Curs Tesut epitelial Studenti(2015)

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    ESUTUL

    EPITELIAL

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    ESUTUL EPITELIAL(epi = pe, deasupra thele = ridictur, mamelon)

    Mase celulare compacte

    www.udel.edu/biology

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    Epiteliile au o suprafa: liber

    n raport cu esutconjunctiv membranbazal

    ESUTUL EPITELIAL

    MB

    http://cnx.org

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    ESUTUL EPITELOID

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    ESUTUL EPITELIALmare diversitate ca form

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    Forme celularecilindric

    (columnar,prismatic)

    cubic

    turtit(scuamoas,

    pavimentoas)

    poliedre

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    Forme nucleare

    ovoidal

    rotund

    turtit

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    Limitele celulare ?ESUTUL EPITELIAL

    http:/www.kidneypathology.com

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    ESUTUL EPITELIAL

    mare diversitate ca funcie formeaznveliuri membranare asigurtransport selectiv de substane

    ntrn structura organelor solide /spongioase rol senzorial rol contractil

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    Ectoderm-epiderm i derivatele sale- glandele tegumentare- glande mamare- epiteliul bucal, anal, nazal- corneea- adenohipofiza

    Mezoderm-endoteliu- mezoteliu- epiteliul tubilor uriniferi

    - epiteliul cilor genitale- CSR

    Endoderm

    - epiteliul tubului digestiv- glandele digestive- epiteliul aparatului respirator- tiroida, paratiroidele, timusul

    ESUTUL EPITELIAL- Origine embriologic-

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    vascularizaie

    inervaie regenerare metaplazie

    ESUTUL EPITELIAL

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    VASCULARIZAIA EPITELIILOR

    http://ocw.tufts.edu

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    Stria vascularis

    www.cram.com

    VASCULARIZAIA EPITELIILOR

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    INERVAIA EPITELIILOR- Senzitiv

    ! Absena terminaiilor nervoasepentru durere:

    epiteliul gastric i intestinal

    epiteliul colului uterin

    - Motorie

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    REGENERAREA EPITELIILOR

    agresiuni din mediu mecanisme dereparare i rennoire

    celule stem adulte activitate mitoticnentrerupt

    localizare

    rata de nlocuire:

    - rapid- lent

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    CARACTERISTICILE CELULEISTEM ADULTE

    - Capacitatea de autoreplicare- Multipotena

    - Reconstrucia esutului

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    Diviziune asimetric

    CARACTERISTICILE CELULEISTEM ADULTE

    http://www.stembook.org

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    IDENTIFICAREACELULEI STEM ADULT

    - marcarea materialului genetic- precursori radioactivi (timidina tritiat)

    - imunocitochimie- nucleozide sintetice (bromodeoxiuridina)

    - marker de suprafa(CD34+, integrin6-)

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    IDENTIFICAREA

    CELULEI STEM ADULTPRIN ICC

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    REGENERAREA EPITELIILOR- celule stem izolate-

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    REGENERAREA EPITELIILOR- zone germinative cu celule stem -

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    REGENERAREA EPITELIILOR- strat bazal (germinativ) -

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    METAPLAZIA ESUTULUIEPITELIAL

    - metaplazie pavimentoas-

    http://www.eurocitology.eu

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    CLASIFICAREA EPITELIILOR

    A. Epitelii de acoperire

    B. Epitelii glandulareC. Epitelii senzoriale

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    EPITELII DE ACOPERIRE

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    EPITELII DE ACOPERIREClasificare:

    1. dupnumrul de straturi celulare2. dupforma celulelor

    A. Epitelii simple B. Epitelii stratificate

    - pavimentoase - pavimentoase

    cheratinizat

    necheratinizat

    - cubice - cubice

    - cilindrice - cilindrice

    Rol:

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    - endoteliu: epiteliul care cptueste vaselesangvine i limfatice- mezoteliu: epiteliul care intra n alctuirea

    seroaselor

    Epiteliu simplu pavimentos

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    Epiteliu pseudostratificat cilindric

    www.nku.edu

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    Epiteliu pseudostratificat cilindric

    http://www.stegen.k12.mo.us

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    Epiteliu pseudostratificat cilindric

    http:/medcell.med.yale.edu

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    Epiteliu de tranziie

    (uroteliu, epiteliu polimorf)

    www.nku.edu

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    Epiteliul cilor urinare

    Epiteliu de tranziie

    (uroteliu, epiteliu polimorf)

    http:/www.gettyimages.com

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    Epiteliu de tranziie

    (uroteliu, epiteliu polimorf)

    http://canvasworksneedlepoint.com

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    Epiteliu de tranziie

    (uroteliu, epiteliu polimorf)

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    http://canvasworksneedlepoint.com

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    EPITELII GLANDULARE

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    ELIMINAREA PRODUSULUI DE

    SECREIE1. celulexocrinn mediul extern

    2. celulendocrinn mediul intern

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    HISTOGENEZA EPITELIULUIGLANDULAR

    Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005

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    GLANDE- exocrine

    - endocrine- mixte (amficrine)

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    CLASIFICAREA GLANDELOREXOCRINE

    1. Structural:a. dup numrul de celule

    - glande unicelulare celula caliciform- glande multicelulare

    localizate ntr-un epiteliu de nveli

    epiteliu secretor de nveli

    grupuri compacte (acini, tubi)

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    Glandunicelular

    Leslie P.Gartner, James L.Hiatt Color Atlas of Histology, Fifth Edition, 2010

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    Glandintraepitelial

    Leslie P.Gartner, James L.Hiatt Color Atlas of Histology, Fifth Edition, 2010

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    Epiteliu secretor

    http://citochemistry.net

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    Glandmulticelular

    http//medicinembbs.blogspot.ro

    CLASIFICAREA GLANDELOR

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    CLASIFICAREA GLANDELOR

    EXOCRINE1. Structural:

    b. dupaspectul sistemului canalicular simple

    compuse

    CLASIFICAREA GLANDELOR

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    CLASIFICAREA GLANDELOR

    EXOCRINE1. Structural:

    c. dupaspectul adenomerului tubulare

    acinoase sau alveolare

    tubuloacinoase sau tubuloalveolare

    CLASIFICAREA GLANDELOR

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    CLASIFICAREA GLANDELOR

    EXOCRINE

    Leslie P.Gartner, James L.Hiatt Color textbook of Histology, Third Edition, 2007

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    CLASIFICAREA GLANDELOREXOCRINE

    2. Dupnatura produsului de secreie:- glande cu secreie mucoas

    - glande cu secreie seroas

    - glande cu secreie mixt muco-seroas

    sero-mucoas

    - glande cu secreie uleioas

    CLASIFICAREA GLANDELOR

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    CLASIFICAREA GLANDELOR

    EXOCRINE3. Dupmecanismul de excreie:

    a. glande merocrine (meros, parte)- majoritatea glandelor exocrine

    b. glande apocrine (apo, din)- glandele mamare

    - glandele ceruminoase- glandele Moll

    c. glande holocrine (holos, tot)

    - glandele sebacee

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    GLANDELE ENDOCRINE

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    GLANDELE ENDOCRINE- lipsete sistemul canalicular

    - majoritatea sunt de origine epitelial > MB- produsul de secreie este eliminat direct

    n mediul intern:

    - imediat dupsintez

    - dupo perioadde stocare

    - intracelular granule de secreie- extracelular

    CLASIFICAREA GLANDELOR

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    CLASIFICAREA GLANDELOR

    ENDOCRINE1. Dupmodul de dispunere al celulelor

    secretorii:- cuiburi celulare

    - cordoane celulare

    - foliculi

    CLASIFICAREA GLANDELOR

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    CLASIFICAREA GLANDELOR

    ENDOCRINE1. Dupmodul de dispunere al celulelor

    secretorii2. Dupnatura chimica produsuluisintetizat:

    - polipeptide mici i amine (SNED)

    - polipeptide mari sau proteine/glicoproteine

    - steroizi

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    GLANDE MIXTE (AMFICRINE)

    Funciile exocrini endocrinse pot desfura:

    - n segmente secretoare diferite pancreas

    - n acelai segment secretor ficat

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    PANCREAS

    Acini pancreatici

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    FICAT

    BBBBilililil

    ---- SomatomedineSomatomedineSomatomedineSomatomedine

    ---- GHRHGHRHGHRHGHRH

    POLARITATEA CELULEI

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    POLARITATEA CELULEI

    EPITELIALE

    Domeniul apical

    Domeniul laterobazal

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    POLARITATEA CELULEIEPITELIALE

    1. Asimetria biochimica domeniilor membranare2. Formarea de jonciuni strnse3. Distribuia componentelor citoscheletuluii a

    organitelor celulare4. Stabilirea de interaciuni celulare

    1. ASIMETRIA BIOCHIMIC A

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    SUPRAFEELOR MEMBRANAREComponenta membranar Membrana apical Membrana laterobazal1. PROTEIN-ENZIME Enzime hidrolitice Na +/K+ATP-aza

    2. PROTEINE DETRANSPORT ICANALE IONICE

    prezente prezente

    3. PROTEINE DE

    ADEZIVITATE

    absente prezente (caderine,integrine)

    4. RECEPTORI HORMONALI abseni insulin, parathormon,factor de cretere

    epidermal

    5. COLESTEROL crescut sczut6. SFINGOMIELIN crescut sczut

    7. FOSFATIDILCOLIN sczut crescut

    8. FOSFATIDILINOZITOL sczut crescut

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    BOALA RINICHIULUI POLICHISTIC

    Redistribuie apicala Na+/K+ ATP-azei i REGF

    http://www.pathologyoutlines.com

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    2. FORMAREA DE JONCIUNI STRNSE

    - secreie- absorbie

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

    Jonciunea strns

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    Jonciunea strns

    (Zonula occludens)

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

    Jonciunea strns

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    Jonciunea strns

    (Zonula occludens)

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

    Jonciunea strns

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    Jonciunea strns

    (Zonula occludens)

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

    Jonciunea strns

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    (Zonula occludens)- Rol:

    - genereazi menine domeniilor membranare- previne micarea laterala proteinelormembranare

    - formeaz o barierimpermeabil

    3. DISTRIBUIA COMPONENTELORCITOSCHELETULUI I A

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    CITOSCHELETULUI I AORGANITELOR CELULARE

    EM Fisch, BA Molitoris 1994

    3. DISTRIBUIA COMPONENTELORCITOSCHELETULUI I A

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    CITOSCHELETULUI I AORGANITELOR CELULARE

    Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005

    3. DISTRIBUIA COMPONENTELORCITOSCHELETULUI I A

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    CITOSCHELETULUI I AORGANITELOR CELULARE

    B.Alberts et al. Molecular Biology of the Cell 5th Edition, 2008

    4. INTERACIUNI CELULARE

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    Molecule de adezivitate celular

    contactcelul-celul

    contact contactcelul-substrat celul -substrat

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

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    4. INTERACIUNI CELULARE

    Molecule de adezivitate celular molecule cu activitate Ca

    2+dependent

    -caderine

    - selectine

    molecule cu activitate Ca2+ independent

    - integrine

    - molecule din superfamilia Ig

    CADERINA E

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    me

    mbranaplas

    maticl

    atera

    l

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

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    CADERINE

    jonciuni de ancorare din domeniul lateral

    1. zonula adherens

    caderina E

    2. macula adherens (desmozom)

    desmocolin, desmoglein

    Jonciuni de ancorare dindomeniul lateral

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    caderina E

    desmocolin

    desmoglein

    filamentde actin

    filamenteintermediare

    proteine deancorare

    citoplasmatice

    proteine deancorare

    citoplasmatice

    Macula adherens(Desmozom)

    Zonula adherens

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

    INTEGRINE

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    membrana plasmaticbazal

    laminina, fibronectina

    subunitatea

    subunitatea

    NH2 NH2

    COOH COOH

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

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    Jonciuni de ancorare dindomeniul bazal

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    proteinede ancorare

    citoplasmatice

    proteinede ancorare

    citoplasmatice

    filamente intermediare

    integrin(64)

    colagen XVII

    laminin

    colagen

    filamentde actin

    Jonciune de ancorare prin

    filamente de actinHemidesmozom

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

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    Rolul caderinelor

    meninerea integrit

    ii straturilor dintr-un

    epiteliu asigurrezistena mecanica epiteliului

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    Rolul integrinelor

    ataarea polului bazal la matricea

    extracelular mecanosenzitivitate

    !!! eseniale n timpul embriogenezeidisintegrine

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    PEMFIGUS VULGARIS

    http://www.dermpedia.org

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    MEMBRANA BAZAL

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    ESUT EPITELIAL

    !!!orice epiteliu este ancorat la

    esutul

    conjunctiv adiacent prin membrana bazal

    strat distinct al matriceiextracelulare acelular,

    amorf i dens

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    MEMBRANA BAZAL Examinare la MO

    grosime variat- col.HE- PAS- impregnare argentic

    aspect variat- structurliniar- structurondulat

    ep. stratificate pavimentoase

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    MEMBRANA BAZAL - col HE

    http://www.ouhsc.edu

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    MEMBRANA BAZAL - PAS

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    MEMBRANA BAZAL

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    - Impregnare argentic-

    http://www.nature.com

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    MEMBRANA BAZAL

    Examinare la ME

    LAMINA BAZAL

    LAMINA RETICULAR

    MEMBRANA BAZAL - ME

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    http://www.cellimagelibrary.org

    1. LAMINA BAZAL

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    1. regiune electronotransparent lamina lucida

    2. regiune electronodens lamina densa

    histology.leeds.ac.uk

    1. LAMINA BAZAL

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    1. regiune electronotransparent lamina lucida ~ 50 nm domeniile extracelulare ale

    moleculelor de adezivitate

    - integrine- distroglicani

    glicoproteine extracelulare- laminina- entactina

    2. regiune electronodens lamina densa

    reea de filamente finecolagen tip IV acoperit de perlecan

    1. LAMINA BAZAL

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    Lamina bazal= Lamina densa ?

    !!! Lamina lucida - artefact de fixare?

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    1. LAMINA BAZAL

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    - MEMBRANA DE FILTRARE -

    Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013

    1. LAMINA BAZAL

    MEMBRANA ALVEOLO CAPILAR

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    - MEMBRANA ALVEOLO-CAPILAR-

    Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013

    1. LAMINA BAZAL

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    structurnumai a esutului epitelial ?

    celule asociate cu esut conjunctiv

    - celule musculare

    - celule Schwann

    - celule adipoase

    lamina externa

    Lamina externa

    C l l l C l l S h

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    Celula muscular Celula Schwann

    http://www.gettyimage.com

    1. LAMINA BAZALcompoziie chimic: 50 tipuri de proteine

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    - compoziie chimic: ~ 50 tipuri de proteine1. proteine fibroase GP

    - laminin- colagen tip IV

    - entactin(nidogen)

    2. proteoglicani- perlecan heparan sulfat

    celule epiteliale

    Laminina 1laminin

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    laminin

    laminin

    integrin

    distroglican

    entactin perlecan

    lamininB.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

    polimer

    de laminin

    Molecula de colagen IV

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    3 lanuri

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    Colagen IV

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    Lanpolipeptidic

    (Monomer de colagen IV)

    domeniu 7S

    domeniu colagenic helicoidaldomeniu NC1

    NH2

    COOH

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    Colagen IV

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    domeniu 7S

    domeniu NC1domeniu colagenic helicoidal

    trimer NC1

    Protomer de colagen IV

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    Colagen IV

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    Protomer de colagen IV(3 lanuri )

    trimer NC1

    hexamer NC1

    Dimer de colagen IV

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    Colagen IV

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    Dimer de colagen IV

    hexamer NC1

    Tetramer de colagen IV

    7S

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    Colagen IV

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    Tetramer de colagen IV

    7S

    hexamer NC17S

    Suprastructura de colagen IV

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    ORGANIZAREA LAMINEIBAZALE

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    http://virtuallaboratory.colorado.edu

    1. LAMINA BAZAL

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    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    ANCORAREA LAMINEI BAZALELA MATRICEA EXTRACELULAR

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    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    ANCORAREA LAMINEI BAZALELA MATRICEA EXTRACELULAR

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    http:mattek.com

    2. LAMINA RETICULAR

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    colagen tip III

    fibre reticulare

    colagen tip I

    fibre de colagen

    fibroblaste

    fibroblaste

    ROLURILE MEMBRANEI BAZALE

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    ROLURILE MEMBRANEI BAZALE Ataarea epiteliului la esutul conjunctiv

    Compartimentalizare Bariercu permeabilitate selectiv

    ! GAG

    Menine citoarhitectonica i polaritateaepiteliului Controleazdiferenierea, proliferarea

    i migrarea celulelor epiteliale

    LAMINA BAZAL

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    celulepitelial

    laminabazal

    colagen

    B.Alberts et al. Molecular Biology of the Cell Fifth Edition, 2008

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    I. Celule epiteliale specializate

    pentru transport- ioni

    - molecule mici- macromolecule

    I.1. Celule epiteliale specializate

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    Celule epiteliale specializatepentru transport de ioni

    pompe ionice

    (activitate ATP-azic)

    Pompa Na+/K+

    (Na+/K+ATP-aza)

    Celula epitelial din tubulcontort proximal

    P ti l iti t t l

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    Particulariti structurale:MO:

    - citoplasmacidofil- la polul apical: margine n perie

    - la polul bazal: aspect striat

    Particulariti structurale

    Celula epitelial din tubulcontort proximal

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    Particulariti structurale:ME:

    numeroi microvili la polul apical invaginri ale membranei plasmatice bazale

    creterea suprafeei active membranare(pompa Na+/K+)

    mitocondrii alungite cu numeroase criste

    jonciuni strnse interdigitaii laterale

    Celula epitelial din tubul

    contort proximal

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    p

    Leslie P.Gartner, James L.Hiatt Color Atlas of Histology, Fifth Edition, 2010

    Celula epitelial din tubul

    contort proximal

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    p

    R V Krstic Human Microscopic Anatomy, Springer-Verlag,1997

    Celula epitelial din tubul

    contort proximal

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    p

    Michael H.Ross, Wojciech Pawlina Histology A text and Atlas, Sixth Edition, 2011

    Celula epitelial din tubulcontort proximal

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    H2O Na+

    Celula epitelial din tubulcontort proximal

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    sensul de transport:

    I. Celule epiteliale specializatepentru transport de ioni

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    pol apical pol bazal

    absorbie

    pol bazal pol apical

    secreie

    - intestin

    - vezicula biliar

    - canale striate

    - TP i TD

    - plexuri coroide

    - procese ciliare

    - gl. sudoripare

    II. Celule epiteliale specializate

    pentru sintezi secreie

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    Duplocul de eliminare a produsului sintetizat:

    - celule exocrine- celule endocrine- celule paracrine

    Dupnatura produsului sintetizat:- proteine

    - glicoproteine- amine i polipeptide mici- lipide

    II.1. Celule epiteliale specializate

    pentru sintezi secreie deproteine

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    p

    celulexocrini endocrin rolul proteinelor sintetizate: enzime digestive celule seroase

    proteine plasmatice hormoni

    secreia de proteine: continu intermitent granule de secreie

    P i l i i l

    Celula epitelial din acinul

    pancreatic

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    Particulariti structurale

    - MO: polaritate tinctorial(col.HE)

    - citoplasma bazofil(pol bazal)

    - citoplasma acidofil(pol apical)

    Celula epitelial din acinul

    pancreatic

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    Celula epitelial din acinul

    pancreatic

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    Celula epitelial din acinul

    pancreaticP ti l iti t t l

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    Particulariti structurale

    - ME: RER subnuclear mitocondrii printre RER

    complex Golgi supranuclear granule de secreie n zona apical

    Celula epitelial din acinul pancreatic

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    Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013

    Etapele ciclului secretor ncelula epitelial din acinul

    pancreatic

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    asimilarea aminoacizilor liberi

    sinteza lanului polipeptidic la nivelulribozomilor din RER

    acumularea produsului de sintezn CG formarea granulelor de secreie (gr. de zimogen) transportul granulelor de secreie spre polul

    apical eliminarea produsului de secreie prin exocitoz

    transportulgr. de zimogen

    exoc toz

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    asimilarea aminoacizilor liberi

    sinteza lanului polipeptidic

    acumularea produsuluide sintez

    formarea gr. de zimogen

    II.2. Celule epiteliale specializate pentru

    sintezi secreie de glicoproteine celul exocrin i endocrin

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    celulexocrini endocrin

    localizare: celule exocrine celule mucoase

    celula caliciform epitelii de suprafa acini mucoi

    celule endocrine celule din adenohipofiz(TSH, Gn)

    Particulariti structurale- MO:

    Celula caliciform

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    formde caliciu (cup)

    nucleu pol bazal citoplasma apical aspect vacuolar

    gr. de mucin

    PAS

    Celula caliciform

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    Celula caliciform

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    Particulariti structurale- ME:

    RER subnuclear

    Celula caliciform

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    RER subnuclear

    mitocondrii printre RER complex Golgi supranuclear granule de secreie

    destind zona apical rari microvili apicali

    proces de secreie

    Celula caliciform

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    Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013

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    II.3. Celule epiteliale specializate

    pentru sintezi secreie deamine i polipeptide mici

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    celulendocrini paracrin celule APUD (Amine Precursor Uptake

    and Decarboxilation)

    localizare: distribuie larg

    izolate / grupuri mici, intraepitelial

    Particulariti structurale

    II.3. Celulepitelialspecializatpentrusinteza i secreia de amine

    i polipeptide mici

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    MO: citoplasma slab bazofil(col.HE)

    precipitare cu sruri de argint

    (celule argentafine i argirofile)

    oxidare cu bicromat de potasiu(celule cromafine)

    imunocitochimie:- anticorpi monoclonali

    - markeri:- NSE (enolaza neuronalspecific)- cromogranine / secretogranine

    hibridizare in situ

    II.3. Celulepitelialspecializatpentrusinteza i secreia de amine

    i polipeptide mici

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    Leslie P.Gartner, James L.Hiatt Color textbook of Histology, Third Edition, 2007

    Particulariti structurale

    MO

    II.3. Celulepitelialspecializatpentrusinteza i secreia de amine

    i polipeptide mici

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    - MO

    - ME:- RER i complex Golgi slab dezvoltate- granule de secreie:

    form

    variat dimensiune variat

    endomembrane, miez dens, halou clar

    aglomerate spre polul bazal exocitoz discontinu

    PrecursoriAmine

    Polipeptide mici

    Cromogranine/Secretogranine

    ATP, ioni

    Celulde tip nchisCelulde tip deschis

    II.3. Celulepitelialspecializatpentrusinteza i secreia de amine

    i polipeptide mici

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    pp

    Anthony L.Mescher Junqueira s Basic Histology Text and Atlas 13th Edition, 2013

    II.4. Celule epiteliale specializate pentru

    sintezi secreie de lipide celulexocrini endocrin

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    localizare: celule exocrine glande sebacee (sebum) celule endocrine celule secretoare de

    hormoni steroizi: celule interstiiale Leydig (testicul) celule foliculare i luteinice (ovar)

    celule din CSR

    Celul epitelial secretoare desteroizi

    Particulariti structurale

    - MO:

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    citoplasma - acidofil- aspect vacuolar

    picturi lipidice

    - precursori ai hormonilor- variaz cantitativ

    Celul epitelial secretoare desteroizi

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    Particulariti structurale

    - MO

    Celul epitelial secretoare desteroizi

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    - ME: REN mitocondrii cu criste tubulo-veziculare

    relaii structurale i funcionale

    REN

    acetat colesterol pregnenolon

    RENhormon sterolic

    mitocondrie

    Celul epitelial secretoare desteroizi

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    Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005

    Celul epitelial secretoare desteroizi

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    Luiz Carlos Junqueira, Jose Carneiro Basic Histology Text and Atlas 11th Edition, 2005

    III. Celule epiteliale cu propieticontractile

    (Celule mioepiteliale)

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    Localizare: ntre lamina bazali membranaplasmaticbazala celulelor din: glandele lacrimale

    glandele salivare glandele mamare glandele sudoripare

    adenomeri /ducte

    III. Celule mioepiteliale

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    http;//en.goldenmap.com

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    Bibliografie selectiv: Anthony L.Mescher Junqueira s Basic Histology Text and

    Atlas 13th Edition 2013

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    Atlas13th Edition, 2013

    Junqueira LC, Carneiro J. Basic Histology, 2010 Ross MH, Wojciech P. Histology A Text and Atlas, 2011 Pakurar AS, Bigbee JW. Digital Histology, 2009 Mitchell BS, Peel A. Histology. An illustrated colour text, 2009

    Alberts B and al. Molecular Biology of the cell, 2008 Kierszenbaum AL. Histology and Cell Biology, 2007 Gartner LP, Hiatt JL. Color Atlas of Histology, 2007

    Pollard TD, Earnshaw WC. Cell Biology, 2004 Stevens A, Lowe J. Histology, 2004