RAPORT AUTOEVALUARE - Paulescu · 1 RAPORT AUTOEVALUARE INSTITUTUL DE DIABET, NUTRIŢIE ŞI BOLI...

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1 RAPORT AUTOEVALUARE INSTITUTUL DE DIABET, NUTRIŢIE ŞI BOLI METABOLICE „PROF. N.C.PAULESCU BUCUREŞTI” Institutul Naţional de Diabet, Nutriţie şi Boli Metabolice "Prof. N. C. Paulescu" Str. Ion Movilă Nr. 5-7 Tel: +4021 210 6460 Bucureşti Sector 2 Fax: 4021 210 2295 79811, România E-mail: [email protected]

Transcript of RAPORT AUTOEVALUARE - Paulescu · 1 RAPORT AUTOEVALUARE INSTITUTUL DE DIABET, NUTRIŢIE ŞI BOLI...

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RAPORT AUTOEVALUARE

INSTITUTUL DE DIABET, NUTRIŢIE

ŞI BOLI METABOLICE

„PROF. N.C.PAULESCU BUCUREŞTI”

IInnssttiittuuttuull NNaaţţiioonnaall ddee DDiiaabbeett,, NNuuttrriiţţiiee şşii

BBoollii MMeettaabboolliiccee ""PPrrooff.. NN.. CC.. PPaauulleessccuu""

Str. Ion Movilă Nr. 5-7 Tel: +4021 210 6460

Bucureşti Sector 2 Fax: 4021 210 2295

79811, România E-mail: [email protected]

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ANEXA 1 (la metodologie)

RAPORT DE AUTOEVALUARE

perioada 2002-2007

1. Datele de autentificare ale unităţii de cercetare-dezvoltare

1.1. Denumirea: Institutul Naţional de Diabet, Nutriţie şi Boli Metabolice „Prof. Dr. NC

Paulescu‖, Bucureşti

1.2. Statutul juridic*1): Institut Naţional

1.3. Actul de înfiinţare*2): Ordinul Ministerului Sănătăţii Nr. 285/15 III 1993

1.4. Numărul de înregistrare în Registrul potenţialilor contractori: 4204151

1.5. Director general/Director: Manager - Cj Robert Agafiţei

1.6. Adresa: Str. Ion Movilă Nr. 5-7, Sector 2, Bucureşti

1.7. Telefon, fax, pagina web, e-mail:

Tel – 210.64.60

Fax – 210.22.95

Web - www.institutuldiabetpaulescu.ro

2. Domeniul de specialitate

2.1. Conform clasificării UNESCO*3): 3206

2.2. Conform clasificării CAEN: 8511

3. Starea unităţii de cercetare-dezvoltare

3.1. Misiunea unităţii de cercetare-dezvoltare, direcţiile de cercetare, dezvoltare, inovare:

(maximum 1.000 de caractere):

În urmă cu aproximativ şase decenii a fost înfiinţat la Bucureşti de către Prof. Ion Pavel

un mic centru antidiabetic, printre primele din Europa. Din acesta s-a dezvoltat Clinica de

Diabet, Nutriţie şi Boli Metabolice de la Spitalul „Dr. Ion Cantacuzino‖, transformată în anul

1993 în Institutul de Diabet, Nutriţie şi Boli Metabolice „Prof. N.C. Paulescu‖. Acesta a fost

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ridicat în anul 2007 la statutul de Institut Naţional. Preocuparea esenţială a instituţiei este

asistenţa de specialitate a bolnavilor cu diabet zaharat şi/sau alte boli de metabolism şi nutriţie.

La aceasta se adaugă partea formativă (de învăţământ) pentru studenţi, rezidenţi, doctoranzi şi

alte categorii de tineri. În acelaşi timp, o componentă puternică a activităţii noastre a fost şi

rămâne cercetarea ştiinţifică şi publicarea de literatură ştiinţifică. Multe dintre studiile efectuate

în perioada 2002-2007 au fost incluse în proiecte şi/sau granturi naţionale sau internaţionale,

soldându-se cu rezultate interesante, ceea ce a permis o valorificare superioară a lor. Au fost

abordate teme legate de genetica diabetului şi a altor dezordini metabolice, teme privind

patogenia şi terapia diabetului, teme privind extensia obezităţii şi combaterea acestui fenomen,

etc. O parte dintre proiectele menţionate vor continua în intervalul următor, lor urmând a li se

adăuga noi teme şi preocupări. O altă cale majoră a muncii de cercetare o reprezintă trialurile

clinice, realizate în cooperare cu marile companii farmaceutice. Ele sunt cel mai adeseori

destinate testării eficienţei şi siguranţei unor noi produse medicamentoase, necesitând

respectarea cu stricteţe a unor reguli de execuţie şi interpretare. În momentul de faţă, activitatea

de cercetare a Institutului „Prof. Dr. N.C. Paulescu‖ trece printr-un profund proces de

reorganizare. Sperăm să preluăm ceea ce a fost bun în trecut şi să ne orientăm spre o cercetare

ştiinţifică de tip intesiv, condusă după principiile managementului modern.

3.2. Modul de valorificare a rezultatelor de cercetare, dezvoltare, inovare şi gradul de

recunoaştere a acestora (maximum 1.000 de caractere):

Valorificarea rezultatelor se face prin prezentări poster şi orale la congrese naţionale şi

internaţionale de profil, precum şi prin publicarea de articole originale in extenso în reviste

internaţionale de prestigiu (cotate ISI sau PubMed), precum şi în reviste naţionale, cotate ISI sau

CNCSIS B. La acestea s-au adăugat în perioada 2002-2007 şi se vor adăuga şi în viitor

monografiile cu caracter „de sinteză‖. Cercetătorii noştri au publicat în ţară şi în străinătate

lucrări de reală valoare în care, pe lângă datele culese din literatura internaţională, au fost incluse

rezultatele obţinute în Institutul „Prof. N.C. Paulescu‖. Astfel de monografii au marele avantaj de

a prezenta cititorilor din toată lumea probleme medicale de actualitate, la rezolvarea cărora

autorii români au adus contribuţii notabile.

3.3. Situaţia financiară - datorii la bugetul de stat: - Fără datorii la bugetul de stat

4. Criterii primare de performanţă

punctaj

4.1. Lucrări ştiinţifice/tehnice publicate în reviste de specialitate cotate ISI*4)

4.1.1. Număr de lucrări ştiinţifice 29 x 30 870 puncte

4.1.2. Punctaj cumulat ISI*5) 278.206 x 5 1391.03 puncte

4.1.3. Număr de citări în reviste de specialitate cotate ISI*6)

155 citari x 5 775 puncte

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(Lista lucrărilor şi citărilor, grupate pe ani, se ataşează ca anexa nr. 4.1)

Total punctaj cap. 4.1: 3036.03 puncte

4.2. Brevete de invenţie*7)

4.2.1. Număr de brevete 0 x 30

4.2.2. Număr de citări de brevete în sistemul ISI 0 x 5

(Lista brevetelor şi citărilor, grupate pe ani, se ataşează ca anexa nr. 4.2)

Total punctaj cap. 4.2: 0 puncte

4.3. Produse şi tehnologii rezultate din activităţi de cercetare, bazate pe brevete, omologări sau

inovaţii proprii. Studii prospective şi tehnologice şi servicii rezultate din activitatea de cercetare-

dezvoltare, comandate de beneficiar

(Se indică contractul şi firma care utilizează produsul, serviciul şi tehnologia).

4.3.1. Număr de produse, tehnologii, studii, servicii 0 x 20

(Lista produselor, serviciilor şi tehnologiilor, grupate pe ani, se ataşează ca anexa nr. 4.3)

Total punctaj cap. 4.3: 0 puncte

Total punctaj cap. 4: 3036.03 puncte

5. Criterii secundare de performanţă

5.1. Lucrări ştiinţifice (tehnice) publicate în reviste de specialitate*8) fără cotaţie ISI

5.1.1. Număr de lucrări 21 x 5 105 puncte

(Lista lucrărilor grupate pe ani se ataşează ca anexa nr. 5.1)

Total punctaj cap. 5.1: 105 puncte

5.2. Lucrări ştiinţifice prezentate la conferinţe internaţionale cu comitet de program

5.2.1. Număr de comunicări prezentate 117 x 5 585 puncte

(Lista comunicărilor grupate pe ani se ataşează ca anexa nr. 5.2)

Total punctaj cap. 5.2: 585 puncte

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5.3. Modele fizice, modele experimentale, modele funcţionale, prototipuri, normative,

proceduri, metodologii, reglementări şi planuri tehnice noi sau perfecţionate, realizate în cadrul

programelor naţionale sau comandate de beneficiar

5.3.1. Număr de modele, normative, proceduri etc.: 0 x 5

(Lista modelelor, normativelor etc., grupate pe ani, se ataşează ca anexa nr. 5.3)

Total punctaj cap. 5.3: 0 puncte

Total punctaj cap. 5: 690 puncte

6. Prestigiul profesional

6.1. Membri (incluzând statutul de recenzor) în colectivele de redacţie ale unor reviste (cotate

ISI sau incluse în baze de date internaţionale) sau în colective editoriale ale unor edituri

internaţionale recunoscute

Număr de prezenţe în perioada pentru care se face evaluarea: 0 x 20

Nr. crt. Nume Titlul revistei/editurii

6.2. Membri în colectivele de redacţie ale revistelor recunoscute naţional (din categoria B în

clasificarea CNCSIS)

Număr de prezenţe: 6 x 10 60 puncte

1. Dan Mircea Cheţa Romanian Journal of Internal Medicine

2. Constantin Ionescu-Tîrgovişte Romanian Journal of Internal Medicine

3. Constantin Ionescu-Tîrgovişte Jurnalul Român de Diabet, Nutritie si Boli Metab

4. Radu Lichiardopol Jurnalul Român de Diabet, Nutritie si Boli Metab

5. Radu Lichiardopol Diabetes Care, Ediţia în limba Română

6. Cristian Guja Jurnalul Român de Diabet, Nutritie si Boli Metab

6.3. Premii internaţionale obţinute printr-un proces de selecţie

Număr de premii: 0 x 20

Nr. crt. Nume Premiul Anul

6.4. Premii naţionale ale Academiei Române

Număr de premii: 0 x 20

Nr. crt. Nume Premiul Anul

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6.5. Conducători de doctorat, membri ai unităţii de cercetare

Număr de conducători de doctorat: 2 x 10 20 puncte

1. Dan Mircea Cheţa

2. Constantin Ionescu-Tîrgovişte

6.6. Număr de doctori în ştiinţă, membri ai unităţii de cercetare

Număr de doctori în ştiinţă: 12 x 10 120 puncte

Total punctaj cap. 6: 200 puncte

Total punctaj cap. 4+5+6: 3926.03 puncte

7. Venituri realizate prin contracte de cercetare în domeniul pentru care se face evaluarea (în

perioada pentru care se face evaluarea):

7.1. Numărul şi valoarea contractelor de cercetare internaţionale finanţate din fonduri

publice*9):

Proiect: Type 1 Diabetes Genetics Consortium

Sponsor: NIH, NIDDK, JDRF

Coordonator Internaţional: Wake Forest University, North Carolina, USA

Coordonator European: Steno Diabetes Center, Copenhaga

Coordonator Naţional: Dr. Cristian Guja din partea IDNBM ―NC Paulescu‖

7.2. Numărul şi valoarea contractelor de cercetare internaţionale finanţate din fonduri private:

7.3. Numărul şi valoarea contractelor de cercetare naţionale finanţate din fonduri publice*10):

Granturi Academia Română

1. IZOLAREA DE INSULE PANCREATICE

Proiect GAR85 (Academia română) Contract Nr 127/2003

Perioada – 2003

Director de Proiect - Prof. Constantin Ionecu-Tîrgovişte

Buget – 2200 RON

2. IZOLAREA DE INSULE PANCREATICE

Proiect GAR85 (Academia română) Contract Nr 120/2004

Perioada – 2004

Contractor titular „IDNMB N Paulescu‖

Director de Proiect - Prof. Constantin Ionecu-Tîrgovişte

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Buget – 3500 RON

3. TRANSPLANTUL DE INSULE PANCREATICE. SURSE PANCREATICE ANIMALE – O NOUA

TERAPIE

Proiect GAR363 Grant al Academiei Române – Contract 112/2006

Perioada 2005-2006

Contractor titular „IDNMB N Paulescu‖

Director de proiect- Prof. Dr. Constantin Ionescu-Tirgoviste

Buget – 6000 RON

4. EVALUAREA BUNĂSTĂRII PSIHOLOGICE, A RATEI STĂRILOR DEPRESIVE ŞI A

CALITĂŢII ÎNGRIJIRILOR LA PACIENŢII DIABETICI TIP 1 (INSULINODEPENDENT)‖

Proiect GAR1246 - Grant al Academiei Române – Contract 132/2006

Perioada 2006

Contractor titular „IDNMB N Paulescu‖

Director de proiect - CPII Mariana Costea

Buget – 5.000 RON

5. INVESTIGAREA RELAŢIEI DINTRE POLIMORFISMELE GENEI VEGF ŞI NEUROPATIILE

PERIFERICE CU INCIDENŢĂ CRESCUTĂ LA COPII ŞI TINERI, UTILIZÂND TEHNICI DE

BIOLOGIE MOLECULARĂ ŞI ANALIZĂ STATISTICĂ

Grant Academia Romana 2007

Perioada: 2007-2009

Contractor titular „IDNMB N Paulescu‖

Director proiect. Cheţa Dan Mircea

Buget 2007 – 5.000 RON

Proiecte PNCDI tip VIASAN, BIOTECH, etc.

1. TRANSPLANTUL DE INSULE PANCREATICE – O POSIBILĂ TERAPIE ÎN DIABETUL

ZAHARAT DE TIP 1

Proiect VIASAN, Contract 92/29.12.2001

Perioada 2001-2003

Contractor titular „IDNMB N Paulescu‖

Director proiect – Prof. Constantin Ionescu-Tîrgovişte

Buget total 140.000 RON

2001 – 20.000 RON

2002 – 60.000 RON,

2003 – 60.000 RON

2. STUDIUL ACTIUNII INSULINOMIMETICE A VANADIULUI LA SOBOLANII BB DIABETICI

SI A EFECTELOR GENETICE INDUSE DE ACESTA

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Proiect VIASAN

Perioada 2003-2004

Contractant IDNBM N Paulescu

Director de proiect- Dr. Daniela Gutu

Fonduri – 95.000 RON

3. PRELEVAREA ŞI IZOLAREA INSULELOR PANCREATICE DE LA DIFERITE SPECII DE

PESTI IN VEDEREA STABILIRII COMPATIBILITĂŢII IMUNE ŞI LA OM. SURSE

ALTERNATIVE DE INSULE LANGERHANS FATA DE DONATORII UMANI.

Proiect PNCDI - VIASAN, Contract 257/27.10.2003 Acronim PESTRA

Perioada 2003 -2005

Contractor titular „IDNMB N Paulescu‖

Director de Proiect - Prof. Constantin Ionecu-Tîrgovişte

Buget 128.100 RON,

2003 – 62.700 RON,

2004 – 65.400 RON

Achizitionat – Sistem Laptop Travel Mate 2501 LC, in valoare de 6027,6 RON (2004)

4. UTILIZAREA UNOR GENE POLIMORFE ÎN STUDIUL DIABETULUI ZAHARAT ŞI A

COMPLICAŢIILOR VASCULARE ASOCIATE. (GENODIABET)

Proiect BIOTECH – PCD Contract No 3-288/01.10.2003

Perioada 2003 – 2005

Contractor titular - Institutul de Biologie şi Patologie Celulară Nicolae Simionescu

Responsabil ştiinţific de proiect- Dr. Cristian Guja din partea IDNBM ‖N. C. Paulescu‖;

Buget - 50.000 RON

2003 – 20.570 RON,

2004 – 10.900 RON

2005 – 18.530 RON

5. IDENTIFICAREA HAPLOTIPURILOR CU SEMNIFICAŢIE PREDICTIVĂ PENTRU EVOLUŢIA

BOLII RENALE LA PACIENŢII DIABETICI DIN ROMÂNIA

Proiect VIASAN Contract 415/2004

Perioada 2004 – 2006

Contractor titular „IDNMB N Paulescu‖

Director Proiect Dr. Cristian Serafinceanu

Partener - Universitatea din Bucuresti - Institutul de Genetica

Buget:

2004 – 3.000 RON

2005 – 7.000 RON

2006 – 4.000 RON

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6. SUSCEPTIBILITATEA GENETICĂ PENTRU NEFROPATIA DIABETICĂ LA PACIENŢII

CAUCAZIENI DIN ROMANIA.

Proiect CNCSIS, Cod CNCSIS-990

Perioada 2004-2005

Contractor titular „IDNMB N Paulescu‖

Director Proiect – Prof. Dan Cheţa/Dr. C Serafinceanu

Buget:

2004 – 37.375 RON

2005 – 50.000 RON

7. ADIPONECTINA – MEDIATOR ÎN SEMNALIZAREA INTRA-CELULARĂ ACTIVATĂ DE

INSULINĂ – IMPLICAŢII CLINICE ÎN OBEZITATEA ASOCIATĂ CU DZ TIP 2.

Proiect VIASAN

Perioada 2004 - 2006

Contractor titular - Institutul de Biologie şi Patologie Celulară Nicolae Simionescu

Responsabil ştiinţific de proiect- Prof. Dr. C. Ionescu-Tirgoviste, din partea IDNBM ‖N. C. Paulescu‖

Proiecte CEEX

1. DEZVOLTAREA UNOR CENTRE CARDIOLOGICE DE DIAGNOSTIC PRECOCE PRIN

SCREENING AL POPULATIEI CU FACTORI DE RISC A DISFUNCTIEI CARDIACE

(CARDIOSCREEN)

Proiect CEEX

Perioada 2005-2008

Contractor titular - UMF Carol Davila Bucureşti

Responsabil ştiinţific de proiect- Prof. Dr. R. Lichiardopol, din partea IDNBM ‖N. C. Paulescu‖;

Buget:

2005 – 50.000 RON,

2006 – 20.000 RON,

2007 – 30.000 RON

Aparatură achiziţionată – Congelator -80 grade in valoare de 55.866 RON

2. INTERACTIUNI CALITATIVE DATORATE TRANSFORMARII SUBSTANTELOR NUTRITIVE

LIPIDICE PE LANTUL ALIMENTAR FURAJ-ANIMAL-CONSUMATOR UMAN IN VEDEREA

STABILIRII UNOR INDICATORI DE IMPACT ASUPRA SANATATII OMULUI‖â (LIPOSAN),

Proiect CEEX

Perioada 2005-2008

Contractor titular IBNA Balotesti

Responsabil ştiinţific de proiect- Prof. Dr. R. Lichiardopol, din partea IDNBM ‖N. C. Paulescu‖

Buget:

2006 – 600.000 RON,

2007 – 500.000 RON

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Aparatură achiziţionată – Aparat electroforeză SEBIAPHORESYS-ABT ~ 20.000 RON

3. ANALIZA FACTORILOR GENETICI CU POTENTIAL EFECT MODULATOR ASUPRA

DINAMICII MATRICEI EXTRACELULARE IN NEFROPATIA DIABETICA

Proiect CEEX cod 53/2005

Perioada 2005-2008

Director proiect Prof Dr Dan Mirce Cheţa

Partener - Universitatea din Bucuresti - Institutul de Genetica

Buget total: 260.000 RON

2005 – 20.000 RON

2006 – 170.000 RON

2007 – 70.000 RON

Aparatură achiziţionată: Ecograf portabil ALOKA, cu preţ de achiziţie de aprox. 100.000 RON (2006)

4. ALTERAREA MECANISMELOR CELULARE SI MOLECULARE SI A EXPRESIEI GENICE IN

BOLI CARDIOVASCULARE SI DIABET/OBEZITATE, AFECTIUNI MAJORE ALE

SINDROMULUI METABOLIC - CERCETARI FUNDAMENTALE SI CLINICE (AMCADO)

Proiect CEEX –Contract nr. 384/2005

Perioada 2005-2008

Contractor titular : Institutul de Biologie şi Patologie Celulară Nicolae Simionescu

Partener 2 : Institutul de diabet, Nutriţie şi Boli Metabolice „N. C. Paulescu‖, responsabil ştiinţific de

proiect - Asis. Univ. Dr. Ana-Maria Tinu

Buget Total – 120.000 RON

2005 – 10.000 RON

2006 – 40.000 RON

2007 – 50.000 RON

2008 – 20.000 RON

Aparatură achiziţionată: Laptop (2005 valoare 7.000 RON), Sistem CGMS Guardian (2006 valoare

14.280 RON)

5. STUDIUL BIOACTIVITĂŢII SINERGICE A ALIMENTELOR FUNCŢIONALE

ANTIOXIDANTE ÎN REVERSIBILITATEA SINDROMULUI METABOLIC (MET-ANTIOX)

Proiect CEEX - Contract CEEX 10/2005

Perioada 2005-2008

Contractor principal – UMF Victor Babes Timişoara

Responsabil ştiinţific de proiect- Conf. Gabriela Radulian, din partea IDNBM ‖N. C. Paulescu‖,

BUGET TOTAL: 190 000 RON

2007 - 105.850 RON

2008 - 84.650 RON

Aparatură achiziţionată 2007: Aparat determinare radicali liberi FORMOX, Centrifuga FORMOX,

Laptop, Xerox.

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6. EFICIENTA MANAGEMENTULUI INTENSIV NUTRITIONAL, FARMACOLOGIC SI

COMPORTAMENTAL AL OBEZITATII – CORELAREA FACTORILOR GENETICI,

BIOMORFOLOGICI SI PSIHOLOGICI

Proiect CEEX cod 163/2006,

Perioada 2006 – 2008

Contractor titular „IDNMB N Paulescu‖

Parteneri :

Universitatea din Bucuresti,

Asociatia Psihoterapii Cognitive si Comportamentale din Romania,

Fundatia pentru Alimentatie Sanatoasa

Director proiect – Prof. Dr. Dan Mircea Cheţa

Buget Total: 970.000 RON

2006 - 35.000 RON

2007 - 561.000 RON

2008 - 374.000 RON

Aparatură achiziţionată:

Sistem informatic tip Laptop – 7.000 RON Procesor Centrino 1,7 GHz, 15,4‖, 512Mb RAM, 80

Gb HDD

Aparat achizitie imagini cu capacitate de

stocare – 2.700 RON

Rezolutie (LF)/LN) 3456 x 2304, CMOS, Card

Memoire

Aparat determinare grad de ocluzie si

rigiditate a sistemului vascular periferic –

VASERA – 32.368 RON

Fonocardiograma, Tensiunea arteriala masurata

concomitent la cele 4 membre, EKG - 1 derivatie

Aprecierea gradului de ocluzie si rigiditate a

sistemului vascular periferic prin calcularea

Indexului ABI (ankle brachial index) si a Indexului

CAVI (cardio ankle vascular index)

Electrocardiograf – 7.497 RON 12 canale, afisare 3 canale simultan

Aparat RT PCR – 124.999,98 RON Nr minim probe 8; 2 fluorocromi cu posibilitate de

crestere numarului a acestora; Soft inclus pentru

trasarea automata a curbei de fluorescenta;

Posibilitate upgradare soft; Alimentare 220V

7. DECOMPRESIA NERVOASĂ MINIM INVAZIVĂ – O SOLUŢIE MODERNĂ ÎN

TRATAMENTUL NEUROPATIEI DIABETICE

Proiect CEEX

Perioada 2006-2008

Contractor principal – UMF Timişoara – Prof. Ionac

Responsabil ştiinţific de proiect- Prof. Dr. Dan Mircea Cheţa, din partea IDNBM ‖N. C. Paulescu‖

Buget Total: 150.000 RON

2007 – 75.000 RON

2008 - 75.000 RON

Aparatură achizitionata: 1. Aparat CASE IV - Sistem computerizat pentru evaluarea perceptiei vibratorii

si senzoriale (cald, rece) – 20.000 Euro; 2. Laptop TOSHIBA - 4.300 RON

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8. STRATEGII NOI ÎN CONDUITA DIAGNOSTICĂ ŞI TERAPEUTICĂ A

HIPERCOLESTEROLEMIEI FAMILIALE PRIN SCREENINGUL MOLECULAR AL MUTAŢIILOR

GENEI RECEPTORULUI LDL (HIFAGEN)

Proiect CEEX 143/2007

Perioada 2006-2008

Contractor Principal – Institutul de Boli Cardio-Vasculare „CC Iliescu‖ Bucureşti, Dr. Coman

Responsabil ştiinţific de proiect- Prof. Dr. Dan Mircea Cheţa, din partea IDNBM ‖N. C. Paulescu‖

Buget Total: 300.000 RON

2006 19.500 RON

2007 170.000 RON

2008 110.500 RON

Aparatură achizitionată:

Sistem informatic tip Laptop – 7000 RON Procesor Centrino 1,7 GHz, 15,4‖, 512Mb RAM, 80

Gb HDD

Calculator – 3565 RON Procesor Pentium 4:2,4 GHz, Monitor 17‖, 1024 Mb

RAM, 80 Gb HDD

9. CERCETARI PRIVIND OBTINEREA SI CARACTERIZAREA UNUI NOU PRODUS

FARMACEUTIC DE NATURA VEGETALA CU ACTIUNE HIPOGLICEMIANTA

Proiect CEEX

Perioada 2006-2008

Contractor titular „IDNMB N Paulescu‖

Parteneri:

1. UMF Carol Davila Bucureşti, Facultatea de Farmacie

2. Centrul de Cercetări Medico Militare Bucureşti

3. Biopharmacy & Pharmacology Research SA, Bucureşti

4. Institutul de Cercetări Chimico Farmaceutice Bucureşti

5. Fabiol SA Bucureşti

Director de Proiect - Prof. Constantin Ionecu-Tîrgovişte

Buget 2008 – 400.000 RON

10. PROMOVAREA PARTICIPĂRII ROMÂNEŞTI LA PROIECTE EUROPENE FP7 ÎN

DOMENIUL IMUNOGENETICII DIABETULUI ZAHARAT SI AL MEDICINII REGENERATIVE

CU CELULE BETA PANCREATICE

Proiect CEEX Modul III

Perioada 2006-2008

Contractor Titular: - Spitalul Clinic Fundeni, Prof. Dr. Irinel Popescu

Responsabil ştiinţific de proiect - Prof. Dr. Constantin Ionescu-Tirgoviste, din partea IDNBM ‖N. C.

Paulescu‖

11. BIODISPONIBILITATEA SARURILOR MINERALE DIN PRODUSELE DE PANIFICATIE

IMBOGATITE IN FIBRE ALIMENTARE

13

Proiect CEEX

Perioada 2006-2008

Contractor principal: Institutul de Bioresurse Alimentare Bucuresti

Responsabil ştiinţific de proiect- Dr. Vladica Maria, din partea IDNBM ‖N. C. Paulescu‖,

Buget total: 150.000 RON

2006 - 15.000 RON

2008 - 135.000 RON

12. IMPACTUL ALIMENTELOR FUNCŢIONALE MULTICOMPONENT ÎN COMBATEREA

OBEZITĂŢII ŞI ATEROSCLEROZEI (ANTIATERO-ALIM)

Proiect CEEX Contract 44/2006

Perioada 2006-2008

Contractor principal – UMF „Victor Babes‖ Timişoara

Responsabil ştiinţific de proiect- Conf. Gabriela Radulian, din partea IDNBM ‖N. C. Paulescu‖,

BUGET TOTAL: 150 000 RON

2006: 43.100 RON

2007: 48.000 RON

2008: 58.900 RON

Aparatură achiziţionată: 2006 - Aparat Bioimpedanţă BIOSPACE INBODY 320

2007 - EKG; - Videoproiector

13. OPTIMIZAREA DIAGNOSTICULUI PRECOCE IN ADENOCARCINOMUL PROSTATIC LA

PACIENTI CU SINDROM METABOLIC PRIN CORELAREA FACTORILOR GENETICI,

ANATOMOPATOLOGICI SI BIOCHIMICI (ADENODIAG)

Proiect CEEX2 Contract nr 41-085

Perioada 2007 - 2010

Contractor titular: SCUMC ―Carol Davila‖ Bucureşti

Responsabil stiintific de proiect - Prof. Dr. Dan Mircea Cheţa din partea IDNBM ‖N. C. Paulescu‖

Buget Total: 611.800 RON

2007 - 83.000 RON

2008 - 269.180 RON

2009 - 220.860 RON

2010 - 38.760 RON

14. STUDIUL MECANISMELOR CELULARE, MOLECULARE SI GENICE PRIN CARE

DISLIPIDEMIA INDUCE REZISTENTA LA INSULINA ; IDENTIFICAREA DE COMPUSI

PROBIOTICI ACTIVI SI METODE DE TRATAMENT

Proiect CEEX2

Perioada 2007-2010

Contractor titular: Institutul de Biologie şi Patologie Celulară „Nicolae Simionescu‖ Bucureşti

Responsabil ştiinţific de proiect – Dr. Maria. Vlădică, din partea IDNBM ‖N. C. Paulescu‖

Buget Total 400.000 RON

2007 - 12.650 RON

14

2008 -161.300 RON

2009 – 148.500 RON

2010 – 77.550 RON

15. ADIPOCITOKINELE, PUNTE DE LEGATURA INTRE HEPATITA CU VIRUS C SI DIABETUL

ZAHARAT TIP 2 (DIADIPOHEP)

Proiect CEEX2 Contract nr 41-008

2007-2010

Contractor titular: IDNBM ―Prof. N. Paulescu‖

Director de proiect Conf. Univ. Dr. Gabriela Radulian

Buget Total: 629.200 RON

2007 - 85.030 RON

2008 - 261.330 RON

2009 - 226.340 RON

2010 - 56.500 RON

7.4. Numărul şi valoarea contractelor de cercetare naţionale finanţate din fonduri private:

7.5. Alte surse: - Nu este cazul

7 bis. Venituri realizate din activităţi economice (servicii, microproducţie): Nu este cazul

8. Resursa umană de cercetare

(situaţia va fi prezentată pe ani)

8.1. Total personal de cercetare care realizează venituri din activitatea de cercetare-

dezvoltare/din care doctori în ştiinţă:

2003 14/6

2004 16/6

2005 16/6

2006 16/6

2007 7/5

Excluzând Asistenţii de Cercetare, Numărul mediu de personal de cercetare pe perioada de

5 ani raportată a fost 12 + 12 + 12 + 14 + 7 = 57/5 = 11.4 persoane/an

8.1.1. Cercetători ştiinţifici gradul 1 (profesori)/din care doctori în ştiinţă:

2003 3/3

2004 3/3

2005 3/3

2006 3/3

2007 3/3

15

8.1.2. Cercetători ştiinţifici gradul 2 (conferenţiari)/din care doctori în ştiinţă:

2003 2/2

2004 2/2

2005 2/2

2006 2/2

2007 1/1

8.1.3. Cercetători ştiinţifici gradul 3 (lectori)/din care doctori în ştiinţă:

2007 1/1

8.1.4. Cercetători ştiinţifici/din care doctori în ştiinţă:

2003 7/1

2004 7/1

2005 7/1

2006 9/1

2007 2/0

8.1.5. Asistenţi de cercetare:

2003 2/0

2004 4/0

2005 4/0

2006 2/0

2007 0/0

8.1.6. Total personal auxiliar de cercetare angajat: - nu este cazul

8.2. Date privind perfecţionarea resursei umane

8.2.1. Număr de doctoranzi şi masteranzi care lucrează în unitatea de cercetare-dezvoltare la

data completării formularului: 25 doctoranzi

8.2.2. Număr de teze de doctorat realizate în unitatea de cercetare-dezvoltare în perioada

pentru care se face evaluarea: 8 teze de doctorat susţinute

9. Infrastructura de cercetare-dezvoltare

9.1. Laboratoare de cercetare-dezvoltare: Nu este cazul

Nr. crt. Denumirea laboratorului Domeniul în care este acreditat

9.2. Lista echipamentelor performante achiziţionate în ultimii 10 ani:

16

Dispozitiv

Data

achizitiei

An

fabricatie Unitati

Valoare

(RON)

Sursa

Fondurilor

1 Maşină de spălat industrială 21.11.2003 2003 2 59677,99 Surse Proprii

2 Hotă de laborator 18.12.2003 2003 1 17865,54 Surse Proprii 3 Biomicroscop Zeiss 19.12.2003 2003 2 98946,12 Surse Proprii 4 Calculator Pentium 24.11.2003 2003 1 3063,99 Surse Proprii 5 Calculator Laptop 18.12.2003 2003 1 10943,59 Surse Proprii

6 Calculator Notebook 31.05.2004 2004 3 18117,09 Surse Proprii

7 Analizor ANALOX GM9 17.06.2004 2004 2 96390 Surse Proprii

8 Analizor glucoză 30.09.2004 2004 1 10872,37 Surse Proprii

9 Multifuncţional Minolta 26.10.2004 2004 1 11017,91 Surse Proprii

10 Maşină de Spălat Legume 28.10.2004 2004 1 4352,85 Surse Proprii

11 Maşină de pasat piure 28.10.2004 2004 1 4352,85 Surse Proprii

12 Videoproiector 29.11.2004 2004 1 8757,19 Surse Proprii

13 Cameră Foto Digitală 29.11.2004 2004 1 9981,83 Surse Proprii

14 Imprimantă 10.11.2004 2004 1 3924,62 Surse Proprii

15 Calculatoare 21.10.2004 2004 5 19908,7 Surse Proprii

16 Angiofluorograf Digital 14.12.2004 2004 1 14978,29 Surse Proprii

17 Analizor Urini 20.07.2005 2005 1 3593,8 Surse Proprii

18 Centrifugă Sterilizare 20.07.2005 2005 1 14898,8 Surse Proprii

19 Centrifugă Laborator 20.07.2005 2005 1 7497 Surse Proprii

20 Autoclav Laborator 28.07.2005 2005 1 21578,86 Surse Proprii

21 Termostat Laborator 28.07.2005 2005 1 10799,25 Surse Proprii

22 Etuvă Sterilizare 28.07.2005 2005 1 7199,5 Surse Proprii

23 Lampă UV 28.07.2005 2005 1 1999,2 Surse Proprii

24 Sterilizator Laborator 29.09.2005 2005 1 21578,86 Surse Proprii

25 Centrală Telefonică 21.11.2005 2005 1 19862,69 Surse Proprii

26 Calculator Laptop 08.12.2005 2005 1 7439,88 Surse Proprii

27 Calculator Laptop 08.12.2005 2005 1 5745,32 Surse Proprii

28 Calculator Laptop 08.12.2005 2005 1 8407,35 Surse Proprii

29 Centrifugă Laborator 16.12.2005 2005 1 19825,83 Surse Proprii

30 Ecocardiograf 22.12.2005 2005 1 298690 Surse Proprii

31 Calculatoare 12.12.2005 2005 3 9928,17 Surse Proprii

32 Analizor Biochimie Hitachi 2005 2005 1 360463

Ministerul

Sănătăţii

33 Microscop Medrom 2005 2005 1 345885,08

Ministerul

Sănătăţii

34 Staţie de lucru PC 2006 2006 1 55038,87

Fonduri

PHARE

35 Centrifugă tip Bench 2006 2006 1 62336,22

Fonduri

PHARE

36 Congelator 2006 2006 1 55866,14 Surse Proprii

37 Ecograf 2006 2006 1 118494,05 Surse Proprii

38 Hotă laborator 2006 2006 1 14497,77 Surse Proprii

39 Climatizor 2006 2006 6 17282,37 Surse Proprii

40 Sistem Electroforeză 2006 2006 1 20000 Surse Proprii

41 Calculatoare PC 2006 2006 9 32086,41 Surse Proprii

17

42 Aparat foto Digital 2006 2006 1 2953,52 Surse Proprii

43 Smart Phome 2006 2006 1 2998,84 Surse Proprii

44 Calculatoare 2006 2006 11 39216,72 Surse Proprii

45 Calculator Notebook 2006 2006 1 7000 Surse Proprii

46 Calculator Notebook 2006 2006 1 7000 Surse Proprii

47 Sistem Momitorizare Glicemie 2006 2006 1 14280 Surse Proprii

48 Analizor Inbody 2006 2006 1 41769 Surse Proprii

49 Microscop NIKON 2006 2006 1 12603,6 Surse Proprii

50 Calculator Laptop 2007 2007 1 3702,09 Surse Proprii

51 Videoproiector 2007 2007 1 8000 Surse Proprii

52 Electrocardiograf 2007 2007 1 15899,99 Surse Proprii

53 Calculatoare 2007 2007 12 32231,82 Surse Proprii

54 Aparat determinare impuls

nervos 2007 2007 1 20000

Surse Proprii

55 Autoturism Logan 2007 2007 1 37981,87 Surse Proprii

56 Analizor Genetică RT-PCR 2007 2007 1 124999,98 Surse Proprii

57 Aparat determinare grad

ocluzie vasculară 2007 2007 1 32368

Surse Proprii

58 Electrocardiograf 2007 2007 1 7497 Surse Proprii

59 Calculator Notebook 2007 2007 1 7790,93 Surse Proprii

60 Calculator Notebook 2007 2007 1 4200,7 Surse Proprii

61 Calculator Notebook 2007 2007 1 3702,09 Surse Proprii

62 Aparat determinare radicali

liberi 2007 2007 1 17000

Surse Proprii

63 Xerox 2007 2007 1 26556,04 Surse Proprii

64 Multifuncţional HP 2007 2007 1 6240,36 Surse Proprii

65 Multifuncţional Samsung 2007 2007 1 3160 Surse Proprii

66 Calculator Laptop 2007 2007 2 13119,99 Surse Proprii

67 Calculatoare PC 2007 2007 3 8063,88 Surse Proprii

68 Analizor CR 2007 2007 1 17998,75 Surse Proprii

69 Sondă transrectală 2007 2007 1 7973 Surse Proprii

70 Videoprinter 2007 2007 1 3986,5 Surse Proprii

71 Centrifugă laborator 2007 2007 1 9996 Surse Proprii

72 Calandru 2007 2007 1 29988 Surse Proprii

-------------------------------

1) Se menţionează forma de organizare şi persoana juridică: dacă unitatea de cercetare-dezvoltare

nu are personalitate juridică, se menţionează denumirea instituţiei cu personalitate juridică care o

reprezintă (de exemplu, Centrul de ............... din cadrul Universităţii ...............).

2) Se menţionează titlul actului, data emiterii, organul emitent şi, după caz, modificările

ulterioare.

3) Domeniile de clasificare UNESCO pot fi accesate la www.mct.ro/ancs.

18

4) Indexate de Thomson Scientific [fost Institute for Scientific Information (ISI) in Science

Citation Index Expanded, Social Sciences Citation Index sau Arts & Humanities Citation Index].

5) Punctajul ISI se obţine prin însumarea factorilor de impact ai publicaţiilor respective. Factorii

de impact pot fi accesaţi la www.cimec.org.ar.

6) Sunt excluse autocitările.

7) Se specifică dacă brevetul este naţional/internaţional (USPTO, EPO, JPO) şi numărul

brevetului.

8) În cazul revistelor româneşti, sunt luate în considerare cele cotate CNCSIS, categoria B (vezi

www.cncsis.ro).

9) Valori defalcate pe ani şi valoarea totală în euro.

10) Datele vor fi prezentate pe tipuri de programe (PNCDI, CEEX, granturi etc.); valorile

contractelor vor fi defalcate pe ani.

19

ANEXA 4.1

LISTA LUCRĂRILOR ŞI CITĂRILOR

20

Anexa 4.1

ARTICOLE FULL TEXT PUBLICATE ÎN REVISTE INDEXATE ISI

2003

1. Cheta D, Orasanu G, Nicolaie T, Iordachescu D, Buligescu S, Constantin C, Hassanain M, Coman

A, Enache M, Negru R, Tica V, Timofte D, Gutu D, Panaite C. (2003) The influence of sodium

metavanadate on the process of diabetogenesis in BB rats. J Cell Mol Med 7:447-454 Impact Factor

2003: 1.694

2. Maier LM, Twells RCJ, Howson JMM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D,

Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E,

Tuomilehto J, Guja C, Ionescu-Tîrgovişte C, Undlien DE, Rønningen KS, Cucca F, Todd JA.

(2003) Testing the possible negative association of type 1 diabetes and atopic disease by analysis of

the interleukin 4 receptor gene. Genes and Immunity 4:469–475 Impact Factor 2003: 3.637

3. Marre M, Garcia Puig J, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A,

Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz M, Hermansen K,

Tuomilehto J, Finizola B, Pozza G, Chastang C, Ollivier JP, Amouyel P, Asmar R. (2003) Effect of

indapamide SR on microalbuminuria--the NESTOR study (Natrilix SR versus Enalapril Study in

Type 2 diabetic hypertensives with micrOalbuminuRia)--rationale and protocol for the main trial. J

Hypertens Suppl 21:S19-24 Impact Factor 2003: 3.572

4. Nejentsev S, Guja C, McCormack R, Cooper J, Howson JMM, Nutland S, Rance H, Walker N,

Undlien D, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, Ionescu-Tîrgovişte C, Gale EAM,

Bingley PJ, Gillespie KM, Savage DA, Carson DJ, Patterson CC, Maxwell AP, Todd JA. (2003)

Association of intercellular adhesion molecule-1 gene with type 1 diabetes. Lancet 362:1723-1724

Impact Factor 2003: 18,316

5. Ueda H, Howson JMM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter

KMD, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RCJ,

Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM,

Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A,

Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE,

Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC,

Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SCL. (2003) Association of

the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506-511

Impact Factor 2003: 30,979

Total Impact Factor 2003 = 58,198

2004

6. Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST, Clayton DG, Cordell HJ, Todd JA. (2004) Remapping the Insulin Gene/IDDM2 locus in Type 1 diabetes. Diabetes 53:1884-1889 Impact Factor 2004: 8,848

21

7. Eftychi C, Howson JMM, Barratt B, Vella A, Payne F, Smyth DJ, Twells RCJ, Walker NM, Rance

H, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C,

Savage D, Todd JA. (2004) Analysis of the type 2 diabetes - associated single nucleotide

polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes. Diabetes 53:870-873

Impact Factor 2004: 8,848 8. Guja C, Guja L, Nutland S, Rance H, Sebastien M, Todd JA, Ionescu-Tirgoviste C. (2004) Type 1

diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania. J Cell Mol Med 8:249-256. Impact Factor 2004: 2.153

9. Hulme JS, Barratt BJ, Twells RCJ, Cooper JD, Lowe CE, Howson JMM, Lam AC, Smink L, Savage DA, Undlien DE, Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA. (2004) Association analysis of the lymphocyte-specific protein tyrosine kinase (LKC) gene in type 1 diabetes. Diabetes 53:2479-2482 Impact Factor 2004: 8,848

10. Ionescu-Tîrgovişte C, Guja C, Călin A, Moţa M. (2004) An increasing trend in the incidence of type 1 diabetes in children aged 0 – 14 years in Romania. Ten years (1988 – 1997) EURODIAB study experience. J Ped Endocrinol Metab 17:983-991 Impact Factor 2004: 0,903

11. Kyvik KO, Nystrom L, Gorus F, Songini M, Oestman J, Castell C, Green A, Guyrus E, Ionescu-Tirgoviste C, McKinney PA, Michalkova D, Ostrauskas R, Raymond NT. (2004) The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children. Diabetologia 47:377-384 Impact Factor 2004: 5.583

12. Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RCJ, Green EA, Savage DA, Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG. (2004) Cost-effective analysis of candidate genes using htSNPs: a staged approach. Genes and Immunity 5:301–305 Impact factor 2004: 3,718

13. Marre M, Puig JG, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A, Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion Junior D, Ruiz M, Hermansen K, Tuomilehto J, Finizola B, Gallois Y, Amouyel P, Ollivier JP, Asmar R. (2004) Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study. J Hypertens 22:1613-1622 Impact Factor 2004: 4.871

14. Nejentsev S, Cooper JD, Godfrey L, Howson JM, Rance H, Nutland S, Walker NM, Guja C, Ionescu-Tirgoviste C, Savage DA, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Gillespie KM, Ring SM, Strachan DP, Widmer B, Dunger D, Todd JA. (2004) Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes. Diabetes 53:2709-2712 Impact Factor 2004: 8,848

15. Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Newport MJ, Clayton DG, Todd JA. (2004) Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet 13:1633-1639 Impact Factor 2004: 7,801

16. Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tirgoviste C, Savage DA, Dunger DB, Widmer B, Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC, Gough SC, Todd JA. (2004) Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53:3020-3023 Impact Factor 2004: 8,848

17. Vella A, Howson JMM, Barratt B, Twells RCJ, Rance H, Nutland S, Tuomilehto-Wolf E,

Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage D, Todd JA.

(2004) Lack of association of the Ala45

Thr polymorphism and other common variants of the NeuroD

gene with type 1 diabetes. Diabetes 53:1158-1161 Impact Factor 2004: 8,848

22

Total Impact Factor 2004 = 78,117

2005

18. Ionescu-Tirgoviste C. (2005) Comment on: Godsland IF, Jeffs JAR, Johnston DG (2004) Loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157-1166. Diabetologia 48:203-24 Impact Factor 2005: 5.337

19. Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink LJ, Fraser H, Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Strachan DP, Peterson LB, Todd JA, Wicker LS, Twells RC. (2005) Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes. BMC Genet 6:9 Impact Factor 2005: 1.769

20. Payne F, Smyth DJ, Pask R, Cooper JD, Masters J, Wang WY, Godfrey LM, Bowden G, Szeszko J, Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Todd JA, Twells RC. (2005) No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. Biochem Biophys Res Commun. 331:435-41 Impact Factor 2005: 3

21. Pozzilli P, Manfrini S, Buzzetti R, Lampeter E, Leeuw ID, Iafusco D, Prisco M, Ionescu-Tirgoviste

C, Kolouskova S, Linn T, Ludvigsson J, Madacsy L, Mrozikiewicz AS, Mrozikiewicz PM, Podar T,

Vavrinec J, Vialettes B, Visalli N, Yilmaz T, Browne PD; IMDIAB group. (2005) Glucose

evaluation trial for remission (GETREM) in type 1 diabetes: a European multicentre study. Diabetes

Res Clin Pract 68:258-264 Impact Factor 2005: 1.236

22. Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf

E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Savage D, Dunger DB,

Twells RC, McArdle WL, Strachan DP, Todd JA. (2005) Assessing the validity of the association

between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet 37:110-111 Impact Factor

2005: 25.797

23. Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, Witte DR, Fuller JH;

EURODIAB Prospective Complications Study Group. (2005) Vascular risk factors and diabetic

neuropathy. N Engl J Med 2005 352:341-350 Impact factor 2005: 44,016

Total Impact Factor 2005 = 81.155

2006

24. Cheta DM. (2006) The metabolic syndrome: Time for a critical appraisal: Joint statement from the

American Diabetes Association and the European Association for the Study of Diabetes: Response

to Kahn et al. Diabetes Care 29:176-177 Impact factor 2006: 7,912 25. Ionescu-Tîrgovişte C, Ioacără S, Guja C, Sabău S, Lichiardopol R, Mihai A, Apetrei E. (2006) A

pathophysiological approach to metabolic syndrome using factor analysis in an adult Romanian population. Arch Physiol Biochem 112:182-188

26. Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, Guja C, Ionescu-Tirgoviste C,

Widmer B, Dunger DB, Savage DA, Walker NM, Clayton DG, Todd JA. (2006) A genome-wide

association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-

induced helicase (IFIH1) region. Nat Genet 38:617-619 Impact factor 2006: 24.176

23

Total Impact Factor 2006 =32,088

2007

27. Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field

SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JHM, Vella A, Nutland S, Stevens

HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam

AAC, Ovington NR, Allen J, Adlem E, Leung H-T, Wallace C, Howson JMM, Guja C, Ionescu-

Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SCL,

Dunger DB, the Wellcome Trust Case Control Consortium, Wicker LS & Clayton DG. (2007)

Robust associations of four new chromosome regions from genome-wide analyses of type 1

diabetes. Nat Genet 39:857 – 864 Impact factor 2006: 24.176

28. Coculescu M, Niculescu D, Lichiardopol R, Purice M. (2007) Insulin resistance and insulin secretion

in non-diabetic acromegalic patients. Exp Clin Endocrinol Diabetes 115:308-316 Impact factor

2006: 1.356

29. Puig JG, Marre M, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A, Ionescu-

Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz M, Hermansen K, Tuomilehto

J, Finizola B, Gallois Y, Amouyel P, Ollivier JP, Asmar R. (2007) Efficacy of indapamide SR

compared with enalapril in elderly hypertensive patients with type 2 diabetes. Am J Hypertens

20:90-97 Impact factor 2006: 3.116

Total Impact Factor 2007 = 28.648

Punctaj ISI cumulat 2003-2007 = 278.206

24

Anexa 4.1

CITĂRI ÎN REVISTE INDEXATE INTERNAŢIONAL OBŢINUTE CU

MOTORUL DE CĂUTARE GOOGLE SCHOLAR

Cheta D, Orasanu G, Nicolaie T, Iordachescu D, Buligescu S, Constantin C, Hassanain

M, Coman A, Enache M, Negru R, Tica V, Timofte D, Gutu D, Panaite C. (2003) The

influence of sodium metavanadate on the process of diabetogenesis in BB rats. J Cell Mol

Med 7:447-454

The influence of sodium metavanadate on the process of diabetogenesis in BB rats - all 3 versions »

D Cheta, G Orasanu, T Nicolaie, D Iordachescu, S … - J. Cell. Mol. Med, 2003 - Blackwell Synergy

... diabetes. There is great interest in orally The influence of sodium metavanadate

on the process of diabetogenesis in BB rats D. Cheta ...

Cited by 3 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. Combined effect of vanadium (V) and chromium (III) on lipid peroxidation in liver and kidney of rats -

all 5 versions »

A Ścibior, H Zaporowska, J Ostrowski, A Banach - Chemico-Biological Interactions, 2006 - Elsevier

Since chromium(III) was demonstrated to have antioxidative action, we have

decided to study the effect of this element on V-induced LPO in liver and kidney

of rats. Outbred 2-month-old, albino male Wistar rats received daily, for a ...

Cited by 2 - Related Articles - Web Search

2. Stat5 constitutive activation rescues defects in spinal muscular atrophy - all 5 versions »

CH Ting, CW Lin, SL Wen, HM Hsieh-Li, H Li - Human Molecular Genetics, 2007 - Oxford Univ Press

Proximal spinal muscular atrophy (SMA) is a motor neuron degeneration disorder

for which there is currently no effective treatment. Here, we report three

compounds (sodium vanadate, trichostatin A and aclarubicin) that ...

Related Articles - Web Search - BL Direct

3. Effects of Vanadium (V) and/or Chromium (III) on L-Ascorbic Acid and Glutathione as well as Iron, …

- all 2 versions »

A Scibior - Journal of Toxicology and Environmental Health, Part A, 2007 - informaworld.com

Journal of Toxicology and Environmental Health, Part A, 70: 696–704, 2007

Copyright © Taylor & Francis Group, LLC ISSN: 1528-7394 print / 1087-2620

online DOI: 10.1080/15287390601187906 ... UTEH Effects of Vanadium(V) ...

Related Articles - Web Search - BL Direct

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Maier LM, Twells RCJ, Howson JMM, Lam AC, Clayton DG, Smyth DJ, Savage D,

Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H,

Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgovişte C, Undlien DE,

Rønningen KS, Cucca F, Todd JA. (2003) Testing the possible negative association of

type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene. Genes

and Immunity 4:469–475

Testing the possible negative association of type 1 diabetes and atopic disease by analysis

of the … - all 3 versions »

… Rance, E Tuomilehto-Wolf, J Tuomilehto, C Guja, C … - Genes and Immunity, 2003 - nature.com

T1D is caused by autoimmune destruction of pancreatic islet -cells, a process

that is genetically determined and susceptible to major, and as yet unknown,

environmental factors. 9 The disease is characterised by inflammation of ...

Cited by 9 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes -

all 5 versions »

LM Maier, J Chapman, JM Howson, DG Clayton, R Pask … - Am J Hum Genet, 2005 - UChicago Press

The genetic analysis of common, multifactorial diseases, such as type 1 diabetes

(T1D [MIM 222100]), that are highly clustered in families is proving to be a

challenging task (Altmuller et al. 2001; Hirschhorn et al. 2002; Ioannidis ...

Cited by 7 - Related Articles - Web Search

2. Coexistence of IgE-Mediated Allergy and Type 1 Diabetes in Childhood - all 6 versions »

C Caffarelli, G Cavagni, R Pierdomenico, G Chiari, … - Int Arch Allergy Immunol, 2004 -

content.karger.com

Background: Autoimmune disorders are considered to be associated with a Th1

immune response while allergic diseases with a Th2 response. We carried out a

study to determine whether there is an inverse relationship between ...

Cited by 5 - Related Articles - Web Search

3. NON-MHC genes in type 1 diabetes. Family-based association studies and functional studies of disease

… - all 3 versions »

OP Kristiansen - Danish Medical Bulletin, 2005 - danmedbul.dk

Type 1 diabetes mellitus (T1DM), formerly called insulin-dependent diabetes

mellitus (IDDM), is a serious chronic disorder characterised by absolute insulin

deficiency caused by an immune-mediated selective destruction of the ...

Related Articles - Cached - Web Search

4. Lack of association of type 1 diabetes with the IL4R gene - all 3 versions »

HQ Qu, MC Tessier, R Fréchette, F Bacot, C … - Diabetologia, 2006 - Springer

Abstract Aims/hypothesis: The association between IL4R and type 1 diabetes has

been tested in many studies in recent years, with contradictory results. The aim

of this study was to re-evaluate the genetic association in type 1 diabetic ...

Related Articles - Web Search

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Marre M, Garcia Puig J, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V,

Scheen A, Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz

M, Hermansen K, Tuomilehto J, Finizola B, Pozza G, Chastang C, Ollivier JP, Amouyel

P, Asmar R. (2003) Effect of indapamide SR on microalbuminuria--the NESTOR study

(Natrilix SR versus Enalapril Study in Type 2 diabetic hypertensives with

micrOalbuminuRia)--rationale and protocol for the main trial. J Hypertens Suppl 21:S19-

24

Effect of indapamide SR on microalbuminuria--the NESTOR study (Natrilix SR versus Enalapril Study in

… - all 2 versions »

M Marre, J Garcia Puig, F Kokot, M Fernandez, G … - J Hypertens Suppl, 2003 - ncbi.nlm.nih.gov

... Marre M, Garcia Puig J, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen

A, Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz ...

Cited by 2 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients … -

all 4 versions »

M Marre, JG Puig, F Kokot, M Fernandez, G Jermendy … - J Hypertens, 2004 - jhypertension.com

August 2004, 22:8 > Equivalence of indapamide SR and... ...

Cited by 35 - Related Articles - Web Search

2. Response

JP Ruiz, LM Medina, FM Parra, JM de la Higuera … - Stroke, 2003 - Am Heart Assoc

We agree that the use of ACEI might be beneficial, but, although members of a

drug class share main actions, they may have clinically important differences in

terms of efficacy and safety, 6 which might explain the differences ...

Related Articles - Web Search

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27

Nejentsev S, Guja C, McCormack R, Cooper J, Howson JMM, Nutland S, Rance H,

Walker N, Undlien D, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, Ionescu-

Tîrgovişte C, Gale EAM, Bingley PJ, Gillespie KM, Savage DA, Carson DJ, Patterson

CC, Maxwell AP, Todd JA. (2003) Association of intercellular adhesion molecule-1 gene

with type 1 diabetes. Lancet 362:1723-1724

Association of intercellular adhesion molecule-1 gene with type 1 diabetes - all 5

versions »

S Nejentsev, C Guja, R McCormack, J Cooper, JMM … - The Lancet, 2003 - Elsevier

Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the

leucocyte integrins, in adhesion of immune cells to endothelial cells and in T

cell activation. The third immuno-globulin-like extracellular domain binds ...

Cited by 13 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Getting under the skin: the immunogenetics of psoriasis.

AM Bowcock, JG Krueger - Nat Rev Immunol, 2005 - ncbi.nlm.nih.gov

Psoriasis is a chronic inflammatory disorder of the skin that is mediated by T

cells, dendritic cells and inflammatory cytokines. We now understand many of the

cellular alterations that underlie this disease, and genomic approaches ...

Cited by 61 - Related Articles - Web Search

2. Type 1 diabetes: pathogenesis and prevention - all 12 versions »

KM Gillespie - Canadian Medical Association Journal, 2006 - Can Med Assoc

Type 1 diabetes results from the autoimmune destruction of insulin-producing ß

cells in the pancreas. Genetic and, as yet undefined, environmental factors act

together to precipitate the disease. The excess mortality associated with ...

Cited by 15 - Related Articles - Web Search - BL Direct

3. ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1

… - all 2 versions »

B Puthothu, M Krueger, M Bernhardt, A Heinzmann - Genes and Immunity, 2006 - nature.com

Intercellular adhesion molecule-1 (ICAM1) acts as ligand for 2-integrin

molecules and mediates leucocyte trafficking to the site of inflammation.

Intercellular adhesion molecule-1-deficient mice show impaired lymphocyte ...

Cited by 4 - Related Articles - Web Search - BL Direct

4. Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary

sclerosing … - all 2 versions »

CL Bowlus, TH Karlsen, U Broomé, E Thorsby, M … - Journal of Hepatology, 2006 - Elsevier

Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in

the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing

cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been ...

Cited by 3 - Related Articles - Web Search

5. ICAM-1 polymorphisms and development of cutaneous malignant melanoma - all 3 versions »

WM Howell, MJ Rose-Zerilli, JM Theaker, AC Bateman - Int. J. Immunogenet, 2005 -

ingentaconnect.com

Summary Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell

adhesion molecules, including intercel- lular adhesion molecule-1 (ICAM-1).

ICAM-1 expression is associated with increasing Breslow thickness of ...

Cited by 2 - Related Articles - Web Search

6. Adulthood-Onset Celiac Disease Is Associated with Intercellular Adhesion Molecule-1 (ICAM-1) Gene

28

… - all 3 versions »

M Abel, C Cellier, N Kumar, N Cerf-Bensussan, J … - Human Immunology, 2006 - Elsevier

Celiac disease (CD) is a multifactorial T-cell–mediated autoimmune disease

characterized by gluten-triggered villous atrophy and malabsorption. Although

human leukocyte antigen (HLA) class II genes are strong susceptibility ...

Cited by 2 - Related Articles - Web Search

7. Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in … - all 6

versions »

J Ma, A Möllsten, M Prázny, H Falhammar, K … - Diabet Med, 2006 - Blackwell Synergy

Results SNPs rs281432(C/G) and rs5498 E469K(A/G) had high heterozygous indexes.

They were significantly associated with T1D [P = 0.026, OR = 1.644 (95% CI

1.138–2.376) and P < 0.001, OR = 2.456 (1.588–3.8)]. Frequencies of the ...

Cited by 2 - Related Articles - Web Search - BL Direct

8. Association of intercellular adhesion molecule 1 polymorphisms with retinopathy in Chinese patients …

- all 4 versions »

L Liu, Q Yu, H Wang, SX Zhang, C Huang, X Chen - Diabetic Medicine, 2006 - Blackwell Synergy

Patients and methods One hundred and seventy-two Chinese patients with Type 2

diabetes and 80 normal control subjects were recruited. Patients with diabetes

were placed into two groups: the diabetic retinopathy (DR) group and the ...

Cited by 1 - Related Articles - Web Search - BL Direct

9. Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical … - all

6 versions »

BR Yacyshyn, A Schievella, KL Sewell, JA Tami - Clinical and Experimental Immunology, 2005 -

Blackwell Synergy

Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/

perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms

in tumour necrosis factor (TNF)- and intercellular adhesion molecule-1 ...

Related Articles - Web Search

10. NON-MHC genes in type 1 diabetes. Family-based association studies and functional studies of disease

… - all 3 versions »

OP Kristiansen - Danish Medical Bulletin, 2005 - danmedbul.dk

Type 1 diabetes mellitus (T1DM), formerly called insulin-dependent diabetes

mellitus (IDDM), is a serious chronic disorder characterised by absolute insulin

deficiency caused by an immune-mediated selective destruction of the ...

Related Articles - Cached - Web Search

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29

Ueda H, Howson JMM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB,

Hunter KMD, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe

C, Twells RCJ, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam

AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker

ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E,

Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-

Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton

DG, Peterson LB, Wicker LS, Todd JA, Gough SCL. (2003) Association of the T-cell

regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506-511

[PDF] Association of the T-cell regulatory gene CTLA 4 with susceptibility to

autoimmune disease - grup din 5 »

H Ueda, JMM Howson, L Esposito, J Heward, H Snook, … - Nature, 2003 - research.dfci.harvard.edu

Page 1. Association of the T-cell regulatory ... of the cytotoxic T lymphocyte antigen

4 gene (CTLA4)—which encodes a vital negative regulatory molecule of ...

Citat de 678 ori - Articole înrudite - Afişare ca HTML - Căutare Web

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Naturally arising CD4 regulatory T cells for immunologic self-tolerance and negative control of … -

grup din 6 »

S Sakaguchi - Annu. Rev. Immunol, 2004 - Annual Reviews

Abstract Naturally occurring CD4 + regulatory T cells, the majority of which

express CD25, are engaged in dominant control of self-reactive T cells,

contributing to the maintenance of immunologic self-tolerance. Their ...

Citat de 847 ori - Articole înrudite - Căutare Web

2. Naturally arising Foxp3-expressing CD25 CD4 regulatory T cells in immunological tolerance to self … -

grup din 7 »

S Sakaguchi - Nature Immunology, 2005 - nature.com

A key issue in immunology is understanding how the immune system is able to

discriminate between self and non-self, inhibiting autoimmune responses but

allowing effective immune responses against microbial antigens. The immune ...

Citat de 507 ori - Articole înrudite - Căutare Web

3. Genome-wide association studies for common diseases and complex traits - grup din 10 »

JN Hirschhorn, MJ Daly - Nature Reviews Genetics, 2005 - binfo.bio.wzw.tum.de

We have recently seen the completion of the human genome sequence 1,2 , the

deposition of millions of SNPs into public databases 3 ,rapid improvements in

SNP genotyping technology and the initiation of the International HapMap ...

Citat de 412 ori - Articole înrudite - Căutare Web

4. Genome-wide association studies: theoretical and practical concerns - grup din 8 »

S Lin, A Chakravarti, DJ Cutler - Nature Genetics, 2004 - nature.com

Risch and Merikangas argued that in an idealized future, disease-association

studies could be carried out with substantial power by typing roughly 1 million

functional single-nucleotide polymorphisms (SNPs; or perfect proxies) in ...

Citat de 276 ori - Articole înrudite - Căutare Web

5. Assessing the impact of population stratification on genetic association studies - grup din 5 »

ML Freedman, D Reich, KL Penney, GJ McDonald, AA … - Nature Genetics, 2004 - nature.com

Nature Genetics, Full text access provided to: Googlebot Access by: Web Services. ...

Citat de 214 ori - Articole înrudite - Căutare Web

30

6. Genetics of multiple sclerosis - grup din 4 »

DA Dyment, GC Ebers, A Dessa Sadovnick - Lancet Neurology, 2004 - Elsevier

Multiple sclerosis (MS) is probably aetiologically heterogeneous. Systematic

genetic epidemiological and molecular genetic studies have provided important

insights. Both genetic and non-genetic (environment, stochastic) factors ...

Citat de 164 ori - Articole înrudite - Căutare Web

7. Strategies for mapping and cloning quantitative trait genes in rodents - grup din 8 »

J Flint, W Valdar, S Shifman, R Mott… - Nature Reviews Genetics, 2005 - nature.com

Many quantitative phenotypes of biomedical interest can be modelled in rodents,

and the chromosomal locations of the genetic variants that contribute to

phenotypic variation can be identified by crosses between inbred strains. ...

Citat de 124 ori - Articole înrudite - Căutare Web

8. Genome scans and candidate gene approaches in the study of common diseases and variable drug … -

grup din 4 »

DB Goldstein, KR Ahmadi, ME Weale, NW Wood - Trends in Genetics, 2003 - Elsevier

There is both tremendous enthusiasm and controversy surrounding genetic

association studies. In this article we use new methods for representing

variation in the human genome that suggest as a few as 170 000 care- fully ...

Citat de 110 ori - Articole înrudite - Căutare Web

9. What makes a good genetic association study? - grup din 4 »

AT Hattersley, MI McCarthy - The Lancet, 2005 - Elsevier

Genetic association studies are central to efforts to identify and characterise

genomic variants underlying susceptibility to multifactorial disease. However,

obtaining robust replication of initial association findings has proved ...

Citat de 110 ori - Articole înrudite - Căutare Web

10. Methods for High-Density Admixture Mapping of Disease Genes - grup din 7 »

N Patterson, N Hattangadi, B Lane, KE Lohmueller, … - The American Journal of Human Genetics,

2004 - UChicago Press

In the search for disease-causing variants in humans, it is desirable to use

whole-genome scans, because they do not require a priori knowledge of the genes

involved in disease. The most successful such method to date linkage ...

Citat de 100 ori - Articole înrudite - Căutare Web

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Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST, Clayton DG, Cordell HJ, Todd JA. (2004) Remapping the Insulin Gene/IDDM2 locus in Type 1 diabetes. Diabetes 53:1884-1889.

Remapping the insulin gene/IDDM2 locus in type 1 diabetes. - all 3 versions »

BJ Barratt, F Payne, CE Lowe, R Hermann, BC Healy, … - Diabetes, 2004 - ncbi.nlm.nih.gov

Click here to read Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold ...

Cited by 58 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Genome-wide association studies for common diseases and complex traits - all 10

versions »

JN Hirschhorn, MJ Daly - Nature Reviews Genetics, 2005 - binfo.bio.wzw.tum.de

We have recently seen the completion of the human genome sequence 1,2 , the

deposition of millions of SNPs into public databases 3 ,rapid improvements in

SNP genotyping technology and the initiation of the International HapMap ...

Cited by 393 - Related Articles - Web Search

2. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-

nucleotide … - all 5 versions »

A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - Am J Hum Genet, 2005 - UChicago Press

Despite hundreds of association studies, few have been consistently replicated

(Dahlman et al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller

et al. 2003). In type 1 diabetes (T1D [MIM 222100]), only four loci have ...

Cited by 53 - Related Articles - Web Search

3. Genetic epidemiology of diabetes - all 3 versions »

MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig

Conventional genetic analysis focuses on the genes that account for specific

phenotypes, while traditional epidemiology is more concerned with the

environmental causes and risk factors related to traits. Genetic ...

Cited by 51 - Related Articles - Web Search

4. Regulatory polymorphisms underlying complex disease traits - all 4 versions »

JC Knight - Journal of Molecular Medicine, 2005 - Springer

Abstract There is growing evidence that genetic variation plays an important

role in the determination of individual susceptibility to complex disease

traits. In contrast to coding sequence polymorphisms, where the ...

Cited by 49 - Related Articles - Web Search

5. [PDF] Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in

1,435 Multiplex Families - all 4 versions »

P Concannon, HA Erlich, C Julier, G Morahan, J … - DIABETES, 2005 - joslinresearch.org

Page 1. Original Article Type 1 Diabetes Evidence for Susceptibility Loci from Four

Genome-Wide Linkage Scans in 1,435 Multiplex Families Patrick Concannon, 1 Henry

A. Erlich, 2 Cecile Julier, 3 Grant Morahan, 4 Jørn Nerup, 5 ...

Cited by 45 - Related Articles - View as HTML - Web Search

32

6. Genetic susceptibility to type 1 diabetes - all 3 versions »

LM Maier, LS Wicker - Current Opinion in Immunology, 2005 - Elsevier

Type 1 diabetes (T1D) is a complex trait with both genetic and environmental

influences. T1D results from immune-mediated destruction of the

insulin-producing β cells of the pancreas. Autoimmune diabetes in the ...

Cited by 24 - Related Articles - Web Search

7. T1DBase, a community web-based resource for type 1 diabetes research - all 7

versions »

LJ Smink, EM Helton, BC Healy, CC Cavnor, AC Lam, … - Nucleic Acids Research - Oxford Univ Press

T1DBase (http://T1DBase.org) is a public website and database that supports the

type 1 diabetes (T1D) research community. The site is currently focused on the

molecular genetics and biology of T1D susceptibility and pathogenesis. It ...

Cited by 22 - Related Articles - Web Search

8. Genetic Approaches to Studying Common Diseases and Complex Traits - all 3

versions »

JN HIRSCHHORN - Pediatric Research, 2005 - IPRF

Most common diseases and most quantitative traits that can be measured in human

populations are complex genetic traits. That is, many genetic and nongenetic

factors interact to determine the final phenotype, whether that phenotype ...

Cited by 21 - Related Articles - Web Search

9. Analysis of Multiple Data Sets Reveals No Association between the Insulin Gene

Variable Number … - all 5 versions »

BL Powell, L Haddad, A Bennett, N Gharani, U Sovio … - Journal of Clinical Endocrinology &

Metabolism, 2005 - Endocrine Soc

Context: Variation at the insulin gene VNTR (variable number tandem repeat)

minisatellite has been reported to be associated with polycystic ovary syndrome

(PCOS), but findings have been inconsistent and all studies have featured ...

Cited by 20 - Related Articles - Web Search

10. Genetic insights into disease mechanisms of autoimmunity - all 4 versions »

MJ Simmonds, SCL Gough - British Medical Bulletin, 2005 - British Council

Educating the immune system to distinguish between self and non-self is critical

to ensure that an immune response is mounted against foreign antigens and not

against self. A breakdown in these mechanisms can lead to the onset of ...

Cited by 18 - Related Articles - Web Search

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Eftychi C, Howson JMM, Barratt B, Vella A, Payne F, Smyth DJ, Twells RCJ, Walker

NM, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C,

Ionescu-Tîrgovişte C, Savage D, Todd JA. (2004) Analysis of the type 2 diabetes -

associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in

type 1 diabetes. Diabetes 53:870-873

Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1,

KCNJ11 … - all 4 versions »

C Eftychi, JMM Howson, BJ Barratt, A Vella, F … - Diabetes, 2004 - Am Diabetes Assoc

... Brief Genetics Report. Analysis of the Type 2 Diabetes-Associated Single Nucleotide

Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes. ...

Cited by 6 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Analysis of Separate and Combined Effects of Common Variation in KCNJ11 and PPARG on Risk of

Type 2 … - all 4 versions » SK Hansen, EMD Nielsen, J Ek, G Andersen, C Glumer … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc The separate and combined effects of the PPARG Pro 12 Ala polymorphism and the KCNJ11 Glu 23 Lys polymorphisms on risk of type 2 diabetes were investigated in relatively large-scale, case-control studies. Separate effects of the ... Cited by 12 - Related Articles - Web Search 2. IRS1, KCNJ11, PPARg2 and HNF-1a: do amino acid polymorphisms in these candidate genes support a

… A Johansen, DP Jensen, R Bergholdt, HB Mortensen, … - Diabetes, Obesity and Metabolism, 2006 - ingentaconnect.com Aims: Type 1 diabetes mellitus (T1DM) is a chronic disorder primarily triggered by environmental and immunolo- gical factors in genetically susceptible individuals. Despite the fact that there are indications of common ... Cited by 1 - Related Articles - Web Search 3. Association of Small Ubiquitin-Like Modifier 4 (SUMO4) Variant, Located in IDDM5 Locus, with

Type 2 … - all 3 versions » S Noso, T Fujisawa, Y Kawabata, K Asano, Y … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Objective: Small ubiquitin-like modifier 4 (SUMO4) has been identified as a candidate gene for the IDDM5 locus and suggested to have possible involvement in immune responses, such as autoimmunity and inflammation. Recent reports ... Cited by 1 - Related Articles - Web Search - BL Direct

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34

Guja C, Guja L, Nutland S, Rance H, Sebastien M, Todd JA, Ionescu-Tirgoviste C. (2004) Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania. J Cell Mol Med 8:249-256.

Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania - all 3 versions »

C Guja, L Guja, S Nutland, H Rance, M Sebastien, … - J. Cell. Mol. Med, 2004 - Blackwell Synergy

Type 1 diabetes mellitus (T1DM) is a common autoimmune disease that arises (at

least in most of the cases) from the specific destruction of insulin secreting

pancreatic β cells by autoreactive T ... C. Guja a *, L. Guja a , S. ...

Cited by 3 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Contribution of Selective HLA-DRB1/DQB1 Alleles and Haplotypes to the Genetic Susceptibility of

Type … - all 5 versions »

FA Al-Jenaidi, SF Wakim-Ghorayeb, A Al-Abbasi, MR … - Journal of Clinical Endocrinology &

Metabolism, 2005 - Endocrine Soc

Context: Human leukocyte antigen (HLA) class II genes contribute to the genetic

susceptibility of type 1 diabetes (T1D), and both susceptible and protective

alleles were implicated with its pathogenesis, which varies among various ...

Cited by 2 - Related Articles - Web Search

2. IL-18 gene promoter 137C/G and 607C/A polymorphisms in Chinese Han children with type 1 diabetes

… - all 3 versions »

GP Dong, ZS Yu, L Liang, CC Zou, JF Fu, CL Wang - International Journal of Immunogenetics, 2007 -

Blackwell Synergy

Skip to main content. ...

Related Articles - Web Search - BL Direct

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35

Ionescu-Tîrgovişte C, Guja C, Călin A, Moţa M. (2004) An increasing trend in the incidence of type 1 diabetes in children aged 0 – 14 years in Romania. Ten years (1988 – 1997) EURODIAB study experience. J Ped Endocrinol Metab 17:983-991.

An increasing trend in the incidence of type 1 diabetes mellitus in children aged 0-14

years in … - all 2 versions »

C Ionescu-Tirgoviste, C Guja, A Calin, M Mota - J Pediatr Endocrinol Metab, 2004 - ncbi.nlm.nih.gov

AIM: To assess the incidence of type 1 diabetes mellitus (DM1) in Romanian

children aged 0-14 years using EURODIAB Study methodology. METHODS: Data were

collected for a 10-year interval (1988-1997) for the whole country, using ...

Cited by 3 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. Parasitic worms and inflammatory diseases - all 4 versions »

P Zaccone, Z Fehervari, JM PHILLIPS, DW DUNNE, A … - Parasite Immunol, 2006 - Blackwell

Synergy

The debate on whether infection precipitates or prevents autoimmunity remains a

contentious one. Recently the suggestion that some unknown microbe can be at the

origin of some chronic inflammatory diseases has been countered by ...

Cited by 5 - Related Articles - Web Search - BL Direct

2. Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania - all 3 versions »

C Guja, L Guja, S Nutland, H Rance, M Sebastien, … - J. Cell. Mol. Med, 2004 - Blackwell Synergy

Type 1 diabetes mellitus (T1DM) is a common autoimmune disease that arises (at

least in most of the cases) from the specific destruction of insulin secreting

pancreatic β cells by autoreactive T ... C. Guja a *, L. Guja a , S. ...

Cited by 3 - Related Articles - Web Search

3. Incidence and trends of childhood Type 1 diabetes in Croatia from 1995 to 2003

G Stipancic, L La Grasta Sabolic, M Malenica, A … - Diabetes Research and Clinical Practice, 2007 -

Elsevier

The incidence data were obtained from two sources. The incidence was calculated

as the number of newly diagnosed Type 1 diabetes patients per 100,000

person-years for the age group 0–14 years, and subgroups 0–4, 5–9, ...

Web Search

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Kyvik KO, Nystrom L, Gorus F, Songini M, Oestman J, Castell C, Green A, Guyrus E, Ionescu-Tirgoviste C, McKinney PA, Michalkova D, Ostrauskas R, Raymond NT. (2004) The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children. Diabetologia 47:377-384

The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children - all 5

versions »

KO Kyvik, L Nystrom, F Gorus, M Songini, J Oestman … - Diabetologia, 2004 - Springer

... incidence rates in The epidemiology of Type 1 diabetes mellitus is not the same

in young adults as in children 379 Table 1. Ascertainment ...

Cited by 22 - Related Articles - Web Search

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1. 1, 25-Dihydroxyvitamin D3 Modulates Expression of Chemokines and Cytokines in Pancreatic Islets: …

- all 5 versions »

CA Gysemans, AK Cardozo, H Callewaert, A Giulietti … - Endocrinology, 2005 - Endocrine Soc

1,25-Dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 ) is an immune modulator that

prevents experimental autoimmune diseases. Receptors for 1,25-(OH) 2 D 3 are

present in pancreatic ß-cells, the target of an autoimmune assault in ...

Cited by 11 - Related Articles - Web Search

2. The ‗accelerator hypothesis‘: relationship between weight, height, body mass index and age at … - all 2

versions »

I Knerr, J Wolf, T Reinehr, R Stachow, M Grabert, … - Diabetologia, 2005 - Springer

Page 1. Diabetologia (2005) 48: 2501–2504 DOI 10.1007/s00125-005-0033-

2 SHORT COMMUNICATION I. Knerr . J. Wolf . T. Reinehr . R. Stachow .

M. Grabert . E. Schober . W. Rascher . RW Holl . on ...

Cited by 10 - Related Articles - Web Search

3. Type 1 Diabetes and Latent Autoimmune Diabetes in Adults: One End of the Rainbow - all 4 versions »

RDG Leslie, R Williams, P Pozzilli - Journal of Clinical Endocrinology & Metabolism, 2006 -

Endocrine Soc

Context: The aim of this review was to explore the pathogenic and clinical

spectrum of type 1 diabetes, which includes a form of adult onset autoimmune

diabetes usually referred to as latent autoimmune diabetes in adults ...

Cited by 11 - Related Articles - Web Search

4. Incidence of Type 1 and Type 2 Diabetes in Adults Aged 30-49 Years: The population-based registry in

… - all 6 versions »

G Bruno, C Runzo, P Cavallo-Perin, F Merletti, M … - Diabetes Care, 2005 - 0-intl-

care.diabetesjournals.org.pugwash.lib.warwick.ac.uk

RESEARCH DESIGN AND METHODS—We extended the study base of the registry of the

province of Turin, Italy, to subjects aged 30–49 years in the period

1999–2001 to estimate the incidences of type 1 and type 2 diabetes. ...

Cited by 2 - Related Articles - Web Search

5. A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes … - all 5

versions »

N Lammi, O Taskinen, E Moltchanova, IL Notkola, JG … - Diabetologia, 2007 - Springer

Abstract Aims/hypothesis The aim of this study was to examine the incidence and

trends of type 1 and type 2 diabetes in the 15–39 year-old population between

1992 and 1996 in Finland. Subjects and methods Data on the nationwide ...

Cited by 1 - Related Articles - Web Search - BL Direct

37

6. Childhood type 1 diabetes mellitus in Newfoundland and Labrador, Canada - all 3 versions »

R Alaghehbandan, KD Collins, LA Newhook, D … - Diabetes Research and Clinical Practice, 2006 -

Elsevier

A total of 894 T1DM hospital separations among children aged 0–19 years were

identified, representing a hospitalization rate of 88.6 per 100,000 person-years

(PY). The CDMS identified 518 incidences of hospitalization (51.2 per ...

Cited by 1 - Related Articles - Web Search

7. Seasonality of birth in children and young adults (0–29 years) with type 1 diabetes in Ukraine - all 6

versions »

AM Vaiserman, B Carstensen, VP Voitenko, MD Tronko … - Diabetologia, 2007 - Springer

Page 1. SHORT COMMUNICATION Seasonality of birth in children and young adults

(0–29 years) with type 1 diabetes in Ukraine AM Vaiserman & B. Carstensen & VP

Voitenko & MD Tronko & VI Kravchenko & MD Khalangot & LV Mechova ...

Related Articles - Web Search - BL Direct

8. [PDF] Perspectives in Diabetes

RDG Leslie, MD Castelli - DIABETES, 2004 - scarlet.be

A decade ago we proposed that environmental factors operating in early life lead

to type 1 diabetes, outlining the evidence and the impli- cations if the

hypothesis was true (1). Today we can be confident that environmental ...

Related Articles - View as HTML - Web Search

9. The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15 …

DMR Rev - Diabetes Metab Res Rev, 2007 - doi.wiley.com

1 Diabetes Research Center, Free University Brussels, Belgium 2 Department of

Pediatrics, University of Antwerp, Antwerp, Belgium 3 Department of Pediatrics,

Paola Children‘s Hospital, Antwerp, Belgium 4 Department of Diabetology ...

Related Articles - Web Search

10. The effect of birth order and parental age on the risk of type 1 and 2 diabetes among young adults - all 2

versions »

N Lammi, E Moltchanova, P Blomstedt, JG Eriksson, … - Diabetologia, 2007 - Springer

Abstract Aims/hypothesis The aim of this study was to examine the effects of

birth order and parental age on the risk of type 1 and type 2 diabetes among

Finnish individuals aged 15– 39 years. Methods Data on all cases of type ...

Related Articles - Web Search

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Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RCJ, Green EA, Savage DA, Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG. (2004) Cost-effective analysis of candidate genes using htSNPs: a staged approach. Genes and Immunity 5:301–305

Cost-effective analysis of candidate genes using htSNPs: a staged approach. - all 2

versions »

… Green, DA Savage, C Guja, C Ionescu-Tirgoviste, E … - Genes Immun, 2004 - ncbi.nlm.nih.gov

We have previously shown that the selection of haplotype tag single nucleotide

polymorphisms (htSNPs) and their statistical analysis in a multi-locus

transmission/disequilibrium test (TDT) results in a more cost-effective ...

Cited by 29 - Related Articles - Web Search

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1. Genome-wide association studies for common diseases and complex traits - all 10

versions »

JN Hirschhorn, MJ Daly - Nature Reviews Genetics, 2005 - binfo.bio.wzw.tum.de

We have recently seen the completion of the human genome sequence 1,2 , the

deposition of millions of SNPs into public databases 3 ,rapid improvements in

SNP genotyping technology and the initiation of the International HapMap ...

Cited by 393 - Related Articles - Web Search

2. Genome-wide association studies: theoretical and practical concerns - all 8 versions »

S Lin, A Chakravarti, DJ Cutler - Nature Genetics, 2004 - nature.com

Risch and Merikangas argued that in an idealized future, disease-association

studies could be carried out with substantial power by typing roughly 1 million

functional single-nucleotide polymorphisms (SNPs; or perfect proxies) in ...

Cited by 270 - Related Articles - Web Search

3. The Future of Association Studies: Gene-Based Analysis and Replication - all 5

versions »

BM Neale, PC Sham - The American Journal of Human Genetics, 2004 - UChicago Press

The past decade has seen a dramatic increase in the use of association studies

for the genetic analysis of complex disorders (Lander and Schork 1994; Risch

2000). The introduction of the transmission/disequilibrium test was one ...

Cited by 139 - Related Articles - Web Search

4. Genetic association studies - all 5 versions »

HJ Cordell, DG Clayton - The Lancet, 2005 - Elsevier

We review the rationale behind and discuss methods of design and analysis of

genetic association studies. There are similarities between genetic association

studies and classic epidemiological studies of environmental risk factors ...

Cited by 104 - Related Articles - Web Search

5. Population structure, differential bias and genomic control in a large-scale, case-

control … - all 6 versions »

DG Clayton, NM Walker, DJ Smyth, R Pask, JD Cooper … - Nature Genetics, 2005 - nature.com

The results reported here concern the first phase of a study that will

eventually include 8,000 cases of type 1 diabetes (T1D; Genetic Resource

Investigating Diabetes study) 6, 7 and 8,000 controls drawn from the 1958 ...

Cited by 80 - Related Articles - Web Search

39

6. Recent developments in genomewide association scans: a workshop summary and

review - all 5 versions »

DC Thomas, RW Haile, D Duggan - Am J Hum Genet, 2005 - UChicago Press

A traditional means of discovering disease genes begins with family-based

linkage scans, looking for regions of the genome that tend to be transmitted

through families in a manner that parallels the transmission of the trait, ...

Cited by 72 - Related Articles - Web Search

7. Shaking the tree: mapping complex disease genes with linkage disequilibrium - all 3

versions »

LJ Palmer, LR Cardon - The Lancet, 2005 - Elsevier

Much effort and expense are being spent internationally to detect genetic

polymorphisms contributing to susceptibility to complex human disease.

Concomitantly, the technology for detecting and genotyping single ...

Cited by 70 - Related Articles - Web Search

8. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-

nucleotide … - all 5 versions »

A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - Am J Hum Genet, 2005 - UChicago Press

Despite hundreds of association studies, few have been consistently replicated

(Dahlman et al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller

et al. 2003). In type 1 diabetes (T1D [MIM 222100]), only four loci have ...

Cited by 53 - Related Articles - Web Search

9. Efficiency and consistency of haplotype tagging of dense SNP maps in multiple

samples - all 5 versions »

X Ke, C Durrant, AP Morris, S Hunt, DR Bentley, P … - Human Molecular Genetics, 2004 - Oxford

Univ Press

Haplotype tagging is a means of retaining most of the information in high

density marker maps, while reducing genotyping requirements. Estimates of the

numbers of tagging SNPs required to cover the human genome have varied ...

Cited by 40 - Related Articles - Web Search

10 A comparison of tagging methods and their tagging space - all 4 versions »

X Ke, MM Miretti, J Broxholme, S Hunt, S Beck, DR … - Human Molecular Genetics, 2005 - Oxford

Univ Press

Single-nucleotide polymorphism (SNP) tagging is widely used as a way of saving

genotyping costs in association studies. A number of different tagging methods

have been developed to reduce the number of markers to be genotyped while ...

Cited by 19 - Related Articles - Web Search

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Marre M, Puig JG, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A, Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion Junior D, Ruiz M, Hermansen K, Tuomilehto J, Finizola B, Gallois Y, Amouyel P, Ollivier JP, Asmar R. (2004) Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study. J Hypertens 22:1613-1622

Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients

… - all 4 versions »

M Marre, JG Puig, F Kokot, M Fernandez, G Jermendy … - J Hypertens, 2004 - jhypertension.com

... Equivalence of indapamide SR and enalapril on microalbuminuria reduction in

hypertensive patients with type 2 diabetes: The NESTOR* study. ...

Cited by 35 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. Microalbuminuria and cardiovascular risk - all 4 versions »

J Karalliedde, G Viberti - American Journal of Hypertension, 2004 - Elsevier

Microalbuminuria is a marker for generalized vascular dysfunction. Its

prevalence in United States and European general population surveys ranges from

6% to 10%. Increased risk for cardiovascular morbidity and mortality begins ...

Cited by 27 - Related Articles - Web Search

2. Evidence for renoprotection by blockade of the renin-angiotensin-aldosterone system in hypertension …

- all 5 versions »

J Karalliedde, G Viberti - J Hum Hypertens, 2006 - nature.com

The incidence of end-stage renal disease (ESRD) is rising worldwide, accompanied

by corresponding increases in the risk of morbidity and mortality. Underlying

this trend are increasing rates of hypertension and diabetes mellitus, the ...

Cited by 22 - Related Articles - Web Search

3. Renal protection in hypertensive patients: selection of antihypertensive therapy - all 8 versions »

RR Wenzel - Drugs, 2005 - drugs.adisonline.com

Hypertension is common in chronic renal disease and is a risk factor for the

faster progression of renal damage, and reduction of blood pressure (BP) is an

efficient way of preventing or slowing the progression of this damage. ...

Cited by 11 - Related Articles - Web Search

4. Diabetes mellitus and stroke - all 3 versions »

I Idris, GA Thomson, JC Sharma - Int J Clin Pract, 2006 - Blackwell Synergy

The combination of diabetes and stroke disease is a major cause of morbidity and

mortality worldwide. Evidence from large clinical trials performed in patients

with diabetes supports the need for aggressive and early intervention to ...

Cited by 8 - Related Articles - Web Search

5. New concepts in blood pressure-lowering management in diabetic patients: the case for early ACE … -

all 6 versions »

CES Mogensen - J. Hum. Hypertens., 2005 - nature.com

Type II diabetes and the dysmetabolic syndrome are becoming more and more

prevalent, not only in the Western world, but also in many developing countries.

The key issue is early prevention and treatment, not only ...

Cited by 4 - Related Articles - Web Search

6. An overview of the pharmacology and clinical efficacy of indapamide sustained release - all 3 versions »

J Sassard, A Bataillard, H McIntyre - Fundam Clin Pharmacol, 2005 - Blackwell Synergy

41

The relationship between blood pressure (BP) and cardiovascular risk is clearly

established; hypertension increases the rate of cardiovascular. High systolic

blood pressure (SBP) may be the main parameter involved in cardiovascular ...

Cited by 4 - Related Articles - Web Search

7. Superior effect of an angiotensin-converting enzyme inhibitor over a diuretic for reducing aortic … - all

3 versions »

XJ Jiang, MF O‘Rourke, YQ Zhang, XY He, LS Liu - J Hypertens, 2007 - jhypertension.com

Background: In recent studies, benefit has been shown for angiotensin-converting

enzyme (ACE) inhibitors and calcium antagonists over a beta-blocker in

hypertension, through a greater reduction in aortic than brachial systolic ...

Cited by 5 - Related Articles - Web Search - BL Direct

8. Efficacy of indapamide 1.5 mg, sustained release, in the lowering of systolic blood pressure - all 3

versions »

GM London - J Hum Hypertens, 2004 - nature.com

The aim of this review is to assess the efficacy of indapamide 1.5mg sustained

release (indapamide SR; brand names: Natrilix SR, Natrilix LP, Natrilix Retard,

Natrilix AP, Fludex LP, Fludex retard, Fludex SR, Fludex 1.5 mg, Tertensif ...

Cited by 4 - Related Articles - Cached - Web Search

9. Indapamide sustained release: a review of its use in the treatment of hypertension - all 7 versions »

DM Robinson, K Wellington - Drugs, 2006 - drugs.adisonline.com

In well controlled 12- to 52-week clinical trials, indapamide SR 1.5 mg/day was

well tolerated and reduced blood pressure as effectively as therapeutic dosages

of amlodipine, candesartan, enalapril, hydrochlorothiazide or indapamide ...

Cited by 1 - Related Articles - Web Search

10. Efficacy of Indapamide SR Compared With Enalapril in Elderly Hypertensive Patients With Type 2 …

- all 3 versions »

JG Puig, M Marre, F Kokot, M Fernandez, G Jermendy … - American Journal of Hypertension, 2007 -

Elsevier

The urinary albumin-to-creatinine ratio decreased by 46% in the indapamide SR

group and 47% in the enalapril group. Noninferiority of indapamide SR over

enalapril was demonstrated (P = .0236; 35% limit of noninferiority) with a ...

Related Articles - Web Search

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Nejentsev S, Cooper JD, Godfrey L, Howson JM, Rance H, Nutland S, Walker NM, Guja C, Ionescu-Tirgoviste C, Savage DA, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Gillespie KM, Ring SM, Strachan DP, Widmer B, Dunger D, Todd JA. (2004) Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes. Diabetes 53:2709-2712

Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes - all 3

versions »

… Howson, H Rance, S Nutland, NM Walker, C Guja, C … - Diabetes, 2004 - Am Diabetes Assoc

Vitamin D is known to modulate the immune system, and its administration has

been associated with reduced risk of type 1 diabetes. Vitamin D acts via its

receptor (VDR). Four single nucleotide polymorphisms (SNPs) of the VDR gene ...

Cited by 24 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. Vitamin D and diabetes - all 4 versions »

C Mathieu, C Gysemans, A Giulietti, R Bouillon - Diabetologia, 2005 - Springer

Abstract Vitamin D deficiency predisposes individuals to type 1 and type 2

diabetes, and receptors for its activated form—1α,25-dihydroxyvitamin D 3

—have been identified in both beta cells and immune cells. Vitamin D ...

Cited by 37 - Related Articles - Web Search

2. Vitamin D and type 1 diabetes mellitus: state of the art - all 5 versions »

C Mathieu, K Badenhoop - Trends in Endocrinology & Metabolism, 2005 - Elsevier

Recent evidence suggests a role for vitamin D in pathogenesis and prevention of

diabetes mellitus. Active vitamin D, 1α,25(OH) 2 D 3 , prevents type 1 diabetes

in animal models, modifies T-cell differentiation, modulates dendritic cell ...

Cited by 16 - Related Articles - Web Search

3. Type 1 diabetes: pathogenesis and prevention - all 12 versions »

KM Gillespie - Canadian Medical Association Journal, 2006 - Can Med Assoc

Type 1 diabetes results from the autoimmune destruction of insulin-producing ß

cells in the pancreas. Genetic and, as yet undefined, environmental factors act

together to precipitate the disease. The excess mortality associated with ...

Cited by 15 - Related Articles - Web Search - BL Direct

4. Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. … -

all 3 versions »

AF Reis, OM Hauache, G Velho - Diabetes and Metabolism, 2005 - Elsevier

S UMMARY The Vitamin D endocrine system regulates multiple aspects of cal- cium

metabolism and cellular differentiation and replication in the immune system,

endocrine pancreas, liver, skeletal muscles and adi- pocytes. It plays an ...

Cited by 7 - Related Articles - Web Search

5. Type 1 diabetes in Japan - all 3 versions »

E Kawasaki, N Matsuura, K Eguchi - Diabetologia, 2006 - Springer

Abstract Type 1 diabetes is a multifactorial disease which results from a

T-cell-mediated autoimmune destruction of the pancreatic beta cells in

genetically predisposed individuals. The risk for individuals of developing ...

Cited by 7 - Related Articles - Web Search

6. Vitamin D receptor polymorphisms and diseases - all 3 versions »

JM Valdivielso, E Fernandez - Clinica Chimica Acta, 2006 - Elsevier

43

The vitamin D endocrine system is central to the control of bone and calcium

homeostasis. Thus, alterations in the vitamin D pathway lead to disturbances in

mineral metabolism. Furthermore, a role for vitamin D has been suggested in ...

Cited by 6 - Related Articles - Web Search

7. Vitamin D Receptor Polymorphisms are Associated with Graves‘ Disease in German and Polish But not

… - all 4 versions »

E Ramos-Lopez, A Kurylowicz, T Bednarczuk, J … - THYROID, 2005 - liebertonline.com

THYROID Volume 15, Number 10, 2005 © Mary Ann Liebert, Inc. ... Elizabeth

Ramos-Lopez, 1 Alina Kurylowicz, 2 Tomasz Bednarczuk, 2 Jane Paunkovic, 3 ...

Christian Seidl, 4 and Klaus Badenhoop 1 ... Diverse genes are candidates ...

Cited by 3 - Related Articles - Web Search

8. Protection From Type 1 Diabetes by Vitamin D Receptor Haplotypes - all 4 versions »

E RAMOS-LOPEZ, T JANSEN, V IVASKEVICIUS, H KAHLES, … - Annals of the New York

Academy of Sciences, 2006 - NYAS

Given the controversial association between polymorphisms within the VDR gene

and type 1 diabetes, we extended our previous report 9 of the polymorphisms Apa

I (rs7975232), Taq I (rs731236), Bsm I (rs1544410), and Fok I (rs10735810) ...

Cited by 2 - Related Articles - Web Search - BL Direct

9. Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic

… - all 10 versions »

SW Guo, VL Magnuson, JJ Schiller, X Wang, Y Wu, S … - American Journal of Epidemiology, 2006 -

Oxford Univ Press

Several polymorphisms in the vitamin D receptor (VDR) gene have been reported to

be associated with the risk of developing type 1 diabetes, yet published

findings have been conflicting. In this study, the authors attempted to ...

Cited by 2 - Related Articles - Web Search - BL Direct

10. Vitamin D and autoimmunity: new aetiological and therapeutic considerations - all 5 versions »

Y Arnson, H Amital, Y Shoenfeld - British Medical Journal, 2007 - ard.bmj.com

ABSTRACT Vitamin D is frequently prescribed by rheumatologists to prevent and

treat osteoporosis. Several observations have shown that vitamin D inhibits

proinflammatory processes by suppressing the enhanced activity of immune ...

Cited by 1 - Related Articles - Web Search - BL Direct

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Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Newport MJ, Clayton DG, Todd JA. (2004) Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet 13:1633-1639.

… high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms

between … - all 5 versions »

S Nejentsev, L Godfrey, H Snook, H Rance, S … - Human Molecular Genetics, 2004 - Oxford Univ Press

... Comparative high-resolution analysis of linkage disequilibrium and tag single

nucleotide polymorphisms between populations in the vitamin D receptor gene. ...

Cited by 53 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. Genome-wide association studies: theoretical and practical concerns - all 8 versions »

S Lin, A Chakravarti, DJ Cutler - Nature Genetics, 2004 - nature.com

Risch and Merikangas argued that in an idealized future, disease-association

studies could be carried out with substantial power by typing roughly 1 million

functional single-nucleotide polymorphisms (SNPs; or perfect proxies) in ...

Cited by 276 - Related Articles - Web Search

2. Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Risk of Advanced Prostate Cancer - all 5

versions »

EM John, GG Schwartz, J Koo, D Van Den Berg, SA … - Cancer Research, 2005 - AACR

Substantial experimental evidence indicates that the hormonal form of vitamin D

promotes the differentiation and inhibits the proliferation, invasiveness, and

metastasis of human prostatic cancer cells. Results from epidemiologic ...

Cited by 45 - Related Articles - Web Search

3. Promoter and 3′-Untranslated-Region Haplotypes in the Vitamin D Receptor Gene Predispose to … - all

8 versions »

AJH Genet - Am. J. Hum. Genet, 2005 - UChicago Press

The vitamin D receptor (VDR [MIM 601769]) (12q13) is a steroid receptor acting

as a transcription factor responding to the biologically active form of the

secosteroid vitamin D hormone. The vitamin D endocrine system is ...

Cited by 26 - Related Articles - Web Search

4. Vitamin D and type 1 diabetes mellitus: state of the art - all 5 versions »

C Mathieu, K Badenhoop - Trends in Endocrinology & Metabolism, 2005 - Elsevier

Recent evidence suggests a role for vitamin D in pathogenesis and prevention of

diabetes mellitus. Active vitamin D, 1α,25(OH) 2 D 3 , prevents type 1 diabetes

in animal models, modifies T-cell differentiation, modulates dendritic cell ...

Cited by 18 - Related Articles - Web Search

5. Molecular genetic studies of gene identification for osteoporosis: a 2004 update - all 3 versions »

YJ Liu, H Shen, P Xiao, DH Xiong, LH Li, RR Recker … - J Bone Miner Res, 2006 -

pubmedcentral.nih.gov

This review summarizes comprehensively the most important and representative

molecular genetics studies of gene identification for osteoporosis published up

to the end of December 2004. It is intended to constitute a sequential ...

Cited by 14 - Related Articles - Web Search - BL Direct

45

6. Vitamin D receptor gene polymorphisms are linked to and associated with adult height - all 6 versions »

DH Xiong, FH Xu, PY Liu, H Shen, JR Long, L Elze, … - British Medical Journal, 2005 - jmg.bmj.com

Methods: We examined the relationship between VDR and adult height in 1873 white

subjects from 406 nuclear families. Four SNPs, namely –4817A/G at intron 1,

FokI C/T at exon 2 start codon, BsmI A/G at intron 8, and TaqI T/C at exon ...

Cited by 14 - Related Articles - Web Search

7. Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. … -

all 3 versions »

AF Reis, OM Hauache, G Velho - Diabetes and Metabolism, 2005 - Elsevier

S UMMARY The Vitamin D endocrine system regulates multiple aspects of cal- cium

metabolism and cellular differentiation and replication in the immune system,

endocrine pancreas, liver, skeletal muscles and adi- pocytes. It plays an ...

Cited by 8 - Related Articles - Web Search

8. Association between a Protein Polymorphism in the Start Codon of the Vitamin D Receptor Gene and …

- all 5 versions »

MJ Taverna, JL Selam, G Slama - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine

Soc

Context: The vitamin D (VD) receptor (VDR) is extensively expressed in retina.

The plasma concentration of 1,25-dihydroxyvitamin D3 has been inversely

correlated with the severity of diabetic retinopathy (DR), which raises the ...

Cited by 8 - Related Articles - Web Search

9. Vitamin D receptor polymorphisms and diseases - all 3 versions »

JM Valdivielso, E Fernandez - Clinica Chimica Acta, 2006 - Elsevier

The vitamin D endocrine system is central to the control of bone and calcium

homeostasis. Thus, alterations in the vitamin D pathway lead to disturbances in

mineral metabolism. Furthermore, a role for vitamin D has been suggested in ...

Cited by 8 - Related Articles - Web Search

10. Fok I Polymorphism, Vitamin D Receptor, and Interleukin-1 Receptor Haplotypes Are Associated with

… - all 4 versions »

T Zemunik, V Skrabic, V Boraska, D Diklic, IM … - Journal of Molecular Diagnostics, 2005 - ASIP

Vitamin D and interleukin (IL)-1 have been suggested to function in the

pathogenesis of type 1 diabetes mellitus (T1DM). Therefore, we examined the

influence of gene polymorphisms in vitamin D receptor (VDR) and ...

Cited by 6 - Related Articles - Web Search

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Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tirgoviste C, Savage DA, Dunger DB, Widmer B, Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC, Gough SC, Todd JA. (2004) Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53:3020-3023.

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with

type … - all 2 versions »

D Smyth, JD Cooper, JE Collins, JM Heward, JA … - Diabetes, 2004 - ncbi.nlm.nih.gov

Click here to read Replication of an association between the lymphoid ... Smyth D, Cooper

JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S ...

Cited by 144 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the

… - all 13 versions »

LA Criswell, KA Pfeiffer, RF Lum, B Gonzales, J … - Am J Hum Genet, 2005 - UChicago Press

Autoimmune diseases share a number of characteristics that suggest common

etiologic pathways or mechanisms, including reactivity to self-antigens by the

humoral and/or cellular immune system, as well as genetic associations with ...

Cited by 100 - Related Articles - Web Search

2. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant - all 5 versions »

T Vang, M Congia, MD Macis, L Musumeci, V Orru, P … - Nat Genet, 2005 - nature.com

nature.com homepage Full text access provided to Googlebot Access by Web Services. ...

Cited by 63 - Related Articles - Web Search

3. Protein tyrosine phosphatases and the immune response.

T Mustelin, T Vang, N Bottini - Nat Rev Immunol, 2005 - ncbi.nlm.nih.gov

Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism

for numerous important aspects of eukaryotic physiology and is catalysed by

kinases and phosphatases. Together, cells of the immune system express at ...

Cited by 54 - Related Articles - Web Search

4. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide … - all

5 versions »

A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - Am J Hum Genet, 2005 - UChicago Press

Despite hundreds of association studies, few have been consistently replicated

(Dahlman et al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller

et al. 2003). In type 1 diabetes (T1D [MIM 222100]), only four loci have ...

Cited by 53 - Related Articles - Web Search

5. Genetic epidemiology of diabetes - all 3 versions »

MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig

Conventional genetic analysis focuses on the genes that account for specific

phenotypes, while traditional epidemiology is more concerned with the

environmental causes and risk factors related to traits. Genetic ...

Cited by 51 - Related Articles - Web Search

6. PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis - all 13

versions »

47

VE Carlton, X Hu, AP Chokkalingam, SJ Schrodi, R … - Am J Hum Genet, 2005 - UChicago Press

Am. J. Hum. Genet., 77:567-581, 2005 0002-9297/2005/7704-0006$15.00 © 2005 by

The American Society of Human Genetics. All rights reserved. ... Received May

26, 2005; accepted for publication July 19, 2005; electronically published ...

Cited by 47 - Related Articles - Web Search

7. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the … -

all 5 versions »

DJ Smyth, JD Cooper, R Bailey, S Field, O Burren, … - Nature genetics, 2006 - nature.com

1 Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation

Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC

Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

Cited by 45 - Related Articles - Web Search - BL Direct

8. [PDF] Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex

Families - all 4 versions »

P Concannon, HA Erlich, C Julier, G Morahan, J … - DIABETES, 2005 - joslinresearch.org

Page 1. Original Article Type 1 Diabetes Evidence for Susceptibility Loci from Four

Genome-Wide Linkage Scans in 1,435 Multiplex Families Patrick Concannon, 1 Henry

A. Erlich, 2 Cecile Julier, 3 Grant Morahan, 4 Jørn Nerup, 5 ...

Cited by 45 - Related Articles - View as HTML - Web Search

9. Association analysis of the 1858C> T polymorphism in the PTPN22 gene in juvenile idiopathic … - all 2

versions »

MK Viken, SS Amundsen, TK Kvien, KM Boberg, IM … - Genes and Immunity, 2005 - nature.com

A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene,

encoding a tyrosine phosphatase, has been reported to be associated with type I

diabetes and some other autoimmune diseases. To further investigate whether ...

Cited by 43 - Related Articles - Web Search

10. Paths to understanding the genetic basis of autoimmune disease - all 6 versions »

JD Rioux, AK Abbas - Nature, 2005 - nature.com

Autoimmune diseases are major causes of morbidity and mortality throughout the

world. Many of these diseases tend to be difficult or impossible to cure, for

the obvious reason that the focus of the immune response — self antigens ...

Cited by 44 - Related Articles - Web Search

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48

Vella A, Howson JMM, Barratt B, Twells RCJ, Rance H, Nutland S, Tuomilehto-Wolf E,

Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage D,

Todd JA. (2004) Lack of association of the Ala45

Thr polymorphism and other common

variants of the NeuroD gene with type 1 diabetes. Diabetes 53:1158-1161

This article has been cited by other articles:

J. S. Szeszko, J. M.M. Howson, J. D. Cooper, N. M. Walker, R. C.J. Twells,

H. E. Stevens, S. L. Nutland, and J. A. Todd

Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1

Diabetes and Hardy-Weinberg Equilibrium Testing

Diabetes, February 1, 2006; 55(2): 559 - 562.

[Abstract] [Full Text] [PDF]

D. Smyth, J. D. Cooper, J. E. Collins, J. M. Heward, J. A. Franklyn, J. M.M.

Howson, A. Vella, S. Nutland, H. E. Rance, L. Maier, et al.

Replication of an Association Between the Lymphoid Tyrosine

Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and

Evidence for Its Role as a General Autoimmunity Locus

Diabetes, November 1, 2004; 53(11): 3020 - 3023.

[Abstract] [Full Text] [PDF]

TOTAL CITĂRI - 2

49

Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink LJ, Fraser H, Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Strachan DP, Peterson LB, Todd JA, Wicker LS, Twells RC. (2005) Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes. BMC Genet 6:9

Construction and analysis of tag single nucleotide polymorphism maps for six human-

mouse orthologous … - all 8 versions »

… , S Nutland, DE Undlien, KS Rønningen, C Guja, C … - feedback, 2005 - biomedcentral.com

One strategy to help identify susceptibility genes for complex, multifactorial

diseases is to map disease loci in a representative animal model of the

disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 ...

Cited by 4 - Related Articles - Cached - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Genetic susceptibility to type 1 diabetes - all 3 versions »

LM Maier, LS Wicker - Current Opinion in Immunology, 2005 - Elsevier

Type 1 diabetes (T1D) is a complex trait with both genetic and environmental

influences. T1D results from immune-mediated destruction of the

insulin-producing β cells of the pancreas. Autoimmune diabetes in the ...

Cited by 24 - Related Articles - Web Search

2. The autoimmune contrivance: Genetics in the mouse model - all 3 versions »

E Melanitou - Clinical Immunology, 2005 - Elsevier

Autoimmunity and inheritance of complex characters behold an explosive interest

in biology over the last 15 years. Research in the genetics of autoimmunity has

been impelled by the isolation of genetic markers allowing tracing of ...

Cited by 3 - Related Articles - Web Search

TOTAL CITĂRI - 2

50

Payne F, Smyth DJ, Pask R, Cooper JD, Masters J, Wang WY, Godfrey LM, Bowden G, Szeszko J, Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Todd JA, Twells RC. (2005) No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. Biochem Biophys Res Commun. 331:435-41.

No evidence for association of the TATA-box binding protein glutamine repeat sequence

or the … - all 4 versions »

… , H Rance, DE Undlien, KS Rønningen, C Guja, C … - Biochemical and Biophysical Research

Communications, 2005 - Elsevier

Susceptibility to the autoimmune disease type 1 diabetes has been linked to

human chromosome 6q27 and, moreover, recently associated with one of the genes

in the region, TATA box-binding protein (TBP). Using a much larger sample ...

Cited by 1 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. Fine mapping of genes within the IDDM8 region in rheumatoid arthritis - all 5 versions »

A Hinks, A Barton, S John, N Shephard, J … - Arthritis Research & Therapy 2006 - arthritis-

research.com

The IDDM8 region on chromosome 6q27, first identified as a susceptibility locus

for type 1 diabetes, has previously been linked and associated with rheumatoid

arthritis (RA). The region contains a number of potential candidate genes, ...

Related Articles - Cached - Web Search - BL Direct

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51

Pozzilli P, Manfrini S, Buzzetti R, Lampeter E, Leeuw ID, Iafusco D, Prisco M, Ionescu-

Tirgoviste C, Kolouskova S, Linn T, Ludvigsson J, Madacsy L, Mrozikiewicz AS,

Mrozikiewicz PM, Podar T, Vavrinec J, Vialettes B, Visalli N, Yilmaz T, Browne PD;

IMDIAB group. (2005) Glucose evaluation trial for remission (GETREM) in type 1

diabetes: a European multicentre study. Diabetes Res Clin Pract 68:258-264

Glucose evaluation trial for remission (GETREM) in type 1 diabetes: a European multicentre study -

all 3 versions »

P Pozzilli, S Manfrini, R Buzzetti, E Lampeter, ID … - Diabetes Research and Clinical Practice, 2005 -

Elsevier

... rights reserved. Glucose evaluation trial for remission (GETREM) in type

1 diabetes: a European multicentre study. P. Pozzilli a ...

Cited by 3 - Related Articles - Web Search

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REVISTE INDEXATE ISI:

1. Shorter Remission Period in Young Versus Older Children with Diabetes Mellitus Type - all 4 versions »

A Dost, A Herbst, K Kintzel, H Haberland, CL Roth, … - Exp Clin Endocrinol Diabetes, 2007 - thieme-

connect.com

Results: Partial remission (insulin <0.5 U/kg/d and HbA1c ≤7.0%) was present

in 1992 children (32.5%) within the first 3 months after diagnosis. Remission

phase lasted in average for 0.74±0.77 years and was significantly shorter ...

Cited by 1 - Related Articles - Web Search

2. Immune intervention at diagnosis–should we treat children to preserve beta-cell function? - all 3 versions

»

J Ludvigsson - Pediatric Diabetes, 2007 - Blackwell Synergy

Abstract: Type 1 diabetes (T1D) is characterized by loss of beta-cell function.

If beta-cell function can be preserved, it will lead to improved metabolic

balance with improved quality of life and fewer acute and late ...

Related Articles - Web Search

3. Dynamic changes in CD4+ CD25 high T cell apoptosis after the diagnosis of type 1 diabetes - all 2

versions »

S Glisic-Milosavljevic, T Wang, M Koppen, J Kramer … - Clinical & Experimental Immunology, 2007 -

ingentaconnect.com

S. Glisic-Milosavljevic,* T. Wang, † M. Koppen,* J. Kramer,* S. Ehlenbach,* J.

Waukau,* P. Jailwala,* S. Jana,* R. Alemzadeh ‡ and S. Ghosh* *The Max McGee

National Center for Juvenile Diabetes and Human Molecular Genetics Center, ...

Related Articles - Web Search - BL Direct

TOTAL CITĂRI - 3

52

Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA. (2005) Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet 37:110-111

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

- all 4 versions »

DJ Smyth, JMM Howson, CE Lowe, NM Walker, AC Lam, … - Nature Genetics, 2005 - nature.com

... this Correspondence. Assessing the validity of the association between the

SUMO4 M55V variant and risk of type 1 diabetes. Deborah J ...

Cited by 32 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. [CITATION] Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-

nucleotide … - all 4 versions »

A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - Am J Hum Genet, 2005 - UChicago Press

Despite hundreds of association studies, few have been consistently replicated

(Dahlman et al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller

et al. 2003). In type 1 diabetes (T1D [MIM 222100]), only four loci have ...

Cited by 54 - Related Articles - Web Search

2. Genetic susceptibility to type 1 diabetes - all 3 versions »

LM Maier, LS Wicker - Current Opinion in Immunology, 2005 - Elsevier

Type 1 diabetes (T1D) is a complex trait with both genetic and environmental

influences. T1D results from immune-mediated destruction of the

insulin-producing β cells of the pancreas. Autoimmune diabetes in the ...

Cited by 26 - Related Articles - Web Search

3. Contribution of Single Nucleotide Polymorphisms within FCRL3 and MAP3K7IP2 to the Pathogenesis

of … - all 4 versions »

MJ Simmonds, JM Heward, J Carr-Smith, H Foxall, JA … - Journal of Clinical Endocrinology &

Metabolism, 2006 - Endocrine Soc

Context: Recently six DNA variants, two of which (M55V and 001Msp) are present

in nuclear factor- B inhibitors SUMO-4 and MAP3K7IP2 and four of which (fcrl3_3,

fcrl3_4, fcrl3_5, and fcrl3_6) modulate nuclear factor- B binding and ...

Cited by 25 - Related Articles - Web Search

4. Genetic progress towards the molecular basis of autoimmunity - all 3 versions »

SHS Pearce, TR Merriman - Trends in Molecular Medicine, 2006 - Elsevier

The past few years have seen the identification of PTPN22 and the confirmation

of CTLA-4 as common autoimmune disease genes. Together with MHC and INS, these

developments have increased the collection of confirmed susceptibility loci ...

Cited by 17 - Related Articles - Web Search

5. A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation - all 3 versions »

D Owerbach, EM McKay, ETH Yeh, KH Gabbay, KM … - Biochemical and Biophysical Research

Communications, 2005 - Elsevier

Four small ubiquitin-related modifier (SUMO) genes have been identified in

humans. However, little is known about the basic biology of SUMO-4. Here, we

report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation ...

Cited by 14 - Related Articles - Web Search

6. The genetics of type 1 diabetes: Lessons learned and future challenges - all 3 versions »

53

S Onengut-Gumuscu, P Concannon - Journal of Autoimmunity, 2005 - Elsevier

Most investigators who study the genetics of T1D would generally agree that

there are at least four chromosomal regions for which there is compelling

evidence of a contribution to T1D risk, the HLA region on chromosome 6p21 ...

Cited by 5 - Related Articles - Web Search

7. Evidence for the Role of Small Ubiquitin-Like Modifier 4 as a General Autoimmunity Locus in the … -

all 4 versions »

M Tsurumaru, E Kawasaki, H Ida, K Migita, A … - Journal of Clinical Endocrinology & Metabolism,

2006 - Endocrine Soc

Context: Recently, an association of a single nucleotide polymorphism, 163A>G

encoding M55V, in the gene SUMO4, which has been shown to be a negative feedback

regulator for nuclear factor B, has been reported in type 1 diabetes.

Cited by 7 - Related Articles - Web Search - BL Direct

8. Genetics of Type 1 Diabetes: Similarities and Differences between Asian and Caucasian Populations - all

4 versions »

H IKEGAMI, T FUJISAWA, Y KAWABATA, S NOSO, T … - Annals of the New York Academy of

Sciences, 2006 - NYAS

Type 1 diabetes mellitus is caused by a complex interaction of genetic and

environmental factors. Genetic factor consists of multiple susceptibility genes

with a major locus encoded by HLA region on chromosome 6p21. 4–6 Class II ...

Cited by 5 - Related Articles - Web Search - BL Direct

9. The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to … - all

4 versions »

LJ Gibbons, W Thomson, E Zeggini, J Worthington, A … - Rheumatology, 2005 - Br Soc Rheumatology

Objectives. Linkage and association of rheumatoid arthritis (RA) and rheumatoid

factor (RF)-negative juvenile idiopathic arthritis (JIA) has previously been

demonstrated to the type 1 diabetes (T1D) locus, IDDM5, on chromosome 6q25. ...

Cited by 3 - Related Articles - Web Search

10. Genetic and Functional Evidence Supporting SUMO4 as a Type 1 Diabetes Susceptibility Gene - all 4

versions »

CYI WANG, R PODOLSKY, JINX SHE - Annals of the New York Academy of Sciences, 2006 - NYAS

Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by

specific destruction of the insulin-secreting beta cells of the pancreatic

islets. 1–3 It is believed that susceptibility to T1DM is determined by ...

Cited by 5 - Related Articles - Web Search - BL Direct

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54

Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, Witte DR,

Fuller JH; EURODIAB Prospective Complications Study Group. (2005) Vascular risk

factors and diabetic neuropathy. N Engl J Med 2005 352:341-350

[CITATION] Vascular Risk Factors and Diabetic Neuropathy - all 7 versions »

S Tesfaye, N Chaturvedi, SEM Eaton, JD Ward, C … - New England Journal of Medicine, 2005

Original Article from The New England Journal of Medicine -- Vascular Risk Factors

and Diabetic Neuropathy. ... Vascular Risk Factors and Diabetic Neuropathy. ...

Cited by 88 - Related Articles - Web Search

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. The 30-Year Natural History of Type 1 Diabetes Complications - all 7 versions »

G Pambianco, T Costacou, D Ellis, DJ Becker, R … - Diabetes, 2006 - Am Diabetes Assoc

Declining incidences in Europe of overt nephropathy, proliferative retinopathy,

and mortality in type 1 diabetes have recently been reported. However,

comparable data for the US and trend data for neuropathy and macrovascular ...

Cited by 13 - Related Articles - Web Search

2. The changing epidemiology of diabetic microangiopathy in type 1 diabetes - all 3 versions »

P Rossing - Diabetologia, 2005 - Springer

Abstract Diabetic microvascular complications in the kidney and the eye are a

major burden for diabetic patients due to increased morbidity and mortality.

Furthermore, diabetic nephropathy is the leading cause of end-stage re- nal ...

Cited by 12 - Related Articles - Web Search

3. Additional causes for distal sensory polyneuropathy in diabetic patients - all 5 versions »

KC Gorson, AH Ropper - British Medical Journal, 2006 - jnnp.bmj.com

Results: Fifty five patients (53%) had potential additional causes for DSP.

These included: neurotoxic medications (seven), alcohol abuse (six), and B12

deficiency and renal disease (four each). The most common laboratory ...

Cited by 17 - Related Articles - Web Search

4. Effectiveness of frequency-modulated electromagnetic neural stimulation in the treatment of painful … -

all 4 versions »

E Bosi, M Conti, C Vermigli, G Cazzetta, E Peretti … - Diabetologia, 2005 - Springer

Abstract Aims/hypothesis: The largely unsatisfactory results reported for the

pharmacological treatment of dia- betic neuropathy has spurred the search for

alternative therapies. The aim of this study was to evaluate the efficacy ...

Cited by 12 - Related Articles - Web Search

5. Impact of Overweight on Chronic Microvascular Complications in Type 1 Diabetic Patients - all 6

versions »

CEM De Block, IH De Leeuw, LF Van Gaal - Diabetes Care, 2005 - 0-intl-

care.diabetesjournals.org.pugwash.lib.warwick.ac.uk

RESEARCH DESIGN AND METHODS—A total of 592 type 1 diabetic patients without

nephropathy were studied (M/F: 324/268; age: 41 ± 12 years; duration: 19 ± 11

years; HbA 1c [A1C]: 7.9 ± 1.1%). Patients were subdivided according to ...

Cited by 8 - Related Articles - Web Search

6. Early detection of diabetic peripheral neuropathy with corneal confocal microscopy - all 3 versions »

P Hossain, A Sachdev, RA Malik - The Lancet, 2005 - Elsevier

One could argue that corneal innervation has little clinical relevance to the

development of somatic neuropathy in diabetic patients. However, in animal

55

studies, corneal sensation is impaired within 3 months in both diabetic 14 ...

Cited by 9 - Related Articles - Web Search

7. Diabetic neuropathy - all 6 versions »

V Bansal, J Kalita, UK Misra - British Medical Journal, 2006 - pmj.bmj.com

Diabetic neuropathy (DN) refers to symptoms and signs of neuropathy in a patient

with diabetes in whom other causes of neuropathy have been excluded. Distal

symmetrical neuropathy is the commonest accounting for 75% DN. Asymmetrical ...

Cited by 8 - Related Articles - Web Search

8. Diabetic neuropathy is associated with activation of the TNF-alpha system in subjects with type 1 … - all

3 versions »

JM Gonzalez-Clemente, D Mauricio, C Richart, M … - Clin. Endo, 2005 - Blackwell Synergy

Results Thirty-six subjects had DN and 84 did not. Subjects with DN received

higher insulin doses (57·6 ± 16·7 vs. 49·2 ± 15·0 IU/day; P = 0·008) and

had higher WHR (0·85 ± 0·07 vs. 0·81 ± 0·10; P = 0·007) and HbA1c ...

Cited by 6 - Related Articles - Web Search

9. Small fibre neuropathies - all 4 versions »

G Lauria - Curr Opin Neurol, 2005 - co-neurology.com

Recent findings: New causes of small fibre neuropathy have been recognized and

advances in neurophysiologic and neuropathologic techniques for investigating

small fibres have been made, increasing the interest in this field. In ...

Cited by 7 - Related Articles - Web Search

10. Idiopathic neuropathy, prediabetes and the metabolic syndrome - all 2 versions »

A Gordon Smith, J Robinson Singleton - Journal of the Neurological Sciences, 2006 - Elsevier

Peripheral neuropathy is a common problem encountered by neurologists and

primary care physicians. While there are many causes for peripheral neuropathy,

none can be identified in a large percentage of patients (―idiopathic ...

Cited by 2 - Related Articles - Web Search

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Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, Guja C, Ionescu-Tirgoviste C, Widmer B, Dunger DB, Savage DA, Walker NM, Clayton DG, Todd JA. (2006) A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 38:617-619.

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes

locus in the … - all 5 versions »

… Burren, LJ Smink, C Guja, C Ionescu-Tirgoviste, B … - Nature genetics, 2006 - nature.com

1 Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation

Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC

Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

Cited by 45 - Related Articles - Web Search - BL Direct

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn …

- all 5 versions »

J Hampe, A Franke, P Rosenstiel, A Till, M Teuber, … - Nature Genetics, 2006 - nature.com

nature.com homepage Full text access provided to Googlebot Access by Web Services. ...

Cited by 66 - Related Articles - Web Search - BL Direct

2. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a … -

all 2 versions »

A Elbaz, LM Nelson, H Payami, JPA Ioannidis, BK … - Lancet Neurology, 2006 - Elsevier

Investigators from three Michael J Fox Foundation for Parkinson's

Research-funded genetics consortia—comprising 14 teams—contributed DNA

samples from 5526 patients with Parkinson's disease and 6682 controls, ...

Cited by 14 - Related Articles - Web Search

3. Genomic DNA pooling for whole-genome association scans in complex disease: empirical

demonstration … - all 4 versions »

S Steer, V Abkevich, A Gutin, HJ Cordell, KL … - Genes and Immunity, 2007 - nature.com

A pragmatic approach that balances the benefit of a whole-genome association

(WGA) experiment against the cost of individual genotyping is to use pooled

genomic DNA samples. We aimed to determine the feasibility of this approach ...

Cited by 11 - Related Articles - Web Search - BL Direct

4. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis - all 3 versions

»

F Lundmark, K Duvefelt, E Iacobaeus, I Kockum, E … - Nat Genet, 2007 - nature.com

Multiple sclerosis is a chronic, often disabling, disease of the central nervous

system affecting more than 1 in 1,000 people in most western countries. The

inflammatory lesions typical of multiple sclerosis show autoimmune features ...

Cited by 11 - Related Articles - Web Search - BL Direct

5. Genetic Mapping at 3-Kilobase Resolution Reveals Inositol 1, 4, 5-Triphosphate Receptor 3 as a Risk …

- all 3 versions »

SNP Typing - Am. J. Hum. Genet, 2006 - UChicago Press

Type 1 diabetes (T1D [MIM 222100]) is the most common chronic disease in

children and affects 1% of the population in high-incidence countries, such as

those of Scandinavia. The incidence of T1D is increasing worldwide by ...

Cited by 5 - Related Articles - Web Search - BL Direct

6. Analysis of protein sequence and interaction data for candidate disease gene prediction - all 5 versions »

RA George, JY Liu, LL Feng, RJ Bryson-Richardson, … - Nucleic Acids Research, 2006 - Oxford Univ

57

Press

Linkage analysis is a successful procedure to associate diseases with specific

genomic regions. These regions are often large, containing hundreds of genes,

which make experimental methods employed to identify the disease gene ...

Cited by 5 - Related Articles - Web Search - BL Direct

7. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene - all 4 versions »

H Hakonarson, SF Grant, JP Bradfield, L Marchand, … - Nature, 2007 - nature.com

Type 1 diabetes (T1D) in children results from autoimmune destruction of

pancreatic beta cells, leading to insufficient production of insulin 1 . A

number of genetic determinants of T1D have already been established through ...

Cited by 4 - Related Articles - Web Search - BL Direct

8. Genomic Polymorphism at the Interferon-Induced Helicase (IFIH1) Locus Contributes to Graves'

Disease … - all 3 versions »

A Sutherland, J Davies, CJ Owen, S Vaikkakara, C … - Journal of Clinical Endocrinology &

Metabolism, 2007 - Endocrine Soc

Context: A recent large-scale analysis of nonsynonymous coding polymorphisms

showed strong evidence that an alanine to threonine amino acid change at codon

946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was ...

Cited by 2 - Related Articles - Web Search - BL Direct

9. Family Based Studies and Genetic Epidemiology: Theory and Practice - all 2 versions »

JH Barrett, NA Sheehan, A Cox, J Worthington, C … - Hum Hered, 2007 - content.karger.com

Family studies have long played a central role in ge- netic epidemiology. Many

genes with a strong influence ondisease risk havebeen identified through linkage

stud- ies. However the familial linkage approach has had a lim- ited ...

Cited by 2 - Related Articles - Web Search - BL Direct

10. Recognition of viruses by innate immunity

O Takeuchi, S Akira - Immunological Reviews, 2007 - ingentaconnect.com

Summary: The innate immune system plays critical roles in recognizing viral

infections and evoking initial anti-viral responses. Nucleotides from RNA

viruses are recognized by retinoic acid-inducible gene I (RIG-I)-like ...

Cited by 1 - Related Articles - Web Search

TOTAL CITĂRI - 10

58

Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JHM, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AAC, Ovington NR, Allen J, Adlem E, Leung H-T, Wallace C, Howson JMM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SCL, Dunger DB, the Wellcome Trust Case Control Consortium, Wicker LS & Clayton DG. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39:857 – 864 [PDF] Robust associations of four new chromosome regions from genome-wide analyses of type 1

diabetes - all 2 versions »

JA Todd, NM Walker, JD Cooper, DJ Smyth, K Downes, … - Nat Genet, 2007 - nature.com

Page 1. Robust associations of four new chromosome regions from genome-wide

analyses of type 1 diabetes John A Todd 1 , Neil M Walker ...

Cited by 42 - Related Articles - View as HTML - Web Search - BL Direct

DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN

REVISTE INDEXATE ISI:

1. Guilt beyond a reasonable doubt - all 2 versions »

D Altshuler, M Daly - Nature Genetics, 2007 - nature.com

The Wellcome Trust Case Control Consortium (WTCCC) now reports in Nature the

largest GWAS thus far 1 , scanning 17,000 individuals for seven diseases, with

two follow-up studies reported in this issue, Todd et al. on type 1 ...

Cited by 8 - Related Articles - Web Search - BL Direct

2. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene - all 4 versions »

H Hakonarson, SF Grant, JP Bradfield, L Marchand, … - Nature, 2007 - nature.com

Type 1 diabetes (T1D) in children results from autoimmune destruction of

pancreatic beta cells, leading to insufficient production of insulin 1 . A

number of genetic determinants of T1D have already been established through ...

Cited by 4 - Related Articles - Web Search - BL Direct

3. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the

… - all 3 versions »

CE Lowe, JD Cooper, T Brusko, NM Walker, DJ Smyth, … - Nature Genetics, 2007 - nature.com

Genome-wide association studies are now identifying disease-associated

chromosome regions. However, even after convincing replication, the localization

of the causal variant(s) requires comprehensive resequencing, extensive ...

Cited by 3 - Related Articles - Web Search - BL Direct

4. Turning the Pump Handle: Evolving Methods for Integrating the Evidence on Gene-Disease Association

- all 7 versions »

JPT Higgins, J Little, JPA Ioannidis, MS Bray, TA … - American Journal of Epidemiology, 2007 -

Oxford Univ Press

Recent findings from genome-wide association studies have demonstrated their

considerable potential for identifying genetic determinants of common diseases

of public health significance such as cancer, heart disease, and diabetes ...

Related Articles - Web Search

5. Genomics of Common Diseases

59

P Revill - Drug News Perspect, 2007 - journals.prous.com

There has been a recent spate of genome-wide association studies reporting new

associations between sequence variations on the human genome and common diseases

such as diabetes. These associations can lead to a better understanding of ...

Web Search

6. Commentary: Genetic association studies see light at the end of the tunnel - all 4 versions »

TM Frayling - International Journal of Epidemiology, 2007 - IEA

The authors‘ efforts are important for two main reasons. First, genetic

associations have been fraught with difficulty over the past 10 years in their

attempts to uncover DNA polymorphisms that alter disease risk. The vast ...

Related Articles - Web Search

7. Allelic variant in CTLA4 alters T cell phosphorylation patterns

LM Maier, DE Anderson, PL De Jager, LS Wicker, DA … - Proceedings of the National Academy of

Sciences, 2007 - National Acad Sciences

Little is known regarding the functional effects of common autoimmune

susceptibility variants on human immune cells. The SNP CT60 (rs3087243; A/G)

located in the 3' UTR of the CTLA4 gene has been associated with autoimmune ...

Web Search

8. Genetic studies of diabetes following the advent of the genome-wide association study: where do we … -

all 3 versions »

TM Frayling, MI McCarthy - Diabetologia, 2007 - Springer

Page 1. COMMENTARY Genetic studies of diabetes following the advent of the

genome-wide association study: where do we go from here? TM Frayling & MI McCarthy

Published online: 25 September 2007 # Springer-Verlag 2007 ...

Related Articles - Web Search

9. Genetic polymorphisms in susceptibility to Type 1 Diabetes - all 2 versions »

BZ Alizadeh, BPC Koeleman - Clinica Chimica Acta, 2007 - Elsevier

Type 1 Diabetes is a serious complex disease caused by several environmental and

genetic factors. It is one of most common childhood diseases, requires life-long

treatment, and is associated with increased mortality, mainly due to ...

Related Articles - Web Search

10. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

S Nejentsev, JMM Howson, NM Walker, J Szeszko, SF … - Nature, 2007 - nature.com

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation

Laboratory, Department of Medical Genetics, Cambridge Institute for Medical

Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge ...

Web Search

TOTAL CITĂRI - 10

60

ANEXA 5.1

LISTA LUCRĂRILOR ÎN REVISTE

FĂRĂ COTAŢIE ISI

61

Anexa 5.1

ARTICOLE FULL TEXT ÎN REVISTE NEINDEXATE INTERNAŢIONAL

2003

1. Dobrin A, Bălan S, Nestorov M, Guja C, Burtea M, Ionescu-Tîrgovişte C, Heltianu C,

Simionescu M. (2003) Insertion/Deletion polymorphism of the angiotensin-

converting enzyme gene in Romanian diabetic patients. Proc Rom Acad Series B

5(3):115-119, ISSN 1454-8267, Cod CNCSIS - 789

2. Mogos T, Bratu D, Panus C, Tanase I, Cheta D. (2003) Evaluation of the metabolic

balance in type 2 diabetes by assay of the hair glucose. Rom J Intern Med 41:61-65,

ISSN 1582-3296, NLM ID: 9304507

2004

3. Guja C, Guja L, Nutland S, Rance H, Todd JA, Ionescu-Tîrgovişte C. Strong

association of insulin gene INS -VNTR polymorphisms with type 1 diabetes in the Romanian population. (2004) Rom J Intern Med 42:313-323, ISSN 1582-3296, NLM ID: 9304507

4. Ionescu-Tîrgoviste C, Guja C, Ioacără S, Dumitrescu D, Tomescu I. (2004) Continuous glucose monitoring: physiologic and pathophysiologic significance. Rom J Intern Med 42:381-393, ISSN 1582-3296, NLM ID: 9304507

5. Ionescu-Tîrgovişte C, Gavrilă L, Brădescu OM, Guja C. (2004) New once-daily intervention for type 2 diabetes mellitus: Diaprel MR. Rom J Intern Med 42:431-440

6. Lichiardopol R. (2004) Atypical antipsychotics and diabetes mellitus. Rom J Intern Med 42:301-312, ISSN 1582-3296, NLM ID: 9304507

7. Mogos T, Vasilescu R, Lazar A, Stoica M, Bratu D. (2004) Proteic sulphur levels in hair, possible tool to manage the balance of IDDM. Rom J Intern Med 42:441-445, ISSN 1582-3296, NLM ID: 9304507

2005

8. Bradescu OM, Georgescu M, Ifrim S, Ioacara S, Ionescu-Tirgoviste C. (2005) Meal

testing and postprandial state of type 2 diabetic patients with metabolic syndrome.

Rom J Intern Med 43:97-113, ISSN 1582-3296, NLM ID: 9304507 9. Nwabudike LC, Ionescu-Tirgoviste C. (2005) Intradermal reactions to purified

protein derivative in patients with diabetes mellitus. Rom J Intern Med 43:127-132, ISSN 1582-3296, NLM ID: 9304507

62

10. Margină D, Vlădică M, Grădinaru D, Mitrea N, Dănciulescu R, Radulian G. (2005)

Clinical study regarding the relationship between the inteleukin 6 level, insulin

resistance and endothelial dysfunction, Farmacia, Vol LII, 6, 2005, 18-24, ISSN

0014-8237, Cod CNCSIS 313

11. Margină D, Vlădică M, Dănciulescu R, Grădinaru D, Mitrea N. (2005) Clinical study

regarding the influence of hygieno-dietetic regimen on hyperglicemic overweight

patients. Archives of the Balkanic Medical Union 40, 3, 2005, 162-166, ISSN 0041-

6940, Cod CNCSIS 391

2006

12. Botez G, Stancu C, Alexandru D, Vlădică M, Sima A. (2006) Glycated LDL induce

lipid loading in human smooth muscle cells, Proceedings of the Romanian Academy,

Series B 8:31-36, ISSN 1454-8267, Cod CNCSIS - 789

13. Cătană-Negreanu CI, Albu R, Glavce C, Vlădică M, Sima A. (2006) Apolipoprotein

E genotype in the romanian population - association with risk factors for metabolic

syndrome, Proceedings of the Romanian Academy Series B, (in press), ISSN 1454-

8267, Cod CNCSIS - 789

14. Cojocaru M, Cheta N, Cheta DM, Cojocaru IM, Farcasiu E. (2006) The effect of

magnesium deficit on serum immunoglobulin concentrations in type 1 diabetes

mellitus. Rom J Intern Med 44:61-67, ISSN 1582-3296, NLM ID: 9304507

15. Margină D, Marin A, Mitrea N, Vlădică M, Dănciulescu R, Grădinaru D. (2006)

Evaluation of the intercellular adhesion molecule 1 (ICAM-1) as marker of the

endothelial dysfunction. Farmacia nr 3, vol LIV, 2006, 18-24, ISSN 0014-8237, Cod

CNCSIS 313

16. Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2006) Lipoproteins from

diabetic and hyperlipidemic patients induce an increase in scavenger receptors CD36

and LOX-1 gene expression in human endothelial cells, Proceedings of the Romanian

Academy, Series B 8:37-42, ISSN 1454-8267, Cod CNCSIS - 789

2007

17. Ioacara S, Cheta D. (2007) Cardiovascular risk factors in type 2 diabetes patients, in

the light of evidence-based medicine. Medicina Modernă Vol XIV, No. 1:6-10, Cod CNCSIS - 475

18. Ioacara S, Sabau SV, Serafinceanu C, Ionescu-Tirgoviste C. (2007) The prospective analysis of mortality in type 2 diabetes subjects in Bucharest, Romania. Proc Rom Acad Series B, 2:141–148, ISSN 1454-8267, Cod CNCSIS - 789

19. Ionescu-Tirgoviste C, Guja C. (2007) Proinsulin, proamylin and the beta cell endoplasmic reticulum: The key for the pathogenesis of different diabetes phenotypes. Proc Rom Acad, Series B, 2:113–139, ISSN 1454-8267, Cod CNCSIS - 789

63

20. Ionescu-Tîrgovişte C, Guja C. (2007) The various phenotypes of diabetes and the endoplasmic reticulum of the beta cell. Rom J Intern Med 45:287-291, ISSN 1582-3296, NLM ID: 9304507

21. Popescu I, Dima S, Guja C, Gheorghe L, Iacob S, Hrehoreţ D, Matei E, Dorobanţu B, Botea F, Sârbu V, Tulbure D, Ionescu-Tîrgovişte C. (2007) Combined liver and islet transplantation using steroid-free immunossupression. Chirurgia (Bucur) 102:597-602, Cod CNCSIS 392

64

ANEXA 5.2

LISTA COMUNICĂRILOR

65

Anexa 5.2

COMUNICĂRI LA CONGRESE INTERNAŢIONALE CU REZUMAT

PUBLICAT ÎN VOLUM DE REZUMATE

2003

1. Guja C, Marshall S, Welsh K, Todd J, Ionescu-Tîrgovişte C. (2003) The study of

Manose-Binding Lectin (MBL) polymorphisms in Romanian T1DM families.

Diabetes 52[Suppl 1]: A508 (Abstract)

2. NICOLAIE T, PREDA M, TIMOFTE D, MITRACHE M, HASSANAIN M,

CONSTANTIN C, COMAN A, GUTU D, VLADICA M, IOSUP A, PANAITE C,

BALAS B, POESINA N, CHETA D. (2003) The Vanadium Insulinmimetic Effect in

Discontinuous Administration. Diabetes 52[Suppl 1]: 2315-PO

3. NWABUDIKE LC, IONESCU-TIRGOVISTE C. (2003) Intradermal Reactions to

Purified Protein Derivative in Patients with Diabetes. Diabetes 52[Suppl 1]: 2290-PO

4. Bacanu E, Ionescu-Tirgoviste C. (2003) Microalbuminuria as marker of generalized

endothelial dysfunction. Diabetes Metab 29:4S351 (Abstract)

5. Burtea M, Cristescu J, Lichiardopol R, Ionescu-Tirgoviste C. (2003) Long term type

1 and type 2 diabetes: different patterns of chronic complications. Diabetes Metab

29:4S180 (Abstract)

6. Farcasiu E, Ionescu M, Simionescu C, Ionescu-Tirgoviste C. (2003) Epidemiology of

diabetes mellitus in Bucharest, 1996-1999. Diabetes Metab 29:4S9 (Abstract)

7. Georgescu O, Gavrila L, Soava L, Marin A, Ionescu-Tirgoviste C. (2003) Certain

aspects of asymmetry in diabetic retinopathy degree. Diabetes Metab

29:4S344(Abstract)

8. Guja C, Marshall S, Welsh K, Todd JA, Ionescu-Tîrgovişte C. (2003) No association

of TGF polymorphisms with T1DM genetic susceptibility in the Romanian

population. Diabetes Metab 29:4S43 (Abstract)

9. Lichiardopol R, Ionescu-Tîrgovişte C Apetrei E, Vlădică M, Kulcsar I, Guja C, Guja

L. (2003) Prevalence of glucose intolerance in a community-dwelling populational

group. Diabetes Metab 29:4S14 (Abstract)

10. Nwabudike LC, Ionescu-Tirgoviste C. (2003) Clinical characteristics of patients with

foot ulcers and diabetes mellitus. Diabetes Metab 29:4S287 (Abstract)

11. Pencea C, Sebestyen L, Savu O, Lichiardopol R, Ionescu-Tirgoviste C. (2003)

Comparative clinical profile in early vs. Late new diagnosed type 2 patients. Diabetes

Metab 29:4S180 (Abstract)

12. Perciun R, Costea M, Simionescu C, Ionescu-Tirgoviste C. (2003) Estimation of

well-being orally treated type 2 diabetic patients before and after 3 months from

insulin treatment start. Diabetes Metab 29:4S365 (Abstract)

13. Preda M, Gutu D, Nicolaie T, Iosup A, Hassanain M, Panaite C, Constantin C,

Coman A, Vladica M, Andronescu M, Timofte D, Balas B, Dimcevici-Poesina N,

Cheta D. (2003) Vanadium salts might induce islet proliferation in animal models.

Diabetes Metab 29:4S74 (Abstract)

14. Pruna S, Grigorescu M, Ionescu-Tirgoviste C. (2003) Diabetes control program by

using a data base management system. Diabetes Metab 29:4S402 (Abstract)

66

15. Radulian G, Vladica M, Panaite C. (2003) Efficacy of diet in obese patients with type

2 diabetes. Diabetes Metab 29:4S203 (Abstract)

16. Serafinceanu C, Pena CM, Mateiciuc SI, Asandei DT, Ionescu-Tirgoviste C. (2003)

Ferritin level has no relevance for clinic and biologic evolution of diabetic

hemodialysed patients. Diabetes Metab 29:4S302 (Abstract)

17. Brădescu O, Caceaune E, Ionescu-Tîrgovişte C. (2003) High incidence of peripheral

diabetic neuropathy in newly diagnosed older age type 2 diabetic patients associated

with early decrease of orthostatic blood pressure. NEURODIAB XIII, St Malo,

France, 30 August 2003

18. Ioacără S, Fărcaşiu E, Brădescu O, Guja C, Ionescu-Tîrgovişte C. (2003) Mortality in

type 1 diabetes patients with onset before age 40 years. Diabetologia 46[Suppl.

2]:A116 (Abstract)

19. Smyth D, Howson J, Twells R, Badhwar P, Walker N, Rance H, Barratt BJ, Savage

D, Carson D, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C,

Undlien D, Ronningen K, Stewart G, Todd JA. (2003) Identification of potential

therapeutic targets in complex diseases: evidence for protection from type1 diabetes

(T1D) by variants of CCR2 and CCR5. Am J Hum Genet 73:2146 (Abstract)

2004

20. CIMPONERIU D, COMAN A, APOSTOL P, RADU I, BALAS B, PANAITE C,

HARABA R, STAVARACHI M, GAVRILA L, PREDA M, CHETA D. (2004) The

IDDM2 and the Susceptibility to Type 1 Diabetes Mellitus (T1DM) in Romanian

Caucasian Population. A Case-Control Study. Diabetes 53[Suppl. 1]:2253-PO

21. NWABUDIKE LC, CORAVU DE, IONESCU-TIRGOVISTE C. (2004) Sensory

Testing in Peripheral Diabetic Neuropathy: A 616-Patient Study. Diabetes 53[Suppl.

1]:2249-PO

22. PANAITE C, COMAN A, GUTU D, BALAS B, CIMPONERIU D, NICOLAIE T,

CHETA D. (2004) The Influence of Silymarin on Diabetic Liver Disease in BB Rats.

Diabetes 53[Suppl. 1]:590-P

23. Vella A, Smyth D, Cooper JD, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE,

Ronningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Dunger DB, Strachan DP,

Ring SM, Todd JA. (2004) Convincing statistical support for association of the

Arg620Trp polymorphism in the PTPN22 locus with type 1 diabetes. Diabetes

53[Suppl. 1]:37-LB (Abstract)

24. Guja C, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Savage DA, Guja L, Ionescu-

Tîrgovişte C, Todd JA. (2004) Analysis of N Acetyl Transferase 2 gene variants in

type 1 diabetes. Diabetologia 47[Suppl. 1]:A133 (Abstract)

25. Guja L, Guja C, Ionescu-Tîrgovişte C, Nutland S, Todd JA. (2004) Strong association

of the insulin gene locus (IDDM2) with type 1 diabetes in the Romanian population.

Diabetologia 47[Suppl. 1]:A134 (Abstract)

26. Ioacără S, Fărcaşiu E, Brădescu O, Guja C, Scutaru G, Savu O, Ionescu-Tîrgovişte C.

(2004) Mortality in type 1 diabetes patients with onset after age 40 years.

Diabetologia 47[Suppl. 1]:A112 (Abstract)

67

27. Lichiardopol R, Niculescu N, Totora A, Pencea C, Ioacara S, Tomescu I, Cinteza M.

(2004) Hyperglycemia during acute myocardial infarction in diabetic and nondiabetic

patients. Diabetologia 47[Suppl. 1]:A430 (Abstract)

28. Pruna S, Ionescu-Tirgoviste C. (2004) A comparative study between color change

plaster for diabetic foot syndrome and electrical impedance change of plantar skin

sweat secretion. Diabetologia 47[Suppl. 1]:A376 (Abstract)

29. Radulian G, Vladica M, Panaite C, Balas B. (2004) The effects of hypocaloric and

hypolipidic diet on metabolic syndrome patients. Diabetologia 47[Suppl. 1]:A242

(Abstract)

30. Vella A, Smyth D, Cooper JD, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE,

Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Dunger DB, Strachan DP,

Ring SM, Todd JA. (2004) Convincing statistical support for association of the

Arg620Trp polymorphism in PTPN22 locus with type 1 diabetes. Diabetologia

47[Suppl. 1]:A133 (Abstract)

31. Ionescu-Tirgoviste C, Pruna S, Guja C, Ioacara S. (2004) Sympathetic sudomotor and

vasoconstrictor activity in type 1 and type 2 diabetic patients versus nondiabetic

subjects. Poster at the 14th Annual Meeting of the Diabetic Neuropathy Study Group

of the EASD NEURODIAB XIV, Joint symposium with the Diabetic Foot Study Group

of the EASD, Regensburg, Germany, September 2-5, 2004 (Abstract)

2005

32. Radulian G, Constantin C, Rusu E. (2005) The effect of the educational program on

the lifestyle of obese patients with dyslipidemia and hypertension. ECO – the 14th

European Congress on Obesity, Athens, 2005 (Abstract)

33. Ioacara S, Ionescu-Tirgoviste C, Glavce C, Bojin A, Popa D. (2005) The prediction of

waist circumference from other variables using multiple regression analysis. Poster at

the 1st International Congress on "Prediabetes" and the Metabolic Syndrome,

Epidemiology, Management and Prevention of Diabetes and Cardiovascular Disease,

Berlin, Germany, April 13-16, 2005.

34. Ionescu-Tirgoviste C, Ioacara S, Caceaune E, Caceaune N, Guja C, Bojin A. (2005)

The waist circumference as a predictor of ultrasound hepatic dimensions in patients

with non-alcoholic fatty liver disease. Poster at the 1st International Congress on

"Prediabetes" and the Metabolic Syndrome, Epidemiology, Management and

Prevention of Diabetes and Cardiovascular Disease, Berlin, Germany, April 13-16,

2005.

35. Ionescu-Tirgoviste C, Ioacara S, Sabau S, Lichiardopol R, Guja C, Bojin A, Apetrei

E. (2005) Factor analysis of the risk variables of the insulin resistance syndrome in

Romania. Poster at the 1st International Congress on "Prediabetes" and the

Metabolic Syndrome, Epidemiology, Management and Prevention of Diabetes and

Cardiovascular Disease, Berlin, Germany, April 13-16, 2005.

36. BRADESCU O, GEORGESCU M, IOACARA S, IONESCU-TIRGOVISTE C.

(2005) Significance of C Reactive Protein in Postprandial State of Type 2 Diabetic

Patients with Metabolic Syndrome. Diabetes 54[Suppl. 1]: 668-P

68

37. CIMPONERIU D, SERAFINCEANU C, APOSTOL P, COMAN A, CRACIUN AM,

PANAITE C, CHETA DM. (2005) Could IDDM2 Influence the Development of

ESRD in T2DM? Diabetes 54[Suppl. 1]: 857-P

38. Guja C, Guja L, Ionescu-Tîrgovişte C. (2005) Genetic susceptibility – necessary for

T1DM occurrence in the Romanian population. Diabetes 54[Suppl. 1]: 1133-P

(Abstract)

39. Ioacără S, Ionescu-Tîrgovişte C, Guja C, Brădescu O, Scutaru G. (2005) Kaplan-

Meier survival curves of type 1 diabetes mellitus patients with onset after 30 years.

Diabetes 54[Suppl. 1]:2431-PO (Abstract)

40. Ionescu-Tîrgovişte C, Apetrei E, Ioacără S, Lichiardopol R, Guja C, Vlădică M,

Culcsar I, Bojin A. (2005) Overweight is both a strong and early component in the

development of the metabolic syndrome. Diabetes 54[Suppl. 1]:1853-P (Abstract)

41. Nwabudike LC, Ionescu-Tîrgovişte C. (2005) Risk factors and clinical characteristics

for foot ulcers in patients with diabetes in Bucharest, Romania. Diabetes 54[Suppl.

1]:2489–PO

42. RADULIAN GN, CONSTANTIN C, PANAITE C. (2005) Adequacy Diet

Management for Metabolic Syndrome Patients. Diabetes 54[Suppl. 1]: 2739-PO

43. SERAFINCEANU C, CIMPONERIU D, CRACIUN AM., COMAN A, PANAITE C,

CHETA DM. (2005) The Vitamin D Receptor and ACE Gene Polymorphisms

Contribution to the Progression of Diabetic Nephropathy to End Stage Renal Disease

in Romanian Population. Diabetes 54[Suppl. 1]: 2284-PO

44. SERAFINCEANU C, STANCIU C, ENCULESCU DI, CHETA DM. (2005) Risk

Factors for Early Death on Hemodialysis in Diabetic Patients. Romanian 10-Year

Experience. Diabetes 54[Suppl. 1]: 2287-PO

45. Brădescu O, Georgescu M, Ioacără S, Ionescu-Tîrgovişte C. (2005) Presence Of

Peripheral Diabetic Neuropathy Associated With More Pronounced Features Of The

Metabolic Syndrome In Type 2 Diabetic Patients, poster la 15th

Neurodiab Meeting,

Porto Heli, Greece, 8-10 September 2005

46. Radulian G, Rusu E, Constantin C. (2005) A low carbohydrate compared with a low

fat diet in elderly patients with type 2 diabetes mellitus. Diabetologia

48[Suppl1]:A269

47. Cătană-Negreanu C, Toma L, Albu R, Glavce C, Vlădică M, Sima A. (2005)

Apolipoprotein E genotype in the Romanian population - association with risk factors

for obesity. 3rd European Meeting on Vascular Biology and Medicine, Hamburg,

Germany, September 28 – 30, Journal of Vascular Research - Abstracts, vol. 42, p.

64, 2005.

48. Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2005) LDL from diabetic and

hypercholesterolemic patients induce an increase in scavenger receptors CD36 and

LOX-1 gene expression in human endothelial cells. 3rd European Meeting on

Vascular Biology and Medicine, Hamburg, Germany, September 28 – 30, Journal of

Vascular Research - Abstracts 2005.

49. Margină D, Vlădică M, Dănciulescu R, Grădinaru D, Mitrea N. (2005) Adiponectin

level and NO synthesis as atherogenic matkers at overweight and obese patients. Al

IV-lea Congres Naţional de Farmacie cu participare internaţională, Sofia, Bulgaria,

iunie 2005; publicată în volumul de rezumate ISSN 0428-0296

69

50. Margină D, Grădinaru D, Mitrea N, Vlădică M. (2005) Aspects regarding

hyperglycemic toxicity evaluated as redox stress parameters. 42nd

Congress of

European Societies of Toxicology, 11-14 September, Cracow, Poland, Eurotox 2005,

publicată în volumul de rezumate, ISSN 0378-4274

51. Cătană-Negreanu C, Toma L, Albu R, Glavce C, Vlădică M, Sima A. (2005)

Apolipoprotein E genotype in the Romanian population - association with risk factors

for obesity. International One Day Symposium ―Combating Cardiovascular Diseases

and Diabetes‖, 14 October 2005, Bucharest

52. Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2005) LDL from diabetic and

hypercholesterolemic patients induce an increase in scavenger receptors CD36 and

LOX-1 gene expression in human endothelial cells. International One Day

Symposium ―Combating Cardiovascular Diseases and Diabetes‖, 14 October 2005,

Bucharest

53. Cătană-Negreanu C, Toma L, Albu R, Glavce C, Vlădică M, Sima A. (2005)

Apolipoprotein E genotype in the Romanian population - association with risk factors

for obesity. International One Day Symposium “New Insights in Molecular

Medicine”, 4 November 2005, Bucharest

54. Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2005) LDL from diabetic and

hypercholesterolemic patients induce an increase in scavenger receptors CD36 and

LOX-1 gene expression in human endothelial cells. International One Day

Symposium “New Insights in Molecular Medicine”, 4 November, 2005, Bucharest

55. Ioacara S. (2005) Hypoglicemia Evaluation Using Continuous Glucose Monitoring

System – Case Presentation. Oral presentation at the Salzburg Columbia Seminar in

Internal Medicine, Salzburg, Austria, June 28 – July 02, 2005.

2006

56. CIMPONERIU D, SERAFINCEANU C, APOSTOL P, CRACIUN AM, PANAITE

C, TOMA M, GAVRILA L, CHETA DM. (2006) Genetic Susceptibility for Diabetic

End Stage Renal Disease. Diabetes 55[Suppl. 1]:2177-PO (Abstract)

57. Guja C, Guja L, Ionescu-Tîrgovişte C, Nutland S, Stevens H, Todd JA. (2006) Effect

of HLA (IDDM1) and insulin gene (IDDM2) in type 1 diabetes patients and their

first-degree relatives in Romania. Diabetes 55[Suppl. 1]:1062-P (Abstract)

58. Ioacără S, Ionescu-Tîrgovişte C, Guja C, Bojin A. Mortality and causes of death in

oral treated type 2 diabetes mellitus patients. (2006) Diabetes 55[Suppl. 1]:913-P

(Abstract)

59. Ioacără S, Ionescu-Tîrgovişte C, Guja C, Bojin A. (2006) The prediction of waist

circumference in normal versus newly discovered type 2 diabetes patients. Diabetes

55[Suppl. 1]:2301-PO (Abstract)

60. Ionescu-Tîrgovişte C, Guja C, Vlădică M, Ioacără S, Bojin A, Filip I. (2006)

Proinsulin levels are significantly increased both in type 1 and type 2 diabetes

compared with normal subjects. Diabetes 55[Suppl. 1]:2473-PO (Abstract)

61. NWABUDIKE LC, CORAVU DE, IONESCU-TIRGOVISTE C, CRISTOFOR C.

(2006) Education Improves Awareness of the Diabetic Foot. Diabetes 55[Suppl.

1]:2352-PO (Abstract)

70

62. VLADICA M, MARGINA D, DANCIULESCU R, RADULIAN G, IOACARA S,

CHETA DM, IONESCU-TIRGOVISTE C. (2006) Inflammatory and Hormonal

Inflammatory and Hormonal Adipocytokines as Markers of Endothelial Dysfunction

as Markers of Endothelial Dysfunction. Diabetes 55[Suppl. 1]:2581-PO

63. Cimponeriu D, Ungureanu FD, Moldovan C, Apostol P, Serafinceanu C, Craciun

AM, Radu I, Stavarachi M, Mihai T, Usurelu D, Dan L, Cherry L, Dumitrescu L,

Gavrila L, Cheta DM. (2006) The MTHFR C677T polymorphism increases the risk

for ESRD in Romanian diabetic and nondiabetic patients. PP114. MOLECULAR

BASIS OF MONOGENIC AND COMPLEX DISEASES. 7th Balkan Meeting on

Human Genetics, BMHG, Skopje, Republica Macedonia, 31 august- 2 septembrie,

2006. (Abstract)

64. Cimponeriu D, Serafinceanu C, Apostol P, Usurelu D, Craciun AM, Panaite C,

Stavarachi M, Toma M, Gavrila L, Cheta

D. (2006) Polymorphisms of some

candidate genes in diabetic nephropathy in Romanian population. European Journal

of Human Genetics, 14[Suppl 1]: 332 (Abstract)

65. DRAGAN S, MANCAS S, CHETA D, VELIMIROVICI D, RADA M, BARBU L,

OTIMAN G. (2006) Design of the met-antiox study: Synergic bioactivity of

antioxidant functional foods in the metabolic syndrome. Atherosclerosis Supplements

7:445 (Abstract)

66. Bugă C, Serafinceanu C, Pătraşcu T, Catrina E, Vâlcu M. (2006) Improving survival

in peritoneal dialysis - a surgeon perspective on peritonitis. Perit Dial Int

26[Suppl.2]:S46 (Abstract)

67. Constantin C, Radulian G, Rusu E. (2006) Role of glycemic index in a diet program

for type 2 diabetes obese patients. 10th International Congress on Obesity, Sydney,

2006 (Abstract)

68. Radulian G, Constantin C, Rusu E. (2006) Diet management for obese patients with

type 2 diabetes. 10th International Congress on Obesity, Sydney, 2006 (Abstract)

69. Bradescu O, Ioacara S, Ionescu-Tirgoviste C. Glycemic variability and chronic

complications in non-insulin-treated type 2 diabetic patients. Diabetic Med 23[Suppl.

4]:675 (Abstract)

70. Farcasiu E, Ioacara S, Florea R, Ionescu-Tirgoviste C. Changes of antihyperglycemic

therapy in adult patients for 2001-2005 period. Diabetic Med 23[Suppl. 4]:580

(Abstract)

71. Ioacără S, Ionescu-Tirgoviste C, Sabau S, Bradescu O, Guja C. (2006) Higher body

mass index at diagnosis is a protective factor for mortality in a prospective trial of

newly discovered type 2 diabetes patients. Diabetic Med 23[Suppl. 4]:178-179 -

Poster la 19th

IDF Congress Cape Town, 3-7 December 2006

72. Ioacără S, Ionescu-Tîrgovişte C, Enachescu C, Guja C, Brădescu O. (2006) The Ideal

Waist Circumference - an emerging treatment target for abdominal obesity. Diabetic

Med 23[Suppl. 4]:582 - Poster la 19th

IDF Congress Cape Town, 3-7 December 2006

73. Ionescu-Tirgoviste C, Guja C, Ioacara S, Vladica M. (2006) Plasma proinsulin could

be a marker of beta-cell dysfunction in both type 2 and type 1 diabetes. Diabetic Med

23[Suppl. 4]:66-67 (Abstract)

74. Ionescu-Tirgoviste C, Scaiceanu L, Ioacara S, Andrada B. Phenotypic particularities

in type 2 diabetes patients with retinopathy and/or nephropathy. Diabetic Med

23[Suppl. 4]:66-67 (Abstract)

71

75. Radulian G, Rusu E, Margina D, Stoian M, Dragomir A, Constantin C. (2006)

Adequacy of glycemic and lipid management in people with type 2 diabetes. Diabetic

Med 23[Suppl. 4], IDF Congress, CapeTown 2006, (Abstract)

76. Rusu E, Radulian G, Vladica M, Margina D, Dragomir A, Constantin C. (2006)

Dietary change – an important role in people with metabolic syndrome. Diabetic Med

23[Suppl. 4], IDF Congress, CapeTown 2006, (Abstract)

77. Stoian M, Radulian G, Sotian B. (2006) Optimizing pre-ESRD care. III-rd World

Congress on „Quality in Clinical Practice‖, Thessaloniki, Greece, Sept. 2006,

(Abstract)

78. Cheta D, Radulian G, Constantin C. (2006) Romanian healthy nutrition foundation –

a real progress. The Ist World Congress of Public Health Nutrition, Barcelona, 2006,

(Abstract)

79. Cheta D, Dragomir A, Panaite C, Radulian G, Rusu E, Constantin C. (2006) Obesity

management: Practitioners point of view. The Ist World Congress of Public Health

Nutrition, Barcelona, 2006, (Abstract)

80. Constantin C, Rusu E, Radulian G, Cheta D. (2006) A nutritional program – Results

after 2 months of observation. The Ist World Congress of Public Health Nutrition,

Barcelona, 2006, (Abstract)

81. Panaite C, Dragomir A, Radulian G, Constantin C, Ion B, Cheta D. The Ist World

Congress of Public Health Nutrition, Barcelona, 2006, (Abstract)

82. Radulian G, Rusu E, Dragomir A. (2006) Diet management on metabolic syndrome

patients. The Ist World Congress of Public Health Nutrition, Barcelona, 2006,

(Abstract)

83. Constantin A, Vlădică M, Glavce C, Sima A, Popov D. (2006) Serum leptin levels

correlate with adiposity index, and not with the leptin receptor gene polymorphism,

Gln223Arg, in the Romanian population. Opening Workshop of CDRTU: ―Combating

Cardiovascular Disease and Diabetes‖, 27-29 April 2006, Bucharest, Abstract book,

p. 43

84. Margină D, Vlădică M, Mitrea N, Grădinaru D, Dănciulescu R. (2006) Evaluation of

the relationships between some parameters of the endothelial status and the body

mass index. International Opening Workshop of CDRTU ―Combating Cardiovascular

Disease and Diabetes‖, 27-29 April, 2006, Bucharest

85. Niculescu L, Baugé E, Vladică M, Fruchart-Najib J, Fruchart J-C, Sima A. (2006)

Distribution of the ApoA5 gene polymorphisms in a Romanian urban population.

Opening Workshop of CDRTU ―Combating Cardiovascular Disease and Diabetes‖,

27-29 April 2006, Bucharest, Abstract book, p. 46

86. Sima A, Cătană-Negreanu C, Albu R, Heltianu C, Vlădică M, Dorobanţu M. (2006)

Plenary lecture: Predictive value of apolipoprotein E genotype in obese patients with/

without CHD risk factors. International Opening Workshop of CDRTU ―Combating

Cardiovascular Disease and Diabetes‖, 27-29 April 2006, Bucharest, Abstract book,

p. 5

87. Stancu C, Botez G, Iordan A, Alexandru D, Vlădică M, Sima A. (2006) Plenary

lecture: Lipoproteins from obese patients induce an increase in scavenger receptors

CD36 and LOX-1 gene expression in human endothelial cells. Opening Workshop of

CDRTU: Combating Cardiovascular Disease and Diabetes, 27-29 April 2006,

Bucharest, Abstract book, p. 22

72

88. Sima A, Cătană-Negreanu C, Albu R, Glavce C, Vlădică M. (2006) Plenary lecture:

Apolipoprotein E Polymorphism – A Genetic Marker for the Metabolic Syndrome.

One Day International Symposium ―Cell and Molecular Biology for the Benefit of

Cardiovascular Diseases‖, 8 June 2006, Iassy, Abstract book, p. 58

89. Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2006) Plenary lecture:

Lipoproteins from obese patients induce an increase in scavenger receptors CD36 and

LOX-1 gene expression in human endothelial cells. One Day International

Symposium ‖Cell and Molecular Biology for the Benefit of Cardiovascular

Diseases‖, 8 June 2006, Iassy, Abstract book, p. 61

90. Niculescu L, Baugé E, Vlădică M, Fruchart-Najib J, Fruchart J-C, Sima A. (2006)

Distribution of the ApoA5 gene polymorphisms in a Romanian urban population. The

2nd

International Congress of Cellular and Molecular Biology, Iassy, 8-10 June 2006,

Abstract book, p. 47

91. Cătană-Negreanu C, Albu R, Glavce C, Vlădică M, Sima A. (2006) Apolipoprotein E

genotypes - a risk factor for obesity. XIVth International Symposium on

Atherosclerosis, 18-22 June 2006, Rome, Italy, Abstract book - Atherosclerosis

Suppl. Vol. 7, Issue 3, June 2006, p. 69

92. Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2006) LDL from obese

patients induce an increase in scavenger receptors CD36 and LOX-1 gene expression

in human endothelial cells. XIVth International Symposium on Atherosclerosis, 18-22

June 2006, Rome, Italy, Abstract book, p. 415

93. Constantin A, Vlădică M, Glavce C, Sima A, Popov D. (2006) Serum leptin levels

correlate with adiposity index, and not with the leptin receptor gene polymorphism,

Gln223Arg, in the Romanian population. The International Symposium “Recent

Advances in Cardio-Diabetology“, Bucharest, 8 September 2006

94. Niculescu L, Baugé E, Vlădică M, Fruchart-Najib J, Fruchart J-C, Sima A. (2006)

Distribution of the APOA5 gene polymorphisms in a Romanian urban population.

The International Symposium “Recent Advances in Cardio-Diabetology”, Bucharest,

8 September 2006

95. Sima A, Albu R, Iordan A, Glavce C, Vlădică M. (2006) Apolipoprotein E genotype

in the Romanian population - association with risk factors for obesity. The

International Symposium “Recent Advances in Cardio-Diabetology”, Bucharest, 8

September 2006

96. Stancu C, Botez G, Iordan A, Alexandru D, Vlădică M, Sima A. (2006) LDL from

diabetic and hypercholesterolemic patients induce an increase in scavenger receptors

CD36 and LOX-1 gene expression in human endothelial cells. The International

Symposium “Recent Advances in Cardio-Diabetology“, Bucharest, 8 September 2006

97. Margină D, Mitrea N, Grădinaru D, Vlădică M. (2006) Clinical study regarding the

influence of thiazolidinediones on some parameters indicating the endothelial

dysfunction. Al IV-lea Simpozion cu participare internaţională „Drug Research

Between Information and Life Science”, 19-20 October 2006, Bucharest, publicată în

volumul de rezumate

98. Ioacara S. (2006) Acute pancreatitis and Type 2 diabetes mellitus – Case

Presentation. Oral presentation at the Salzburg Columbia Seminar in Internal

Medicine, Salzburg, Austria, 04-08 July, 2006

73

2007

99. Ionescu-Tîrgovişte C, Ioacără S, Guja C, Moţa M, Mihai A, Lichiardopol R, Apetrei E. (2007) Insulin resistance and metabolic syndrome in an adult Romanian population. Diab Vasc Dis Res 4[Suppl. 1]:S75 (Abstract)

100. Ionescu-Tîrgovişte C, Mihai A, Guja C, Vlădică M, Ioacără S, Lichiardopol R, Apetrei E. (2007) Differences in prevalence of metabolic syndrome in subjects with impaired glucose tolerance. Diab Vasc Dis Res 4[Suppl. 1]:S108-S109 (Abstract)

101. Ionescu-Tîrgovişte C, Guja C, Vlădică M, Ioacără S, Mihai A, Florea L, Bulgăr

A, L. Guja. (2007) The relationship between proinsulin level and body mass index

in various diabetic phenotypes, including obesity and the metabolic syndrome.

Diab Vasc Dis Res 4[Suppl. 1]:S109 (Abstract) 102. Mihai A, Ionescu-Tîrgovişte C, Guja C, Bulancea M, Florea L, Tinca M. (2007)

Prevalence of the metabolic syndrome in women over 50 years old with type 2 diabetes. Diab Vasc Dis Res 4[Suppl. 1]:S74 (Abstract)

103. Stoian MI, Radulian G, Stoian B. (2007) The diagnosis of fatty liver with ultrasound and computerised tomography. Diab Vasc Dis Res 4[Suppl. 1]:S171 (Abstract)

104. BRADESCU OM, IOACARA S, IONESCU-TIRGOVISTE C. (2007) Clinical

and Biochemical Determinants of Plasma Glucose Variability in Non-insulin-

treated Type 2 Diabetic Patients. Diabetes 56[Suppl. 1]:2695-PO

105. CIMPONERIU DG, VLADICA M, APOSTOL PP, PANAITE C, CRACIUN

AM, UNGUREANU D, MOLDOVAN C, CHETA DM. (2007) The MTHFR

C677T and eNOS ID Polymorphisms Increase the Risk for ESRD in Romanian

Diabetic and Nondiabetic Patients. Diabetes 56[Suppl. 1]:0350-OR

106. FARCASIU E, IOACARA S. (2007) The Analysis of IMC trend in the 1996-2000

period for diabetic patients, in terms of age group, sex and type of diabetes.

Diabetes 56[Suppl. 1]:2483-PO

107. Guja C, Guja L, Ionescu-Tîrgovişte C. (2007) Association analysis of HLA-B in

type 1 diabetes in Romanian families. Diabetes 56[Suppl. 1]:1108-P (Abstract)

108. Ioacără S, Ionescu-Tîrgovişte C, Sabău S, Fărcaşiu E, Brădescu O, Guja C,

Pallayova M, Cristea A. (2007) Mortality changes over six decades in type 1

diabetes patients with onset before 40 years. Diabetes 56[Suppl. 1]:1031-P

(Abstract)

109. Ionescu-Tîrgovişte C, Guja C, Moţa M, Ioacără S, Vlădică M, Pascu M, Mihai A.

(2007) Plasma proinsulin levels in long standing diabetes: Marker for a

dysfunctional beta cell regeneration? Diabetes 56[Suppl. 1]:1667-P (Abstract)

110. RADULIAN G, RUSU E, DRAGOMIR AD, STOIAN M, VLADICA M. (2007)

The Effects of Low Carbohydrate Diet as Compared with a Low Fat Diet in

Elderly Patients with Type 2 Diabetes Mellitus. Diabetes 56[Suppl. 1]:1773-P

111. Todd JA, Clayton DG, Downes K, Dunger DB, Guja C, Leung H-T, Nutland S,

Plagnol V, Smyth DJ, Stevens HE, Ionescu-Tîrgovişte C, Tuomilehto J, Walker

N, Wellcome Trust Case-Control Consortium, Widmer B. (2007) A genome-wide

assessment of the genetic basis of type 1 diabetes and its biology. Diabetes

56[Suppl. 1]:393-OR (Abstract)

74

112. Rusu E, Radulian G, Vladica M, Dragomir A. (2007) The effects of hypocaloric

and hypolipidic diet on metabolic syndrome patients. International Journal of

Obesity 31[Suppl 1] ECO – 15th

European Congress on Obesity, Budapest, 2007

(Abstract)

113. Ioacără S, Ionescu-Tîrgovişte C, Fărcaşiu E, Brădescu O, Guja C, Pallayova M.

(2007) Changes in mortality pattern over the last six decades in type 2 diabetes

patients with onset between 30 and 60 years. Diabetologia 50[Suppl1]:S146

(Abstract)

114. Lichiardopol R, Coculescu M, Niculescu D, Pencea C, Vlădică M. (2007) Insulin

resistance, beta cell function and glucose intolerance in acromegaly. Diabetologia

50[Suppl1]:S283 (Abstract)

115. Vlădica M, Margină D, Grădinaru D, Ioacără S, Dănciulescu R. (2007) Redox

stress parameters in type 2 diabetes mellitus. Diabetologia 50[Suppl1]:S298

(Abstract) 116. Margina D, Mitrea N, Gradinaru D, Vladica M, Radulian G, Danciulescu R.

(2007) Study regarding the influence of thiazolidinediones on some inflammatory

and redox markers of the endothelial status. European Journal of Drug

Metabolism and Pharmakokinetics (Abstract)

117. Pallayova M, Donic V, Tomori Z, Ioacara S. Nocturnal glycemic variability in

severe sleep apnea diabetics before and under CPAP. Sleep and Biological

Rhythms 5[Suppl. 1]: A125 (Abstract) Poster presentation at 5th

Congress of the

World Federation of Sleep Research and Sleep Medicine Societies, Cairns,

Australia 2–6 September 2007