RON (din 737590 RON)

Precursori/rezultate intermediare

Dotarea Centrului de Cercetari in Nanomedicina model experimental de cancer pancreatic uman reprodus

la soarecii tip CD 1

Investitii in echipamente de cercetare: 1700RON

ECHIPAMENTE CD CO UMF

1Hota

microbiologicaFact

9206408/06.08.2009 16999.991 microbiologica 9206408/06.08.2009 16999.99

Stagiu de pregatire 07.09.2008-06.10.2008 pentru 3 doctoranzi ai UMF Iuliu Hatieganu la Centrul de Nanotehnologii al Universitatii Little Rock SUAHatieganu la Centrul de Nanotehnologii al Universitatii Little Rock, SUA,.

3 teme de doctorat in domeniul terapiei tintite molecular a cancerelor 3 teme de doctorat in domeniul terapiei tintite molecular a cancerelor utilizand nanotuburi specific functionalizate:

“Nanoterapia in cancerul de pancreas - modele experimentale.”-p p pdrd. Mocan Lucian

“Implicatiile stresului oxidativ in relatie cu nanomaterialele”drd.Mocan Teodora

“Functionalizarea nanotuburilor de carbon cu aplicatii in nanomedicina”drd. Simon Stefania

Nr.

PubliIcatii in baze de date indexate ISI (cu IF=0.3-6.02) 21

Prezentari la manifestari internationale 18

235th ACS National Meeting, New Orleans, LA, United States, Aprilie, 2008 3

64th Southwest Regional Meeting of the American Chemical Society, Little R k AR U i d S O b i 2008

4Rock, AR, United States, Octombrie, 2008

IEEE Annual Meeting, Industrial Aplication Society, Edmonton, Canada, Octombrie 2008.

2

Materials Research Society Fall Meeting, Boston, USA, Decembrie 2008. 2

CANCER TARGETING BY NANOMATERIALS, MIAMI, FLORIDA, USA SEPTEMBRIE, 2008 5

“ Nanotech Conference”,Houston, TX, USA,Mai, 2009 1

International Congress of Physiological Sciences, Kyoto, 2009, Japan august, 2009 1

Nanobiotechnology and Nanobiophotonics--Opportunities and ChallengesMRS Meeting 2009, Harvard University Boston

1

Lista cu lucrări ştiinţifice publicate in reviste cotate ISI 2008

1. Reginald B. Little, A. R. Biris, D. Lupu, Yang Xu, Zhongrui Li, Enkeleda Dervishi, and Alexandru S. Biris, “On the dynamical ferromagnetic, quantum Hall, and relativistic effects on the carbon nanotubes nucleation and growth mechanism”, Journal of Magnetism and Magnetic Materials, 320(3,4), 540-547, 2008. [IF=1.031]

2. A. R. Biris, Z. Li, E. Dervishi, D. Lupu, Y. Xu, V. Saini, F. Watanabe, A.S. Biris, “Effect of hydrogen on the growth and

morphology of single wall carbon nanotubes synthesized on Fe-Mo/MgO catalytic system”, Physics Letters A, Physics

Letters A, 372(17) (2008),3051-3057 [IF=1.71]

3. Z. Li, H. R. Kandel, E. Dervishi, V. Saini, Y. Xu, A. R. Biris, D. Lupu, G. J. Salamo, A. S. Biris, “Comparative Study on

Different Carbon Nanotube Materials in Terms of Transparent Conductive Coatings” Langmuir, 24(6) (2008) 2655-2662.

[IF=4.09]

4. A.R. Biris, D. Lupu, I. Misan, E. Dervishi, Z. Li, Y. Xu, S. Trigwell A. S. Biris, “High Cristallinity Multi Wall Carbon

Nanotubes Synthetized by Inductive Heating CCVD” J Optoelectronics and Advanced Materials 10(9) (2008)2311 2316Nanotubes Synthetized by Inductive Heating CCVD” J. Optoelectronics and Advanced Materials, 10(9) (2008)2311-2316

[IF=1.138]

5. Li Zhongrui; Dervishi Enkeleda; Xu Yang; Ma Xiaodong; Saini Viney; Biris Alexandru S; Little Reginald; Biris Alexandru R; Lupu Dan, “Effects of the Fe-Co interaction on the growth of multiwall carbon nanotubes”, The Journal of chemical

physics (2008), 129(7),074712. [IF=3.044]

6. A. R. Biris, D. Lupu, A. Grüneis, P.Ayala, M. H. Rümmel, T. Pichler, Z. Li, I. Misan, E. Dervishi, Alexandru S. Biris,

“High Quality Double Wall Carbon Nanotubes Grown by a Cold-Wall Radio Frequency Chemical Vapor Deposition

Process”, Chemistry of Materials, -20(10), (2008), 3466-3472. [IF=4.82]

7. Li Zhongrui; Xu Yang; Ma Xiaodong; Dervishi Enkeleda; Saini Viney; Biris Alexandru R.; Lupu Dan; Biris Alexandru S.

“CO2 enhanced carbon nanotube synthesis from pyrolysis of hydrocarbons”, Chemical Communications, y py y y , ,

(2008),(28),3260-3262. [IF=5.14]

8. Li, Zhongrui; Dervishi, Enkeleda; Xu, Yang; Ma, Xiaodong; Saini, Viney; Biris, Alexandru S.; Little, Reginald; Biris, Alexandru R.; Lupu, Dan, “Effects of the Fe-Co interaction on the growth of multiwall carbon nanotubes”, Journal of

Chemical Physics, (2008),129(7), 074712/1-074712/6. [IF=3,044]

9. Biris, Alexandru R.; Lupu, Dan; Dervishi, Enkeleda; Li, Zhongrui; Xu, Yang; Trigwell, Steve; Misan, Ioan; Biris,

Alexandru S., “Multiwall carbon nanotubes synthesized by RF-CCVD on novel CaO supported catalysts”, Physics Letters

A (2008), 372(42), 6416-6419 [IF=1.71]

Lista cu lucrări ştiinţifice publicate in reviste cotate ISI 2008

9 Li, Zhongrui; Little, Reginald; Dervishi, Enkeleda; Saini, Viney; Xu, Yang; Biris, Alexandru R.; Lupu, Dan; Trigwell,

Steve; Saini, Divey; Biris, Alexandru S., “Micro-Raman spectroscopy analysis of catalyst morphology for carbon

nanotubes synthesis”, Chemical Physics (2008), 353(1-3), 25-31 [IF=1.805]

10 L. Olenic, G. Mihailescu, S. Pruneanu D. Lupu, A.R. Biris, P. Margineanu, “Investigation of Carbon Nanofibers as

Support for Bioactive Substances”, Journal of Materials Science: Materials in Medicine, DOI 10.1007/s 10856-008-

3550-y. [IF=1.081]3550 y. [IF 1.081]

11 Xu, Yang; Li, Zhongrui; Dervishi, Enkeleda; Saini, Viney; Cui, Jingbiao; Biris, Alexandru R.; Lupu, Dan; Biris, Alexandru S., “Surface area and thermal stability effect of the MgO supported catalysts for the synthesis of carbon

nanotubes”, Journal of Materials Chemistry (2008),18(47),5738-5745. [IF=4.34]

12 Yang Xu Meena Mahmood Zhongrui Li Enkeleda Dervishi Steve Trigwell Vladimir P Zharov Nawab Ali Viney12 Yang Xu, Meena Mahmood, Zhongrui Li, Enkeleda Dervishi, Steve Trigwell, Vladimir P. Zharov, Nawab Ali, Viney

Saini, Alexandru R. Biris, Dan Lupu, Dorin Boldor, Alexandru S. Biris,„Cobalt nanoparticles coated with graphitic

shells as localized radio frequency absorbers for cancer therapy”, Nanotechnology, 19,(2008),435102. [IF=3.310]

13 Viney Saini, Alexandru S. Biris, Enkeleda Dervishi, Zhongrui Li, Alexandru R. Biris, Dan Lupu, Reginald B. Little,

Steve Trigwell, Zia Rahman, Divey Saini, “Carbon Nanotubes Grown by RF Heating and Their Morphological and

Structural Properties” Particulate Science and Technology, 26: 521–528, 2008. [IF=0.310]

14 A.R. Biriş, D. Lupu, E. Dervishi, Z. Li, D. Saini, S. Trigwell, M. K. Mazumder, R. Sharma, A. S. Biris, “ Hydrogen

storage in Carbon-Based Nanostructures Materials”, Particulate Science and Technology, 26: 297-305, 2008. [IF=0.310]

15 M. Mahmood1 , D.A. Casciano1*, C. Iancu2 T. Mocan2, , Y. Xu1, L. Mocan2, D. Todea Iancu2, E. Dervishi1, Z. Li1 , AR.

Biris3, N Ali1, A S. Biris2, “Cytotoxicity and Biological Effects of Functional Nanomaterials Delivered to Various Cell

Lines” -Journal of Toxicology, In Press [IF=1.8]

Lista cu lucrări prezentate la manifestari stiintifice participare internationala 2008

1. Alexandru R. Biris, Dan. Lupu, Alexander Grüneis, Paolla Ayala, Mark h. Rümmel, Thomas Pichler, Zhongrui Li,

Ioan Misan, Enkeleda Dervishi, Alexandru S. Biris, “High quality double wall carbon nanotubes synthesized by RF chemical

vapor deposition”, Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008 (2008),

PHYS-407.

2 Y X Al d S Bi i Zh i Li E k l d D i hi Vi S i i Ol id D O hi Al d R Bi i2. Yang Xu, Alexandru S. Biris, Zhongrui Li, Enkeleda Dervishi, Viney Saini, Olumide D. Oshin, Alexandru R. Biris, Dan Lupu, “Controlled growth of carbon nanotubes on the high surface area magnesium oxide by RF CCVD”, presented at the

Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008 (2008), PHYS-407.

3. Zhongrui Li, Enkeleda Dervishi, Viney Saini, Yang Xu, Alexandru R. Biris, Dan Lupu, Steve Trigwell, Alexandru S.

Biris, “Influences of the Active Species Dispersion and the Fe-Co Interaction on the Growth of Carbon Nanotubes”, Abstracts of

Papers 235th ACS National Meeting New Orleans LA United States April 6-10 2008 (2008) PHYS-407Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008 (2008), PHYS-407.

4. Saini, Viney; Li, Zhongrui; Bourdo, Shawn; Dervishi, Enkeleda; Xu, Yang; Ma, Xiaodong; Viswanathan, Tito; Biris,

Alexandru S.; Biris, Alexandru R.; Lupu, Dan; Saini, Divey, “Conducting Polymer-Carbon Nanotube Composites Synthesized

by in-Situ Polymerization”, Abstracts, 64th Southwest Regional Meeting of the American Chemical Society, Little Rock, AR,

United States, October 1-4 (2008)

S S5. Xu, Yang; Li, Zhongrui; Dervishi, Enkeleda; Saini, Viney; Biris, Alexandru R.; Lupu, Dan; Biris, Alexandru S.,

“Single Walled Carbon Nanotubes Grown on Different Surface Area MgO”, Abstracts, 64th Southwest Regional Meeting of the

American Chemical Society, Little Rock, AR, United States, October 1-4 (2008), SWRM-078.

6. Dervishi, Enkeleda; Li, Zhongrui; Xu, Yang; Saini, Viney; Watanabe, Fumiya; Biris, Alexandru R.; Lupu, Dan; Mahmood, Meena W.; Biris, Alexandru S., “The Effect of the Synthesis Temperature on the Carbon Nanotube Morphological

Properties” Abstracts 64th Southwest Regional Meeting of the American Chemical Society Little Rock AR United StatesProperties , Abstracts, 64th Southwest Regional Meeting of the American Chemical Society, Little Rock, AR, United States,

October 1-4 (2008), SWRM-077

7. Li, Zhongrui; Xu, Yang; Dervishi, Enkeleda; Saini, Viney; Ma, Xiaodong; Biris, Alexandru R.; Lupu, Dan; Biris, Alexandru S., “CO2 Enhanced Carbon Nanotube Synthesis from Pyrolysis of Hydrocarbons”, Abstracts, 64th Southwest

Regional Meeting of the American Chemical Society, Little Rock, AR, United States, October 1-4 (2008), SWRM-076

8. Meena Mahmood, Yang Xu, Zhogrui Li, Enkeleda Dervishi, Nawab Ali, Steve Trigwell, Vladimir P. Zharov, Viney

Saini, Alexandru R. Biris, Dan Lupu, Alexandru S. Biris, “Graphitic Materials for RF Thermal Ablation of Tumors”, IEEE

Annual Meeting, Industrial Aplication Society, Edmonton, Canada, October 2008.

Lista cu lucrări prezentate la manifestari stiintifice participare internationala 2008

9. A.S. Biris, Z. Li, Y. Xu, V. Saini, E. Dervishi, R. Sharma, S. Trigwell, F. Watanabe, M.K. Mazumder, A.R. Biris, D. Lupu, “Multifunctional Coating with Carbon Nanotubes for Electrostatic Mitigation and Their Formation by Laser Heating”, IEEE

Annual Meeting, Industrial Aplication Society, Edmonton, Canada, October 2008.

10. Enkeleda Dervishi, Fumiya Watanabe, Yang Xu, Viney Saini, Alexandru R. Biris, and Alexandru S. Biris, “The

influence of reaction temperature on the size of the catalyst nanoparticles and the carbon nanotube diameter distributions”influence of reaction temperature on the size of the catalyst nanoparticles and the carbon nanotube diameter distributions ,

Materials Research Society Fall Meeting, Boston, USA, December 2008.

11. Zhongrui Li,

Enkeleda Dervishi, Yang Xu, Viney Saini, Meena Mahmood, Olumide Dereck Oshin, Alexandru S. Biris,

Alexandru R. Biris, Dan Lupu, “Carbon Nanotubes Growth on Calcium Carbonate Supported Molybdenum-Transition Metal

C t l t ” M t i l R h S i t F ll M ti B t USA D b 2008Catalysts” Materials Research Society Fall Meeting, Boston, USA, December 2008

12. A. Biris, T. Mocan “Cytotoxicity of Carbon Nanomaterials: Single-Wall Nanotube, Multi-Wall Nanotube”, CANCER

TARGETING BY NANOMATERIALS, MIAMI, FLORIDA, 25-29 SEPTEMBRIE, 2008

13. A. Biris, D.Todea-Iancu, “Interactions of Nanomaterials with Biological Systems”, CANCER TARGETING BY NANOMATERIALS,13. A. Biris, D.Todea Iancu, Interactions of Nanomaterials with Biological Systems , CANCER TARGETING BY NANOMATERIALS,

MIAMI, FLORIDA, 25-29 SEPTEMBRIE, 2008

14. D.Todea-Iancu, “Optimal nanomaterial administration methods for human cancer treatment”, CANCER TARGETING BY

NANOMATERIALS, MIAMI, FLORIDA, 25-29 SEPTEMBRIE, 2008

15. T. Mocan , “Selectivity optimization of nanotargeting the pancreatic cancer cells”, CANCER TARGETING BY NANOMATERIALS,

MIAMI, FLORIDA, 25-29 SEPTEMBRIE, 2008

16. L.Mocan, A. Biris “Nanotherapy in pancreatic cancer, experimental models”, CANCER TARGETING BY NANOMATERIALS,

MIAMI, FLORIDA, 25-29 SEPTEMBRIE, 2008MIAMI, FLORIDA, 25 29 SEPTEMBRIE, 2008

Publicatii ISI 2009

1. E. Dervishi, Z. Li, Y. Xu, V. Saini, A.R. Biris, D. Lupu, A.S. Biris, „Carbon Nanotubes: Synthesis, Properties, and Applications”, Particul. Sci. Technol., 27(2), 107-125, 2009.

2. E. Dervishi, Z. Li, F. Watanabe, Y. Xu, V. Saini, A. R. Biris, A. S. Biris, “Thermally controlled synthesis of single-wall carbon nanotubes with selective diameters”, J. Mater. Chem., 19(19), 3004-30012, 2009.

3 E Dervishi Z Li Y Xu V Saini F Watanabe A R Biris A Bonpain J J Garbay A Meriet M3. E. Dervishi, Z. Li, Y. Xu, V. Saini, F. Watanabe, A.R. Biris, A. Bonpain, J.J. Garbay, A. Meriet, M. Richard, A.S. Biris, “The influence of Fe-Co/MgO Catalyst composition on the growth properties of carbon nanotubes”, Particul. Sci. Technol., 27(3), 222-237, 2009.

4. C Iancu, IR Ilie, CE Georgescu, R Ilie,. AR Biris, T Mocan, LC Mocan, F Zaharie, D Todea-Iancu, S Susman, D Rus Ciuca, AS. Biris “Applications of Nanomaterials in Cell Stem Therapies and the Onset of Nanomedicine”. Particulate Science and Technology, In Press, 2009

5 M Mahmood D A Casciano T Mocan C Iancu Y Xu L Mocan D Todea-Iancu E Dervishi Z Li5. M. Mahmood, D.A. Casciano, T. Mocan, C. Iancu, Y Xu, L Mocan, D. Todea Iancu, E. Dervishi, Z. Li, AR Biris, M. Abdalmuhsen, N. Ali, AS. Biris “Cytotoxicity and Biological Effects of Functional Nanomaterials Delivered to Various Cell Lines”: Journal of Toxicology and Applied Pharmacology, In press, 2009

6. M. Mahmood1, C. Iancu2, T. Mocan2, L. Mocan2, D. Todea Iancu2, Y. Xu1, E. Dervishi1, Z.Li1, A. R.

Biris3, Ra. Agarwal1, N. Ali1, E. I. Galanzha4, V. Zharov4, A.S. Biris4- “Synergistic Enhancement of Cancer Therapy Using a Combination of Carbon Nanotubes and Chemotherapeutic Drugs”-Nanomedicine, Dec 2009, Vol. 4, No. 8, Pages 883-893.. [IF=6.024]

Prezentari la congrese internationale de specialitate 20091. E. Dervishi, Z. Li, Y. Xu, F. Watanabe, V. Saini, A.R. Biris, A.S. Biris,„Horizontally oriented

long carbon nanotubes grown on Si substrates by using a catalytic Chemical VaporDeposition process”, “ Nanotech Conference”, May 3-7, 2009, Houston, TX.

2 T Mocan LC Mocan D Todea Iancu B Diaconu S Simon D Lupu AS Biris AR2. T. Mocan, LC Mocan, D. Todea-Iancu , B. Diaconu, S. Simon, D. Lupu , AS. Biris., ARBiris, C Iancu, “Evaluation of ss-DNA –CNT effects on HeLa, HEPG2 and PANC-1 cell linesin vitro”, 36-th International Congress of Physiological Sciences, Kyoto, 2009, Japan (IUPS2009

3. Alokita Karmakar1, Meena W. Mahmood1, Ashley Fejleh1, Philip Fejleh1, Yang Xu1,Enkeleda Dervishi1 Anindya Ghosh1 Samuel L Collom1 Samar Hassan1 TeodoraEnkeleda Dervishi1, Anindya Ghosh1, Samuel L. Collom1, Samar Hassan1, TeodoraMocan2, Cornel Iancu2, Lucian Mocan2, Dana T. Iancu2 and Alexandru S.Biris1;Targeted Killing of Pancreatic Cancer Cells with Epidermal GrowthFactor. 1University of Arkansas at Little Rock, Little Rock, Arkansas; 2University ofMedicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania.