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ISBN:97859735693536058,!pg.!113!–!123!!3.!M.Grigorescu,!C.Stanciu,!Actualitati!in!diagnosticul!si!tratamentul!hepatitei!cronice!virale!2011!Capitol!carte:!“Tratamentul!hepatitei!virale!C!la!populatiile!speciale!,!Editura!Medicala!universitara!“Iuliu!Hatieganu”!Cluj!Napoca,!2010!ISBN:97859735693543650,!pg.!113!–!123!!4.!Dan!Olteanu!,!Mioara!Rizescu!Caiete!de!Gastroenterologie!si!Hepatologie!,!!vol.1!Capitol!carte!:!Program!de!supraveghere!prin!sistem!informatizat!a!leziunilor!esofagiene!si!gastrice!cu!potential!malign!Editura!SemnE!,!ISBN!97859735624560657!,2008!!5.!Dan!Olteanu!,!Mioara!Rizescu!Caiete!de!Gastroenterologie!si!Hepatologie!,!!vol.2!Capitol!carte!:!Semiologia!endoscopica!a!esofagului!Barrett!in!contextul!endoscopiei!conventionale!si!cu!magnificatie!Editura!SemnE!,!ISBN!97859735624560657!,2008!!&ARTICOLE&ISI&CU&FI&&1.David!T.!Rubin,Marc!Bradette,!Libor!Gabalec,!Daniela&Dobru,!Juan!Márquez,!Susi!Inglis,Elizabeth!Magee,!Dory!Solomon,!Geert!D'Haens!5!Ulcerative!Colitis!Remission!Status!After!Induction!With!Mesalazine!Predicts!Maintenance!Outcomes:!the!MOMENTUM!Trial!!!J!Crohns!Colitis!(2016)!10!(8):!9255933!https://academic.oup.com/ecco0jcc/article0lookup/doi/10.1093/ecco0jcc/jjw049;FI&6.585&&2.&&Ofelia!Daniela!Pascarenco,!Marius!Florin!Coroş!,!Ghenadie!Pascarenco,!Alina!Mioara!Boeriu,!Silvia!Cosmina!Draşovean,!Danusia!Maria!Onişor,!Olga!Brusnic,&Daniela&Dobru.&A!Preliminary!Feasibility!Study:!Narrow5Band!Imaging!Targeted!versus!Standard!White!Light!Endoscopy!Non!Targeted!Biopsies!in!a!Surveillance!Barrett's!Population!!Digestive!and!Liver!Disease!48!(2016)!1048–1053!!http://www.sciencedirect.com/science/article/pii/S1590865816304182;FI&2.719&&3.Peter!Akabah! ,Simona!Mocan,!Daniela& Dobru.Gastric! Adenocarcinoma!on! Incidental!Upper!GI!Endoscopy.!J!Gastrointestin!Liver!Dis,!June!2016!Vol.!25!No!2:!136!http://www.jgld.ro/wp/y2016/n2/a2.pdf;FI&1.891!&4.Pedro! Pimentel! Nunes,Diogo! Libânio,Jorge! Lage,Diogo! Abrantes,Miguel! Coimbra,Gianluca!Esposito,David! Hormozdi,Mike! Pepper,Silvia! Drasovean,JonathanR.!White,Daniela& Dobru,& James!Buxbaum,Krish!Ragunath,Bruno!Annibale,Mário!Dinis!Ribeiro.!A!multicentre!prospective!study!of!the!real!time!use!of!NBI!in!the!diagnosis!of!premalignant!gastric!conditions!and!lesions!.!Endoscopy!2016!,!48:7235730!DOI!http://dx.doi.org/10.1055/s500425108435!

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&&ARTICOLE&BDI&&1.!Drasovean!Silvia!Cosmina,!Morărașu!Diana!Elena,!Pascarenco!Ofelia!Daniela,!Brsunic!Olga,!Onișor!Danusia!Maria,!Boeriu!Alina,!Dobru&Daniela&Ecaterina.&Gastric!Intestinal!Metaplasia:!Prevalence,!Clinical!Presentation,!Endoscopic!and!Histological!Features.!Acta!Medica!Marisiensis!2016;62(1):56559!http://actamedicamarisiensis.ro/wp0content/uploads/2015/08/amma0201500061.pdf;!2.Kozma!Bela,!Pop!Crina,!Petrut!Madalina,!Drasovean!Silvia,!Dobru&Daniela!.Is!NAFLD!a!Risk!Factor!for!Colorectal!Polyps?!An!Analysis!of!Single!Romanian!Centre!Acta!Medica!Marisiensis!.2015;61(3):1655167!http://actamedicamarisiensis.ro/wp0content/uploads/2015/08/amma0201503_0065.pdf;!3.!Alina!Boeriu,!Cristian!Boeriu,!Silvia!Drasovean,!Ofelia!Pascarenco,!Simona!Mocan,!Mircea!Stoian!,!Daniela&Dobru!.!Narrow5band!imaging!with!magnifying!endoscopy!for!the!evaluation!of!gastrointestinal!lesions.!World!J!Gastrointest!Endosc!2015!February!16;!7(2):!15000!ISSN!194855190!http://www.wjgnet.com/esps/ArticleSearchResult.;;4.Boeriu!Alina1*,!Pascarenco!Ofelia1,!Brusnic!Olga1,!OnisorDanusia1,!Boeriu!Cristian2,!Dobru&Daniela1.The!Usefulness!Of!Narrow!Band!Imaging!Endoscopy!For!The!Real!Time!Characterization!Of!Colonic!Lesions.Acta!Medica!Marisiensis!2016;62(2):1825186!http://actamedicamarisiensis.ro/wp0content/uploads/2016/01/amma0201600004.pdf;!5.Gabriella!Gábos,!Dumitru!Moldovan,!Daniela&Dobru!5Hereditary!Angioedema:!a!Challenging!Diagnosis!for!the!Gastroenterologist.Journal!of!Interdisciplinary!Medicine!2016;1(3):2875292!http://www.interdisciplinary.ro/article/hereditary0angioedema0challenging0diagnosis0gastroenterologist/;!6.!Pop!Crina,!Kozma!B,!Drasovean!Silvia,!Dobru&Daniela,!Boeriu!Alina!.Predictors!of!hepatocellular!carcinoma!in!patients!with!liver!cirrhosis.!Acta!Medica!Marisiensis!2015;61(1):47550!http://actamedicamarisiensis.ro/predictors0of0hepatocellular0carcinoma0in0patients0with0liver0cirrhosis/;;7.Hintea!A,!Dobre!A,!Coroș!M,!Roșca!Ancuța,!Dobru&Daniela!.Individual!Prognostic!Factors!in!Gastric!Cancer!Acta!Medica!Marisiensis!2015;61(2):67570!http://actamedicamarisiensis.ro/individual0prognostic0factors0in0gastric0cancer/;!!8.Gabos!Gabriella,!Friciu!Adina,!Diac!Raluca,!Magdas!Annamaria,!Crăciun!C,!Coroș!M,!Dobru&Daniela&.Surgical!Risk!Factors!of!Patients!with!Operable!Gist!Acta!Medica!Marisiensis!2015;61(2):1005104!http://actamedicamarisiensis.ro/surgical0risk0factors0of0patients0with0operable0gist/;!

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9.Silivastru!(Cozlea)!Ionela,!Cozlea!Daniel!Laurentiu,!Keresztesi!Arthur!Attila,!Asofie!Gabriela,!Cozlea!Laurentiu,!Oltean!Galafteon,!Dobru&Daniela!.!The!Risk/Benefit!Analysis!of!Oral!Anticoagulant!Treatment!in!Atrial!Fibrillation!Using!HAS5BLED!and!CHA2DS25VASc!Score!Acta!Medica!Marisiensis!,2015;61(4):2695272!http://actamedicamarisiensis.ro/wp0content/uploads/2015/08/amma0201500056.pdf;!10.Diac!Andreea!Raluca,!Brusnic!Olga,!Gabos!Gabriella,!Onisor!Danusia,!Drasoveanu!Silvia!Cosmina,!Boeriu!Alina,!Dobru&Daniela&Ecaterina.!The!Assessment!of!the!Colo5rectal!Polyps!in!Order!to!the!New!Diagnostic!and!Therapeutic!Strategies.!Acta!Medica!Marisiensis!2015;61(3):1615164!http://actamedicamarisiensis.ro/wp0content/uploads/2015/08/amma0201503_0060.pdf;!11.!Pop!C,!Kozma!B,!Drașovean!S,!Dobru&D,!Boeriu!A.!Predictors!of!hepatocellular!carcinoma!in!patients!with!liver!cirrhosis.!Acta!Medica!Marisiensis!2014,!ISSN!206853324,!http://www.ammjournal.ro/;!12.!Boeriu!A,Brusnic!O,!Onișor!D,Pascarenco!O,Boeriu!C,Dobru&D.The!usefulness!of!white!light!endoscopy,!narrow!band!imaging,!and!magnification!for!the!optimization!of!diagnosis!in!Barrett’s!esophagus.!Acta!Medica!Marisiensis!2014,!60(6):244(248,ISSN!206853324!http://actamedicamarisiensis.ro/the0usefulness0of0white0light0endoscopy0narrow0band0imaging0and0magnification0for0the0optimization0of0diagnosis0in0barretts0esophagus/;!13.!.!Onișor!DM,!Dobru&D,!Boeriu!A,!Pascarenco!O,!Brusnic!O,!Stoian!A,!Stoian!M,!Cozma!D.!Endoscopia!cu!magnificație!și!cromoendoscopia!în!gastrita!atrofică,!metaplazia!intestinală!și!displazia!gastrică.!Acta!Medica!Transilvanica!2012,!2:32(!34,ISSN145351968!http://www.amtsibiu.ro/Arhiva/2012/Nr2(en/Onisor.pdf;!14.Boeriu!A,!Dobru&D,!Pascarenco!O,!Mocan!S,!Onișor!D.!Chromoendoscopy!and!magnification!for!the!evaluation!of!the!intragastric!extent!of!atrophic!gastritis!and!intestinal!metaplasia.!Acta!Medica!Marisiensis!2012,!58(6):!371(373,!ISSN!206853324!http://www.ammjournal.ro/index.php/AMM/article/view/!!15.Pascarenco!O,!Dobru&D,!Boeriu!A,!Brusnic!O,!Galeanu!I,!Onișor!D,!Stoian!M.!The!Usefulness!of!Magnifying!Chromoendoscopy!with!Methylene!Blue!in!the!Detection!of!Specialized!Intestinal!Metaplasia!and!Dysplasia!in!Barrett’s!Esophagus!a!Preliminary!Report.!Acta!Medica!Marisiensis!2012,!58(3):"!1725174,!ISSN206853324!http://www.hvm.bioflux.com.ro/docs/HVM_4.1.8.1.pdf;!16.Pascarenco!O,!Dobru&D,!Boeriu!A,!Brusnic!O,!Onișor!D,!Stoian!M,!Pascarenco!G,!Găleanu!M.The!importance!of!magnification!chromoendoscopy!with!methylene!blue!in!detecting!specialized!intestinal!metaplasia!in!short!segment!Barrett’s!esophagus.!Human!Veterinary!Medicine.!International!Journal!of!the!Bioflux!Society!2012,4(1):40544,ISSN!206657655!http://www.hvm.bioflux.com.ro/docs/HVM_4.1.8.1.pdf;;17.P.Olah,M.Maruseri,M.Suciu,H.Suciu,Daniela&Dobru.Building!an!effective!user5interface!for!medical!databases.!Public!Health!and!Management.!vol.II,nr.4,2012!:1805182!!http://www.amtsibiu.ro/Arhiva/2012/Nr40en/Olah_en.pdf;!18.!.!Boeriu!Alina,!Dobru&Daniela,!Pascarenco!Ofelia,!Mocan!Simona.!The!detection!of!

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premalignant!and!malignant!gastric!lesions!by!conventional!endoscopy!in!a!general!population!sample,!Acta!Medica!Marisiensis,!vol!57,!2011:!1365141!!19.!Alina!M.!Boeriu,!Daniela&E.!Dobru,!Simona!Mocan,!Ofelia!Pascarenco,!Mircea!Stoian,!Cristian!Boeriu.!Endoscopic!examination:!a!present!and!future!challenge.!Acta!Medica!Marisiensis,!vol!57!nr.6/2011:!7655768!!20.!Ana5Maria!Boțianu,!Daniela&Dobru,!E.!Carașca,!Ofelia!Pascarenco,!Alina!Boeriu,!P.!Boțianu,!Mirela!Gliga5!Nonvariceal!Acute!Upper!Gastrointestinal!Bleeding:!Value!of!prognostic!scores!for!the!length!of!hospital!stay!in!noncritical5nonsurgical!patients,!Acta!Medica!Marisiensis,!vol!56,!2010:!2015204!!21.!Boeriu!Alina!,!Dobru&Daniela!,!Pascarenco!Ofelia!,!Mocanu!Simona!,!Stoian!Mircea!,!Georgescu!Anca!.!The!Detection!of!Premalignant!Gastric!Lesion!by!Conventional!and!Magnifying!Endoscopy!.!Acta!Medica!Marisiensis!,vol!57!,!nr.5/2011:!4185421!!22.!Pascarenco!Ofelia!,!Daniela&Dobru!,!Boeriu!Alina!,!Pascarenco!G!,!David!Cristina!,!Brusnic!Olga!.!Value!of!Liver!Contrast5enhanced!Sonography!to!Diagnose!Malignant!or!Benign!Tumors.!Acta!Medica!Marisiensis,!vol!57!nr.6/2011:7135716!!23.!Stolnicu!S!,!Radulescu!D!,!Plesa!IE!,&Daniela&Dobru!,!Podoleanu!C!,!Pintilei!DR!The!value!of!intraoperative!diagnosis!in!brest!lesions.!Rom.!J!Morphol!Embryol.,!2006!;!47!(2)!:!119523!!24.!Daniela!Dobru!,!N.Seuchea!,!Marian!Dorin!,!V.Căreianu!.!Blue!Rubber!Bleb!Nevus!Syndrome!:!case!Report!and!Literature!Review!.!Roumanian!Journal!of!Gastroenterology!,!2004!,!vol.13!Nr.3!,!2375240!!25.!Dobru&D,!Pascu!O,!Tantau!M,!Gheorghe!C,!Goldis!A,!Balan!G,!Coman!F,!Fraticiu!A,!Dumitru!E,!Mutescu!E,!Saftoiu!A,!Bacarea!V.!An!epidemiological!study!of!gastric!cancer!in!the!adult!population!referred!to!gastroenterology!medical!services!in!Romania!55!a!multicentric!study.!Rom!J!Gastroenterol.!2004!Dec;13(4):27559.!PubMed!PMID:!15624023!!26.!The!prevalence!of!coeliac!disease!at!endoscopy!units!in!Romania:!routine!biopsies!during!gastroscopy!are!mandatory!(a!multicentre!study).!Dobru&D,!Pascu!O,!Tanţă!M,!Gheorghe!C,!Goldiş!A,!Bălan!G,!Olteanu!I,!Fraticiu!A,!Dumitru!E,!Miuţescu!E,!Mulder!C,!Podoleanu!S.!Rom!J!Gastroenterol.!2003!Jun;12(2):975100!!27.!Turcu!A!.,!Cotoi!S.,!Seuchea!N.,!Daniela&Dobru.!Relatia!refluxului!gastroesofagian!cu!angina!pectorala!si!tulburarile!de!ritm!cardiac.!Sibiul!Medical!1992,!nr.3!,!70575!.!!!ARTICOLE&,&B&!1.&Daniela&Dobru&,Oliviu!Pascu,!Mircea!Diculescu!,!Ioan!Sporea,!Simona!Muresan!,!Alina!Boeriu!,!Nicolae!Seuchea!,!Mircea!Muresan!,!Peter!Olah!,!Marius!Muji!.!Program!de!supraveghere!prin!sistem!informatizat!a!leziunilor!esofagiene!şi!gastrice!cu!potenţial!

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malign.!.!Revista!de!Medicină!şi!Farmacie!Tg.!Mureş!,!2007!,!vol!53!:!54557.!!2.!Daniela&Dobru!,!Simona!Muresan,!Angela!Borda!,!Simona!Mocanu!,!Simona!Stolnicu!.!Corelarea!aspectelor!endoscopice!ale!mucoasei!gastrice!obţinute!prin!endoscopia!cu!magnificaţie!,!cu!aspecte!clinicopatologice!.!.!Revista!de!Medicină!şi!Farmacie!Tg.!Mureş!,!2007!,!vol!53!:!1185123.!!3.&Daniela&Dobru!,!A.Goldis!,!S.Muresan!,!F.Buicu!,!G.Buicu!,!S.Stolnicu!,!M.Muresan!,!C.Podoleanu!,!D.Marian.!Noi!perspective!in!diagnosticul!precoce!al!cancerului!incipient!de!tub!digestive!superior.!Satu!Mare!–!Studii!si!Comunicari!Stiintele!Naturale!,!vol.VI!,!2006,!ISSN!15825201X!,!1585161!!4.!Daniela&Dobru,!Angela!Borda!.!Aportul!endoscopiei!cu!magnificaţie!şi!a!cromoscopiei!în!diagnosticul!Esofagului!Barrett!:!studiu!comparativ!.Satu5Mare5!Studii!şi!comunicări!,!seria!ştiinţele!naturale!,!vol.VII!(!2006!),!ISSN!15825201X!,!1335136!!5.&Daniela&Dobru!.Semiologia!endoscopică!a!Esofagului!Barrett!în!contextul!endoscopiei!convenţionale!şi!cu!magnificaţie.!.Satu!Mare5!Studii!şi!comunicări!,!seria!ştiinţele!naturale!Satu5Mare!,!vol.VII!(!2006!)!,!ISSN!15825201X!,!1375142!!6.!Alina!Boeriu!,!Daniela&Dobru!,!Simona!Muresan!.!Infecţia!cu!Helicobacter!Pylori!–!corelaţia!cu!afecţiunile!preneoplazice!şi!cancerul!gastric.!Revista!de!Medicină!şi!Farmacie!Vol.!52!,!4!,!2006!;!2115215.!!7.!C.Podoleanu!,!Doina!Podoleanu!,!Monica!Dorgo!,!E.Carasca!,!A.Incze!,!Daniela&Dobru!,!Simona!Stolnicu!,!Oana!Marginean!,!C.Marginean!,!F.Buicu!.!Monitorizarea!ambulatorie!autonoma!a!tensiunii!arteriale!.!Satu!Mare!–!Studii!si!comunicari!Seria!Ştiinţele!naturale!,!vol.VII!(!2006)!pp!:!1235126!!8.!Cristian!Podoleanu!,!Doina!Podoleanu!,!Daniela!Dobru!,!Monica!Dorgo!,!Simona!Stolnicu!,!Florin!Buicu!,!Alexandru!Incze!,!Emilian!Carasca!.!Factori!clinici!cu!valoare!predictivă!pentru!rezultatul!testului!de!înclinare!la!pacienţii!cu!sincopă.!Satu!–Mare!Studii!şi!Comunicări!,!Seria!Ştiinţele!Naturale!,!vol.VI!,!2005!,!ISSN!15825201X!,!2355238!!9.!Simona!Stolnicu!,!Doiniţa!Rădulescu!,!Marius!Florin!Coroş!,!Angela!Borda!,!Daniela&Dobru!,!Cristian!Podoleanu.!Tumoră!carcinoidă!ovariană!mixtă!primară!asociată!cu!teratom!matur!chistic!controlateral.!Satu!–Mare!Studii!şi!Comunicări!,!Seria!Ştiinţele!Naturale!,!vol.VI!,!2005!,!ISSN!:!15825201X!,!2385242!!10.!Simona!Stolnicu!,!Marius!Florin!Coroş!,!Doiniţa!Rădulescu!,!Maria!daniela!Podeanu!,!Daniela&Dobru!,!Cristian!Podoleanu!,!Monica!Dohan!,!Ovidiu!Cotoi!.!Importanţa!evaluării!aspectului!morfologic!şi!imunohistochimic!în!tumorile!cu!celule!de!granuloasă!de!tip!adult!asociate!cu!o!componentă!fibrotecală.!Satu!–Mare!Studii!şi!Comunicări!,!Seria!Ştiinţele!Naturale!,!vol.VI!,!2005!,!ISSN!:!15825201X!,!2425247!!11.!Dorin!Marian!,!Serban!Bancu!,!Constantin!Copotoiu!,!Bogdan!Păltineanu!,!Leonard!Azamfirei!,!Ruxandra!Copotoiu!,!Daniela&Dobru!,!Ligia!Bancu!,!Mihai!Turcu!,!I.Simu!.!Analiza!multifactorială!a!morbidităţii!şi!mortalităţii!din!chirurgia!icterului!mecanic.!Satu!–Mare!Studii!şi!Comunicări!,!Seria!Ştiinţele!Naturale!,!vol.VI!,!2005!,!ISSN!:!15825201X!,!3095313!

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!12.!Dorin!Marian!,!Bela!Fazakas!,!Serban!Bancu!,!Constantin!Copotoiu!,!Bogdan!Păltineanu!,!Leonard!Azamfirei!,!Ruxandra!Copotoiu!,!F.!Gavrilaş!,!I.O.!Avram!,!Marius!Măruşteri!,!Florin!Buicu!,!Daniela&Dobru!,!Ligia!Bancu!,!Simona!Stolnicu!,!Daniela!Frandeş!,!Horaţiu!Suciu!,!Oana!Mărginean!,!Mihai!Turcu!,!I.Simu.!Parzitoze!rare!ale!căilor!biliare.!Satu!–Mare!Studii!şi!Comunicări!,!Seria!Ştiinţele!Naturale!,!vol.VI!,!2005!,!ISSN!:!15825201X!,!3135316!!13.!C.Cijevschi!,!Daniela&Dobru!,!C.!Gheorghe!,!C.!Mihai!,!A.!Saftoiu!,!I.Sporea!,!M.Tantau!Consens!National!:!Tratamentul!hemoragiei!digestive!superioare!non5variceala!.!Revista!pentru!educatie!medicala!continua!–!gastroenterologie!,!vol.4!,!Nr.1!,!2005!!14.&Daniela&Dobru!Abordarea!pacientului!cu!hemoragie!inferioară!acută!.!Revista!pentru!educaţie!medicală!continuă!–!gastroenterologie!,!2004!,!vol.3!,!nr.3!,!74579!!15.&Daniela&Dobru!,!C.Copotoiu!,!C.Molnar!,!Sanda!Copotoiu!.!Importanţa!enteroscopiei!intraoperatorii!în!diagnosticul!hemoragiilor!digestive!de!cauză!necunoscută!.!Prezentare!de!caz.!Revista!pentru!educaţie!medicală!continuă!–!gastroenterologie!,!2004!,!vol.3!,!nr.3!70573.!!16.!A.Goldiş!,!O.Pascu!,!S.Iobagiu!,!Anca!Trifan!,!G.Bălan!,!G.Constantinescu!,!C.Gheorghe!,!A.Fraticiu!,!Daniela&Dobru!,!E.Miutescu!,!A.!Saftoiu!,!E.Dumitru!.!Studiu!prospectiv!multicentric!privind!mortalitatea!prin!hemoragie!digestivă!superioară5!date!preliminarii.!Revista!pentru!educaţie!continuă!–!gastroenterologie!,!2004!,!vol.3!,!nr.3!,!31534.!!17.&Daniela&Dobru,!Alina!Boeriu!,!N.Seuchea!,!Simona!Mureşan!,!C.Boeriu.!Aplicaţii!clinice!a!metodei!de!coagulare!cu!plasma!argon!în!endoscopia!digestivă.!Revista!de!Medicină!şi!Farmacie!Tg.Mureş!,!2004!,!nr.50!,!156.!!18.&Daniela&Dobru!.!Chronic!Hepatitis!C!with!normal!aminotransferase!levels!,!detectable!HCVRNA!and!mild!histologic!hepatitis!–!What!to!do!?!Case!report!and!literature!review.!Revista!de!Medicină!şi!Farmacie!Tg.!Mureş!,!2004!,!nr.!50!:!35538!!19.&Daniela&Dobru.!Esofag!Barrett!.!Program!de!screening!şi!supraveghere!endoscopică!–!argumente!pro!şi!contra.!Revista!pentru!educaţie!continuă!–!gastroenterologie!,!2004!,!vol.3!,!nr.3.,!92595!!20.&Daniela&Dobru!,!N.Seuchea!,!Ioana!Ioancio!,!Simona!Podoleanu!,Simona!Mocanu!.!Particularităţi!endoscopice!şi!histologice!ale!pacienţilor!cu!dispepsie!ulcer5like.Revista!pentru!educaţie!medicală!continuă!–!gastroenterologie!,!vol!2,!nr.2,2003!,!17523.!!21.&Daniela&Dobru!,!N.Seuchea!,!E.!Brânzaniuc!,!Claudia!Cozma!,!J.Bogatay.!Studiul!privind!asocierea!dispepsiei!funcţionale!cu!sindromul!de!intestin!iritabil.!Revista!pentru!educaţie!medicală!continuă!–!gastroenterologie!,!vol.2,!nr.2!,!2003!,!36545.!!22.&Daniela&E.Dobru!–!Approach!to!the!patient!with!malabsorption!.!Revista!de!Medicină!şi!Farmacie!Tg.Mureş!,!2003!,!49!:!1455150!!23.&Daniela&E.Dobru!–!Management!of!esophageal!varices!.!Revista!de!Medicină!şi!Farmacie!Tg.Mureş!,!2003!,!49!:2105215!!

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24.!Daniela&Dobru!,Miliana!Pop.!Implicarea!infectiei!cu!Helicobacter!pylori!,!evidentiata!endoscopic!,!in!sindromul!dispeptic!neulceros.!Revista!de!Medicina!si!Farmacie!Tg.Mures!,!1996!,vol.42!,nr.1,!82586.!!!REZUMATE&IN&REVISTE&ISI&&1.!Boeriu!A,!Dobru&D,!Brusnic!O,!Onișor!D,!Drașovean!S,!Pop!C,!Mocan!S.The!study!of!gastric!lesions!detected!by!conventional!gastrointestinal!endoscopy!with!biopsies.!Journal!of!Gastrointestinal!and!Liver!Diseases!2014;!23!(Suppl.1):!196,!ISSN!1841(8724,!FI:1,849!!2.!Boeriu!A,!Dobru&D,Pascarenco!O,!Mocan!S.!The!role!of!magnifying!endoscopy!and!chromoendoscopy!in!the!evaluation!of!premalignant!lesions!of!gastric!mucosa.Gut!2012!61!(Suppl!3)/Endoscopy!44!(Suppl!1):!A!361!(P!1233)!ISSN!0017(5749/1438(8812,!FI:!3,255/5,735!!3.!OnișorD,!Boeriu!A,!Brusnic!O,!Pascarenco!O,!Drașoveanu!S,Kosma!B,!Petruț!M,!Morărașu!D,!Dobru&D.!Clinical!and!epidemiological!aspects!and!diagnosis!of!the!premalignant!gastric!conditions!and!lesions.!Journal!of!Gastrointestinal!and!Liver!Diseases!2014;23(Suppl.1):25,ISSN1841(8724,!FI:1,849!!4.!Brusnic!O,Onișor!D,Boeriu!A,Drașovean!S,Pascarenco!O,DobruD.Ulcerative!colitis!in!a!tertiary!gastroenterology!center.!Retrospective!study!of!5!years.Journal!of!Gastrointestinal!and!Liver!Diseases!2014;!23!(Suppl.1):!105,!ISSN!1841(8724,!!FI:1,849!!5.!Drașovean!S,!Boeriu!A,!Onișor!D,!Brusnic!O,!Pop!C,!Kozma!B,!Morărașu!D,!Mocan!S,Pascarenco!O,!Dobru&D.!Narrow!band!imaging!endoscopy!for!the!diagnosis!of!gastric”!intestinal!metaplasia!and!dysplasia.!Journal!of!Gastrointestinal!and!Liver!Diseases!2014;23(Suppl.1):214,ISSN!1841(8724,!FI:1,849!!6.!Onișor!D,&Dobru&D,!Boeriu!A,!Pascarenco!O,!Brusnic!O,!Drasoveanu!S,!Mocan!S.!The!contribution!of!narrow!band!imaging!in!the!diagnosing!of!gastric!premalignant!lesions.Journal!of!Gastrointestinal!and!Liver!Diseases!2013;22(Suppl.1):11(12,ISSN!1841(8724,FI:1,849!!7.!Brusnic!O,Dobru&D,!Boeriu!A,!Onisor!D,!Pascarenco!O,!et!al.!Ulcerative!colitis!in!a!tertiary!gastroenterology!center.!Retrospective!study!of!5!years.!Journal!of!Gastrointestinal!and!Liver!Diseases!2013;22(Suppl.1):81,ISSN184158724,!FI:1,849!!8.!P630!Epidemiological!and!phenotypic!characteristics!of!IBD!patients!in!Romania!–!results!of!a!nationwide!hospital5based!registryC.!Gheorghe!,!A.!Dimitriu!,!R.!Iacob!,!M.!Cojocaru!,!C.!Lupei!,!R.!Vadan!,!D.&Dobru!,!A.!Trifan!,!M.!Tantau!,!A.!Goldis!,!G.!Constantinescu!,!S.!Gologan!,!B.!Mateescu!,!D.!Gheonea!,!L.!Gheorghe!,!M.!Diculescu!,!on!behalf!of!the!IBDPROSPECT!Study!Group!!

12

Journal!of!Crohn!and!Colitis!,!vol!8,supp1,February!2014,!pag.S3285S329!https://www.ecco0ibd.eu/index.php/publications/congress0abstract0s/abstracts02014/item/p6300epidemiological0and0phenotypic0characteristics0of0ibd0patients0in0romania0results0of0a0nationwide0hospital0based0registry.html;;!9.!P626!Extraintestinal!manifestations!in!Romanian!IBD!patients!–!evaluation!of!a!cohort!of!over!1000!patients!R.!Iacob!,!L.!Guinea!,!R.!Vadan!,!M.!Greere!,!C.!Preda!,!D.&Dobru!,!C.!Cijevschi5Prelipcean!,!A.!Tantau!,!A.!Goldis!,!M.!Ilie!,!M.!Andrei!,!L.!Negreanu!,!C.!Gheorghe!,!M.!Diculescu!,!L.!Gheorghe!,!on!behalf!of!the!IBDPROSPECT!Study!Group!Journal!of!Crohn!and!Colitis!(2014)!8!(Supplement!1):!S331!!DOI:http://dx.doi.org/10.1016/S187359946(14)6074657!S331!!First!published!online:!1!February!2014!https://www.ecco0ibd.eu/index.php/publications/congress0abstract0s/abstracts02014/item/p6260extraintestinal0manifestations0in0romanian0ibd0patients0evaluation0of0a0cohort0of0over010000patients.html;!10.!P590!The!features!of!IBD!in!young!patients!–!evaluation!of!a!batch!of!more!than!1,000!patients!A.!Goldis!,!D.&Dobru!,!L.!Gheorghe!,!C.!Gheorghe!,!C.!Chijevschi!,!M.!Tantau!,!G.!Constantinescu!,!I.!Ratiu!,!D.!Lazar!,!R.!Iacob!,!M.!Diculescu!!Journal!of!Crohns!an!Colitis,!Volume!8,!Issue!Supplement!1,!1!February!2014!!DOI:!http://dx.doi.org/10.1016/S187359946(14)6071058!!S314!First!published!online:!1!February!2014!https://www.ecco0ibd.eu/index.php/publications/congress0abstract0s/abstracts02014/item/p5900the0features0of0ibd0in0young0patients0evaluation0of0a0batch0of0more0than010000patients.html;!11.!Is!anamia!a!prognostic!factor!for!disease!behaviour!in!IBD!?!A!Romanian!National!Register!based!evidence!study!.!A!Lupu!,!C.Cijevski!,!C!Mihai!,!R!Iacob!,!L!Gheorghe!,!D.Dobru&,!A!Tantau!,Goldis,!M.!Ilie,!C.!Gheorghe,!M.!Ciocirlan,!M.!Diculescu,!Journal!of!Crohns!an!Colitis!8!(!Supplement!1!)!,!S1455S146!!DOI:!http://dx.doi.org/10.1016/S187359946(14)6032154!!First!published!online:!1!February!2014!Impact!factor!:!6.234!https://www.ecco0ibd.eu/index.php/publications/congress0abstract0s/abstracts02014/;!!12.L.!Gheorghe,!R.!Iacob,!S.!Iacob,!R.!Vadan,!L.!Guinea,!M.!Greere,!B.!Cotruta,&D.&Dobru,!C.!Mihai,!G.!Stefanescu,!R.!Zaharie,!M.!Ilie,!M.!Jinga,!M.!Diculescu,!C.!Gheorghe.!IBD!in!elderly!Romanian!patients:!epidemiological!and!phenotypical!characteristics!Journal!of!Crohns!and!Colitis!,Volume!8,!Issue!Supplement!1,!1!February!2014!DOI:!http://dx.doi.org/10.1016/S187359946(14)6074056!S3285S329!First!published!online:!1!February!2014!https://www.ecco0ibd.eu/index.php/publications/congress0abstract0s/abstracts02014/!!13.PP366!PREVALENCE!OF!MALNUTRITION!IN!PATIENTS!REFERRED!TO!TERTIARY!GASTROENTEROLOGY!ASSISTANCE!IN!ROMANIA:!A!MULTICENTRIC!STUDY!C.!Gheroghe,!O.!Pascu,!R.!Iacob,!L.S.!Gheorghe,!A.!Goldis,!M.!Tantau,!E.!Dumitru,!D.&Dobru,!E.!Miutescu,!S.!Iacob,!R.!Vadan,!A.!Saftoiu,!A.!Fraticiu,!I.!Bancila,!M.!Diculescu!Clinical!Nutrition!,Volume!5,!Issue!2,!Page!166!,!2010!DOI:!http://dx.doi.org/10.1016/S174451161(10)7044155!

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!!14.!Razvan!Iacob!,!Roxana!Vadan!,!Irma!Eva!Csiki!,!Liana!Gheorghe!,!Cristina!Cijevschi!,!Anca!Trifan!,!Daniela&Dobru!,!Marcel!Tantau!,Adrian!Goldis!,!Gabriel!Constaninescu!,!Mircea!Diculescu!.!Phenotypical!Characteristics!of!Romanian!IBD!patients!according!to!residence!area:!results!of!a!nationwide!multicentric!cohort.!Journal!of!Gastrointestinal!and!liver!disease!,!june!2015!Vol!24!Suppl.1!!15.!Saracut!Claudiu!,!Copotoiu!Constantin!,!Molnar!Calin!,!Rusu!Cristian!,!Turdean!Sabin!,!Dobru&Daniela&.!The!exposure!to!secondary!bile!acids!of!the!mouse!colon!induces!flat!adenomas!and!colitis5!experimental!study.!!Journal!of!Gastrointestinal!and!liver!disease!,!june!2015!Vol!24!Suppl.1!!16.!Gabriella!Gabos!,!Daniela&Dobru!,!Dumitru!Moldovan!.!First!laparoscopic!recording!during!an!abdominal!attack!due!to!hereditary!angioedema!.Journal!of!Gastrointestinal!and!liver!disease!,!june!2015!Vol!24!Suppl.1!!17.Ioan!Sporea,!Alina!Popescu,!Simona!Bota,!Carmen!Dorobăț,!Manuela!Curescu!,!Cristina!Cijevschi!Prelipcean,!Ciprian!Brisc,!Carmen!Fierbințeanu5Braticevici,!Dana&Dobru,!Petru!Mircea,!Roberta!Mânzat,!Felix!Bende!How!Is!LIver!fIbrosIs!evaluated!In!chronIc!B!and!c!hepatItIs!PatIents!In!daily!clInIcal!PractIce?!–!a!romanIan!multIcenter!study!Supplement!1!Journal!of!Gastrointestinal!and!Liver!Diseases!5!vol.!22!June/2013!!18.Vlad!Borhidi,!Silvia!Draşoveanu,!Bela!Kozma,!Mădălina!Petruț,!Lajos!Nagy,!Olga!Brusnic,!Daniela&Dobru&Real!TIme!evaluatIon!of!colonIc!polyps!usIng!NBI!endoscopy!Supplement!1!Journal!of!Gastrointestinal!and!Liver!Diseases!5!vol.!22!June/2013!!19.Ioan!Sporea,!Alina!Popescu1,!Tudor!Moga,!Cristian!Gheorghe,!Mircea!Diculescu,!Gabriel!Constantinescu,!Cristina!Cijevschi!Prelipcean,!Mariana!Jinga,!Nicolaie!Tudor,!Radu!Voiosu,!Daniela&Dobru,!Adrian!Săftoiu,!Dan!Gheonea,!Petru!Mircea1,!Simona!Vălean,!Dan!Dumitraşcu,!Ligia!Bancu,!Simona!Băţagă,!Eftimie!Miuţescu,!Valentina!Cleescu,!Carmen!Fierbințeanu5Braticevici,!Ion!Dina,!Ciprian!Brisc,!Ovidiu!Frăţilă,!Augustin!Lenghel,!Eugen!Dumitru,!Ioan!Demeter,!Nadia!Ignat,!Felicia!Coman,!Dorina!Chişevescu!The!PractIce!of!colonoscopy!In!RomanIa!In!2011!and!2012!5a!multIcentre!study!Supplement!1!Journal!of!Gastrointestinal!and!Liver!Diseases!5!vol.!22!June/2013!!20.Mădălina!Petruț,Alina!Boeriu,!Danusia!Onișor,Ofelia!Pascarenco,Daniela&Dobru&Case!report:!Optical!diagnosis!of!sessile!serrated!adenomas!and!polyps!using!the!WASP!!classification!.!Journal!of!Gastrointestinal!and!Liver!Diseases!,June!2016!Vol!25!Suppl!2!!21.Olga!Brusnic,!Danusia!Onisor,!Silvia!Drasovean,!Alina!Boeriu,Daniela&Dobru&Utility!and!significance!of!pANCA!and!!ASCA!in!patients!with!inflammatory!bowel!disease.!Journal!of!Gastrointestinal!and!Liver!Diseases!,June!2016!Vol!25!Suppl!2!!22.Danusia!Onișor,!Alina!Boeriu,!Olga!Brusnic,!Silvia!Drasoveanu,!Madalina!Petrut,!Daniela&Dobru&Secondary!giant!inflammatory!rectosigmoid!polyps!caused!by!Crohn’s!disease!–a!case!presentation!Journal!of!Gastrointestinal!and!Liver!Diseases!,June!2016!Vol!25!Suppl!2!

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!23.Alina!Boeriu,!Danusia!Onișor,!Olga!Brusnic,!Mădălina!Petruț,!Daniela&Dobru&Optical!diagnosis!of!colonic!polyps!by!using!narrow5band!imaging!magnifying!endoscopy.!Journal!of!Gastrointestinal!and!Liver!Diseases!,June!2016!Vol!25!Suppl!2!!24.Silvia!Drasovean,!Ofelia!Pascarenco,!Danusia!Onișor,!Olga!Brusnic,!Daniela&Dobru&Gastric!xanthomas:!a!case!report!Journal!of!Gastrointestinal!and!Liver!Diseases!,June!2016!Vol!25!Suppl!2!!25.!Pimentel5Nunes,D.!Libanio!,J.!Lage,D.!Abrantes,!M.!Coimbra!,G.!Esposito,!D.!Hormozdi,!M.!Pepper,!S.!Drasovean,!J.!White,!D.&Dobru,J.!Buxbaum,!K.!Ragunath,!B.!Annibale,!M.!Dinis5Ribeiro!P1354!A!MULTICENTRE!PROSPECTIVE!STUDY!OF!THE!REAL!TIME!USE!OF!NBI!IN!THE!DIAGNOSIS!OF!PREMALIGNANT!GASTRIC!CONDITIONS!AND!LESIONS!United!European!Gastroenterology!Journal!3(5S),2015!http://ueg.sagepub.com/content/3/5_suppl/146.full.pdf+html;!!26.!Alexandru!Lupu!,!Robu!Georgiana!,!Cristina!Cijevschi!,!Mihai!C!,!Razvan!Iacob!,!Liana!Gheorghe!,!Daniela!Dobru!,!Alina!tantau!,!Adrian!Goldis!,!M.Ilie!,!Cristian!Gheorghe!,!Mihai!Ciocarlan!,!Roxana!vadan.!Anemia!la!pacientii!cu!BII5!rezultatele!analizei!IBD!prospect!timp!de!un!an!.!!Gastrointestinal!and!Liver!Diseases!2014;!23!(Suppl.1):!105,!ISSN!184158724,!pg21!FI:1,849!!27.!Adrian!Goldis!,!Cristina!Chijevschi!,!Liana!Gheorghe!,!Cristian!Gheorghe!,!Daniela!Dobru!,!Alina!Tantau!,!Razvan!iacob!,!Mircea!Diculescu!.!Are!there!any!geographical!differences!in!IBd!features!in!Romania!?!Gastrointestinal!and!Liver!Diseases!2014;!23!(Suppl.1):!105,!ISSN!184158724,!pg72!FI:1,849!!28.!Gheorghe!Cristian!,!Dimitriu!Anca!,!Iacob!razvan!,!Cojocaru!Monica!,!radu!Cristina!,!Vadan!Roxana,!daniela!Dobru!,!Lupei!Cristina!,!Trifan!Anca!,!tantau!Marcel!,!Goldis!Adrian!,!Constantinescu!Gabriel!,!Gologan!Serban!,!Mateescu!Bogdan!.!Epidemiological!and!phenotypic!characteristics!of!IBD!patients!in!Romania!5!results!of!a!nationalwide!hospital5!based!registry.!Gastrointestinal!and!Liver!Diseases!2014;!23!(Suppl.1):!105,!ISSN!184158724,!pg41!FI:1,849!!!Rezumate&in&reviste&,volumele&unor&manifestări&ştiinţifice&cu&ISBN/ISSN&&1.Boeriu!A,!Borhidi!V,!Onișor!D,!Brusnic!O,!Dobru!D.!The!usefulness!of!narrow!band!imaging!colonoscopy!in!the!evaluation!of!colorectal!polyps.!Acta!Medica!Marisiensis!2013,59(Suppl4):38,ISSN2068(3324!2.Boeriu!A,!Dobru!D,!Pascarenco!O,!Onișor!D,Brusnic!O,!Drașoveanu!S,!Mocan!S.!Clinical!applications!of!magnification!endoscopy!with!narrow!band!imaging.!Acta!Medica!Marisiensis!2012,58(Suppl3):40,ISSN!2068(3324!3.Diac!AR,!Brusnic!O,!Onișor!D,!Gaboș!G,!Drașoveanu!S,!Boeriu&!A,!Dobru!D.!The!assessment!of!the!colo5rectal!polyps!in!order!to!the!new!diagnostic!and!therapeutic!strategies.Acta!MedicaMarisiensis2014,60(Suppl4):19,ISSN2068(3324!4.!Pop!C,Kozma!B,!Drașovean!S,!Dobru!D,!Boeriu&!A.!Predictors!of!hepatocellular!

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carcinoma!in!patients!with!liver!cirrhosis.Acta!Medica!Marisiensis!2014,!60!(Suppl4):!23,ISSN!206853324!5.!DrașoveanS,!Morărașu!D,!Pascarenco!O,!Brusnic!O,!Onișor!D,!Boeriu&!A,!DobruD.!Gastric!intestinal!metaplasia:!prevalence,!clinical,!endoscopic!and!histological!features.Acta!Medica!Marisiensis!2014,!60!(Suppl!4):!24,!ISSN!206853324!6.!Onișor!D,!Boeriu&!A,!Brusnic!O,!Pascarenco!O,!DiacR,!DrașoveanuS,Dobru!D.!Predictive!factors!for!the!malignancy!of!gastric!ulcers.!Acta!Medica!Marisiensis!2014,!60(Suppl4):91,ISSN206853324!7.!BrusnicO,!BoeriuA,!Pascarenco!O,!Onisor!D,!Diac!R,!Drasoveanu!S,Dobru!D.!Predictive!factors!of!antiviral!treatment!response!in!chronic!!viral!!hepatitis!B!and!C.!Acta!Medica!Marisiensis!2014,!60!(Suppl!4):91(92,ISSN!206853324!!!!!GRANTURI&CASTIGATE&PRIN&COMPETITIE&&&1.PROIECT!DE!CERCETARE!PE!BAZĂ!DE!CONTRACT!între!UMF!Tg.Mureş!şi!AstraZeneca!,!reprezentanţa!România!–!DIRECTOR!DE!PROIECT!Titlul!:!„Supportive!Test!for!Acid!Related!Symptoms!with!esomeprazol!and!following!75week,!double!blind!,!randomized!,!placebo!controlled!tretment!period!in!subjects!with!upper!gastrointestinal!„!Valoare!:!300!de!euro!Perioada!:!Sept.20045!Dec.!2005!!2.!GRANT!CEEX!MODUL!I!(proiecte!de!dezvoltare!–!cercetare!complexe!)!–!DIRECTOR!DE!PROIECT!Titlu!:!OPTIMIZAREA!DIAGNOSTICULUI!PRECOCE!ŞI!TERAPIEI!CANCERULUI!INCIPIENT!DE!TUB!DIGESTIV!SUPERIOR!ÎN!CONTEXTUL!CROMODIAGNOSTICULUI!ŞI!A!ENDOSCOPIEI!CU!MAGNIFICAŢIE.!VALOARE!:!11644000000!ROL!CONTRACT!NR.68/!2006!Perioada!de!derulare!:!1.!sep.2006531.aug.2008!!3.!GRANT!STRUCTURAT!IMPACT!CU!ACCESARE!DE!FONDURI!EUROPENE!,!domeniul!de!intervenţie!D2!,operaţiunea!O.2.1.!–!DIRECTOR!DE!PROIECT!Titlu!:!CENTRU!DE!CERCETARE!A!PREVENTIEI!NEOPLAZIILOR!DE!TUB!DIGESTIV!PRIN!SISTEM!INFORMATIONAL!DE!TELEDIAGNOSTIC!2007!,!sesiunea!ianuarie!VALOARE!:!300000!euro!Perioada!de!derulare!:!200752009!!4.!Proiect!de!cercetare!câștigat!în!competiția!20115Program!IDEI_Workshop5uri!exploratorii=!Perspective!de!viitor!în!endoscopia!digestivă!superioară:!contribuția!noilor!tehnici!imagistice!Cod!înregistrare!WE:!PN5II5ID5WE520115051!Instituția=!UMF!Tîrgu!Mureș!Statutul!în!proiect=!MEMBRU!!

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5.!!Grant!de!cercetare!cu!finantare!privata!:Importanța!și!rolul!aparatelor!de!sutură!mecanică!în!chirurgia!abdominală!5!impactul!asupra!stării!de!sănătate!a!pacienților.!5!2015!5!1478/10.02.2015!Membru!!!PROIECTE&ATRIBUITE&!GRANT!POSTDOCTORAL!in!domeniul!:!Cercetari!clinice!si!fundamentale!in!diagnos!t!icul!si!tratamentul!oncologic!.!Tema!:!Studiul!clinic!,!endoscopoc!,!histologic!,!al!leziunilor!premaligne!si!maligne!de!tract!digestiv!superior!.!Cercetare!interdisciplinara!"!cod!contract!:!POSDRU/89/1.5/S/60782!Beneficiar!:!UMF!Tg.Mures!Statutul!în!proiect!:TUTORE!CERCETATOR!POSTDOCTORAL!!!!!STUDII&NATIONALE&,&INVESTIGATOR&PRINCIPAL&1.!Studiu!naţional!multicentric!iniţiat!de!Societatea!Română!de!Endoscopie!Digestivă!(!SRGE!)!:!Studiu!epidemiologic!al!cancerului!gastric!în!cadrul!populaţiei!adulte!ce!apelează!la!serviciile!de!gastroenterologie!în!România!,!.5!2004!13!2.!Studiu!naţional!multicentric!iniţiat!de!Societatea!Română!de!Endoscopie!Digestivă!:!Studiu!naţional!multicentric!privind!incidenţa!şi!prevalenţa!Esofagului!Barett!în!România!–!2004!3.!Studiu!naţional!multicentric!iniţiat!de!Societatea!Română!de!Endoscopie!Digestivă!:!Prevalenţa!malnutriţiei!la!pacienţii!ce!se!adresează!serviciilor!de!asistenţă!medicală!terţiară!de!gastroenterologie!din!România!“!5!2004!4.!Studiu!naţional!multicentric!iniţiat!de!Societatea!Română!de!Endoscopie!Digestivă!:!Studiu!multicentric!prospectiv!privind!mortalitatea!prin!HDS!în!România!–!2004!5.!Studiu!naţional!multicentric!iniţiat!de!Societatea!Română!de!Endoscopie!Digestivă!:!Studiu!epidemiologic!al!bolilor!inflamatorii!intestinale!idiopatice!(!RCUH!şi!Boală!Crohn!)!în!cadrul!populaţiei!adulte!ce!apelează!la!serviciile!de!gastroenterologie!,!în!România!,!5!2003!6.!The!prevalence!of!Coeliac!Disease!at!Endoscopy!Units!in!Romania!:!Routine!Biopsies!during!Gastroscopy!are!Mandatory!(!A!Multicentre!Study!)!52002!!STUDII&INTERNATIONALE,&INVESTIGATOR&PRINCIPAL&1!Studiul!internaţional!:!“Randomised!,!comparative!,!double5!blind!,!parallel!group!,!multicentre!Phase!III!Study!to!eradicate!Helicobacter!Pylori!,!heal!gastric!ulcer!and!prevent!relapse!in!gastric!ulcer!subjects!with!esomeprazol!in!combination!with!amoxicilin!and!clarithromicin!“!–!investigator!principal!,!2004!2!Studiu!internaţional!:.!“SR121463!B!in!Cirrhotic!Ascites!Treatment!with!Hyponatriemia!:!A!placebo5!controlled!,!dose!–comparison!study”!–!investigator!principal!,!2004!3!Studiu!internaţional!:!“!Study!for!the!Prevention!of!Ascitis!(!SPA)!:!Comparison!of!fixed!doses!of!SR121463!B!versus!placebo!in!the!reduction!of!recurrence!of!cirrhotic!ascites”!–!investigator!principal,!2004!4.Studiu!internaţional!:!Randomised!Multicentre!,!Placebo5!Controlled!Study!to!Assess!the!Efficacy!and!Optimal!Duration!of!Lamivudine!Treatment!in!Precore!Mutant!HBV.5!investigator!principal!,!2002!

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5.Studiu!internaţional!:!Supportive!Test!for!Acid!Related!Symptoms!(!STARS!I!)!with!esomeprazol!and!following!75week!,!double!blind!,!randomized!,!placebo!controlled!treatment!period!in!subjects!with!upper!gastrointestinal!symptoms!and!with!normal!findings!at!esophagogastroduodenoscopy.!,!200352004!,!investigator!principal!6.!Studiul!internaţional!:Lamrom!4001!(!faza!III!B!).5!investigator!principal!,!200252005!7.!Studiu!internaţional!:!SR!121463B!in!ascita!cronică!cu!hiponatriemie!(!expo5CAT!)!:!studiu!cu!tratament!pe!termen!lung!simplu5orb!,!placebocontrolat!–!martie!20055aprilie!2007!8.Studiu!internaţional!:!SR!121463!B!în!tratamentul!ascitei!cronice!cu!hiponatriemie!(!Hypo!CAT!)!,!studiu!cu!doze!comparabile!,!placebocontrolat.!–!nov.20045martie2005!9.!Studiu!internaţional!:Multicenter!,!double5blind!,!double!–!dummy!,!controlled!,!randomised!phase!III!study!on!the!tolerability!and!efficacy!of!Diclofenac!Sodium!150!mg!o.d.!in!comparison!to!Voltaren!50!mg!tid!and!Voltaren!Dispers!tid!in!patients!with!osteoartritis!of!the!hip!,!knee!or!fingers!over!a!treatment!of!two!weeks.,!mai5octombrie!2005!10.!Studiu!internaţional!:A!randomised!,!double!–blind!,!parallel5group!,!placebo!controlled!study!od!esomeprazole!i.v.(!bolus!infusion!of!80!mg!followed!by!a!continous!infusion!of!8!mg!per!our!)!administered!for!72!hours!to!assess!prevention!of!rebleeding!in!subjects!that!have!undergone!successful!primary!endoscopic!haemostasis!of!bleeding!peptic!ulcer.5!ian.20065!martie!2007!11.Studiu!internaţional!de!fază!III!,!multicentric!,!randomizat!,!dublu5orb!,!placebocontrolat!,!pe!grupuri!paralele!asupra!eficacităţii!şi!siguranţei!tabletelor!OPC56535!în!tratamentul!subiecţilor!cu!colită!ulceroasă!activă.!,!ianuarie5mai!2006!12.!Studiu!international!:!CATS5!Satavaptan!(SR121463!B)!Cirrhotic!Ascites!Treatment!Study!:!a!double!–!blind!,!randomized!,!parallel5group!comparison!treatment!with!satavaptan!at!5!to!10!mg!daily!versus!placebo!on!top!of!conventional!treatment!in!patients!with!ascites!due!to!cirrhosis!of!the!liver—Sanofi!Aventis!:!noiembrie!20065!2008!13.!Studiu!international!:!SPARe525!Satavaptan!(SR121463!B)!Cirrhotic!Ascites!Treatment!Study!:!a!double!–!blind!,!randomized!,!parallel5group!comparison!treatment!with!satavaptan!at!5!to!10!mg!daily!versus!placebo!in!the!absence!of!diuretics!in!patients!with!recurrent!ascites!due!to!cirrhosis!of!the!liver5!Sanofi!Aventis:!noiembrie!2006!5!2009!14.!Studiu!international!:!Sym!To5!A!randomized,!duble!–blind!,!placebo!controlled!,!multicentre!phase!IIA!study!to!assess!the!effect!on!GERD!symptoms,!pharmacokinetics,!safety!and!tolerability!of!four!weeks!treatment!with!AZD!3355,!65!mg!bid!as!add5on!treatment!to!PPI!in!patient!with!an!incomplete!response!to!PPI!treatment!–!ianuarie!2007!5!2009!15.!Studiu!international!:!Obelix!–!A!randomized,!double!–blind!,!parallel5!group,!multicentre,!phase!III!study!to!assess!the!effect!of!omeprazole!20!and!40!mg!od!versus!placebo!on!the!occurrence!of!peptic!ulcers!during!26!weeks!in!subjects!on!continous!low!dose!acetylsalicylic!acid!(ASA).5!martie!2007!16.A!phase!2!,!Double5blinded,!Placebo5controlled,!Randomized,!Multi5center!Study!of!MDX51100!(anti5CXCL10!Human!Monoclonal!Antibody)!in!subjects!with!active!ulcerative!colitis!Aug!2007!–!Nov!2009!17.!SPD4765304:!A!phase!III,!randomized,!multi5center,!double5blinded,!parallel!group,!active!comparator!study!to!compare!the!efficacy!and!safety!of!SPD476!(mesalazine)!2.4g/day!once!daily!(QD)!versus!Asacol!1.6g/day!twice!daily!(BID)!in!the!maintenance!of!remission!in!patients!with!ulcerative!colitis!Mai!2008!–!Nov!2009!18.Efficacy!and!safety!of!oral!Budesonide5MMX!3mg!and!9!mg!extended!release!tablets!(CB501502)!in!subjects!with!mild!or!moderate!active!ulcerative!colitis.!a!pilot!dose5finding!multicentre!comparative!study!versus!placebo!Ian!2009!5!Dec!2009!

18

20.A!125week,!randomized,!double5blinded,!placebo5controled,!multi5center,!phase!II5b!dose!finding!study!to!asses!the!effect!of!GERD!symptoms,!safety!and!tolerability!during!four!weeks!treatment!with!AZD3355!in!doses:!60mg,!120mg,!180mg,!and!240mg!BID!as!add5on!treatment!to!a!PPI!in!patients!with!GERD!that!are!partially!responders!to!PPI!treatment!Sep!2009!–!Aug!2010!21.A!Phase!III,!Randomized,!Double5Blind,!Dose5Response,!Stratified,!Placebo5Controlled,!Study!Evaluating!the!Safety!and!Efficacy!of!SPD476!versus!Placebo!over!104!Weeks!in!the!Prevention!of!Recurrence!of!Diverticulitis!Jun!2009!5!Feb!2012!22.A!Phase!II/III,!Multicenter,!Randomized,!Placebo5Controlled,!Double5Blind!Study!to!Evaluate!the!Safety!and!Efficacy!of!Golimumab!induction!therapy!administered!intravenously!in!subjects!with!moderately!to!severely!active!ulcerative!colitis!Feb!2010!–!Feb!2011!23.Randomised,!Double5Blind!study!of!Nitazoxanide!plus!PegInterferon!alfa52a!and!Ribavirin!or!Nitazoxanide!plus!Peginterferon!alfa52a!without!Ribavirin!compared!to!Placebo!plus!Peginterferon!alfa52a!and!Ribavirin!in!treatment!naive!patients!with!Chronic!Hepatitis!C!Genotype!1!Sep!2010!–!Dec!2011!24.A!Phase!II/III,!Multicenter,!Randomized,!Placebo5Controlled,!Double5Blind!Study!to!Evaluate!the!Safety!and!Efficacy!of!Golimumab!mentenancy!therapy!administered!subcutanously!in!subjects!with!moderately!to!severely!active!ulcerative!colitis!Feb!2011!–!Feb!2015!25.A!phase!3b/4,!open5label,!prospective!study!to!evaluate!the!effect!of!remission!status!on!the!ability!to!maintenance!or!achieve!clinical!and!endoscopic!remission!during!a!125month,!long5term!maintenance!phase!with!2,4!g/day!MMXÒ!mesalamine/Mesalazine!once!daily!in!adult!subjects!with!ulcerative!colitis!Feb!2011!–!Jan!2013!26.A!phase!III,!randomised,!open5label,!active5controlled!trial!comparing!xxxx!with!xxxx!for!the!treatment!of!iron!deficiency!anemia!Apr!2011!–!Jan!2012!27.A!randomised,!double5blind,!placebo5controlled!trial!to!evaluate!the!efficacy,!quality!of!life,!safety!and!tolerability!of!long5term!treatment!(24!weeks)!with!prucalopride!in!subjects!aged!≥18!years!with!chronic!constipation!Mai!2011!–!Feb!2013!28.Phase!III,!Parallel5group,!Placebo!Controlled,!Double5blind,!Randomized,!Multicentre!International!Study!to!Investigate!the!Safety!and!Efficacy!of!Propionyl5L5carnitine!Hydrochloride!(ST!261)!Modified!Release!Tablets!in!Patients!Affected!by!Mild!Ulcerative!Colitis!under!Oral!Stable!Treatment!Mart.!2012!–!Oct.!2013!29.!A!Multicentre!Randomized!Double5blind!Placebo!Controlled,!Parallel!group!Study!of!oral!CP!690,550!as!an!Induction!Therapy!in!Subjects!with!Moderate!to!Severe!Ulcerative!Colitis!Apr!2013!–!Mar!2015!30.A!125Week!Double5Blind,!Randomized,!Placebo5Controlled!Parallel5!Group!Phase!Iii!Study,!Followed!By!A!45Week!Randomized!Withdrawal!Period!To!Evaluate!The!Efficacy!And!Safety!Of!Oral!Ibodutant!10!Mg!Once!Daily!In!Female!Patients!With!Irritable!Bowel!Syndrome!With!Diarrhea!(IBS5D)!19!Jun!2014!–!13!Ian!2015!31.An!Open5Label,!Multicenter,!Efficacy!And!Safety!Study!To!Evaluate!Two!Treatment!Algorithms!In!Subjects!With!Moderate!To!Severe!Crohn’s!Disease!