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SEPSIS

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Leziuni

persistente

la cel putinun organ

FIZIOPATOLOGIA STARII DE SEPTICEMIE

SI A SOCULUI INFECTIOS

Bacil Gram negativ

Peptidoglican

Macrofage

Liza bacterian

Membrana citoplasmatica interna

Membrana externa (lipopolizaharide)

Activarea neutrofilelor,

eliberare de radicali

oxigenati si de proteaze

Activare

plachetara

Metabolismul acidului

arahidonic, eliberare de

tromboxani A2,

prostaglandine,

leucotriene.

Eliberare de limfociteT de IL2, interferon g,

GMCSF

TNF a,

IL-1

IL-6

etc.

Activarea

coagularii

complementului

Leziuni

endotelialeSEPSIS

Raspuns

inflamatorgeneral

SINDROM

SEPTICLeziuni persistente la

cel putin un organ si

hipotensiune

SOC

SEPTIC

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Forme de Sepsis:

- Forma medie

- Forma severa

- Forma ultra severa

CID

MSOF

SOC INFECTIOS SOC IREVERSIBIL

DECES

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SOCUL INFECTIOS

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SIRS +HoTAs (< 90mmHg MX sau cu 40 mmHg >

comparativ cu TA N timp de 1 ora fara alta cauza

infectioasa

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