Curs Tesut epitelial Studenti(2015)
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Transcript of Curs Tesut epitelial Studenti(2015)
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ESUTUL
EPITELIAL
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ESUTUL EPITELIAL(epi = pe, deasupra thele = ridictur, mamelon)
Mase celulare compacte
www.udel.edu/biology
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Epiteliile au o suprafa: liber
n raport cu esutconjunctiv membranbazal
ESUTUL EPITELIAL
MB
http://cnx.org
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ESUTUL EPITELOID
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ESUTUL EPITELIALmare diversitate ca form
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Forme celularecilindric
(columnar,prismatic)
cubic
turtit(scuamoas,
pavimentoas)
poliedre
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Forme nucleare
ovoidal
rotund
turtit
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Limitele celulare ?ESUTUL EPITELIAL
http:/www.kidneypathology.com
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ESUTUL EPITELIAL
mare diversitate ca funcie formeaznveliuri membranare asigurtransport selectiv de substane
ntrn structura organelor solide /spongioase rol senzorial rol contractil
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Ectoderm-epiderm i derivatele sale- glandele tegumentare- glande mamare- epiteliul bucal, anal, nazal- corneea- adenohipofiza
Mezoderm-endoteliu- mezoteliu- epiteliul tubilor uriniferi
- epiteliul cilor genitale- CSR
Endoderm
- epiteliul tubului digestiv- glandele digestive- epiteliul aparatului respirator- tiroida, paratiroidele, timusul
ESUTUL EPITELIAL- Origine embriologic-
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vascularizaie
inervaie regenerare metaplazie
ESUTUL EPITELIAL
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VASCULARIZAIA EPITELIILOR
http://ocw.tufts.edu
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Stria vascularis
www.cram.com
VASCULARIZAIA EPITELIILOR
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INERVAIA EPITELIILOR- Senzitiv
! Absena terminaiilor nervoasepentru durere:
epiteliul gastric i intestinal
epiteliul colului uterin
- Motorie
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REGENERAREA EPITELIILOR
agresiuni din mediu mecanisme dereparare i rennoire
celule stem adulte activitate mitoticnentrerupt
localizare
rata de nlocuire:
- rapid- lent
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CARACTERISTICILE CELULEISTEM ADULTE
- Capacitatea de autoreplicare- Multipotena
- Reconstrucia esutului
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Diviziune asimetric
CARACTERISTICILE CELULEISTEM ADULTE
http://www.stembook.org
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IDENTIFICAREACELULEI STEM ADULT
- marcarea materialului genetic- precursori radioactivi (timidina tritiat)
- imunocitochimie- nucleozide sintetice (bromodeoxiuridina)
- marker de suprafa(CD34+, integrin6-)
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IDENTIFICAREA
CELULEI STEM ADULTPRIN ICC
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REGENERAREA EPITELIILOR- celule stem izolate-
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REGENERAREA EPITELIILOR- zone germinative cu celule stem -
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REGENERAREA EPITELIILOR- strat bazal (germinativ) -
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METAPLAZIA ESUTULUIEPITELIAL
- metaplazie pavimentoas-
http://www.eurocitology.eu
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CLASIFICAREA EPITELIILOR
A. Epitelii de acoperire
B. Epitelii glandulareC. Epitelii senzoriale
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EPITELII DE ACOPERIRE
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EPITELII DE ACOPERIREClasificare:
1. dupnumrul de straturi celulare2. dupforma celulelor
A. Epitelii simple B. Epitelii stratificate
- pavimentoase - pavimentoase
cheratinizat
necheratinizat
- cubice - cubice
- cilindrice - cilindrice
Rol:
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- endoteliu: epiteliul care cptueste vaselesangvine i limfatice- mezoteliu: epiteliul care intra n alctuirea
seroaselor
Epiteliu simplu pavimentos
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Epiteliu pseudostratificat cilindric
www.nku.edu
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Epiteliu pseudostratificat cilindric
http://www.stegen.k12.mo.us
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Epiteliu pseudostratificat cilindric
http:/medcell.med.yale.edu
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Epiteliu de tranziie
(uroteliu, epiteliu polimorf)
www.nku.edu
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Epiteliul cilor urinare
Epiteliu de tranziie
(uroteliu, epiteliu polimorf)
http:/www.gettyimages.com
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Epiteliu de tranziie
(uroteliu, epiteliu polimorf)
http://canvasworksneedlepoint.com
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Epiteliu de tranziie
(uroteliu, epiteliu polimorf)
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
http://canvasworksneedlepoint.com
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EPITELII GLANDULARE
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ELIMINAREA PRODUSULUI DE
SECREIE1. celulexocrinn mediul extern
2. celulendocrinn mediul intern
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HISTOGENEZA EPITELIULUIGLANDULAR
Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005
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GLANDE- exocrine
- endocrine- mixte (amficrine)
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CLASIFICAREA GLANDELOREXOCRINE
1. Structural:a. dup numrul de celule
- glande unicelulare celula caliciform- glande multicelulare
localizate ntr-un epiteliu de nveli
epiteliu secretor de nveli
grupuri compacte (acini, tubi)
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Glandunicelular
Leslie P.Gartner, James L.Hiatt Color Atlas of Histology, Fifth Edition, 2010
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Glandintraepitelial
Leslie P.Gartner, James L.Hiatt Color Atlas of Histology, Fifth Edition, 2010
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Epiteliu secretor
http://citochemistry.net
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Glandmulticelular
http//medicinembbs.blogspot.ro
CLASIFICAREA GLANDELOR
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CLASIFICAREA GLANDELOR
EXOCRINE1. Structural:
b. dupaspectul sistemului canalicular simple
compuse
CLASIFICAREA GLANDELOR
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CLASIFICAREA GLANDELOR
EXOCRINE1. Structural:
c. dupaspectul adenomerului tubulare
acinoase sau alveolare
tubuloacinoase sau tubuloalveolare
CLASIFICAREA GLANDELOR
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CLASIFICAREA GLANDELOR
EXOCRINE
Leslie P.Gartner, James L.Hiatt Color textbook of Histology, Third Edition, 2007
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CLASIFICAREA GLANDELOREXOCRINE
2. Dupnatura produsului de secreie:- glande cu secreie mucoas
- glande cu secreie seroas
- glande cu secreie mixt muco-seroas
sero-mucoas
- glande cu secreie uleioas
CLASIFICAREA GLANDELOR
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CLASIFICAREA GLANDELOR
EXOCRINE3. Dupmecanismul de excreie:
a. glande merocrine (meros, parte)- majoritatea glandelor exocrine
b. glande apocrine (apo, din)- glandele mamare
- glandele ceruminoase- glandele Moll
c. glande holocrine (holos, tot)
- glandele sebacee
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GLANDELE ENDOCRINE
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GLANDELE ENDOCRINE- lipsete sistemul canalicular
- majoritatea sunt de origine epitelial > MB- produsul de secreie este eliminat direct
n mediul intern:
- imediat dupsintez
- dupo perioadde stocare
- intracelular granule de secreie- extracelular
CLASIFICAREA GLANDELOR
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CLASIFICAREA GLANDELOR
ENDOCRINE1. Dupmodul de dispunere al celulelor
secretorii:- cuiburi celulare
- cordoane celulare
- foliculi
CLASIFICAREA GLANDELOR
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CLASIFICAREA GLANDELOR
ENDOCRINE1. Dupmodul de dispunere al celulelor
secretorii2. Dupnatura chimica produsuluisintetizat:
- polipeptide mici i amine (SNED)
- polipeptide mari sau proteine/glicoproteine
- steroizi
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GLANDE MIXTE (AMFICRINE)
Funciile exocrini endocrinse pot desfura:
- n segmente secretoare diferite pancreas
- n acelai segment secretor ficat
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PANCREAS
Acini pancreatici
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FICAT
BBBBilililil
---- SomatomedineSomatomedineSomatomedineSomatomedine
---- GHRHGHRHGHRHGHRH
POLARITATEA CELULEI
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POLARITATEA CELULEI
EPITELIALE
Domeniul apical
Domeniul laterobazal
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POLARITATEA CELULEIEPITELIALE
1. Asimetria biochimica domeniilor membranare2. Formarea de jonciuni strnse3. Distribuia componentelor citoscheletuluii a
organitelor celulare4. Stabilirea de interaciuni celulare
1. ASIMETRIA BIOCHIMIC A
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SUPRAFEELOR MEMBRANAREComponenta membranar Membrana apical Membrana laterobazal1. PROTEIN-ENZIME Enzime hidrolitice Na +/K+ATP-aza
2. PROTEINE DETRANSPORT ICANALE IONICE
prezente prezente
3. PROTEINE DE
ADEZIVITATE
absente prezente (caderine,integrine)
4. RECEPTORI HORMONALI abseni insulin, parathormon,factor de cretere
epidermal
5. COLESTEROL crescut sczut6. SFINGOMIELIN crescut sczut
7. FOSFATIDILCOLIN sczut crescut
8. FOSFATIDILINOZITOL sczut crescut
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BOALA RINICHIULUI POLICHISTIC
Redistribuie apicala Na+/K+ ATP-azei i REGF
http://www.pathologyoutlines.com
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2. FORMAREA DE JONCIUNI STRNSE
- secreie- absorbie
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
Jonciunea strns
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Jonciunea strns
(Zonula occludens)
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
Jonciunea strns
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Jonciunea strns
(Zonula occludens)
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
Jonciunea strns
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Jonciunea strns
(Zonula occludens)
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
Jonciunea strns
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(Zonula occludens)- Rol:
- genereazi menine domeniilor membranare- previne micarea laterala proteinelormembranare
- formeaz o barierimpermeabil
3. DISTRIBUIA COMPONENTELORCITOSCHELETULUI I A
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CITOSCHELETULUI I AORGANITELOR CELULARE
EM Fisch, BA Molitoris 1994
3. DISTRIBUIA COMPONENTELORCITOSCHELETULUI I A
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CITOSCHELETULUI I AORGANITELOR CELULARE
Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005
3. DISTRIBUIA COMPONENTELORCITOSCHELETULUI I A
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CITOSCHELETULUI I AORGANITELOR CELULARE
B.Alberts et al. Molecular Biology of the Cell 5th Edition, 2008
4. INTERACIUNI CELULARE
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Molecule de adezivitate celular
contactcelul-celul
contact contactcelul-substrat celul -substrat
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
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4. INTERACIUNI CELULARE
Molecule de adezivitate celular molecule cu activitate Ca
2+dependent
-caderine
- selectine
molecule cu activitate Ca2+ independent
- integrine
- molecule din superfamilia Ig
CADERINA E
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me
mbranaplas
maticl
atera
l
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
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CADERINE
jonciuni de ancorare din domeniul lateral
1. zonula adherens
caderina E
2. macula adherens (desmozom)
desmocolin, desmoglein
Jonciuni de ancorare dindomeniul lateral
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caderina E
desmocolin
desmoglein
filamentde actin
filamenteintermediare
proteine deancorare
citoplasmatice
proteine deancorare
citoplasmatice
Macula adherens(Desmozom)
Zonula adherens
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
INTEGRINE
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membrana plasmaticbazal
laminina, fibronectina
subunitatea
subunitatea
NH2 NH2
COOH COOH
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
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Jonciuni de ancorare dindomeniul bazal
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proteinede ancorare
citoplasmatice
proteinede ancorare
citoplasmatice
filamente intermediare
integrin(64)
colagen XVII
laminin
colagen
filamentde actin
Jonciune de ancorare prin
filamente de actinHemidesmozom
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
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Rolul caderinelor
meninerea integrit
ii straturilor dintr-un
epiteliu asigurrezistena mecanica epiteliului
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Rolul integrinelor
ataarea polului bazal la matricea
extracelular mecanosenzitivitate
!!! eseniale n timpul embriogenezeidisintegrine
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PEMFIGUS VULGARIS
http://www.dermpedia.org
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MEMBRANA BAZAL
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ESUT EPITELIAL
!!!orice epiteliu este ancorat la
esutul
conjunctiv adiacent prin membrana bazal
strat distinct al matriceiextracelulare acelular,
amorf i dens
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MEMBRANA BAZAL Examinare la MO
grosime variat- col.HE- PAS- impregnare argentic
aspect variat- structurliniar- structurondulat
ep. stratificate pavimentoase
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MEMBRANA BAZAL - col HE
http://www.ouhsc.edu
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MEMBRANA BAZAL - PAS
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
MEMBRANA BAZAL
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- Impregnare argentic-
http://www.nature.com
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MEMBRANA BAZAL
Examinare la ME
LAMINA BAZAL
LAMINA RETICULAR
MEMBRANA BAZAL - ME
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http://www.cellimagelibrary.org
1. LAMINA BAZAL
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1. regiune electronotransparent lamina lucida
2. regiune electronodens lamina densa
histology.leeds.ac.uk
1. LAMINA BAZAL
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1. regiune electronotransparent lamina lucida ~ 50 nm domeniile extracelulare ale
moleculelor de adezivitate
- integrine- distroglicani
glicoproteine extracelulare- laminina- entactina
2. regiune electronodens lamina densa
reea de filamente finecolagen tip IV acoperit de perlecan
1. LAMINA BAZAL
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Lamina bazal= Lamina densa ?
!!! Lamina lucida - artefact de fixare?
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
1. LAMINA BAZAL
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- MEMBRANA DE FILTRARE -
Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013
1. LAMINA BAZAL
MEMBRANA ALVEOLO CAPILAR
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- MEMBRANA ALVEOLO-CAPILAR-
Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013
1. LAMINA BAZAL
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structurnumai a esutului epitelial ?
celule asociate cu esut conjunctiv
- celule musculare
- celule Schwann
- celule adipoase
lamina externa
Lamina externa
C l l l C l l S h
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Celula muscular Celula Schwann
http://www.gettyimage.com
1. LAMINA BAZALcompoziie chimic: 50 tipuri de proteine
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- compoziie chimic: ~ 50 tipuri de proteine1. proteine fibroase GP
- laminin- colagen tip IV
- entactin(nidogen)
2. proteoglicani- perlecan heparan sulfat
celule epiteliale
Laminina 1laminin
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laminin
laminin
integrin
distroglican
entactin perlecan
lamininB.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
polimer
de laminin
Molecula de colagen IV
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3 lanuri
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
Colagen IV
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Lanpolipeptidic
(Monomer de colagen IV)
domeniu 7S
domeniu colagenic helicoidaldomeniu NC1
NH2
COOH
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
Colagen IV
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domeniu 7S
domeniu NC1domeniu colagenic helicoidal
trimer NC1
Protomer de colagen IV
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
Colagen IV
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Protomer de colagen IV(3 lanuri )
trimer NC1
hexamer NC1
Dimer de colagen IV
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
Colagen IV
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Dimer de colagen IV
hexamer NC1
Tetramer de colagen IV
7S
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
Colagen IV
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Tetramer de colagen IV
7S
hexamer NC17S
Suprastructura de colagen IV
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
ORGANIZAREA LAMINEIBAZALE
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http://virtuallaboratory.colorado.edu
1. LAMINA BAZAL
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Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
ANCORAREA LAMINEI BAZALELA MATRICEA EXTRACELULAR
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Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
ANCORAREA LAMINEI BAZALELA MATRICEA EXTRACELULAR
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http:mattek.com
2. LAMINA RETICULAR
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colagen tip III
fibre reticulare
colagen tip I
fibre de colagen
fibroblaste
fibroblaste
ROLURILE MEMBRANEI BAZALE
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ROLURILE MEMBRANEI BAZALE Ataarea epiteliului la esutul conjunctiv
Compartimentalizare Bariercu permeabilitate selectiv
! GAG
Menine citoarhitectonica i polaritateaepiteliului Controleazdiferenierea, proliferarea
i migrarea celulelor epiteliale
LAMINA BAZAL
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celulepitelial
laminabazal
colagen
B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008
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I. Celule epiteliale specializate
pentru transport- ioni
- molecule mici- macromolecule
I.1. Celule epiteliale specializate
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Celule epiteliale specializatepentru transport de ioni
pompe ionice
(activitate ATP-azic)
Pompa Na+/K+
(Na+/K+ATP-aza)
Celula epitelial din tubulcontort proximal
P ti l iti t t l
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Particulariti structurale:MO:
- citoplasmacidofil- la polul apical: margine n perie
- la polul bazal: aspect striat
Particulariti structurale
Celula epitelial din tubulcontort proximal
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Particulariti structurale:ME:
numeroi microvili la polul apical invaginri ale membranei plasmatice bazale
creterea suprafeei active membranare(pompa Na+/K+)
mitocondrii alungite cu numeroase criste
jonciuni strnse interdigitaii laterale
Celula epitelial din tubul
contort proximal
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p
Leslie P.Gartner, James L.Hiatt Color Atlas of Histology, Fifth Edition, 2010
Celula epitelial din tubul
contort proximal
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p
R V Krstic Human Microscopic Anatomy, Springer-Verlag,1997
Celula epitelial din tubul
contort proximal
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p
Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011
Celula epitelial din tubulcontort proximal
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H2O Na+
Celula epitelial din tubulcontort proximal
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sensul de transport:
I. Celule epiteliale specializatepentru transport de ioni
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pol apical pol bazal
absorbie
pol bazal pol apical
secreie
- intestin
- vezicula biliar
- canale striate
- TP i TD
- plexuri coroide
- procese ciliare
- gl. sudoripare
II. Celule epiteliale specializate
pentru sintezi secreie
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Duplocul de eliminare a produsului sintetizat:
- celule exocrine- celule endocrine- celule paracrine
Dupnatura produsului sintetizat:- proteine
- glicoproteine- amine i polipeptide mici- lipide
II.1. Celule epiteliale specializate
pentru sintezi secreie deproteine
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p
celulexocrini endocrin rolul proteinelor sintetizate: enzime digestive celule seroase
proteine plasmatice hormoni
secreia de proteine: continu intermitent granule de secreie
P i l i i l
Celula epitelial din acinul
pancreatic
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Particulariti structurale
- MO: polaritate tinctorial(col.HE)
- citoplasma bazofil(pol bazal)
- citoplasma acidofil(pol apical)
Celula epitelial din acinul
pancreatic
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Celula epitelial din acinul
pancreatic
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Celula epitelial din acinul
pancreaticP ti l iti t t l
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Particulariti structurale
- ME: RER subnuclear mitocondrii printre RER
complex Golgi supranuclear granule de secreie n zona apical
Celula epitelial din acinul pancreatic
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Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013
Etapele ciclului secretor ncelula epitelial din acinul
pancreatic
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asimilarea aminoacizilor liberi
sinteza lanului polipeptidic la nivelulribozomilor din RER
acumularea produsului de sintezn CG formarea granulelor de secreie (gr. de zimogen) transportul granulelor de secreie spre polul
apical eliminarea produsului de secreie prin exocitoz
transportulgr. de zimogen
exoc toz
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asimilarea aminoacizilor liberi
sinteza lanului polipeptidic
acumularea produsuluide sintez
formarea gr. de zimogen
II.2. Celule epiteliale specializate pentru
sintezi secreie de glicoproteine celul exocrin i endocrin
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celulexocrini endocrin
localizare: celule exocrine celule mucoase
celula caliciform epitelii de suprafa acini mucoi
celule endocrine celule din adenohipofiz(TSH, Gn)
Particulariti structurale- MO:
Celula caliciform
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formde caliciu (cup)
nucleu pol bazal citoplasma apical aspect vacuolar
gr. de mucin
PAS
Celula caliciform
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Celula caliciform
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Particulariti structurale- ME:
RER subnuclear
Celula caliciform
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RER subnuclear
mitocondrii printre RER complex Golgi supranuclear granule de secreie
destind zona apical rari microvili apicali
proces de secreie
Celula caliciform
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Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013
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II.3. Celule epiteliale specializate
pentru sintezi secreie deamine i polipeptide mici
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celulendocrini paracrin celule APUD (Amine Precursor Uptake
and Decarboxilation)
localizare: distribuie larg
izolate / grupuri mici, intraepitelial
Particulariti structurale
II.3. Celulepitelialspecializatpentrusinteza i secreia de amine
i polipeptide mici
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MO: citoplasma slab bazofil(col.HE)
precipitare cu sruri de argint
(celule argentafine i argirofile)
oxidare cu bicromat de potasiu(celule cromafine)
imunocitochimie:- anticorpi monoclonali
- markeri:- NSE (enolaza neuronalspecific)- cromogranine / secretogranine
hibridizare in situ
II.3. Celulepitelialspecializatpentrusinteza i secreia de amine
i polipeptide mici
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Leslie P.Gartner, James L.Hiatt Color textbook of Histology, Third Edition, 2007
Particulariti structurale
MO
II.3. Celulepitelialspecializatpentrusinteza i secreia de amine
i polipeptide mici
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- MO
- ME:- RER i complex Golgi slab dezvoltate- granule de secreie:
form
variat dimensiune variat
endomembrane, miez dens, halou clar
aglomerate spre polul bazal exocitoz discontinu
PrecursoriAmine
Polipeptide mici
Cromogranine/Secretogranine
ATP, ioni
Celulde tip nchisCelulde tip deschis
II.3. Celulepitelialspecializatpentrusinteza i secreia de amine
i polipeptide mici
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pp
Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013
II.4. Celule epiteliale specializate pentru
sintezi secreie de lipide celulexocrini endocrin
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localizare: celule exocrine glande sebacee (sebum) celule endocrine celule secretoare de
hormoni steroizi: celule interstiiale Leydig (testicul) celule foliculare i luteinice (ovar)
celule din CSR
Celul epitelial secretoare desteroizi
Particulariti structurale
- MO:
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citoplasma - acidofil- aspect vacuolar
picturi lipidice
- precursori ai hormonilor- variaz cantitativ
Celul epitelial secretoare desteroizi
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Particulariti structurale
- MO
Celul epitelial secretoare desteroizi
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- ME: REN mitocondrii cu criste tubulo-veziculare
relaii structurale i funcionale
REN
acetat colesterol pregnenolon
RENhormon sterolic
mitocondrie
Celul epitelial secretoare desteroizi
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Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005
Celul epitelial secretoare desteroizi
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Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005
III. Celule epiteliale cu propieticontractile
(Celule mioepiteliale)
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Localizare: ntre lamina bazali membranaplasmaticbazala celulelor din: glandele lacrimale
glandele salivare glandele mamare glandele sudoripare
adenomeri /ducte
III. Celule mioepiteliale
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http;//en.goldenmap.com
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Bibliografie selectiv: Anthony L.Mescher Junqueira s Basic Histology Text and
Atlas 13th Edition 2013
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Atlas13th Edition, 2013
Junqueira LC, Carneiro J. Basic Histology, 2010 Ross MH, Wojciech P. Histology A Text and Atlas, 2011 Pakurar AS, Bigbee JW. Digital Histology, 2009 Mitchell BS, Peel A. Histology. An illustrated colour text, 2009
Alberts B and al. Molecular Biology of the cell, 2008 Kierszenbaum AL. Histology and Cell Biology, 2007 Gartner LP, Hiatt JL. Color Atlas of Histology, 2007
Pollard TD, Earnshaw WC. Cell Biology, 2004 Stevens A, Lowe J. Histology, 2004